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Search results 3701 to 3800 out of 6467 for Myc

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Type Details Score
Genotype
Symbol: Brca1/Brca1 Tg(LGB-cre)74Acl/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(Prrx1-Hand2)7Eno/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(HCRT-MJD)1Stak/?
Background: B6.Cg-Tg(HCRT-MJD)1Stak
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(PF4MER)6Kra/?
Background: FVB/N-Tg(PF4MER)6Kra
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(IghMyc)22Bri/? Xiap/Xiap
Background: B6.Cg-Xiap Tg(IghMyc)22Bri
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kat5/Kat5<+> Tg(IghMyc)22Bri/? Trp53/Trp53<+>
Background: involves: 129 * C57BL * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(HCRT-MJD)1Stak/?
Background: involves: C57BL/6 * DBA/1
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(IghMyc)186Brn/? Rpl24/Rpl24<+>
Background: involves: C57BL/LiA * C57BLKS * CBA/BrA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(MMTV-Cdc37)1Stp/? Tg(MMTV-Myc)141-3Led/?
Background: involves: C57BL/6 * CD-1 * DBA/2 * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Osr2/Osr2
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mdm4/Mdm4<+> Tg(IghMyc)22Bri/?
Background: involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Vim*R113C)1Tmm/?
Background: B6.CBA-Tg(Vim*R113C)1Tmm
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Pkd1/Pkd1
Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Tg(Alb1-Ren)3Unc/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Apc/Apc<+> Del(15Rr357-Rr303293)2Jta/Del(15Rr357-Rr303293)2Jta
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Plcg2/Plcg2 Tg(IghMyc)22Bri/?
Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Plxna4/Plxna4<+> Sema6a/Sema6a<+>
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(EEF1A1-Socs6)1Pwg/?
Background: B6.129P2-Tg(EEF1A1-Socs6)1Pwg
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(EEF1A1-Socs6)2Pwg/?
Background: B6.129P2-Tg(EEF1A1-Socs6)2Pwg
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Bcl2l11/Bcl2l11<+> Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bcl2l11/Bcl2l11 Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bcl2l11/Bcl2l11<+> Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bcl2l11/Bcl2l11 Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bcl2l11/Bcl2l11<+> Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bcl2l11/Bcl2l11 Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-TARDBP)96Dwc/?
Background: involves: C57BL/6 * C3H
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APOE-FGF23*R176Q)#Ack/?
Background: involves: C57BL/6J * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-TARDBP*M337V)106Dwc/?
Background: involves: C57BL/6 * C3H
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Apc/Apc<+> Rr21/Rr21<+>
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Trp53/Trp53<+> Tg(IghMyc)22Bri/?
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Igs2/Igs2
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Bok/Bok Tg(IghMyc)22Bri/?
Background: involves: BALB/cJ * C57BL * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Il6/Il6 Tg(H2-K-IL6)2Srj/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-TARDBP)96Dwc/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Myh6-Mybpc3*)24Rbns/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Myh6-MYL2*E22K)4Dsc/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/? Tg(Atoh1-cre)1Bfri/?
Background: B6.Cg-Gt(ROSA)26Sor Tg(Atoh1-cre)1Bfri/Btar
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(GFAP-tTA)110Pop/? Tg(tetO-DISC1*)1302BPlet/?
Background: B6.Cg-Tg(GFAP-tTA)110Pop Tg(tetO-DISC1*)1302BPlet
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Cebpb-tTA)5Bjd/? Tg(tetO-MYC,-OVAL)#Gtgm/?
Background: B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Trp53/Trp53<+> Tg(IghMyc)22Bri/?
Background: involves: 129 * C57BL * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(BCL2)36Wehi/? Tg(IghMyc)22Bri/? Zfp574/Zfp574
Background: B6.Cg-Zfp574 Tg(BCL2)36Wehi Tg(IghMyc)22Bri
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Rho-cre)2Yzl/?
Background: involves: 129 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: B6;129-Gt(ROSA)26Sor/J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Bienz B
Year: 1984
Journal: EMBO J
Title: Analysis of the gene coding for the murine cellular tumour antigen p53.
Volume: 3
Issue: 9
Pages: 2179-83
Publication
First Author: Kawauchi D
Year: 2012
Journal: Cancer Cell
Title: A mouse model of the most aggressive subgroup of human medulloblastoma.
Volume: 21
Issue: 2
Pages: 168-80
Publication
First Author: Gustafson WC
Year: 2014
Journal: Cancer Cell
Title: Drugging MYCN through an allosteric transition in Aurora kinase A.
Volume: 26
Issue: 3
Pages: 414-427
Publication
First Author: Trimboli AJ
Year: 2008
Journal: Cancer Res
Title: Direct evidence for epithelial-mesenchymal transitions in breast cancer.
Volume: 68
Issue: 3
Pages: 937-45
Publication
First Author: Christensen CL
Year: 2014
Journal: Cancer Cell
Title: Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
Volume: 26
Issue: 6
Pages: 909-922
Publication
First Author: Yoneda Y
Year: 1993
Journal: Neurosci Lett
Title: Selectively high expression of the transcription factor AP1 in telencephalic structures of epileptic E1 mice.
Volume: 161
Issue: 2
Pages: 161-4
Publication
First Author: Shen-Li H
Year: 2000
Journal: Genes Dev
Title: Essential role for Max in early embryonic growth and development.
Volume: 14
Issue: 1
Pages: 17-22
Publication  
First Author: Zacarías-Fluck MF
Year: 2021
Journal: Life Sci Alliance
Title: The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
Volume: 4
Issue: 5
Publication  
First Author: Screen M
Year: 2024
Journal: Life Sci Alliance
Title: RNA helicase EIF4A1-mediated translation is essential for the GC response.
Volume: 7
Issue: 2
Publication
First Author: Benitah SA
Year: 2005
Journal: Science
Title: Stem cell depletion through epidermal deletion of Rac1.
Volume: 309
Issue: 5736
Pages: 933-5
Publication
First Author: Strasser A
Year: 1993
Journal: Oncogene
Title: E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.
Volume: 8
Issue: 1
Pages: 1-9
Publication
First Author: Wang B
Year: 2019
Journal: Cell Rep
Title: Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4.
Volume: 27
Issue: 12
Pages: 3473-3485.e5
Publication
First Author: Gu Y
Year: 2017
Journal: Cancer Cell
Title: Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Volume: 32
Issue: 1
Pages: 115-128.e7
Publication
First Author: Fan H
Year: 1996
Journal: FEBS Lett
Title: A link between ferritin gene expression and ribonucleotide reductase R2 protein, as demonstrated by retroviral vector mediated stable expression of R2 cDNA.
Volume: 382
Issue: 1-2
Pages: 145-8
Publication
First Author: Wanzel M
Year: 2008
Journal: Nat Cell Biol
Title: A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
Volume: 10
Issue: 9
Pages: 1051-61
Publication
First Author: Arvanitis C
Year: 2005
Journal: Cancer Lett
Title: Conditionally MYC: insights from novel transgenic models.
Volume: 226
Issue: 2
Pages: 95-9
Publication
First Author: Adler AS
Year: 2006
Journal: Nat Genet
Title: Genetic regulators of large-scale transcriptional signatures in cancer.
Volume: 38
Issue: 4
Pages: 421-30
Publication
First Author: Lindeman GJ
Year: 1994
Journal: Immunity
Title: B-lymphoid to granulocytic switch during hematopoiesis in a transgenic mouse strain.
Volume: 1
Issue: 6
Pages: 517-27
Publication
First Author: Kuehl WM
Year: 2008
Journal: Cancer Cell
Title: Modeling multiple myeloma by AID-dependent conditional activation of MYC.
Volume: 13
Issue: 2
Pages: 85-7
Publication
First Author: Borrello MG
Year: 2008
Journal: Cancer Lett
Title: Inflammation and cancer: the oncogene-driven connection.
Volume: 267
Issue: 2
Pages: 262-70
Publication
First Author: Beltran H
Year: 2014
Journal: Mol Cancer Res
Title: The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential.
Volume: 12
Issue: 6
Pages: 815-22
Publication
First Author: Mustachio LM
Year: 2020
Journal: Cancer Res
Title: Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers.
Volume: 80
Issue: 10
Pages: 1905-1911
Publication  
First Author: Winkler R
Year: 2022
Journal: Cells
Title: Lessons from Using Genetically Engineered Mouse Models of MYC-Induced Lymphoma.
Volume: 12
Issue: 1
Publication
First Author: Le Good JA
Year: 1998
Journal: Science
Title: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Volume: 281
Issue: 5385
Pages: 2042-5
Publication
First Author: Beringer M
Year: 2016
Journal: Mol Cell
Title: EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells.
Volume: 64
Issue: 4
Pages: 645-658
Protein
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
Publication
First Author: Comino-Méndez I
Year: 2011
Journal: Nat Genet
Title: Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.
Volume: 43
Issue: 7
Pages: 663-7
Publication  
First Author: Mejia-Martinez F
Year: 2017
Journal: Genes (Basel)
Title: The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans.
Volume: 8
Issue: 11
Publication
First Author: Johnson DW
Year: 2014
Journal: PLoS Genet
Title: The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals.
Volume: 10
Issue: 4
Pages: e1004278
Publication
First Author: Casamayor A
Year: 1999
Journal: Curr Biol
Title: Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
Volume: 9
Issue: 4
Pages: 186-97
Publication
First Author: Gräub R
Year: 2003
Journal: J Basic Microbiol
Title: Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Volume: 43
Issue: 6
Pages: 473-82
Publication
First Author: Bimbó A
Year: 2005
Journal: Mol Biol Cell
Title: Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Volume: 16
Issue: 7
Pages: 3162-75
Publication
First Author: Alessi DR
Year: 1997
Journal: Curr Biol
Title: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Volume: 7
Issue: 4
Pages: 261-9
Publication  
First Author: Currie RA
Year: 1999
Journal: Biochem J
Title: Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
Volume: 337 ( Pt 3)
Pages: 575-83
Publication  
First Author: Di Blasio L
Year: 2017
Journal: Cancers (Basel)
Title: Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination.
Volume: 9
Issue: 3
Publication  
First Author: Gagliardi PA
Year: 2018
Journal: Semin Cancer Biol
Title: PDK1: At the crossroad of cancer signaling pathways.
Volume: 48
Pages: 27-35
Publication  
First Author: Kobayashi T
Year: 1999
Journal: Biochem J
Title: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
Volume: 339 ( Pt 2)
Pages: 319-28
Publication
First Author: Fiory F
Year: 2005
Journal: Mol Cell Biol
Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
Volume: 25
Issue: 24
Pages: 10803-14
Publication
First Author: Mora A
Year: 2005
Journal: Biochem J
Title: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
Volume: 385
Issue: Pt 3
Pages: 639-48
Protein Domain
Type: Family
Description: This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [], and Ksg1 []and Ppk21 from S. pombe [].PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [, ]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) []and the members of protein kinase C (PKC) family []. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc []. It is a key regulator of cell migration and tumor invasion []. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling []. Deficiency of PDK1 in liver results in glucose intolerance [].
Protein Domain
Type: Family
Description: In mouse embryonic stem cells (mESCs), the transcriptional network can be divided into three functionally distinct modules: Polycomb, Core, and Myc, and the Polycomb module represses developmental genes []. This family includes the polycomb repressive complex 2-associated factor EPOP (Elongin BC and Polycomb Repressive Complex 2 (PRC2) Associated Protein, also termed C17orf96, esPRC2p48, E130012A19Rik), a scaffold protein expressed in the inner cell mass of the mouse blastocyst serving as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex, and fine-tuning the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells. Both EPOP and Elongin BC are required to maintain low levels of expression at PRC2 genomic targets []. EPOP interacts with the H2B deubiquitinase USP7 to modulate transcriptional processes in mESCs similar to MYC [].Another member of the family is the uncharacterized SKI/DACH domain-containing protein 1.
Protein Domain
Type: Family
Description: Protein max is a transcription regulator that forms a complex with MYC or MAD []. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. MAX is also a component of the E2F6.com-1 []and MLL1 complexes []. Mutations in the MAX gene are associated with hereditary pheochromocytoma, which is a tumour of the chromaffin tissue of the adrenal medulla or sympathetic paraganglia resulting in hypertension [].This entry also includes Mxl-1 and Mxl-3 from Caenorhabditis elegans. Mxl-1 forms complexes with Mdl1. The Mdl-1:Mxl-1 complex functions in both the insulin signaling and dietary restriction pathways and is involved in the control of lifespan in response to dietary restriction []. Mxl-3 is a transcription factor that modulates the inhibition of lipolysis. It also regulates lipid metabolism during nutritional excess [].
Publication
First Author: Ou XM
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.
Volume: 103
Issue: 29
Pages: 10923-8
Protein
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
Publication
First Author: Chen K
Year: 2005
Journal: J Biol Chem
Title: R1, a novel repressor of the human monoamine oxidase A.
Volume: 280
Issue: 12
Pages: 11552-9
Publication
First Author: Bezsonova I
Year: 2009
Journal: Biochemistry
Title: Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.
Volume: 48
Issue: 44
Pages: 10542-8
Publication
First Author: Chan TS
Year: 2016
Journal: Cancer Res
Title: JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
Volume: 76
Issue: 9
Pages: 2802-12
Publication
First Author: Hendrix J
Year: 2014
Journal: J Biol Chem
Title: Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.
Volume: 289
Issue: 18
Pages: 12494-506
Publication
First Author: Maertens GN
Year: 2006
Journal: J Cell Sci
Title: Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.
Volume: 119
Issue: Pt 12
Pages: 2563-71