| Type |
Details |
Score |
| Genotype |
| Symbol: |
Lyn/Lyn<+> |
| Background: |
C57BL/6J-Lyn |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shih NY |
| Year: |
1999 |
| Journal: |
Science |
| Title: |
Congenital nephrotic syndrome in mice lacking CD2-associated protein. |
| Volume: |
286 |
| Issue: |
5438 |
| Pages: |
312-5 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, congenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peters I |
| Year: |
2006 |
| Journal: |
J Am Soc Nephrol |
| Title: |
IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
1644-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grunkemeyer JA |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency. |
| Volume: |
280 |
| Issue: |
33 |
| Pages: |
29677-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schiffer M |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. |
| Volume: |
279 |
| Issue: |
35 |
| Pages: |
37004-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JM |
| Year: |
2003 |
| Journal: |
Science |
| Title: |
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. |
| Volume: |
300 |
| Issue: |
5623 |
| Pages: |
1298-300 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Russo LM |
| Year: |
2013 |
| Journal: |
FEBS Lett |
| Title: |
Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin. |
| Volume: |
587 |
| Issue: |
22 |
| Pages: |
3738-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsuji K |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Re-characterization of the Glomerulopathy in CD2AP Deficient Mice by High-Resolution Helium Ion Scanning Microscopy. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
8321 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schiffer M |
| Year: |
2002 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Inhibitory smads and tgf-Beta signaling in glomerular cells. |
| Volume: |
13 |
| Issue: |
11 |
| Pages: |
2657-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saurus P |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
10731 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kuusela S |
| Year: |
2016 |
| Journal: |
Cell Death Dis |
| Title: |
Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. |
| Volume: |
7 |
|
| Pages: |
e2302 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tossidou I |
| Year: |
2012 |
| Journal: |
Mol Cell Biol |
| Title: |
CD2AP regulates SUMOylation of CIN85 in podocytes. |
| Volume: |
32 |
| Issue: |
6 |
| Pages: |
1068-79 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wasik AA |
| Year: |
2012 |
| Journal: |
Mol Biol Cell |
| Title: |
Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking. |
| Volume: |
23 |
| Issue: |
17 |
| Pages: |
3370-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tolvanen TA |
| Year: |
2015 |
| Journal: |
J Cell Sci |
| Title: |
Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. |
| Volume: |
128 |
| Issue: |
24 |
| Pages: |
4588-600 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cochran JN |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. |
| Volume: |
24 |
| Issue: |
23 |
| Pages: |
6667-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ojelade SA |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. |
| Volume: |
28 |
| Issue: |
7 |
| Pages: |
1799-1813.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tossidou I |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes. |
| Volume: |
282 |
| Issue: |
10 |
| Pages: |
7457-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Srivatsan S |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production. |
| Volume: |
191 |
| Issue: |
12 |
| Pages: |
5933-40 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 564, Anthony Rosenzweig |
| Allele Type: |
Transgenic |
| Attribute String: |
Constitutively active, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 20, Anthony Rosenzweig |
| Allele Type: |
Transgenic |
| Attribute String: |
Constitutively active, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hadas R |
| Year: |
2020 |
| Journal: |
JCI Insight |
| Title: |
Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells. |
| Volume: |
5 |
| Issue: |
22 |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 2, William Muller |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
leukocyte-associated Ig-like receptor 1; targeted mutation 1, John E Coligan |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 138, M Permutt |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
tensin 2; endonuclease-mediated mutation 1, Nobuya Sasaki |
| Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Rous sarcoma oncogene; targeted mutation 1, Goro Kato |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Rous sarcoma oncogene; targeted mutation 2, Goro Kato |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd2ap/Cd2ap |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd2ap/Cd2ap<+> |
| Background: |
Not Specified |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siyanova EY |
| Year: |
1994 |
| Journal: |
Oncogene |
| Title: |
Tyrosine kinase gene expression in the mouse small intestine. |
| Volume: |
9 |
| Issue: |
7 |
| Pages: |
2053-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ito Y |
| Year: |
1994 |
| Journal: |
Eur J Biochem |
| Title: |
Structural analysis of the functional gene and pseudogene encoding the murine granulocyte colony-stimulating-factor receptor. |
| Volume: |
220 |
| Issue: |
3 |
| Pages: |
881-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takata H |
| Year: |
2000 |
| Journal: |
Genes Cells |
| Title: |
A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors. |
| Volume: |
5 |
| Issue: |
1 |
| Pages: |
57-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sekerková G |
| Year: |
2003 |
| Journal: |
J Neurosci |
| Title: |
Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53. |
| Volume: |
23 |
| Issue: |
4 |
| Pages: |
1310-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li JM |
| Year: |
2007 |
| Journal: |
Mol Endocrinol |
| Title: |
Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. |
| Volume: |
21 |
| Issue: |
2 |
| Pages: |
499-511 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dahl ME |
| Year: |
2000 |
| Journal: |
Genes Cells |
| Title: |
Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis. |
| Volume: |
5 |
| Issue: |
2 |
| Pages: |
143-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Timson Gauen LK |
| Year: |
1996 |
| Journal: |
J Cell Biol |
| Title: |
Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization. |
| Volume: |
133 |
| Issue: |
5 |
| Pages: |
1007-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takemoto Y |
| Year: |
1996 |
| Journal: |
Int Immunol |
| Title: |
Distinct binding patterns of HS1 to the Src SH2 and SH3 domains reflect possible mechanisms of recruitment and activation of downstream molecules. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
1699-705 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johnson TM |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain. |
| Volume: |
275 |
| Issue: |
43 |
| Pages: |
33353-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu L |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. |
| Volume: |
272 |
| Issue: |
14 |
| Pages: |
8983-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamkin TD |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP. |
| Volume: |
272 |
| Issue: |
16 |
| Pages: |
10396-401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tridandapani S |
| Year: |
2002 |
| Journal: |
J Immunol |
| Title: |
Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. |
| Volume: |
169 |
| Issue: |
8 |
| Pages: |
4370-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nomme J |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1. |
| Volume: |
286 |
| Issue: |
50 |
| Pages: |
43352-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Delbrück H |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
An Src homology 3-like domain is responsible for dimerization of the repressor protein KorB encoded by the promiscuous IncP plasmid RP4. |
| Volume: |
277 |
| Issue: |
6 |
| Pages: |
4191-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feese MD |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain. |
| Volume: |
276 |
| Issue: |
8 |
| Pages: |
5959-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ziemnicka-Kotula D |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. |
| Volume: |
273 |
| Issue: |
22 |
| Pages: |
13681-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tu Y |
| Year: |
1998 |
| Journal: |
Mol Biol Cell |
| Title: |
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. |
| Volume: |
9 |
| Issue: |
12 |
| Pages: |
3367-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan M |
| Year: |
2006 |
| Journal: |
Oncogene |
| Title: |
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. |
| Volume: |
25 |
| Issue: |
23 |
| Pages: |
3286-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rouka E |
| Year: |
2015 |
| Journal: |
J Biol Chem |
| Title: |
Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). |
| Volume: |
290 |
| Issue: |
42 |
| Pages: |
25275-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yogo K |
| Year: |
2006 |
| Journal: |
Endocrinology |
| Title: |
Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. |
| Volume: |
147 |
| Issue: |
7 |
| Pages: |
3307-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki-Inoue K |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation. |
| Volume: |
276 |
| Issue: |
2 |
| Pages: |
1643-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
King TR |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of phosphatidylinositol 3'-kinase. |
| Volume: |
275 |
| Issue: |
46 |
| Pages: |
36450-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsui C |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF. |
| Volume: |
283 |
| Issue: |
47 |
| Pages: |
33006-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsuji S |
| Year: |
2001 |
| Journal: |
J Exp Med |
| Title: |
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. |
| Volume: |
194 |
| Issue: |
4 |
| Pages: |
529-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aspenström P |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. |
| Volume: |
312 |
| Issue: |
12 |
| Pages: |
2180-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tridandapani S |
| Year: |
1999 |
| Journal: |
J Immunol |
| Title: |
Protein interactions of Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP): association with Shc displaces SHIP from FcgammaRIIb in B cells. |
| Volume: |
162 |
| Issue: |
3 |
| Pages: |
1408-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Andrews TD |
| Year: |
2012 |
| Journal: |
Open Biol |
| Title: |
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. |
| Volume: |
2 |
| Issue: |
5 |
| Pages: |
120061 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rizzuto G |
| Year: |
2022 |
| Journal: |
Nature |
| Title: |
Establishment of fetomaternal tolerance through glycan-mediated BÂ cell suppression. |
| Volume: |
603 |
| Issue: |
7901 |
| Pages: |
497-502 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nelson BR |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. |
| Volume: |
110 |
| Issue: |
29 |
| Pages: |
11881-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hawley SP |
| Year: |
2011 |
| Journal: |
Dev Dyn |
| Title: |
Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development. |
| Volume: |
240 |
| Issue: |
1 |
| Pages: |
221-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Christy BA |
| Year: |
1991 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. |
| Volume: |
88 |
| Issue: |
5 |
| Pages: |
1815-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee GH |
| Year: |
1995 |
| Journal: |
Genetics |
| Title: |
Identification of hepatocarcinogen-resistance genes in DBA/2 mice. |
| Volume: |
139 |
| Issue: |
1 |
| Pages: |
387-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tamm C |
| Year: |
2011 |
| Journal: |
J Cell Sci |
| Title: |
Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. |
| Volume: |
124 |
| Issue: |
Pt 7 |
| Pages: |
1136-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wolf I |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. |
| Volume: |
22 |
| Issue: |
1 |
| Pages: |
231-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hartweger H |
| Year: |
2014 |
| Journal: |
J Immunol |
| Title: |
Themis2 is not required for B cell development, activation, and antibody responses. |
| Volume: |
193 |
| Issue: |
2 |
| Pages: |
700-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
1995 |
| Journal: |
Genomics |
| Title: |
cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs. |
| Volume: |
27 |
| Issue: |
3 |
| Pages: |
389-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoon SH |
| Year: |
2009 |
| Journal: |
FEBS Lett |
| Title: |
Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling. |
| Volume: |
583 |
| Issue: |
7 |
| Pages: |
1164-70 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
629
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1000
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
232
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suen KL |
| Year: |
1993 |
| Journal: |
Mol Cell Biol |
| Title: |
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. |
| Volume: |
13 |
| Issue: |
9 |
| Pages: |
5500-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Minichiello L |
| Year: |
2002 |
| Journal: |
Neuron |
| Title: |
Mechanism of TrkB-mediated hippocampal long-term potentiation. |
| Volume: |
36 |
| Issue: |
1 |
| Pages: |
121-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kirchgessner H |
| Year: |
2001 |
| Journal: |
J Exp Med |
| Title: |
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. |
| Volume: |
193 |
| Issue: |
11 |
| Pages: |
1269-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uhles S |
| Year: |
2007 |
| Journal: |
FASEB J |
| Title: |
Selective gene activation by spatial segregation of insulin receptor B signaling. |
| Volume: |
21 |
| Issue: |
7 |
| Pages: |
1609-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sakaue M |
| Year: |
1995 |
| Journal: |
Mol Cell Biol |
| Title: |
A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
379-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Galisteo ML |
| Year: |
1995 |
| Journal: |
J Biol Chem |
| Title: |
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. |
| Volume: |
270 |
| Issue: |
35 |
| Pages: |
20242-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith MJ |
| Year: |
2010 |
| Journal: |
EMBO J |
| Title: |
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. |
| Volume: |
29 |
| Issue: |
5 |
| Pages: |
884-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Buerger C |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. |
| Volume: |
278 |
| Issue: |
39 |
| Pages: |
37610-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin S |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β). |
| Volume: |
286 |
| Issue: |
51 |
| Pages: |
44023-44034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wilks AF |
| Year: |
1989 |
| Journal: |
Gene |
| Title: |
The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. |
| Volume: |
85 |
| Issue: |
1 |
| Pages: |
67-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ben-David Y |
| Year: |
1991 |
| Journal: |
EMBO J |
| Title: |
A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
317-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Akilesh S |
| Year: |
2001 |
| Journal: |
J Immunol |
| Title: |
Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection. |
| Volume: |
167 |
| Issue: |
9 |
| Pages: |
5143-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ichikawa N |
| Year: |
2009 |
| Journal: |
J Cell Sci |
| Title: |
Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. |
| Volume: |
122 |
| Issue: |
Pt 2 |
| Pages: |
289-99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Serfas MS |
| Year: |
1993 |
| Journal: |
Am J Physiol |
| Title: |
HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts. |
| Volume: |
265 |
| Issue: |
3 Pt 1 |
| Pages: |
G506-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Valenzuela DM |
| Year: |
1995 |
| Journal: |
Genomics |
| Title: |
Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor. |
| Volume: |
25 |
| Issue: |
1 |
| Pages: |
157-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kurosaki T |
| Year: |
1999 |
| Journal: |
Annu Rev Immunol |
| Title: |
Genetic analysis of B cell antigen receptor signaling. |
| Volume: |
17 |
|
| Pages: |
555-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Texido G |
| Year: |
2000 |
| Journal: |
Mol Cell Biol |
| Title: |
The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. |
| Volume: |
20 |
| Issue: |
4 |
| Pages: |
1227-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Davidson D |
| Year: |
2003 |
| Journal: |
Mol Cell Biol |
| Title: |
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. |
| Volume: |
23 |
| Issue: |
6 |
| Pages: |
2017-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Swindell WR |
| Year: |
2009 |
| Journal: |
Exp Gerontol |
| Title: |
Accelerated failure time models provide a useful statistical framework for aging research. |
| Volume: |
44 |
| Issue: |
3 |
| Pages: |
190-200 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yi T |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. |
| Volume: |
43 |
| Issue: |
4 |
| Pages: |
764-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rinke de Wit TF |
| Year: |
1996 |
| Journal: |
Int Immunol |
| Title: |
Expression of tyrosine kinase gene in mouse thymic stromal cells. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
1787-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo A |
| Year: |
2014 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
372-87 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
Not specified |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Shc2/Shc2 Shc3/Shc3 |
| Background: |
involves: 129 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fgr/Fgr Hck/Hck |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Blk/Blk Fyn/Fyn Lyn/Lyn |
| Background: |
either: B6.129-Lyn Fyn Blk or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Igh/Igh Lyn/Lyn |
| Background: |
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|