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Search results 3801 to 3900 out of 8321 for Src

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Igh/Igh Lyn/Lyn
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Isl1/Isl1<+> Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myl1/Myl1<+> Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shb/Shb<+>
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1<+> Tg(MMTV-PyVT)634Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1<+> Tg(MMTV-PyVT)634Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1<+> Tg(MMTV-PyVT)634Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Igh-7/Igh-7 Lyn/Lyn
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shf/Shf<+>
Background: C57BL/6N-Shf/BayMmucd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+>
Background: C57BL/6N-Lyn/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc3/Shc3<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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Publication
27246398 | J:244469
First Author: Marusugi K
Year: 2016
Journal: J Vet Med Sci
Title: Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing.
Volume: 78
Issue: 9
Pages: 1413-1420
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Protein
F6RBX1
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
F6ZDJ1
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Publication
16412388 | -
First Author: Katoh Y
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
Volume: 341
Issue: 1
Pages: 143-9
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Protein Domain
IPR027429 | TOM1L2
Type: Family
Description: Target of Myb1 (TOM1)-like 2 (TOM1L2) has a probable role in protein transport []. It acts as a negative regulator of growth factor-induced Src mitogenic signaling [].
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Publication
24225949 | -
First Author: Yamamoto H
Year: 2013
Journal: J Biol Chem
Title: In planta mutagenesis of Src homology 3 domain-like fold of NdhS, a ferredoxin-binding subunit of the chloroplast NADH dehydrogenase-like complex in Arabidopsis: a conserved Arg-193 plays a critical role in ferredoxin binding.
Volume: 288
Issue: 51
Pages: 36328-37
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Publication
9038154 | -
First Author: Polte TR
Year: 1997
Journal: J Biol Chem
Title: Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs.
Volume: 272
Issue: 9
Pages: 5501-9
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Publication
9692543 | -
First Author: Song JS
Year: 1998
Journal: Oncogene
Title: Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta.
Volume: 16
Issue: 26
Pages: 3357-68
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Publication
8034026 | J:19199
First Author: Larsson-Blomberg L
Year: 1994
Journal: FEBS Lett
Title: Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.
Volume: 348
Issue: 2
Pages: 119-25
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Publication
10790433 | J:71006
First Author: Brdicka T
Year: 2000
Journal: J Exp Med
Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Volume: 191
Issue: 9
Pages: 1591-604
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Publication
28916834 | J:255555
First Author: Tsuji K
Year: 2017
Journal: Sci Rep
Title: Ultrastructural Characterization of the Glomerulopathy in Alport Mice by Helium Ion Scanning Microscopy (HIM).
Volume: 7
Issue: 1
Pages: 11696
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Publication
14623907 | J:86655
First Author: Kano A
Year: 2003
Journal: J Exp Med
Title: Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.
Volume: 198
Issue: 10
Pages: 1517-25
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Publication
16971418 | J:129738
First Author: Zhang X
Year: 2006
Journal: FASEB J
Title: Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury.
Volume: 20
Issue: 12
Pages: 2156-8
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Publication
26073036 | J:225647
First Author: Weins A
Year: 2015
Journal: Am J Pathol
Title: Dendrin ablation prolongs life span by delaying kidney failure.
Volume: 185
Issue: 8
Pages: 2143-57
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Publication
27531950 | J:246082
First Author: Teng B
Year: 2016
Journal: Diabetes
Title: CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.
Volume: 65
Issue: 12
Pages: 3667-3679
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Publication
21911934 | J:178223
First Author: Yaddanapudi S
Year: 2011
Journal: J Clin Invest
Title: CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
Volume: 121
Issue: 10
Pages: 3965-80
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Publication
16352665 | J:108384
First Author: Matsui T
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Effects of chronic Akt activation on glucose uptake in the heart.
Volume: 290
Issue: 5
Pages: E789-97
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Allele
Tg(Amhr2-Pik3ca*,-GFP)#Lzh | MGI:3832594
Name: transgene insertion, Lin Zhang
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Publication
19172191 | J:144834
First Author: Liang S
Year: 2009
Journal: PLoS One
Title: Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.
Volume: 4
Issue: 1
Pages: e4295
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Allele
Itgb3<tm1Aja> | MGI:3844533
Name: integrin beta 3; targeted mutation 1, Ararat J Ablooglu
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Stat2<p117> | MGI:4830698
Name: signal transducer and activator of transcription 2; pedigree p117
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph
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Publication
7544006 | J:56331
First Author: Webster MA
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene.
Volume: 92
Issue: 17
Pages: 7849-53
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Strain
MGI:5308466 | B6.Cg-Lair1<tm1Jco>/J
Attribute String: mutant strain, targeted mutation, congenic
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Strain
MGI:5308620 | B6.Cg-Lair1<tm1Jco>
Attribute String: congenic, targeted mutation, mutant strain
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Publication
11733558 | J:73141
First Author: Bernal-Mizrachi E
Year: 2001
Journal: J Clin Invest
Title: Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia.
Volume: 108
Issue: 11
Pages: 1631-8
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Allele
Tg(EEF1A1-SHC1)1Ravi | MGI:5613976
Name: transgene insertion 1, Kodi S Ravichandran
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:5613974 | B6.129S-Tg(EEF1A1-SHC1)1Ravi/J
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:6474551 | FVB.Cg-Tns2<em1Nsas>/NsasRbrc
Attribute String: congenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6353223 | B6NCrSlc.129S-Src<tm1Goka>/GokaRbrc
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6353224 | B6NCrSlc.129S-Src<tm2Goka>/GokaRbrc
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Stat3/Stat3 Tg(Tek-cre)1Xyfu/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1)564Anr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1)20Anr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1)20Anr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Amhr2-Pik3ca*,-GFP)#Lzh/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lair1/Lair1
Background: B6.Cg-Lair1
Zygosity: hm
Has Mutant Allele: true
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Publication
1377109 | J:1184
First Author: Armstrong E
Year: 1992
Journal: Cytogenet Cell Genet
Title: The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25.
Volume: 60
Issue: 2
Pages: 119-20
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Publication
9000133 | J:37676
First Author: Costello PS
Year: 1996
Journal: Oncogene
Title: Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.
Volume: 13
Issue: 12
Pages: 2595-605
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Publication
9605877 | J:47774
First Author: Fowler KJ
Year: 1997
Journal: Cytogenet Cell Genet
Title: Chromosomal localization of mouse Cenpa gene.
Volume: 79
Issue: 3-4
Pages: 298-301
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Publication
9872323 | J:52472
First Author: Liu SK
Year: 1998
Journal: Oncogene
Title: Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Volume: 17
Issue: 24
Pages: 3073-82
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Publication
29467163 | J:261962
First Author: Polster A
Year: 2018
Journal: J Gen Physiol
Title: Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1.
Volume: 150
Issue: 4
Pages: 613-624
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Publication
12483226 | J:81182
First Author: Holzenberger M
Year: 2003
Journal: Nature
Title: IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Volume: 421
Issue: 6919
Pages: 182-7
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Publication
15705776 | J:98292
First Author: Garlow SJ
Year: 2005
Journal: Endocrinology
Title: Genetic analysis of the hypothalamic corticotropin-releasing factor system.
Volume: 146
Issue: 5
Pages: 2362-8
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Publication
14576154 | J:87560
First Author: Faisal A
Year: 2004
Journal: J Biol Chem
Title: Non-redundant role of Shc in Erk activation by cytoskeletal reorganization.
Volume: 279
Issue: 5
Pages: 3202-11
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Publication
11877420 | J:76516
First Author: Tarr PE
Year: 2002
Journal: J Biol Chem
Title: Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Volume: 277
Issue: 19
Pages: 16798-804
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Publication
9013573 | J:38680
First Author: Kannan S
Year: 1997
Journal: J Biol Chem
Title: Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
Volume: 272
Issue: 6
Pages: 3330-5
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Publication
25771685 | J:311147
First Author: Yang Y
Year: 2015
Journal: Cell Res
Title: Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap.
Volume: 25
Issue: 4
Pages: 496-516
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Publication
26680585 | J:230032
First Author: Muthusamy BP
Year: 2015
Journal: PLoS Biol
Title: ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.
Volume: 13
Issue: 12
Pages: e1002325
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Publication
17673906 | J:200409
First Author: Lee MK
Year: 2007
Journal: EMBO J
Title: TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.
Volume: 26
Issue: 17
Pages: 3957-67
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Publication
8479540 | J:200364
First Author: Rozakis-Adcock M
Year: 1993
Journal: Nature
Title: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
Volume: 363
Issue: 6424
Pages: 83-5
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Publication
8940013 | J:201945
First Author: Chook YM
Year: 1996
Journal: J Biol Chem
Title: The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.
Volume: 271
Issue: 48
Pages: 30472-8
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Publication
11088019 | J:66125
First Author: Luzi L
Year: 2000
Journal: Curr Opin Genet Dev
Title: Evolution of Shc functions from nematode to human.
Volume: 10
Issue: 6
Pages: 668-74
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Publication
12486127 | J:81992
First Author: Tong J
Year: 2003
Journal: J Biol Chem
Title: Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity.
Volume: 278
Issue: 8
Pages: 6111-9
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Publication
17417601 | J:121631
 
First Author: Xie L
Year: 2007
Journal: Mol Vis
Title: Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.
Volume: 13
Pages: 397-407
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Publication
20685851 | J:182837
First Author: Almeida M
Year: 2010
Journal: Mol Endocrinol
Title: Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Volume: 24
Issue: 10
Pages: 2030-7
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Publication
23769981 | J:204123
First Author: Ito H
Year: 2013
Journal: Biochim Biophys Acta
Title: MAGI-1 acts as a scaffolding molecule for NGF receptor-mediated signaling pathway.
Volume: 1833
Issue: 10
Pages: 2302-10
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Publication
10872802 | J:62510
First Author: Iseki M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Volume: 272
Issue: 1
Pages: 45-54
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Publication
16731527 | J:116450
First Author: Udell CM
Year: 2006
Journal: J Biol Chem
Title: Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation.
Volume: 281
Issue: 30
Pages: 20949-57
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Publication
9049631 | J:38486
First Author: Zimmerman JE
Year: 1997
Journal: Genome Res
Title: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.
Volume: 7
Issue: 2
Pages: 128-41
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Publication
16249387 | J:129312
First Author: Ahn E
Year: 2006
Journal: Blood
Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Volume: 107
Issue: 4
Pages: 1521-7
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Publication
16200063 | J:101891
First Author: Herron BJ
Year: 2005
Journal: Nat Genet
Title: A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice.
Volume: 37
Issue: 11
Pages: 1210-2
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Publication
12192036 | J:78594
First Author: Craig AW
Year: 2002
Journal: Mol Cell Biol
Title: Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells.
Volume: 22
Issue: 18
Pages: 6363-74
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Protein Coding Gene
MGI:99515 | Syk
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22496641 | J:195394
First Author: Lu R
Year: 2012
Journal: PLoS Pathog
Title: CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.
Volume: 8
Issue: 4
Pages: e1002597
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Publication
31723089 | J:296747
First Author: Sasaki H
Year: 2020
Journal: Exp Anim
Title: Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB/N mouse strain.
Volume: 69
Issue: 2
Pages: 135-143
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Publication
15123627 | J:91612
First Author: Fischer AM
Year: 2004
Journal: J Biol Chem
Title: Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.
Volume: 279
Issue: 28
Pages: 29816-20
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Publication
12386807 | J:79667
First Author: Weiss WA
Year: 2002
Journal: Oncogene
Title: Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.
Volume: 21
Issue: 49
Pages: 7453-63
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Strain
MGI:3785472 | B6.Cg-Hck<tm1Hev> Fgr<tm1Hev> Lyn<tm1Sor>
Attribute String: congenic, targeted mutation
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Genotype
Genotype
Symbol: Shc1/Shc1 Tg(Myh6-cre)2182Mds/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Isl1/Isl1<+> Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myl1/Myl1<+> Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myl1/Myl1<+> Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myl1/Myl1<+> Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgr/Fgr Hck/Hck Lyn/Lyn
Background: B6.Cg-Hck Fgr Lyn
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Lyn/Lyn<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn Myd88/Myd88 Tg(Itgax-cre)1-1Reiz/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE102973 | Identification of Latrophilin-2, a Specific Cell-surface Marker for Cardiac Progenitor Cells, and its Functional Significance in Heart Development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE181358 | Mutation of the EPHA2 tyrosine-kinase domain dysregulates cell pattern formation and cytoskeletal gene expression in the lens
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
I6L9J4
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Publication
17825559 | -
First Author: Jospin M
Year: 2007
Journal: Curr Biol
Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Volume: 17
Issue: 18
Pages: 1595-600
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Publication
18336069 | -
First Author: Yeh E
Year: 2008
Journal: PLoS Biol
Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
Volume: 6
Issue: 3
Pages: e55
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Protein Domain
IPR031542 | UNC80_N
Type: Domain
Description: UNC80 is a protein associated with the NALCN sodium channel complex, and is required for the activation of this channel by the neuropeptide substance P. NALCN activation is G-protein-independent, but requires Src kinases. NUNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN []. NCA-1 and UNC-80 regulate neuronal activity in C. elegans [].This entry represents the N-terminal domain of UNC80.
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Publication
22968113 | J:188115
First Author: Chang H
Year: 2012
Journal: Dev Biol
Title: Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Volume: 370
Issue: 2
Pages: 187-97
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Publication
2574141 | J:10133
First Author: Ceci JD
Year: 1989
Journal: Genomics
Title: A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes.
Volume: 5
Issue: 4
Pages: 699-709
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Publication
22118527 | J:178927
First Author: Cui W
Year: 2011
Journal: Immunity
Title: An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.
Volume: 35
Issue: 5
Pages: 792-805
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