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Search results 3901 to 4000 out of 8814 for Clock

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Type Details Score
Publication
16759393 | -
 
First Author: Nissen RM
Year: 2006
Journal: BMC Dev Biol
Title: A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression.
Volume: 6
Pages: 28
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Publication
24465139 | -
First Author: Park J
Year: 2013
Journal: Exp Neurobiol
Title: New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome.
Volume: 22
Issue: 4
Pages: 244-8
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Publication
27033726 | -
First Author: Leslie EJ
Year: 2016
Journal: Hum Mol Genet
Title: A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.
Volume: 25
Issue: 13
Pages: 2862-2872
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Protein Domain
IPR018394 | DNA_photolyase_1_CS_C
Type: Conserved_site
Description: The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes []. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.This entry represents a number of conserved sequence regions found in the C-terminal region of the class 1 cryptochrome/DNA photolyase.
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Protein Domain
IPR002081 | Cryptochrome/DNA_photolyase_1
Type: Family
Description: The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes []. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.This entry represents the class1 cryptochrome/DNA photolyase family. Its members include cryptochromes, DNA photolyases and cryptochrome-DASH (Cry-DASH). The Cry-DASH family members have been shown to act as photolyases with high degree of specificity for cyclobutane pyrimidine dimers in ssDNA [].
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Protein Domain
IPR020190 | Procorazonin
Type: Family
Description: In Drosophila melanogaster (Fruit fly) the preprocorazonin consists of an 19 amino acid signal peptide, the 11 amino acid corazonin sequence followed by a 39 amino acid corazonin-precursor-related peptide (CPRP) and finally the 85 amino acid propeptide, [].Corazonin is a cardioactive peptide of insects, which is probably involved in the physiological regulation of the heart beat. Drosophila clock (clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner []. Corazonin is expressed in neurosecretory neurons of the pars lateralis of the protocerebrum and transported via nervi corporis cardiaci to the storage lobes of the corpora cardiaca. The peptide occurs with a single isoform in all insects studied so far, with the exception of the Coleoptera in which none could be detected [].
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Protein Domain
IPR034965 | Deadenylase_nocturnin
Type: Domain
Description: This entry represents the C-terminal catalytic domain of the deadenylase nocturnin, and related domains. Nocturnin is a poly(A)-specific 3' exonuclease that specifically degrades the 3' poly(A) tail of RNA in a process known as deadenylation. This nuclease activity is manganese dependent. Nocturnin is expressed in the cytoplasm of Xenopus laevis retinal photoreceptor cells in a rhythmic fashion, and it has been proposed that it participates in posttranscriptional regulation of the circadian clock or its outputs, and that the mRNA target(s) of this deadenylase are circadian clock-related []. In mouse, the nocturnin gene, mNoc, is expressed in a circadian pattern in a range of tissues including retina, spleen, heart, kidney, and liver. It is highly expressed in bone-marrow stromal cells, adipocytes and hepatocytes []. In mammals, nocturnin plays a role in regulating mesenchymal stem-cell lineage allocation, perhaps through regulating PPAR-gamma (peroxisome proliferator-activated receptor-gamma) nuclear translocation [].
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Protein Domain
IPR032673 | DNA_photolyase_2_CS
Type: Conserved_site
Description: The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes []. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.This entry represents a number of conserved sequence regions found in the C-terminal region of the class 2 DNA photolyases.
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Protein Domain
IPR007959 | Dino_Luciferase_N
Type: Domain
Description: Proteins in this entry belong to a family of dinoflagellate luciferase and luciferin binding proteins. Luciferase is involved in catalysing the light emitting reaction in bioluminescence and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme and therefore switching off the bioluminescence function. The expression of these two proteins is controlled by a circadian clock at the translational level, with synthesis and degradation occurring on a daily basis [].This entry consists of a presumed N-terminal domain that is conserved between dinoflagellateluciferase and luciferin binding proteins. This domain is not, however, the catalytic part of the protein. It has been suggested that this region may mediate an interaction between LBP and Luciferase or their association with the vacuolar membrane [].
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Protein Domain
IPR023569 | Prokineticin_domain
Type: Domain
Description: The prokineticin family includes prokinectin itself and related proteins such as BM8 and the AVIToxins. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock [].The prokinectin domain is found in the prokinectin family and the hainantoxins, where it comprises the whole length of the protein. This domain is also found at the C terminus of some members of the Dickkopf family.
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Protein Domain
IPR008148 | DNA_photolyase_2
Type: Family
Description: The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes []. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.Similar to the distantly related microbial class I photolyases, class 2 enzymes repair UV-induced cyclobutane pyrimidine dimer (CPD) lesions within duplex DNA using blue/near-UV light []. There are a number of conserved sequence regions in all known class 2 DNA photolyases, especially in the C-terminal part. The structures of the class 2 DNA photolyase from archaea and rice have been solved [, ].
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Protein Domain
IPR045159 | DCAF7-like
Type: Family
Description: This entry represents a group of WD repeat-containing proteins, including DCAF7 from animals, LWD1/2/TTG1 from Arabidopsis and YPL247C from budding yeasts. In general, WD40 repeat domain-containing proteins are scaffolding elements for the assembly of multi-subunit protein complexes. DCAF7, also known as WDR68, interacts with Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A, a Down's syndrome-associated protein kinase) []and is required for Endothelin-1 (EDN1) signalling []. It also acts as a DDB1- and CUL4-associated factor []. Mutations in the DCAF7 gene have been linked to cleft lip with or without cleft palate (CL/P) []. In Arabidopsis, LWD1 and LWD2 serve as clock proteins involved in photoperiod flowering control []. TRANSPARENT TESTA GLABRA 1 (TTG1) is a regulator of early developmental traits and is also involved in flowering time regulation [].
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Protein Domain
IPR031297 | DDB1
Type: Family
Description: This entry represents the DNA damage-binding protein 1 (DDB1) family, whose members are involved in DNA repair.The fission yeast members in this family includes Rik1 and Ddb1. Rik1 is a component of the Rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation []. Ddb1 is a component of cullin 4A ubiquitin ligases, which regulates the selective proteolysis of key proteins in DNA repair, replication and transcription [, ].Mammalian Ddb1 is apart of the CUL4-DDB1 ubiquitin E3 ligase that regulates cell-cycle progression, replication and DNA damage response. The CUL4-DDB1 ubiquitin E3 ligase interacts with multiple WD40-repeat proteins and regulates histone methylation []. This complex also regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 [].The plant Ddb1 is part of the CUL4-DDB1-DDB2 E3 ligase involved in maintaining genome integrity upon UV stress [].
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Publication
15980066 | J:101219
First Author: Harada Y
Year: 2005
Journal: J Biol Chem
Title: Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.
Volume: 280
Issue: 36
Pages: 31714-21
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Publication
17303680 | J:121989
First Author: Masana MI
Year: 2007
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout.
Volume: 292
Issue: 6
Pages: R2357-67
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Publication
15451375 | J:92980
First Author: Alvarez-López C
Year: 2004
Journal: Brain Res
Title: Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration.
Volume: 1024
Issue: 1-2
Pages: 137-45
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HT Experiment
E-GEOD-59460 | Transcription profiling by array of liver tissues from wild type and Rev-erb{alpha} knockout (Nr1d1-/-) mice to study direct targets of Nr1d1 in rhythmic (circadian) transcription
Series Id: GSE59460
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE171993 | Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell Transcriptomics
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE75475 | Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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HT Experiment
GSE224446 | Circadian transcriptomic analysis of mouse liver
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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HT Experiment
E-AFMX-1 | Transcription profiling of human, chimp and mouse brain
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE241218 | Transcriptomic analysis of cortex tissue from neuron-specific Bmal1 KO mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE81875 | CPEB4 prevents hepatic steatosis [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE138019 | Decapping enzyme NUDT12 partners with BLMH for cytoplasmic surveillance of NAD-capped RNAs
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE201207 | Defining the age-dependent and tissue-specific circadian transcriptome in male mice
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
E-GEOD-70440 | Loss of EZH2 results in precocious mammary gland development and the activation of STAT5-dependent genes
Series Id: GSE70440
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE226855 | Comparative transcriptome data of multi tissues in response to different environmental light-dark cycles
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
15263010 | -
First Author: Delumeau O
Year: 2004
Journal: J Biol Chem
Title: Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C.
Volume: 279
Issue: 39
Pages: 40927-37
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Protein Domain
IPR006906 | Timeless_N
Type: Domain
Description: This entry represents the N-terminal domain of the Timeless protein. The timeless gene in Drosophila melanogasteris involved in circadian rhythm control []. Drosophila contains two paralogs, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively. The mammalian TIMELESS (TIM) protein, originally identified based on its similarity to Drosophila dTIM, interacts with the clock proteins dCRY and dPER and is essential for circadian rhythm generation and photo-entrainment in the fly []. However, phylogenetic sequence analysis has demonstrated that dTIM2 is likely to be the orthologue of mammalian TIM and other widely conserved TIM-like proteins in eukaryotes []. These proteins include Saccharomyces cerevisiae Tof1, Schizosaccharomyces pombe Swi1, and Caenorhabditis elegans TIM. These proteins are not involved in the core clock mechanism, but instead play important roles in chromosome integrity, efficient cell growth and/or development [, ], with the exception of dTIM-2, that has an additional function in retinal photoreception [].Saccharomyces cerevisiae Tof1 is a subunit of a replication-pausing checkpoint complex (Tof1-Mrc1-Csm3) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA [, ]. Schizosaccharomyces pombe Swi1 and Swi3 form the fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks []. In humans timeless forms a stable complex with its partner protein Tipin. The Timeless-Tipin complex has been reported to travel along with the replication fork during unperturbed DNA replication. Moreover, the Timeless-Tipin-Claspin complex contributes to full activation of the ATR-Chk1 signaling pathway through the recruitment of Chk1 to arrested replication forks for sufficient ATR-mediated phosphorylation. It also interacts with PARP-1, and this interaction is required for efficient homologous recombination repair [].
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Protein Domain
IPR007725 | TIMELESS_C
Type: Domain
Description: This entry represents the C-terminal domain found in the Timeless (TIM) proteins. This domain can be found in TIM homologues mostly from animals. This domain found in hTIM has been shown to bind to the PARP-1 catalytic domain [].The timeless gene in Drosophila melanogasteris involved in circadian rhythm control []. Drosophila contains two paralogs, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively. The mammalian TIMELESS (TIM) protein, originally identified based on its similarity to Drosophila dTIM, interacts with the clock proteins dCRY and dPER and is essential for circadian rhythm generation and photo-entrainment in the fly []. However, phylogenetic sequence analysis has demonstrated that dTIM2 is likely to be the orthologue of mammalian TIM and other widely conserved TIM-like proteins in eukaryotes []. These proteins include Saccharomyces cerevisiae Tof1, Schizosaccharomyces pombe Swi1, and Caenorhabditis elegans TIM. These proteins are not involved in the core clock mechanism, but instead play important roles in chromosome integrity, efficient cell growth and/or development [, ], with the exception of dTIM-2, that has an additional function in retinal photoreception [].Saccharomyces cerevisiae Tof1 is a subunit of a replication-pausing checkpoint complex (Tof1-Mrc1-Csm3) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA [, ]. Schizosaccharomyces pombe Swi1 and Swi3 form the fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks []. In humans timeless forms a stable complex with its partner protein Tipin. The Timeless-Tipin complex has been reported to travel along with the replication fork during unperturbed DNA replication. Moreover, the Timeless-Tipin-Claspin complex contributes to full activation of the ATR-Chk1 signaling pathway through the recruitment of Chk1 to arrested replication forks for sufficient ATR-mediated phosphorylation. It also interacts with PARP-1, and this interaction is required for efficient homologous recombination repair [].
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Protein Domain
IPR044998 | Timeless
Type: Family
Description: The timeless gene in Drosophila melanogasteris involved in circadian rhythm control []. Drosophila contains two paralogs, dTIM and dTIM2, acting in clock/photoreception and chromosome integrity/photoreception respectively. The mammalian TIMELESS (TIM) protein, originally identified based on its similarity to Drosophila dTIM, interacts with the clock proteins dCRY and dPER and is essential for circadian rhythm generation and photo-entrainment in the fly []. However, phylogenetic sequence analysis has demonstrated that dTIM2 is likely to be the orthologue of mammalian TIM and other widely conserved TIM-like proteins in eukaryotes []. These proteins include Saccharomyces cerevisiae Tof1, Schizosaccharomyces pombe Swi1, and Caenorhabditis elegans TIM. These proteins are not involved in the core clock mechanism, but instead play important roles in chromosome integrity, efficient cell growth and/or development [, ], with the exception of dTIM-2, that has an additional function in retinal photoreception [].Saccharomyces cerevisiae Tof1 is a subunit of a replication-pausing checkpoint complex (Tof1-Mrc1-Csm3) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA [, ]. Schizosaccharomyces pombe Swi1 and Swi3 form the fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks []. In humans timeless forms a stable complex with its partner protein Tipin. The Timeless-Tipin complex has been reported to travel along with the replication fork during unperturbed DNA replication. Moreover, the Timeless-Tipin-Claspin complex contributes to full activation of the ATR-Chk1 signaling pathway through the recruitment of Chk1 to arrested replication forks for sufficient ATR-mediated phosphorylation. It also interacts with PARP-1, and this interaction is required for efficient homologous recombination repair [].
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Publication
24247982 | J:219162
First Author: Sakhi K
Year: 2014
Journal: J Physiol
Title: Daily variation in the electrophysiological activity of mouse medial habenula neurones.
Volume: 592
Issue: 4
Pages: 587-603
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Publication
24278295 | J:209783
First Author: Ono D
Year: 2013
Journal: PLoS One
Title: Postnatal constant light compensates Cryptochrome1 and 2 double deficiency for disruption of circadian behavioral rhythms in mice under constant dark.
Volume: 8
Issue: 11
Pages: e80615
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Publication
37141220 | J:352920
First Author: Gaitonde KD
Year: 2023
Journal: PLoS One
Title: Diurnal regulation of metabolism by Gs-alpha in hypothalamic QPLOT neurons.
Volume: 18
Issue: 5
Pages: e0284824
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Protein
Q9R1X4
Organism: Mus musculus/domesticus
Length: 1197  
Fragment?: false
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Protein
Q3U574
Organism: Mus musculus/domesticus
Length: 1196  
Fragment?: false
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Publication
11710984 | -
First Author: Rosato E
Year: 2001
Journal: Philos Trans R Soc Lond B Biol Sci
Title: Flies, clocks and evolution.
Volume: 356
Issue: 1415
Pages: 1769-78
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Publication
15367656 | -
First Author: Noguchi E
Year: 2004
Journal: Mol Cell Biol
Title: Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.
Volume: 24
Issue: 19
Pages: 8342-55
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Publication
12944972 | -
First Author: Katou Y
Year: 2003
Journal: Nature
Title: S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.
Volume: 424
Issue: 6952
Pages: 1078-83
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Publication
26344098 | -
First Author: Xie S
Year: 2015
Journal: Mol Cell
Title: Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.
Volume: 60
Issue: 1
Pages: 163-76
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Publication
19819872 | -
First Author: Bando M
Year: 2009
Journal: J Biol Chem
Title: Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks.
Volume: 284
Issue: 49
Pages: 34355-65
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Publication
10417378 | -
First Author: Ceriani MF
Year: 1999
Journal: Science
Title: Light-dependent sequestration of TIMELESS by CRYPTOCHROME.
Volume: 285
Issue: 5427
Pages: 553-6
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Publication
10899011 | -
First Author: Benna C
Year: 2000
Journal: Curr Biol
Title: A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim.
Volume: 10
Issue: 14
Pages: R512-3
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Publication
32469068 | -
First Author: Grabarczyk DB
Year: 2020
Journal: Nucleic Acids Res
Title: Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.
Volume: 48
Issue: 12
Pages: 6996-7004
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Publication
30174302 | J:272007
First Author: Chaix A
Year: 2019
Journal: Cell Metab
Title: Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Volume: 29
Issue: 2
Pages: 303-319.e4
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Publication
15799026 | J:100371
First Author: Okada A
Year: 2005
Journal: Birth Defects Res A Clin Mol Teratol
Title: Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.
Volume: 73
Issue: 4
Pages: 229-38
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Publication
28751364 | J:244975
First Author: Kriebs A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
Volume: 114
Issue: 33
Pages: 8776-8781
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Publication
20852621 | J:209480
First Author: Zhang EE
Year: 2010
Journal: Nat Med
Title: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.
Volume: 16
Issue: 10
Pages: 1152-6
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Publication
24158435 | J:207239
First Author: Gao P
Year: 2013
Journal: J Biol Chem
Title: Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length.
Volume: 288
Issue: 49
Pages: 35277-86
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Publication
23297224 | J:193710
First Author: Valekunja UK
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.
Volume: 110
Issue: 4
Pages: 1554-9
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Publication
21193487 | J:173726
First Author: Kang TH
Year: 2011
Journal: Nucleic Acids Res
Title: Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein.
Volume: 39
Issue: 8
Pages: 3176-87
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Publication
15860530 | J:134129
First Author: Masuki S
Year: 2005
Journal: J Physiol
Title: Reduced alpha-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock.
Volume: 566
Issue: Pt 1
Pages: 213-24
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Publication
21521686 | J:326904
First Author: Czarna A
Year: 2011
Journal: J Biol Chem
Title: Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock.
Volume: 286
Issue: 25
Pages: 22414-25
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Publication
38834239 | J:348800
     
First Author: Clark JF
Year: 2024
Journal: Genes Dev
Title: Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development.
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Publication
7813451 | -
First Author: Yasui A
Year: 1994
Journal: EMBO J
Title: A new class of DNA photolyases present in various organisms including aplacental mammals.
Volume: 13
Issue: 24
Pages: 6143-51
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Publication
31294688 | J:277685
   
First Author: Petkau N
Year: 2019
Journal: Elife
Title: Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
Volume: 8
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Publication
17095659 | J:116164
First Author: Dequéant ML
Year: 2006
Journal: Science
Title: A complex oscillating network of signaling genes underlies the mouse segmentation clock.
Volume: 314
Issue: 5805
Pages: 1595-8
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Publication
15731404 | J:97659
First Author: Vermot J
Year: 2005
Journal: Science
Title: Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo.
Volume: 308
Issue: 5721
Pages: 563-6
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Publication
33931651 | J:317588
First Author: Hayter EA
Year: 2021
Journal: Nat Commun
Title: Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.
Volume: 12
Issue: 1
Pages: 2472
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Publication
12481140 | J:81502
First Author: Ruby NF
Year: 2002
Journal: Science
Title: Role of melanopsin in circadian responses to light.
Volume: 298
Issue: 5601
Pages: 2211-3
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Publication
21393543 | J:169669
First Author: Feng D
Year: 2011
Journal: Science
Title: A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
Volume: 331
Issue: 6022
Pages: 1315-9
•
•
•
•
•
Publication
12086606 | J:97146
First Author: Harmar AJ
Year: 2002
Journal: Cell
Title: The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.
Volume: 109
Issue: 4
Pages: 497-508
•
•
•
•
•
Publication
12399594 | J:278996
First Author: Hirata H
Year: 2002
Journal: Science
Title: Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Volume: 298
Issue: 5594
Pages: 840-3
•
•
•
•
•
Publication
37878694 | J:342247
First Author: Barone I
Year: 2023
Journal: Sci Adv
Title: Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
Volume: 9
Issue: 43
Pages: eadj1010
•
•
•
•
•
Publication
9427364 | J:46335
First Author: Tafti M
Year: 1997
Journal: Neuroreport
Title: Localization of candidate genomic regions influencing paradoxical sleep in mice.
Volume: 8
Issue: 17
Pages: 3755-8
•
•
•
•
•
Publication
9695846 | J:47892
First Author: Green CB
Year: 1998
Journal: Trends Cell Biol
Title: How cells tell time.
Volume: 8
Issue: 6
Pages: 224-30
•
•
•
•
•
Publication
18006707 | J:128505
First Author: Yin L
Year: 2007
Journal: Science
Title: Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.
Volume: 318
Issue: 5857
Pages: 1786-9
•
•
•
•
•
Publication
21566258 | J:224281
First Author: Yu EA
Year: 2011
Journal: Aging (Albany NY)
Title: Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes.
Volume: 3
Issue: 5
Pages: 479-93
•
•
•
•
•
Publication
31300477 | J:278167
First Author: Shafi AA
Year: 2019
Journal: Cancer Res
Title: Cancer and the Circadian Clock.
Volume: 79
Issue: 15
Pages: 3806-3814
•
•
•
•
•
Publication
37791313 | J:356221
First Author: Mia S
Year: 2023
Journal: JACC Basic Transl Sci
Title: Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology.
Volume: 8
Issue: 9
Pages: 1141-1156
•
•
•
•
•
Protein Coding Gene
MGI:104662 | Pml
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
20123978 | J:161722
First Author: Kurabayashi N
Year: 2010
Journal: Mol Cell Biol
Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.
Volume: 30
Issue: 7
Pages: 1757-68
•
•
•
•
•
Publication
35188462 | J:343962
   
First Author: Marcheva B
Year: 2022
Journal: Elife
Title: P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure.
Volume: 11
•
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•
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•
Publication
32817420 | J:295973
First Author: Liu Z
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Circadian regulation of c-MYC in mice.
Volume: 117
Issue: 35
Pages: 21609-21617
•
•
•
•
•
HT Experiment
E-GEOD-9471 | Transcription profiling of mouse prefrontal cortex of C57Bl/6J mice at Zeitgeber Time (ZT) 3, 9, 15, and 21
Series Id: GSE9471
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
HT Experiment
E-GEOD-38624 | Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [Bmal1 KO]
Series Id: GSE38624
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
HT Experiment
E-GEOD-38623 | Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [Anagen]
Series Id: GSE38623
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
HT Experiment
E-GEOD-38622 | Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [telogen]
Series Id: GSE38622
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
HT Experiment
GSE284053 | Comparative transcriptomic rhythms in the mouse and human prefrontal cortex
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
HT Experiment
GSE252364 | Effect of methionine/choline deficient diet on liver and suprachiasmatic nucleus circadian transcriptome.
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
HT Experiment
GSE81283 | Translational contributions to tissue-specificity in rhythmic and constitutive gene expression
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
Publication
23145013 | J:195353
First Author: Takasu NN
Year: 2012
Journal: PLoS One
Title: Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.
Volume: 7
Issue: 11
Pages: e48892
•
•
•
•
•
Protein
Q99JJ1
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
•
•
•
•
•
Publication
7604260 | -
First Author: Park HW
Year: 1995
Journal: Science
Title: Crystal structure of DNA photolyase from Escherichia coli.
Volume: 268
Issue: 5219
Pages: 1866-72
•
•
•
•
•
Publication
15213381 | -
First Author: Kort R
Year: 2004
Journal: Acta Crystallogr D Biol Crystallogr
Title: DNA apophotolyase from Anacystis nidulans: 1.8 A structure, 8-HDF reconstitution and X-ray-induced FAD reduction.
Volume: 60
Issue: Pt 7
Pages: 1205-13
•
•
•
•
•
Publication
23133608 | J:295378
First Author: Molusky MM
Year: 2012
Journal: PLoS One
Title: Peroxisomal localization and circadian regulation of ubiquitin-specific protease 2.
Volume: 7
Issue: 11
Pages: e47970
•
•
•
•
•
Publication
- | J:24195
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSB Panel Mapping Data
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0018586 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0021622 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGI:1915243 | Nudt12
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0021819 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0020620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0023767 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0023968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0020574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0023725 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0023926 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0020552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0023696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0023895 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
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