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Search results 3901 to 4000 out of 8321 for Src

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Type Details Score
Publication
First Author: Blandino-Rosano M
Year: 2012
Journal: Diabetologia
Title: Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip.
Volume: 55
Issue: 5
Pages: 1380-9
Publication
First Author: Jarad G
Year: 2006
Journal: J Clin Invest
Title: Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier.
Volume: 116
Issue: 8
Pages: 2272-9
Publication
First Author: Fatrai S
Year: 2006
Journal: Diabetes
Title: Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.
Volume: 55
Issue: 2
Pages: 318-25
Publication
First Author: Gray JD
Year: 2013
Journal: Hum Mol Genet
Title: LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.
Volume: 22
Issue: 21
Pages: 4267-81
Allele  
Name: interleukin 7 receptor; targeted mutation 1, Ninan Abraham
Allele Type: Targeted
Publication
First Author: Rhee JM
Year: 2006
Journal: Genesis
Title: In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice.
Volume: 44
Issue: 4
Pages: 202-18
Allele  
Name: integrin beta 3; targeted mutation 2, Ararat J Ablooglu
Allele Type: Targeted
Strain
Attribute String: coisogenic, mutant strain, chemically induced mutation
Genotype
Symbol: Stat2/Stat2
Background: C57BL/6J-Stat2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3<+> Tg(Prrx1-cre)1Cjt/?
Background: involves: C57BL/6 * SJL/J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3 Tg(Prrx1-cre)1Cjt/?
Background: involves: C57BL/6 * SJL/J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3 Tg(Prrx1-cre)1Cjt/?
Background: involves: C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3<+> Tg(Prrx1-cre)1Cjt/?
Background: involves: C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Akerblom B
Year: 2007
Journal: Mol Cell Endocrinol
Title: A role of FRK in regulation of embryonal pancreatic beta cell formation.
Volume: 270
Issue: 1-2
Pages: 73-8
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
Publication
First Author: Bruyns E
Year: 1996
Journal: Genomics
Title: Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.
Volume: 38
Issue: 1
Pages: 79-83
Publication
First Author: Bruyns E
Year: 1995
Journal: J Biol Chem
Title: Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45.
Volume: 270
Issue: 52
Pages: 31372-6
Publication
First Author: Ju H
Year: 2009
Journal: Neoplasia
Title: A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.
Volume: 11
Issue: 12
Pages: 1340-7
Protein Domain
Type: Family
Description: This group represents protein tyrosine phosphatase receptor type C (PTPRC)-associated protein, also known as CD45-associated protein [, ]. It is a positive regulator of PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis [].
Protein Domain
Type: Homologous_superfamily
Description: Members of this superfamily are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding [].
Protein Domain
Type: Family
Description: Members of this family are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding [].
Publication
First Author: Sharma A
Year: 2003
Journal: Nat Struct Biol
Title: Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum.
Volume: 10
Issue: 3
Pages: 197-203
Publication
First Author: Zambrowicz BP
Year: 1998
Journal: Nature
Title: Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.
Volume: 392
Issue: 6676
Pages: 608-11
Publication
First Author: Marth JD
Year: 1985
Journal: Cell
Title: A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.
Volume: 43
Issue: 2 Pt 1
Pages: 393-404
Publication
First Author: Holtzman DA
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.
Volume: 84
Issue: 23
Pages: 8325-9
Publication
First Author: Reith AD
Year: 1995
Journal: Mamm Genome
Title: Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase.
Volume: 6
Issue: 9
Pages: 689
Publication    
First Author: Manz BN
Year: 2015
Journal: Elife
Title: Small molecule inhibition of Csk alters affinity recognition by T cells.
Volume: 4
Publication
First Author: Schmedt C
Year: 1998
Journal: Nature
Title: Csk controls antigen receptor-mediated development and selection of T-lineage cells.
Volume: 394
Issue: 6696
Pages: 901-4
Publication
First Author: Nada S
Year: 1994
Journal: Oncogene
Title: Identification of major tyrosine-phosphorylated proteins in Csk-deficient cells.
Volume: 9
Issue: 12
Pages: 3571-8
Publication
First Author: Larsen NJ
Year: 1996
Journal: Cytogenet Cell Genet
Title: Seven genes from human chromosome 18 map to chromosome 24 in the bovine.
Volume: 73
Issue: 3
Pages: 184-6
Publication
First Author: Ma J
Year: 2019
Journal: PLoS Biol
Title: Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
Volume: 17
Issue: 10
Pages: e3000461
Publication
First Author: Pitman JL
Year: 2011
Journal: J Lipid Res
Title: Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.
Volume: 52
Issue: 10
Pages: 1775-86
Publication
First Author: Panicker N
Year: 2015
Journal: J Neurosci
Title: Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
Volume: 35
Issue: 27
Pages: 10058-77
Publication  
First Author: Kong MS
Year: 2019
Journal: Sci Signal
Title: Inhibition of T cell activation and function by the adaptor protein CIN85.
Volume: 12
Issue: 567
Publication
First Author: Ablooglu AJ
Year: 2009
Journal: Blood
Title: Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets.
Volume: 113
Issue: 15
Pages: 3585-92
Publication
First Author: Ritter N
Year: 2019
Journal: Dev Cell
Title: The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development.
Volume: 50
Issue: 5
Pages: 644-657.e8
Publication
First Author: Rolny C
Year: 2005
Journal: Exp Cell Res
Title: Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling.
Volume: 308
Issue: 2
Pages: 381-93
Publication
First Author: Koponen E
Year: 2004
Journal: Mol Cell Neurosci
Title: Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning.
Volume: 26
Issue: 1
Pages: 166-81
Publication
First Author: Okazaki T
Year: 1993
Journal: Genomics
Title: Molecular diversity of the SCG10/stathmin gene family in the mouse.
Volume: 18
Issue: 2
Pages: 360-73
Publication
First Author: Goodwin RG
Year: 1991
Journal: Mol Cell Biol
Title: Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.
Volume: 11
Issue: 6
Pages: 3020-6
Publication
First Author: Cabodi S
Year: 2006
Journal: Cancer Res
Title: p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.
Volume: 66
Issue: 9
Pages: 4672-80
Publication
First Author: Goodwin RG
Year: 1993
Journal: Eur J Immunol
Title: Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor.
Volume: 23
Issue: 10
Pages: 2631-41
Publication
First Author: Samuels AL
Year: 2009
Journal: Blood
Title: Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.
Volume: 113
Issue: 16
Pages: 3845-56
Publication
First Author: Wu G
Year: 1996
Journal: Int Immunol
Title: Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes.
Volume: 8
Issue: 7
Pages: 1159-64
Publication
First Author: Klages S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.
Volume: 91
Issue: 7
Pages: 2597-601
Publication
First Author: Molina TJ
Year: 1992
Journal: Nature
Title: Profound block in thymocyte development in mice lacking p56lck.
Volume: 357
Issue: 6374
Pages: 161-4
Publication
First Author: Thuveson M
Year: 1995
Journal: Biochem Biophys Res Commun
Title: iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine.
Volume: 209
Issue: 2
Pages: 582-9
Publication
First Author: Cory GO
Year: 2002
Journal: J Biol Chem
Title: Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
Volume: 277
Issue: 47
Pages: 45115-21
Publication
First Author: Trobridge PA
Year: 2001
Journal: J Immunol
Title: Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors.
Volume: 166
Issue: 2
Pages: 809-18
Publication
First Author: Wei Q
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Lck bound to coreceptor is less active than free Lck.
Volume: 117
Issue: 27
Pages: 15809-15817
Publication
First Author: Ziegler SF
Year: 1987
Journal: Mol Cell Biol
Title: Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.
Volume: 7
Issue: 6
Pages: 2276-85
Publication
First Author: Couture C
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.
Volume: 91
Issue: 12
Pages: 5301-5
Publication
First Author: Drebin JA
Year: 1995
Journal: Oncogene
Title: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk).
Volume: 10
Issue: 3
Pages: 477-86
Publication
First Author: Campi G
Year: 2005
Journal: J Exp Med
Title: Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.
Volume: 202
Issue: 8
Pages: 1031-6
Publication
First Author: Schoenborn JR
Year: 2011
Journal: Sci Signal
Title: Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
Volume: 4
Issue: 190
Pages: ra59
Publication
First Author: van Oers NS
Year: 1996
Journal: Immunity
Title: alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.
Volume: 5
Issue: 5
Pages: 429-36
Publication
First Author: Birkeland ML
Year: 1995
Journal: Eur J Immunol
Title: Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein.
Volume: 25
Issue: 4
Pages: 926-30
Publication
First Author: Popova NV
Year: 2003
Journal: Carcinogenesis
Title: Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis.
Volume: 24
Issue: 3
Pages: 417-25
Publication  
First Author: Popova NV
Year: 2004
Journal: Curr Top Microbiol Immunol
Title: Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci.
Volume: 280
Pages: 111-37
Publication
First Author: Threadgill DS
Year: 1994
Journal: Genomics
Title: Syntenic assignment of human chromosome 1 homologous loci in the bovine.
Volume: 22
Issue: 3
Pages: 626-30
Publication
First Author: Namba T
Year: 2014
Journal: Neuron
Title: Pioneering axons regulate neuronal polarization in the developing cerebral cortex.
Volume: 81
Issue: 4
Pages: 814-29
Publication
First Author: Sinai L
Year: 2012
Journal: Genes Brain Behav
Title: Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression.
Volume: 11
Issue: 5
Pages: 559-67
Publication
First Author: Lee HJ
Year: 2016
Journal: PLoS One
Title: Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.
Volume: 11
Issue: 1
Pages: e0146841
Publication
First Author: Takatsuka A
Year: 2008
Journal: Dev Biol
Title: Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.
Volume: 315
Issue: 2
Pages: 474-88
Publication
First Author: Sun C
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of Csk in intestinal epithelial barrier function and protection against colitis.
Volume: 504
Issue: 1
Pages: 109-114
Publication
First Author: Honda K
Year: 2007
Journal: Carcinogenesis
Title: Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk.
Volume: 28
Issue: 10
Pages: 2074-81
Publication
First Author: Takayama Y
Year: 1997
Journal: FEBS Lett
Title: Role of Csk in neural differentiation of the embryonic carcinoma cell line P19.
Volume: 406
Issue: 1-2
Pages: 11-6
Publication
First Author: Osborne LC
Year: 2007
Journal: J Exp Med
Title: Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice.
Volume: 204
Issue: 3
Pages: 619-31
Publication
First Author: Osborne LC
Year: 2011
Journal: J Immunol
Title: Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia.
Volume: 186
Issue: 4
Pages: 1981-8
Publication  
First Author: Chen LS
Year: 2009
Journal: J Biomed Sci
Title: STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response.
Volume: 16
Pages: 22
Publication
First Author: Iyer SS
Year: 2010
Journal: J Immunol
Title: Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages.
Volume: 185
Issue: 11
Pages: 6599-607
Publication
First Author: Zhou H
Year: 2011
Journal: Bone
Title: Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species.
Volume: 49
Issue: 3
Pages: 404-11
Publication
First Author: Kim JS
Year: 2016
Journal: Endocrinology
Title: Leptin Signaling Is Not Required for Anorexigenic Estradiol Effects in Female Mice.
Volume: 157
Issue: 5
Pages: 1991-2001
Publication
First Author: Schell C
Year: 2015
Journal: PLoS One
Title: Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.
Volume: 10
Issue: 6
Pages: e0129424
Publication
First Author: Lee KH
Year: 2003
Journal: Science
Title: The immunological synapse balances T cell receptor signaling and degradation.
Volume: 302
Issue: 5648
Pages: 1218-22
Publication
First Author: Matsui T
Year: 2002
Journal: J Biol Chem
Title: Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart.
Volume: 277
Issue: 25
Pages: 22896-901
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: transgene insertion 1, Denis R Alexander
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
Genotype
Symbol: Il7r/Il7r
Background: B6.129S4-Il7r
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3 Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Itgb3/Itgb3
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Itgb3/Itgb3
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Lair1/Lair1 Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3<+> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/?
Background: involves: CD-1
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat3/Stat3 Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/?
Background: involves: CD-1
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Hayashi T
Year: 2007
Journal: Genes Cells
Title: PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.
Volume: 12
Issue: 8
Pages: 929-39
Publication
First Author: Garçon F
Year: 2004
Journal: J Immunol
Title: Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain.
Volume: 173
Issue: 2
Pages: 770-5
Publication
First Author: Nikonova AS
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Nedd9 restrains renal cystogenesis in Pkd1-/- mice.
Volume: 111
Issue: 35
Pages: 12859-64
Publication
First Author: Guiet R
Year: 2008
Journal: Eur J Cell Biol
Title: Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis.
Volume: 87
Issue: 8-9
Pages: 527-42
Protein Domain
Type: Domain
Description: HCK is a member of the Src non-receptor type tyrosine kinase (SFK) family. HCK is expressed as two isoforms, p59Hck and p61Hck, in phagocytes. It plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration [, ]. Like the other members of the Src family the SH2 domain in addition to binding the target, also plays an autoinhibitory role by binding to its C-terminal tail []. This entry represents the SH2 domain of HCK.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
Protein Domain
Type: Domain
Description: Blk is a member of the Src non-receptor type tyrosine kinase family of proteins. Blk is involved in B-cell receptor signaling and B-cell development []. Unlike most other Src members Blk lacks cysteine residues in the SH4 domain that undergo palmitylation. Blk is required for the development of IL-17-producing gamma-delta T cells []. This entry represents the SH2 domain of Blk.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Dao T
Year: 2004
Journal: Eur J Immunol
Title: Development of CD1d-restricted NKT cells in the mouse thymus.
Volume: 34
Issue: 12
Pages: 3542-52
Publication
First Author: Kanazawa S
Year: 1996
Journal: Blood
Title: p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.
Volume: 87
Issue: 3
Pages: 865-70
Publication
First Author: Cherpokova D
Year: 2015
Journal: Blood
Title: SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
Volume: 125
Issue: 1
Pages: 185-94
Publication
First Author: Wybenga-Groot LE
Year: 2015
Journal: Cell Signal
Title: RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling.
Volume: 27
Issue: 2
Pages: 267-74
Publication
First Author: Kazi JU
Year: 2012
Journal: PLoS One
Title: Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.
Volume: 7
Issue: 12
Pages: e53509
Publication
First Author: Moharram SA
Year: 2016
Journal: Oncotarget
Title: Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling.
Volume: 7
Issue: 36
Pages: 57770-57782