| Type |
Details |
Score |
| Publication |
| First Author: |
Blandino-Rosano M |
| Year: |
2012 |
| Journal: |
Diabetologia |
| Title: |
Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip. |
| Volume: |
55 |
| Issue: |
5 |
| Pages: |
1380-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jarad G |
| Year: |
2006 |
| Journal: |
J Clin Invest |
| Title: |
Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. |
| Volume: |
116 |
| Issue: |
8 |
| Pages: |
2272-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fatrai S |
| Year: |
2006 |
| Journal: |
Diabetes |
| Title: |
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. |
| Volume: |
55 |
| Issue: |
2 |
| Pages: |
318-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray JD |
| Year: |
2013 |
| Journal: |
Hum Mol Genet |
| Title: |
LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure. |
| Volume: |
22 |
| Issue: |
21 |
| Pages: |
4267-81 |
|
•
•
•
•
•
|
| Allele |
| Name: |
interleukin 7 receptor; targeted mutation 1, Ninan Abraham |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rhee JM |
| Year: |
2006 |
| Journal: |
Genesis |
| Title: |
In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice. |
| Volume: |
44 |
| Issue: |
4 |
| Pages: |
202-18 |
|
•
•
•
•
•
|
| Allele |
| Name: |
integrin beta 3; targeted mutation 2, Ararat J Ablooglu |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, chemically induced mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat2/Stat2 |
| Background: |
C57BL/6J-Stat2 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3<+> Tg(Prrx1-cre)1Cjt/? |
| Background: |
involves: C57BL/6 * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3 Tg(Prrx1-cre)1Cjt/? |
| Background: |
involves: C57BL/6 * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3 Tg(Prrx1-cre)1Cjt/? |
| Background: |
involves: C57BL/6J * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3<+> Tg(Prrx1-cre)1Cjt/? |
| Background: |
involves: C57BL/6J * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Akerblom B |
| Year: |
2007 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
A role of FRK in regulation of embryonal pancreatic beta cell formation. |
| Volume: |
270 |
| Issue: |
1-2 |
| Pages: |
73-8 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
197
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
197
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
134
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bruyns E |
| Year: |
1996 |
| Journal: |
Genomics |
| Title: |
Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. |
| Volume: |
38 |
| Issue: |
1 |
| Pages: |
79-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bruyns E |
| Year: |
1995 |
| Journal: |
J Biol Chem |
| Title: |
Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. |
| Volume: |
270 |
| Issue: |
52 |
| Pages: |
31372-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ju H |
| Year: |
2009 |
| Journal: |
Neoplasia |
| Title: |
A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. |
| Volume: |
11 |
| Issue: |
12 |
| Pages: |
1340-7 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This group represents protein tyrosine phosphatase receptor type C (PTPRC)-associated protein, also known as CD45-associated protein [, ]. It is a positive regulator of PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
Members of this superfamily are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Members of this family are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma A |
| Year: |
2003 |
| Journal: |
Nat Struct Biol |
| Title: |
Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
197-203 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
1998 |
| Journal: |
Nature |
| Title: |
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. |
| Volume: |
392 |
| Issue: |
6676 |
| Pages: |
608-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marth JD |
| Year: |
1985 |
| Journal: |
Cell |
| Title: |
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. |
| Volume: |
43 |
| Issue: |
2 Pt 1 |
| Pages: |
393-404 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Holtzman DA |
| Year: |
1987 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. |
| Volume: |
84 |
| Issue: |
23 |
| Pages: |
8325-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reith AD |
| Year: |
1995 |
| Journal: |
Mamm Genome |
| Title: |
Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase. |
| Volume: |
6 |
| Issue: |
9 |
| Pages: |
689 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Manz BN |
| Year: |
2015 |
| Journal: |
Elife |
| Title: |
Small molecule inhibition of Csk alters affinity recognition by T cells. |
| Volume: |
4 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schmedt C |
| Year: |
1998 |
| Journal: |
Nature |
| Title: |
Csk controls antigen receptor-mediated development and selection of T-lineage cells. |
| Volume: |
394 |
| Issue: |
6696 |
| Pages: |
901-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nada S |
| Year: |
1994 |
| Journal: |
Oncogene |
| Title: |
Identification of major tyrosine-phosphorylated proteins in Csk-deficient cells. |
| Volume: |
9 |
| Issue: |
12 |
| Pages: |
3571-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Larsen NJ |
| Year: |
1996 |
| Journal: |
Cytogenet Cell Genet |
| Title: |
Seven genes from human chromosome 18 map to chromosome 24 in the bovine. |
| Volume: |
73 |
| Issue: |
3 |
| Pages: |
184-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma J |
| Year: |
2019 |
| Journal: |
PLoS Biol |
| Title: |
Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin. |
| Volume: |
17 |
| Issue: |
10 |
| Pages: |
e3000461 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pitman JL |
| Year: |
2011 |
| Journal: |
J Lipid Res |
| Title: |
Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites. |
| Volume: |
52 |
| Issue: |
10 |
| Pages: |
1775-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Panicker N |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. |
| Volume: |
35 |
| Issue: |
27 |
| Pages: |
10058-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kong MS |
| Year: |
2019 |
| Journal: |
Sci Signal |
| Title: |
Inhibition of T cell activation and function by the adaptor protein CIN85. |
| Volume: |
12 |
| Issue: |
567 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ablooglu AJ |
| Year: |
2009 |
| Journal: |
Blood |
| Title: |
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. |
| Volume: |
113 |
| Issue: |
15 |
| Pages: |
3585-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ritter N |
| Year: |
2019 |
| Journal: |
Dev Cell |
| Title: |
The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. |
| Volume: |
50 |
| Issue: |
5 |
| Pages: |
644-657.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rolny C |
| Year: |
2005 |
| Journal: |
Exp Cell Res |
| Title: |
Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. |
| Volume: |
308 |
| Issue: |
2 |
| Pages: |
381-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koponen E |
| Year: |
2004 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. |
| Volume: |
26 |
| Issue: |
1 |
| Pages: |
166-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki T |
| Year: |
1993 |
| Journal: |
Genomics |
| Title: |
Molecular diversity of the SCG10/stathmin gene family in the mouse. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
360-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goodwin RG |
| Year: |
1991 |
| Journal: |
Mol Cell Biol |
| Title: |
Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. |
| Volume: |
11 |
| Issue: |
6 |
| Pages: |
3020-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cabodi S |
| Year: |
2006 |
| Journal: |
Cancer Res |
| Title: |
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. |
| Volume: |
66 |
| Issue: |
9 |
| Pages: |
4672-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goodwin RG |
| Year: |
1993 |
| Journal: |
Eur J Immunol |
| Title: |
Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. |
| Volume: |
23 |
| Issue: |
10 |
| Pages: |
2631-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Samuels AL |
| Year: |
2009 |
| Journal: |
Blood |
| Title: |
Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. |
| Volume: |
113 |
| Issue: |
16 |
| Pages: |
3845-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu G |
| Year: |
1996 |
| Journal: |
Int Immunol |
| Title: |
Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
1159-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klages S |
| Year: |
1994 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family. |
| Volume: |
91 |
| Issue: |
7 |
| Pages: |
2597-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Molina TJ |
| Year: |
1992 |
| Journal: |
Nature |
| Title: |
Profound block in thymocyte development in mice lacking p56lck. |
| Volume: |
357 |
| Issue: |
6374 |
| Pages: |
161-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thuveson M |
| Year: |
1995 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine. |
| Volume: |
209 |
| Issue: |
2 |
| Pages: |
582-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cory GO |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. |
| Volume: |
277 |
| Issue: |
47 |
| Pages: |
45115-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trobridge PA |
| Year: |
2001 |
| Journal: |
J Immunol |
| Title: |
Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors. |
| Volume: |
166 |
| Issue: |
2 |
| Pages: |
809-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei Q |
| Year: |
2020 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Lck bound to coreceptor is less active than free Lck. |
| Volume: |
117 |
| Issue: |
27 |
| Pages: |
15809-15817 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ziegler SF |
| Year: |
1987 |
| Journal: |
Mol Cell Biol |
| Title: |
Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. |
| Volume: |
7 |
| Issue: |
6 |
| Pages: |
2276-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Couture C |
| Year: |
1994 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation. |
| Volume: |
91 |
| Issue: |
12 |
| Pages: |
5301-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Drebin JA |
| Year: |
1995 |
| Journal: |
Oncogene |
| Title: |
Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
477-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Campi G |
| Year: |
2005 |
| Journal: |
J Exp Med |
| Title: |
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. |
| Volume: |
202 |
| Issue: |
8 |
| Pages: |
1031-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schoenborn JR |
| Year: |
2011 |
| Journal: |
Sci Signal |
| Title: |
Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. |
| Volume: |
4 |
| Issue: |
190 |
| Pages: |
ra59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van Oers NS |
| Year: |
1996 |
| Journal: |
Immunity |
| Title: |
alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. |
| Volume: |
5 |
| Issue: |
5 |
| Pages: |
429-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Birkeland ML |
| Year: |
1995 |
| Journal: |
Eur J Immunol |
| Title: |
Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. |
| Volume: |
25 |
| Issue: |
4 |
| Pages: |
926-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Popova NV |
| Year: |
2003 |
| Journal: |
Carcinogenesis |
| Title: |
Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
417-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Popova NV |
| Year: |
2004 |
| Journal: |
Curr Top Microbiol Immunol |
| Title: |
Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci. |
| Volume: |
280 |
|
| Pages: |
111-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Threadgill DS |
| Year: |
1994 |
| Journal: |
Genomics |
| Title: |
Syntenic assignment of human chromosome 1 homologous loci in the bovine. |
| Volume: |
22 |
| Issue: |
3 |
| Pages: |
626-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Namba T |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
Pioneering axons regulate neuronal polarization in the developing cerebral cortex. |
| Volume: |
81 |
| Issue: |
4 |
| Pages: |
814-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sinai L |
| Year: |
2012 |
| Journal: |
Genes Brain Behav |
| Title: |
Impaired social memories in 129P2 inbred mice are rescued by reduced Csk expression. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
559-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee HJ |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
e0146841 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takatsuka A |
| Year: |
2008 |
| Journal: |
Dev Biol |
| Title: |
Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility. |
| Volume: |
315 |
| Issue: |
2 |
| Pages: |
474-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun C |
| Year: |
2018 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Role of Csk in intestinal epithelial barrier function and protection against colitis. |
| Volume: |
504 |
| Issue: |
1 |
| Pages: |
109-114 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Honda K |
| Year: |
2007 |
| Journal: |
Carcinogenesis |
| Title: |
Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk. |
| Volume: |
28 |
| Issue: |
10 |
| Pages: |
2074-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takayama Y |
| Year: |
1997 |
| Journal: |
FEBS Lett |
| Title: |
Role of Csk in neural differentiation of the embryonic carcinoma cell line P19. |
| Volume: |
406 |
| Issue: |
1-2 |
| Pages: |
11-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Osborne LC |
| Year: |
2007 |
| Journal: |
J Exp Med |
| Title: |
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. |
| Volume: |
204 |
| Issue: |
3 |
| Pages: |
619-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Osborne LC |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia. |
| Volume: |
186 |
| Issue: |
4 |
| Pages: |
1981-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen LS |
| Year: |
2009 |
| Journal: |
J Biomed Sci |
| Title: |
STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. |
| Volume: |
16 |
|
| Pages: |
22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iyer SS |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. |
| Volume: |
185 |
| Issue: |
11 |
| Pages: |
6599-607 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou H |
| Year: |
2011 |
| Journal: |
Bone |
| Title: |
Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species. |
| Volume: |
49 |
| Issue: |
3 |
| Pages: |
404-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JS |
| Year: |
2016 |
| Journal: |
Endocrinology |
| Title: |
Leptin Signaling Is Not Required for Anorexigenic Estradiol Effects in Female Mice. |
| Volume: |
157 |
| Issue: |
5 |
| Pages: |
1991-2001 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schell C |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
e0129424 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee KH |
| Year: |
2003 |
| Journal: |
Science |
| Title: |
The immunological synapse balances T cell receptor signaling and degradation. |
| Volume: |
302 |
| Issue: |
5648 |
| Pages: |
1218-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsui T |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. |
| Volume: |
277 |
| Issue: |
25 |
| Pages: |
22896-901 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Denis R Alexander |
| Allele Type: |
Transgenic |
| Attribute String: |
Dominant negative, Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Il7r/Il7r |
| Background: |
B6.129S4-Il7r |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3 Tg(Nes-cre)1Kln/? |
| Background: |
involves: C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Itgb3/Itgb3 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Itgb3/Itgb3 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lair1/Lair1 Tg(Cd4-cre)1Cwi/? |
| Background: |
involves: C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3<+> Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/? |
| Background: |
involves: CD-1 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat3/Stat3 Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/? |
| Background: |
involves: CD-1 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hayashi T |
| Year: |
2007 |
| Journal: |
Genes Cells |
| Title: |
PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
929-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garçon F |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain. |
| Volume: |
173 |
| Issue: |
2 |
| Pages: |
770-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nikonova AS |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Nedd9 restrains renal cystogenesis in Pkd1-/- mice. |
| Volume: |
111 |
| Issue: |
35 |
| Pages: |
12859-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guiet R |
| Year: |
2008 |
| Journal: |
Eur J Cell Biol |
| Title: |
Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis. |
| Volume: |
87 |
| Issue: |
8-9 |
| Pages: |
527-42 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
HCK is a member of the Src non-receptor type tyrosine kinase (SFK) family. HCK is expressed as two isoforms, p59Hck and p61Hck, in phagocytes. It plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration [, ]. Like the other members of the Src family the SH2 domain in addition to binding the target, also plays an autoinhibitory role by binding to its C-terminal tail []. This entry represents the SH2 domain of HCK.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Blk is a member of the Src non-receptor type tyrosine kinase family of proteins. Blk is involved in B-cell receptor signaling and B-cell development []. Unlike most other Src members Blk lacks cysteine residues in the SH4 domain that undergo palmitylation. Blk is required for the development of IL-17-producing gamma-delta T cells []. This entry represents the SH2 domain of Blk.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dao T |
| Year: |
2004 |
| Journal: |
Eur J Immunol |
| Title: |
Development of CD1d-restricted NKT cells in the mouse thymus. |
| Volume: |
34 |
| Issue: |
12 |
| Pages: |
3542-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kanazawa S |
| Year: |
1996 |
| Journal: |
Blood |
| Title: |
p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes. |
| Volume: |
87 |
| Issue: |
3 |
| Pages: |
865-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cherpokova D |
| Year: |
2015 |
| Journal: |
Blood |
| Title: |
SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. |
| Volume: |
125 |
| Issue: |
1 |
| Pages: |
185-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wybenga-Groot LE |
| Year: |
2015 |
| Journal: |
Cell Signal |
| Title: |
RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling. |
| Volume: |
27 |
| Issue: |
2 |
| Pages: |
267-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kazi JU |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. |
| Volume: |
7 |
| Issue: |
12 |
| Pages: |
e53509 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moharram SA |
| Year: |
2016 |
| Journal: |
Oncotarget |
| Title: |
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. |
| Volume: |
7 |
| Issue: |
36 |
| Pages: |
57770-57782 |
|
•
•
•
•
•
|