Type |
Details |
Score |
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
Allele |
Name: |
acid phosphatase 5, tartrate resistant; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Roland Schule |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Daewon Jeong |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Rene St-Arnaud |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Acp5-Fhl2)#Rosc/? |
Background: |
FVB/N-Tg(Acp5-Fhl2)#Rosc |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Acp5-Selenow)#Djeo/? |
Background: |
involves: FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 3, Rachel A Davey |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 4, Rachel A Davey |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Publication |
First Author: |
Alanne MH |
Year: |
2012 |
Journal: |
J Cell Biochem |
Title: |
Phenotypic characterization of transgenic mice harboring Nf1+/- or Nf1-/- osteoclasts in otherwise Nf1+/+ background. |
Volume: |
113 |
Issue: |
6 |
Pages: |
2136-46 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, G David Roodman |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 11.40, Mouse Clinical Institute |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
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•
•
•
•
•
|
Publication |
First Author: |
Jiang H |
Year: |
2015 |
Journal: |
FASEB J |
Title: |
Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss. |
Volume: |
29 |
Issue: |
6 |
Pages: |
2281-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyagawa K |
Year: |
2023 |
Journal: |
JCI Insight |
Title: |
Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation. |
Volume: |
8 |
Issue: |
14 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Su W |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development. |
Volume: |
5 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Rindone AN |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution. |
Volume: |
12 |
Issue: |
1 |
Pages: |
6219 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reddy SV |
Year: |
2001 |
Journal: |
Endocrinology |
Title: |
Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts. |
Volume: |
142 |
Issue: |
7 |
Pages: |
2898-905 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ilk/Ilk Tg(Acp5-cre)1Star/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Scin/Scin Tg(Acp5-cre)4Rda/? |
Background: |
either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * CBA) |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, transgenic, congenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Calcr/Calcr Tg(Acp5-cre)4Rda/? |
Background: |
B6.Cg-Calcr Tg(Acp5-cre)4Rda |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Günther T |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts. |
Volume: |
24 |
Issue: |
17 |
Pages: |
3049-56 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 28-4-3, Peter Maye |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Adjei-Sowah E |
Year: |
2024 |
Journal: |
Sci Adv |
Title: |
Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing. |
Volume: |
10 |
Issue: |
25 |
Pages: |
eadn2332 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwarz T |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3. |
Volume: |
394 |
Issue: |
4 |
Pages: |
890-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwarz T |
Year: |
2010 |
Journal: |
J Cell Biochem |
Title: |
The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts. |
Volume: |
109 |
Issue: |
5 |
Pages: |
967-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sträter N |
Year: |
2005 |
Journal: |
J Mol Biol |
Title: |
Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop. |
Volume: |
351 |
Issue: |
1 |
Pages: |
233-46 |
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•
•
•
•
•
|
Publication |
First Author: |
del Pozo JC |
Year: |
1999 |
Journal: |
Plant J |
Title: |
A type 5 acid phosphatase gene from Arabidopsis thaliana is induced by phosphate starvation and by some other types of phosphate mobilising/oxidative stress conditions. |
Volume: |
19 |
Issue: |
5 |
Pages: |
579-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu H |
Year: |
2005 |
Journal: |
Plant Mol Biol |
Title: |
Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower. |
Volume: |
59 |
Issue: |
4 |
Pages: |
581-94 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes purple acid phosphatases (EC 3.1.3.2), which are metal dependent, binding two metal ions. Metal binding ligands and residues involved in resistance to tartrate inhibition are conserved [].Purple acid phosphatase 3, 4, 7, 8 and 17 are found in plants, bind zinc and iron, and the genes are predominantly transcribed in flowers []. Purple acid phosphatase 17 (PAP17) is induced in response to phosphate starvation, a condition occurring in phosphate-poor soils, and the plant hormone abscisic acid (ABA) and salt stress. Like mammalian acid phosphatase 5, PAP17 has peroxidation activity [].Acid phosphatase 5 (ACP5; EC 3.1.3.2) removes the mannose 6-phosphate recognition marker from lysosomal proteins. The exact site of dephosphorylation is not clear. Evidence suggests dephosphorylation may take place in a prelysosomal compartment as well as in the lysosome []. ACP5 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) co-ordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues []. |
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•
•
•
•
•
|
Publication |
First Author: |
Xie H |
Year: |
2014 |
Journal: |
Nat Med |
Title: |
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. |
Volume: |
20 |
Issue: |
11 |
Pages: |
1270-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2258 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davey RA |
Year: |
2008 |
Journal: |
J Bone Miner Res |
Title: |
Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. |
Volume: |
23 |
Issue: |
8 |
Pages: |
1182-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ni S |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5643 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Acp5-cre)3Rda/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Acp5-cre)4Rda/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu R |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors. |
Volume: |
27 |
Issue: |
11 |
Pages: |
4018-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chawalitpong S |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway. |
Volume: |
8 |
Issue: |
1 |
Pages: |
5625 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ripoll VM |
Year: |
2008 |
Journal: |
Gene |
Title: |
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. |
Volume: |
413 |
Issue: |
1-2 |
Pages: |
32-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bronisz A |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). |
Volume: |
289 |
Issue: |
1 |
Pages: |
326-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li D |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export. |
Volume: |
21 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
327
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dossa T |
Year: |
2010 |
Journal: |
J Cell Biochem |
Title: |
Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption. |
Volume: |
110 |
Issue: |
4 |
Pages: |
960-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiu WS |
Year: |
2004 |
Journal: |
Genesis |
Title: |
Transgenic mice that express Cre recombinase in osteoclasts. |
Volume: |
39 |
Issue: |
3 |
Pages: |
178-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maye P |
Year: |
2009 |
Journal: |
BMC Biotechnol |
Title: |
A BAC-bacterial recombination method to generate physically linked multiple gene reporter DNA constructs. |
Volume: |
9 |
|
Pages: |
20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fretz JA |
Year: |
2008 |
Journal: |
Mol Endocrinol |
Title: |
Receptor activator of nuclear factor-kappaB ligand-induced nuclear factor of activated T cells (C1) autoregulates its own expression in osteoclasts and mediates the up-regulation of tartrate-resistant acid phosphatase. |
Volume: |
22 |
Issue: |
3 |
Pages: |
737-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Le PT |
Year: |
2021 |
Journal: |
Bone |
Title: |
The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche. |
Volume: |
144 |
|
Pages: |
115832 |
|
•
•
•
•
•
|
Publication |
First Author: |
Otero JE |
Year: |
2010 |
Journal: |
J Bone Miner Res |
Title: |
IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. |
Volume: |
25 |
Issue: |
6 |
Pages: |
1282-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu Y |
Year: |
2015 |
Journal: |
Genesis |
Title: |
Derivation of chondrocyte and osteoblast reporter mouse embryonic stem cell lines. |
Volume: |
53 |
Issue: |
3-4 |
Pages: |
294-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
European Mouse Mutant Archive |
Year: |
2003 |
Journal: |
Unpublished |
Title: |
Information obtained from the European Mouse Mutant Archive (EMMA) |
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•
•
•
•
•
|