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Search results 401 to 500 out of 568 for Adam17

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Type Details Score
Publication
First Author: DeBerge MP
Year: 2013
Journal: PLoS One
Title: ADAM17-mediated processing of TNF-α expressed by antiviral effector CD8+ T cells is required for severe T-cell-mediated lung injury.
Volume: 8
Issue: 11
Pages: e79340
Publication
First Author: Federici M
Year: 2005
Journal: J Clin Invest
Title: Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Volume: 115
Issue: 12
Pages: 3494-505
Publication
First Author: Teupser D
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.
Volume: 103
Issue: 1
Pages: 123-8
Publication
First Author: Rowlands DJ
Year: 2011
Journal: J Clin Invest
Title: Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels.
Volume: 121
Issue: 5
Pages: 1986-99
Publication
First Author: Yan F
Year: 2009
Journal: Gastroenterology
Title: Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
Volume: 136
Issue: 4
Pages: 1297-1307, e1-3
Publication
First Author: Zhao J
Year: 2001
Journal: Dev Biol
Title: Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.
Volume: 232
Issue: 1
Pages: 204-18
Publication
First Author: Yoon S
Year: 2013
Journal: J Biol Chem
Title: Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation.
Volume: 288
Issue: 40
Pages: 28435-46
Publication
First Author: Xu H
Year: 2012
Journal: Nat Immunol
Title: Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Volume: 13
Issue: 7
Pages: 642-50
Publication
First Author: Haxaire C
Year: 2018
Journal: Blood
Title: Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.
Volume: 132
Issue: 10
Pages: 1064-1074
Publication
First Author: Biswas S
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.
Volume: 477
Issue: 4
Pages: 661-666
Publication
First Author: Kobayashi T
Year: 2015
Journal: Immunity
Title: Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
Volume: 42
Issue: 4
Pages: 756-66
Publication
First Author: Casari C
Year: 2018
Journal: Blood Adv
Title: Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.
Volume: 2
Issue: 12
Pages: 1417-1428
Publication  
First Author: Diener N
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.
Volume: 118
Issue: 38
Publication
First Author: Yamazaki K
Year: 1998
Journal: Genomics
Title: Genetic mapping of mouse tumor necrosis factor-alpha converting enzyme (TACE) to chromosome 12.
Volume: 49
Issue: 2
Pages: 336-7
Publication
First Author: Khan AA
Year: 2008
Journal: J Leukoc Biol
Title: SEB-induced signaling in macrophages leads to biphasic TNF-alpha.
Volume: 83
Issue: 6
Pages: 1363-9
Publication  
First Author: Moreno-Càceres J
Year: 2014
Journal: Cell Death Dis
Title: Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.
Volume: 5
Pages: e1326
Publication
First Author: Zhou HM
Year: 2004
Journal: Mol Cell Biol
Title: Essential role for ADAM19 in cardiovascular morphogenesis.
Volume: 24
Issue: 1
Pages: 96-104
Publication
First Author: Zhang C
Year: 2010
Journal: Dev Dyn
Title: Adam10 is essential for early embryonic cardiovascular development.
Volume: 239
Issue: 10
Pages: 2594-602
Publication
First Author: Yang LT
Year: 2005
Journal: Mol Biol Cell
Title: Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.
Volume: 16
Issue: 2
Pages: 927-42
Publication
First Author: Voisin B
Year: 2023
Journal: Immunity
Title: Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin.
Volume: 56
Issue: 7
Pages: 1561-1577.e9
Publication
First Author: Yousif AS
Year: 2021
Journal: Immunity
Title: The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells.
Volume: 54
Issue: 2
Pages: 235-246.e5
Publication
First Author: Shi W
Year: 2003
Journal: Dev Biol
Title: TACE is required for fetal murine cardiac development and modeling.
Volume: 261
Issue: 2
Pages: 371-80
Publication
First Author: Higashiyama S
Year: 2005
Journal: Biochim Biophys Acta
Title: ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.
Volume: 1751
Issue: 1
Pages: 110-7
Publication
First Author: Kurey I
Year: 2009
Journal: Immunogenetics
Title: Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection.
Volume: 61
Issue: 9
Pages: 619-33
Publication
First Author: Meng Q
Year: 2014
Journal: PLoS One
Title: Expression of signaling components in embryonic eyelid epithelium.
Volume: 9
Issue: 2
Pages: e87038
Publication
First Author: Sierro F
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.
Volume: 104
Issue: 37
Pages: 14759-64
Publication
First Author: Weber S
Year: 2011
Journal: Development
Title: The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.
Volume: 138
Issue: 3
Pages: 495-505
Publication
First Author: Kim IM
Year: 2005
Journal: J Biol Chem
Title: The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.
Volume: 280
Issue: 23
Pages: 22278-86
Publication
First Author: Torregrosa-Carrión R
Year: 2021
Journal: Sci Adv
Title: Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development.
Volume: 7
Issue: 46
Pages: eabj5445
Publication
First Author: Leilei Y
Year: 2014
Journal: PLoS One
Title: iRhom2 mutation leads to aberrant hair follicle differentiation in mice.
Volume: 9
Issue: 12
Pages: e115114
Publication
First Author: Chang B
Year: 2005
Journal: Vis Neurosci
Title: Mouse models of ocular diseases.
Volume: 22
Issue: 5
Pages: 587-93
Publication  
First Author: Besschetnova TY
Year: 2015
Journal: Matrix Biol
Title: Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.
Volume: 42
Pages: 56-73
Publication
First Author: Adissu HA
Year: 2014
Journal: Dis Model Mech
Title: Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Volume: 7
Issue: 5
Pages: 515-24
Publication
First Author: Rosendahl AH
Year: 2022
Journal: J Biol Chem
Title: Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
Volume: 298
Issue: 4
Pages: 101787
Publication
First Author: Cullen M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Volume: 108
Issue: 14
Pages: 5759-64
Publication    
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
Publication
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 1710
Description: Cleavage; by ADAM17
Type: site
End: 1711
UniProt Feature
Begin: 588
Description: Cleavage; by ADAM17
Type: site
End: 589
UniProt Feature
Begin: 79
Description: Cleavage; by ADAM17
Type: site
End: 80
HT Experiment
Series Id: GSE38830
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
UniProt Feature
Begin: 354
Description: Cleavage; by ADAM10 and ADAM17
Type: site
End: 355
Publication
First Author: Tellier E
Year: 2006
Journal: Exp Cell Res
Title: The shedding activity of ADAM17 is sequestered in lipid rafts.
Volume: 312
Issue: 20
Pages: 3969-80
Publication  
First Author: Li R
Year: 2018
Journal: J Cell Sci
Title: Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK.
Volume: 131
Issue: 4
Publication
First Author: Xu J
Year: 2019
Journal: Hypertension
Title: Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation.
Volume: 73
Issue: 6
Pages: 1266-1274
Publication
First Author: Salem ES
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice.
Volume: 306
Issue: 6
Pages: F629-39
Publication
First Author: Riera M
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Paricalcitol modulates ACE2 shedding and renal ADAM17 in NOD mice beyond proteinuria.
Volume: 310
Issue: 6
Pages: F534-46
Publication      
First Author: Lartey NL
Year: 2021
Journal: bioRxiv
Title: ADAM17 inhibition prevents neutrophilia and lung injury in a mouse model of Covid-19.
Publication  
First Author: Tian Y
Year: 2023
Journal: Front Mol Neurosci
Title: The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer's disease.
Volume: 16
Pages: 1125932
GO Term
Publication
First Author: Heurich A
Year: 2014
Journal: J Virol
Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
Volume: 88
Issue: 2
Pages: 1293-307
GXD Expression
Probe: MGI:6690292
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6690294
Age: embryonic day 15.5
Image: 4C
Note: Expression was detected in neurons in the substantia nigra and the ventral tegmental area and co-localized with Adam17 immunostaining.
Specimen Label: 4C
Detected: true
Specimen Num: 2
Allele
Name: a disintegrin and metallopeptidase domain 17; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
GXD Expression
Probe: MGI:3580797
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3580832
Age: postnatal adult
Image: 5H, 5I
Note: Expression was detected in the cell membrane. Expression did not colocalize with Adam17 in the cell membranes of the islets of Langerhans.
Specimen Label: 5H, 5I
Detected: true
Specimen Num: 3
Publication
First Author: Düsterhöft S
Year: 2013
Journal: J Am Chem Soc
Title: Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.
Volume: 135
Issue: 15
Pages: 5776-81
Protein Domain
Type: Domain
Description: This entry represents the membrane-proximal domain (MPD) of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) from animals. ADAM17 is a major sheddase responsible for the regulation of a wide range of biological processes, such as cellular differentiation, regeneration, and cancer progression. This MPD region acts as the sheddase switch. PDI (protein-disulfide isomerase) interacts with ADAM17 and down-regulates its enzymatic activity. The interaction is directly with the MPD, the region of dimerisation and substrate recognition, where it catalyses an isomerisation of disulfide bridges within the thioredoxin motif CXXC. This isomerisation results in a major structural change between an active, open state and an inactive, closed state of the MPD. This change is thought to act as a molecular switch, allowing a global reorientation of the extracellular domains in ADAM17 and regulating its shedding activity [].
Publication  
First Author: Killar L
Year: 1999
Journal: Ann N Y Acad Sci
Title: Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE).
Volume: 878
Pages: 442-52
Protein Domain
Type: Domain
Description: This entry includes proteins with reprolysin-like metallopeptidase domains and includes ADAM10 (also known as myelin-associated metalloendopeptidase, MEROPS identifier M12.210), ADAM17 (also known as tumour necrosis factor alpha-convertase, MEROPS identifier M12.217), kuzbanian (MEROPS identifiers M12.211 and M12.322) and ADM-4 (MEROPS identifier M12.329) [].
Publication
First Author: Sun H
Year: 2021
Journal: Genes Brain Behav
Title: iRhom1 rescues cognitive dysfunction in multiple sclerosis via preventing myelin injury.
Volume: 20
Issue: 8
Pages: e12771
Publication  
First Author: Revandkar A
Year: 2016
Journal: Nat Commun
Title: Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence.
Volume: 7
Pages: 13719
Publication  
First Author: Lee HJ
Year: 2021
Journal: Biology (Basel)
Title: Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD.
Volume: 10
Issue: 9
Publication
First Author: Song WM
Year: 2018
Journal: J Exp Med
Title: Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Volume: 215
Issue: 3
Pages: 745-760
Publication  
First Author: Dombernowsky SL
Year: 2015
Journal: Nat Commun
Title: The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.
Volume: 6
Pages: 7518