| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vranová E |
| Year: |
2001 |
| Journal: |
J Exp Bot |
| Title: |
The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C. |
| Volume: |
52 |
| Issue: |
354 |
| Pages: |
181-2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang L |
| Year: |
2017 |
| Journal: |
Biol Open |
| Title: |
Akt3 is responsible for the survival and proliferation of embryonic stem cells. |
| Volume: |
6 |
| Issue: |
6 |
| Pages: |
850-861 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang R |
| Year: |
2020 |
| Journal: |
FASEB J |
| Title: |
Inflammatory-sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration. |
| Volume: |
34 |
| Issue: |
3 |
| Pages: |
3554-3569 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barthel A |
| Year: |
1998 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes. |
| Volume: |
243 |
| Issue: |
2 |
| Pages: |
509-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Taniyama Y |
| Year: |
2005 |
| Journal: |
J Mol Cell Cardiol |
| Title: |
Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. |
| Volume: |
38 |
| Issue: |
2 |
| Pages: |
375-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Herrera JL |
| Year: |
2024 |
| Journal: |
Cell Rep |
| Title: |
Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1. |
| Volume: |
43 |
| Issue: |
3 |
| Pages: |
113837 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ding L |
| Year: |
2017 |
| Journal: |
JCI Insight |
| Title: |
Akt3 inhibits adipogenesis and protects from diet-induced obesity via WNK1/SGK1 signaling |
| Volume: |
2 |
| Issue: |
22 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng L |
| Year: |
2017 |
| Journal: |
Oncotarget |
| Title: |
Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
808-818 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rasoulpour T |
| Year: |
2006 |
| Journal: |
Endocrinology |
| Title: |
Akt1 suppresses radiation-induced germ cell apoptosis in vivo. |
| Volume: |
147 |
| Issue: |
9 |
| Pages: |
4213-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown C |
| Year: |
2010 |
| Journal: |
Biol Reprod |
| Title: |
Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1. |
| Volume: |
82 |
| Issue: |
2 |
| Pages: |
246-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
DeBosch B |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Akt2 regulates cardiac metabolism and cardiomyocyte survival. |
| Volume: |
281 |
| Issue: |
43 |
| Pages: |
32841-51 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Protein kinase B (PKB), also called Akt or RAC, is a phosphatidylinositol 3'-kinase (PI3K)-dependent Ser/Thr kinase which alters the activity of the targeted protein []. Akt regulates numerous cellular processes, including cell growth, differentiation, proliferation, apoptosis, and glucose metabolism. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues [, ]. Human Akt has three isoforms derived for distinct genes: Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma.This entry represents Akt3 from mammals and related proteins. Akt3 inhibits adipogenesis via WNK1/SGK1 signaling []. It is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal brain size []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reed NP |
| Year: |
2013 |
| Journal: |
Genes Immun |
| Title: |
Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
7-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Legnini I |
| Year: |
2017 |
| Journal: |
Mol Cell |
| Title: |
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. |
| Volume: |
66 |
| Issue: |
1 |
| Pages: |
22-37.e9 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
303
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
469
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
46
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
285
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu C |
| Year: |
2017 |
| Journal: |
Theranostics |
| Title: |
Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction. |
| Volume: |
7 |
| Issue: |
11 |
| Pages: |
2863-2877 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Zinc finger proteins 608 and 609 (ZNF608/ZNF609) are putative transcription factors. ZNF608 represses the expression of ZNF609, which in turn represses recombination-activating gene 1 (Rag1) and Rag2 expression in thymocytes []. Interestingly, ZNF609 generates circular RNA (Cir-ZNF609), a novel kind of noncoding RNA that form loop structures without 5'-3' polarities and polyadenylated tails. Cir-ZNF609 has been found to regulate myoblast proliferation and AKT3 expression [, ]. Cir-ZNF609 has also been linked to vascular endothelial dysfunction []. |
|
•
•
•
•
•
|
| Allele |
| Name: |
thymoma viral proto-oncogene 1; targeted mutation 1, Morris J Birnbaum |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho H |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. |
| Volume: |
276 |
| Issue: |
42 |
| Pages: |
38349-52 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ha JM |
| Year: |
2019 |
| Journal: |
FEBS Open Bio |
| Title: |
Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
801-813 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen YC |
| Year: |
2012 |
| Journal: |
Genes Brain Behav |
| Title: |
Akt1 deficiency modulates reward learning and reward prediction error in mice. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
157-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li LF |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. |
| Volume: |
12 |
| Issue: |
2 |
| Pages: |
e0172571 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kiessling S |
| Year: |
2007 |
| Journal: |
Cell Death Differ |
| Title: |
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
186-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernández-Hernando C |
| Year: |
2009 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. |
| Volume: |
29 |
| Issue: |
12 |
| Pages: |
2033-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogers R |
| Year: |
2008 |
| Journal: |
Toxicol Sci |
| Title: |
Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis. |
| Volume: |
106 |
| Issue: |
2 |
| Pages: |
497-508 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Emamian ES |
| Year: |
2004 |
| Journal: |
Nat Genet |
| Title: |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. |
| Volume: |
36 |
| Issue: |
2 |
| Pages: |
131-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IY |
| Year: |
2021 |
| Journal: |
Korean J Intern Med |
| Title: |
Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease. |
| Volume: |
36 |
| Issue: |
4 |
| Pages: |
962-974 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen YW |
| Year: |
2014 |
| Journal: |
Schizophr Bull |
| Title: |
A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis. |
| Volume: |
40 |
| Issue: |
2 |
| Pages: |
388-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang CY |
| Year: |
2016 |
| Journal: |
Sci Rep |
| Title: |
Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions. |
| Volume: |
6 |
|
| Pages: |
33095 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nojima A |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Haploinsufficiency of akt1 prolongs the lifespan of mice. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
e69178 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beiser DG |
| Year: |
2010 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest. |
| Volume: |
298 |
| Issue: |
6 |
| Pages: |
H1761-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moriya N |
| Year: |
2018 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation. |
| Volume: |
314 |
| Issue: |
5 |
| Pages: |
R741-R751 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen YW |
| Year: |
2011 |
| Journal: |
Neuroscience |
| Title: |
Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics. |
| Volume: |
174 |
|
| Pages: |
178-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo DZ |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
647 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyazaki M |
| Year: |
2020 |
| Journal: |
Physiol Rep |
| Title: |
Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation. |
| Volume: |
8 |
| Issue: |
19 |
| Pages: |
e14599 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
LaRocca J |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1. |
| Volume: |
6 |
| Issue: |
9 |
| Pages: |
e24432 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jin SY |
| Year: |
2014 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Insulin regulates monocyte trans-endothelial migration through surface expression of macrophage-1 antigen. |
| Volume: |
1842 |
| Issue: |
9 |
| Pages: |
1539-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim IY |
| Year: |
2023 |
| Journal: |
Exp Cell Res |
| Title: |
Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition. |
| Volume: |
424 |
| Issue: |
2 |
| Pages: |
113509 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xin X |
| Year: |
2007 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Akt activation and augmented fibronectin production in hyperhexosemia. |
| Volume: |
293 |
| Issue: |
4 |
| Pages: |
E1036-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Krawczyk CM |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. |
| Volume: |
115 |
| Issue: |
23 |
| Pages: |
4742-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
DeBosch B |
| Year: |
2006 |
| Journal: |
Circulation |
| Title: |
Akt1 is required for physiological cardiac growth. |
| Volume: |
113 |
| Issue: |
17 |
| Pages: |
2097-104 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kent LN |
| Year: |
2012 |
| Journal: |
Int J Dev Biol |
| Title: |
Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development. |
| Volume: |
56 |
| Issue: |
4 |
| Pages: |
255-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jacobs SR |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. |
| Volume: |
180 |
| Issue: |
7 |
| Pages: |
4476-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Larson-Casey JL |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. |
| Volume: |
289 |
| Issue: |
52 |
| Pages: |
36204-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lai WS |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. |
| Volume: |
103 |
| Issue: |
45 |
| Pages: |
16906-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jee HJ |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS. |
| Volume: |
383 |
| Issue: |
3 |
| Pages: |
358-62 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Akt1/Akt1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Akt1/Akt1 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Akt1/Akt1 |
| Background: |
B6.129P2-Akt1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Akt1/Akt1<+> |
| Background: |
B6.129P2-Akt1 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Subbotina E |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Musclin is an activity-stimulated myokine that enhances physical endurance. |
| Volume: |
112 |
| Issue: |
52 |
| Pages: |
16042-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nishi J |
| Year: |
2008 |
| Journal: |
Circ Res |
| Title: |
Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. |
| Volume: |
103 |
| Issue: |
3 |
| Pages: |
261-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yun SJ |
| Year: |
2014 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells. |
| Volume: |
1842 |
| Issue: |
11 |
| Pages: |
2184-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernández-Hernando C |
| Year: |
2007 |
| Journal: |
Cell Metab |
| Title: |
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. |
| Volume: |
6 |
| Issue: |
6 |
| Pages: |
446-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim ST |
| Year: |
2012 |
| Journal: |
Reprod Sci |
| Title: |
Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
31-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mogi M |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Akt signaling regulates side population cell phenotype via Bcrp1 translocation. |
| Volume: |
278 |
| Issue: |
40 |
| Pages: |
39068-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dickey CA |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Akt and CHIP coregulate tau degradation through coordinated interactions. |
| Volume: |
105 |
| Issue: |
9 |
| Pages: |
3622-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Piantadosi CA |
| Year: |
2008 |
| Journal: |
Circ Res |
| Title: |
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. |
| Volume: |
103 |
| Issue: |
11 |
| Pages: |
1232-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mathew B |
| Year: |
2015 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury. |
| Volume: |
309 |
| Issue: |
12 |
| Pages: |
L1420-9 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Akt1/Akt1<+> Flt1/Flt1<+> |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dillon RL |
| Year: |
2010 |
| Journal: |
Cancer Res |
| Title: |
Distinct biological roles for the akt family in mammary tumor progression. |
| Volume: |
70 |
| Issue: |
11 |
| Pages: |
4260-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mende I |
| Year: |
2001 |
| Journal: |
Oncogene |
| Title: |
Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. |
| Volume: |
20 |
| Issue: |
32 |
| Pages: |
4419-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou C |
| Year: |
2022 |
| Journal: |
Adv Sci (Weinh) |
| Title: |
Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia. |
| Volume: |
9 |
| Issue: |
17 |
| Pages: |
e2104986 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma M |
| Year: |
2018 |
| Journal: |
Development |
| Title: |
Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. |
| Volume: |
145 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ezell SA |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. |
| Volume: |
109 |
| Issue: |
10 |
| Pages: |
E613-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mirzaa G |
| Year: |
2014 |
| Journal: |
Nat Genet |
| Title: |
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. |
| Volume: |
46 |
| Issue: |
5 |
| Pages: |
510-515 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meng S |
| Year: |
2023 |
| Journal: |
Nat Cell Biol |
| Title: |
Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells. |
| Volume: |
25 |
| Issue: |
9 |
| Pages: |
1319-1331 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Whiteman EL |
| Year: |
2002 |
| Journal: |
Trends Endocrinol Metab |
| Title: |
Role of Akt/protein kinase B in metabolism. |
| Volume: |
13 |
| Issue: |
10 |
| Pages: |
444-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zou W |
| Year: |
2000 |
| Journal: |
Sheng Li Ke Xue Jin Zhan |
| Title: |
[Protein kinase B and its role in the signal transduction pathway mediated by phosphoinositide 3-kinase]. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
120-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Manning BD |
| Year: |
2017 |
| Journal: |
Cell |
| Title: |
AKT/PKB Signaling: Navigating the Network. |
| Volume: |
169 |
| Issue: |
3 |
| Pages: |
381-405 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hammerman PS |
| Year: |
2005 |
| Journal: |
Blood |
| Title: |
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. |
| Volume: |
105 |
| Issue: |
11 |
| Pages: |
4477-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
d'Uscio LV |
| Year: |
2008 |
| Journal: |
Hypertension |
| Title: |
Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1. |
| Volume: |
52 |
| Issue: |
1 |
| Pages: |
93-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carraway MS |
| Year: |
2010 |
| Journal: |
Circ Res |
| Title: |
Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. |
| Volume: |
106 |
| Issue: |
11 |
| Pages: |
1722-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Larson-Casey JL |
| Year: |
2016 |
| Journal: |
Immunity |
| Title: |
Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. |
| Volume: |
44 |
| Issue: |
3 |
| Pages: |
582-596 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saji M |
| Year: |
2011 |
| Journal: |
Oncogene |
| Title: |
Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer. |
| Volume: |
30 |
| Issue: |
42 |
| Pages: |
4307-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng C |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. |
| Volume: |
115 |
| Issue: |
3 |
| Pages: |
626-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Calamito M |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
Akt1 and Akt2 promote peripheral B-cell maturation and survival. |
| Volume: |
115 |
| Issue: |
20 |
| Pages: |
4043-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Di Lorenzo A |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. |
| Volume: |
106 |
| Issue: |
34 |
| Pages: |
14552-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Juntilla MM |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. |
| Volume: |
115 |
| Issue: |
20 |
| Pages: |
4030-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ackah E |
| Year: |
2005 |
| Journal: |
J Clin Invest |
| Title: |
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. |
| Volume: |
115 |
| Issue: |
8 |
| Pages: |
2119-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goncalves MD |
| Year: |
2010 |
| Journal: |
PLoS One |
| Title: |
Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition. |
| Volume: |
5 |
| Issue: |
9 |
| Pages: |
e12707 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koral K |
| Year: |
2014 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Akt recruits Dab2 to albumin endocytosis in the proximal tubule. |
| Volume: |
307 |
| Issue: |
12 |
| Pages: |
F1380-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maruyama S |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism. |
| Volume: |
286 |
| Issue: |
37 |
| Pages: |
32790-800 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ju R |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. |
| Volume: |
289 |
| Issue: |
1 |
| Pages: |
510-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schleicher M |
| Year: |
2009 |
| Journal: |
Sci Signal |
| Title: |
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. |
| Volume: |
2 |
| Issue: |
82 |
| Pages: |
ra41 |
|
•
•
•
•
•
|