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Search results 401 to 500 out of 568 for Akt3

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Type Details Score
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Vranová E
Year: 2001
Journal: J Exp Bot
Title: The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C.
Volume: 52
Issue: 354
Pages: 181-2
Publication
First Author: Wang L
Year: 2017
Journal: Biol Open
Title: Akt3 is responsible for the survival and proliferation of embryonic stem cells.
Volume: 6
Issue: 6
Pages: 850-861
Publication
First Author: Wang R
Year: 2020
Journal: FASEB J
Title: Inflammatory-sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration.
Volume: 34
Issue: 3
Pages: 3554-3569
Publication
First Author: Barthel A
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes.
Volume: 243
Issue: 2
Pages: 509-13
Publication
First Author: Taniyama Y
Year: 2005
Journal: J Mol Cell Cardiol
Title: Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy.
Volume: 38
Issue: 2
Pages: 375-85
Publication
First Author: Herrera JL
Year: 2024
Journal: Cell Rep
Title: Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1.
Volume: 43
Issue: 3
Pages: 113837
Publication  
First Author: Ding L
Year: 2017
Journal: JCI Insight
Title: Akt3 inhibits adipogenesis and protects from diet-induced obesity via WNK1/SGK1 signaling
Volume: 2
Issue: 22
Publication
First Author: Peng L
Year: 2017
Journal: Oncotarget
Title: Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.
Volume: 8
Issue: 1
Pages: 808-818
Publication
First Author: Rasoulpour T
Year: 2006
Journal: Endocrinology
Title: Akt1 suppresses radiation-induced germ cell apoptosis in vivo.
Volume: 147
Issue: 9
Pages: 4213-21
Publication
First Author: Brown C
Year: 2010
Journal: Biol Reprod
Title: Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1.
Volume: 82
Issue: 2
Pages: 246-56
Publication
First Author: DeBosch B
Year: 2006
Journal: J Biol Chem
Title: Akt2 regulates cardiac metabolism and cardiomyocyte survival.
Volume: 281
Issue: 43
Pages: 32841-51
Protein Domain
Type: Family
Description: Protein kinase B (PKB), also called Akt or RAC, is a phosphatidylinositol 3'-kinase (PI3K)-dependent Ser/Thr kinase which alters the activity of the targeted protein []. Akt regulates numerous cellular processes, including cell growth, differentiation, proliferation, apoptosis, and glucose metabolism. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues [, ]. Human Akt has three isoforms derived for distinct genes: Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma.This entry represents Akt3 from mammals and related proteins. Akt3 inhibits adipogenesis via WNK1/SGK1 signaling []. It is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal brain size [].
Publication
First Author: Reed NP
Year: 2013
Journal: Genes Immun
Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.
Volume: 14
Issue: 1
Pages: 7-12
Publication
First Author: Legnini I
Year: 2017
Journal: Mol Cell
Title: Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
Volume: 66
Issue: 1
Pages: 22-37.e9
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: true
Publication
First Author: Liu C
Year: 2017
Journal: Theranostics
Title: Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.
Volume: 7
Issue: 11
Pages: 2863-2877
Protein Domain
Type: Family
Description: Zinc finger proteins 608 and 609 (ZNF608/ZNF609) are putative transcription factors. ZNF608 represses the expression of ZNF609, which in turn represses recombination-activating gene 1 (Rag1) and Rag2 expression in thymocytes []. Interestingly, ZNF609 generates circular RNA (Cir-ZNF609), a novel kind of noncoding RNA that form loop structures without 5'-3' polarities and polyadenylated tails. Cir-ZNF609 has been found to regulate myoblast proliferation and AKT3 expression [, ]. Cir-ZNF609 has also been linked to vascular endothelial dysfunction [].
Allele
Name: thymoma viral proto-oncogene 1; targeted mutation 1, Morris J Birnbaum
Allele Type: Targeted
Attribute String: Null/knockout
Publication
First Author: Cho H
Year: 2001
Journal: J Biol Chem
Title: Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
Volume: 276
Issue: 42
Pages: 38349-52
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Ha JM
Year: 2019
Journal: FEBS Open Bio
Title: Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage.
Volume: 9
Issue: 4
Pages: 801-813
Publication
First Author: Chen YC
Year: 2012
Journal: Genes Brain Behav
Title: Akt1 deficiency modulates reward learning and reward prediction error in mice.
Volume: 11
Issue: 2
Pages: 157-69
Publication
First Author: Li LF
Year: 2017
Journal: PLoS One
Title: Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway.
Volume: 12
Issue: 2
Pages: e0172571
Publication
First Author: Kiessling S
Year: 2007
Journal: Cell Death Differ
Title: Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha.
Volume: 14
Issue: 1
Pages: 186-9
Publication
First Author: Fernández-Hernando C
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.
Volume: 29
Issue: 12
Pages: 2033-40
Publication
First Author: Rogers R
Year: 2008
Journal: Toxicol Sci
Title: Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis.
Volume: 106
Issue: 2
Pages: 497-508
Publication
First Author: Emamian ES
Year: 2004
Journal: Nat Genet
Title: Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Volume: 36
Issue: 2
Pages: 131-7
Publication
First Author: Kim IY
Year: 2021
Journal: Korean J Intern Med
Title: Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease.
Volume: 36
Issue: 4
Pages: 962-974
Publication
First Author: Chen YW
Year: 2014
Journal: Schizophr Bull
Title: A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis.
Volume: 40
Issue: 2
Pages: 388-98
Publication  
First Author: Chang CY
Year: 2016
Journal: Sci Rep
Title: Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.
Volume: 6
Pages: 33095
Publication
First Author: Nojima A
Year: 2013
Journal: PLoS One
Title: Haploinsufficiency of akt1 prolongs the lifespan of mice.
Volume: 8
Issue: 7
Pages: e69178
Publication
First Author: Beiser DG
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest.
Volume: 298
Issue: 6
Pages: H1761-8
Publication
First Author: Moriya N
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation.
Volume: 314
Issue: 5
Pages: R741-R751
Publication  
First Author: Chen YW
Year: 2011
Journal: Neuroscience
Title: Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.
Volume: 174
Pages: 178-89
Publication
First Author: Luo DZ
Year: 2020
Journal: Sci Rep
Title: Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models.
Volume: 10
Issue: 1
Pages: 647
Publication
First Author: Miyazaki M
Year: 2020
Journal: Physiol Rep
Title: Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation.
Volume: 8
Issue: 19
Pages: e14599
Publication
First Author: LaRocca J
Year: 2011
Journal: PLoS One
Title: Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Volume: 6
Issue: 9
Pages: e24432
Publication
First Author: Jin SY
Year: 2014
Journal: Biochim Biophys Acta
Title: Insulin regulates monocyte trans-endothelial migration through surface expression of macrophage-1 antigen.
Volume: 1842
Issue: 9
Pages: 1539-48
Publication
First Author: Kim IY
Year: 2023
Journal: Exp Cell Res
Title: Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition.
Volume: 424
Issue: 2
Pages: 113509
Publication
First Author: Xin X
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Akt activation and augmented fibronectin production in hyperhexosemia.
Volume: 293
Issue: 4
Pages: E1036-44
Publication
First Author: Krawczyk CM
Year: 2010
Journal: Blood
Title: Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.
Volume: 115
Issue: 23
Pages: 4742-9
Publication
First Author: DeBosch B
Year: 2006
Journal: Circulation
Title: Akt1 is required for physiological cardiac growth.
Volume: 113
Issue: 17
Pages: 2097-104
Publication
First Author: Kent LN
Year: 2012
Journal: Int J Dev Biol
Title: Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Volume: 56
Issue: 4
Pages: 255-61
Publication
First Author: Jacobs SR
Year: 2008
Journal: J Immunol
Title: Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
Volume: 180
Issue: 7
Pages: 4476-86
Publication
First Author: Larson-Casey JL
Year: 2014
Journal: J Biol Chem
Title: Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis.
Volume: 289
Issue: 52
Pages: 36204-19
Publication
First Author: Lai WS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.
Volume: 103
Issue: 45
Pages: 16906-11
Publication
First Author: Jee HJ
Year: 2009
Journal: Biochem Biophys Res Commun
Title: UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS.
Volume: 383
Issue: 3
Pages: 358-62
Genotype
Symbol: Akt1/Akt1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Akt1/Akt1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Akt1/Akt1
Background: B6.129P2-Akt1
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Akt1/Akt1<+>
Background: B6.129P2-Akt1
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Subbotina E
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Musclin is an activity-stimulated myokine that enhances physical endurance.
Volume: 112
Issue: 52
Pages: 16042-7
Publication
First Author: Nishi J
Year: 2008
Journal: Circ Res
Title: Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.
Volume: 103
Issue: 3
Pages: 261-8
Publication
First Author: Yun SJ
Year: 2014
Journal: Biochim Biophys Acta
Title: Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells.
Volume: 1842
Issue: 11
Pages: 2184-92
Publication
First Author: Fernández-Hernando C
Year: 2007
Journal: Cell Metab
Title: Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.
Volume: 6
Issue: 6
Pages: 446-57
Publication
First Author: Kim ST
Year: 2012
Journal: Reprod Sci
Title: Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.
Volume: 19
Issue: 1
Pages: 31-42
Publication
First Author: Mogi M
Year: 2003
Journal: J Biol Chem
Title: Akt signaling regulates side population cell phenotype via Bcrp1 translocation.
Volume: 278
Issue: 40
Pages: 39068-75
Publication
First Author: Dickey CA
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Akt and CHIP coregulate tau degradation through coordinated interactions.
Volume: 105
Issue: 9
Pages: 3622-7
Publication
First Author: Piantadosi CA
Year: 2008
Journal: Circ Res
Title: Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
Volume: 103
Issue: 11
Pages: 1232-40
Publication
First Author: Mathew B
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury.
Volume: 309
Issue: 12
Pages: L1420-9
Genotype
Symbol: Akt1/Akt1<+> Flt1/Flt1<+>
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Dillon RL
Year: 2010
Journal: Cancer Res
Title: Distinct biological roles for the akt family in mammary tumor progression.
Volume: 70
Issue: 11
Pages: 4260-4
Publication
First Author: Mende I
Year: 2001
Journal: Oncogene
Title: Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.
Volume: 20
Issue: 32
Pages: 4419-23
Publication
First Author: Zhou C
Year: 2022
Journal: Adv Sci (Weinh)
Title: Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia.
Volume: 9
Issue: 17
Pages: e2104986
Publication  
First Author: Sharma M
Year: 2018
Journal: Development
Title: Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis.
Volume: 145
Issue: 5
Publication
First Author: Ezell SA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.
Volume: 109
Issue: 10
Pages: E613-21
Publication
First Author: Mirzaa G
Year: 2014
Journal: Nat Genet
Title: De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
Volume: 46
Issue: 5
Pages: 510-515
Publication
First Author: Meng S
Year: 2023
Journal: Nat Cell Biol
Title: Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells.
Volume: 25
Issue: 9
Pages: 1319-1331
Publication
First Author: Whiteman EL
Year: 2002
Journal: Trends Endocrinol Metab
Title: Role of Akt/protein kinase B in metabolism.
Volume: 13
Issue: 10
Pages: 444-51
Publication
First Author: Zou W
Year: 2000
Journal: Sheng Li Ke Xue Jin Zhan
Title: [Protein kinase B and its role in the signal transduction pathway mediated by phosphoinositide 3-kinase].
Volume: 31
Issue: 2
Pages: 120-4
Publication
First Author: Manning BD
Year: 2017
Journal: Cell
Title: AKT/PKB Signaling: Navigating the Network.
Volume: 169
Issue: 3
Pages: 381-405
Publication
First Author: Hammerman PS
Year: 2005
Journal: Blood
Title: Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.
Volume: 105
Issue: 11
Pages: 4477-83
Publication
First Author: d'Uscio LV
Year: 2008
Journal: Hypertension
Title: Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1.
Volume: 52
Issue: 1
Pages: 93-9
Publication
First Author: Carraway MS
Year: 2010
Journal: Circ Res
Title: Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
Volume: 106
Issue: 11
Pages: 1722-30
Publication
First Author: Larson-Casey JL
Year: 2016
Journal: Immunity
Title: Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.
Volume: 44
Issue: 3
Pages: 582-596
Publication
First Author: Saji M
Year: 2011
Journal: Oncogene
Title: Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer.
Volume: 30
Issue: 42
Pages: 4307-15
Publication
First Author: Peng C
Year: 2010
Journal: Blood
Title: PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
Volume: 115
Issue: 3
Pages: 626-35
Publication
First Author: Calamito M
Year: 2010
Journal: Blood
Title: Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Volume: 115
Issue: 20
Pages: 4043-50
Publication
First Author: Di Lorenzo A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.
Volume: 106
Issue: 34
Pages: 14552-7
Publication
First Author: Juntilla MM
Year: 2010
Journal: Blood
Title: AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Volume: 115
Issue: 20
Pages: 4030-8
Publication
First Author: Ackah E
Year: 2005
Journal: J Clin Invest
Title: Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.
Volume: 115
Issue: 8
Pages: 2119-27
Publication
First Author: Goncalves MD
Year: 2010
Journal: PLoS One
Title: Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.
Volume: 5
Issue: 9
Pages: e12707
Publication
First Author: Koral K
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
Volume: 307
Issue: 12
Pages: F1380-9
Publication
First Author: Maruyama S
Year: 2011
Journal: J Biol Chem
Title: Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism.
Volume: 286
Issue: 37
Pages: 32790-800
Publication
First Author: Ju R
Year: 2014
Journal: J Biol Chem
Title: Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.
Volume: 289
Issue: 1
Pages: 510-9
Publication
First Author: Schleicher M
Year: 2009
Journal: Sci Signal
Title: The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo.
Volume: 2
Issue: 82
Pages: ra41