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Search results 401 to 491 out of 491 for Atf6

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein
Q8CHX6
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein Coding Gene
MGI:2444506 | Mbtps2
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Tg(ACTA1-Atf6)3Jmol | MGI:6505473
Name: transgene insertion 3, Jeffery Molkentin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6474813 | C57BL/6JSmoc-Atf6<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
11779464 | -
First Author: Yoshida H
Year: 2001
Journal: Cell
Title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
Volume: 107
Issue: 7
Pages: 881-91
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GO Term
GO:1903891 | regulation of ATF6-mediated unfolded protein response
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Protein Coding Gene
MGI:1927235 | Mbtps1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WTZ2
Organism: Mus musculus/domesticus
Length: 1052  
Fragment?: false
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Strain
MGI:6505477 | STOCK Tg(ACTA1-Atf6)3Jmol/J
Attribute String: transgenic, mutant stock
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Protein Coding Gene
MGI:1922090 | Manf
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15665855 | J:217998
First Author: Kondo S
Year: 2005
Journal: Nat Cell Biol
Title: OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes.
Volume: 7
Issue: 2
Pages: 186-94
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Publication
11158310 | -
First Author: Yoshida H
Year: 2001
Journal: Mol Cell Biol
Title: Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.
Volume: 21
Issue: 4
Pages: 1239-48
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Protein
G3UXQ6
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: false
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Publication
14973138 | -
First Author: Thuerauf DJ
Year: 2004
Journal: J Biol Chem
Title: Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
Volume: 279
Issue: 20
Pages: 21078-84
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Publication
19693772 | -
First Author: Guan D
Year: 2009
Journal: J Cell Biochem
Title: N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha.
Volume: 108
Issue: 4
Pages: 825-31
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Protein Domain
IPR029809 | ATF6B
Type: Family
Description: The unfolded protein response (UPR) is mediated by three ER membrane-bound proteins: double-stranded RNA-dependent protein kinase (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6) []. ATF6 has two isoforms, alpha and beta; this entry represents the isoform beta. ATF6 is a transcription factor that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER []. It contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and its cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [, ]. ATF6-beta can be cleaved and generate a nuclear form that inhibits ATF6-alpha mediated ER stress response gene activation [, ]. N-glycosylation of ATF6-beta is essential for its transcriptional repressor function to ATF6-alpha [].
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HT Experiment
E-GEOD-30628 | Gene expression analysis of ER-stressed growth plate chondrocytes in two mouse models of Schmid chondrodysplasia
Series Id: GSE30628
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
A2AC84
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
9659902 | J:47332
First Author: Rawson RB
Year: 1997
Journal: Mol Cell
Title: Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
Volume: 1
Issue: 1
Pages: 47-57
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Publication
19361614 | -
First Author: Oeffner F
Year: 2009
Journal: Am J Hum Genet
Title: IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response.
Volume: 84
Issue: 4
Pages: 459-67
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Publication
20672378 | -
First Author: Aten E
Year: 2010
Journal: Hum Mutat
Title: Keratosis Follicularis Spinulosa Decalvans is caused by mutations in MBTPS2.
Volume: 31
Issue: 10
Pages: 1125-33
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Publication
10419520 | -
First Author: Zelenski NG
Year: 1999
Journal: J Biol Chem
Title: Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins.
Volume: 274
Issue: 31
Pages: 21973-80
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Publication
24099002 | -
First Author: Schneider JS
Year: 2013
Journal: Biochim Biophys Acta
Title: Function of site-2 proteases in bacteria and bacterial pathogens.
Volume: 1828
Issue: 12
Pages: 2808-14
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Protein Domain
IPR029801 | ATF6A
Type: Family
Description: The unfolded protein response (UPR) is mediated by three ER membrane-bound proteins: double-stranded RNA-dependent protein kinase (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6) []. This entry represents the isoform alpha of ATF6. ATF6 is a transcription factor that transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins are accumulated in the ER []. It contains a basic leucine zipper (bZIP) domain that has regulatory function and a transmembrane domain that associates with the ER. Under ER stress the protein is cleaved at the membrane, and its cleaved N-terminal cytoplasmic domain (contains the bZIP domain) translocates into the nucleus where it activates the transcription of target genes that are mediated by ER stress-responsive and cyclic AMP-responsive elements [, ].
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Protein Domain
IPR001193 | MBTPS2
Type: Family
Description: This entry represents the membrane-bound transcription factor site-2 protease (MBTPS2, also known as S2P) []. MBTPS2 is a membrane-embedded zinc metalloprotease that activates signaling proteins involved in sterol control of transcription and ER stress response []. It cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Its known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6 [, ]. Mutations in the MBTPS2 gene cause IFAP syndrome with or without BRESHECK syndrome (IFAPS) and Keratosis follicularis spinulosa decalvans X-linked (KFSDX) [, ]. S2Ps are widely distributed in bacteria and participate in diverse pathways that control functions such as membrane integrity, sporulation, lipid biosynthesis, pheromone production, virulence, and others [].
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Publication
24945730 | J:213560
First Author: Le Pape S
Year: 2014
Journal: FEBS Lett
Title: Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury.
Volume: 588
Issue: 17
Pages: 3062-7
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HT Experiment
GSE252089 | Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:1903893 | positive regulation of ATF6-mediated unfolded protein response
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GO Term
GO:1903892 | negative regulation of ATF6-mediated unfolded protein response
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Protein
O35451
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: false
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Protein
G3UX19
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
A0A0A0MQ69
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
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Protein
Q3TXP5
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
Q3UJ07
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: false
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Publication
27669143 | J:238094
   
First Author: Vanhoutte D
Year: 2016
Journal: Elife
Title: Thrombospondin expression in myofibers stabilizes muscle membranes.
Volume: 5
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Publication
17059562 | J:119960
First Author: Omura T
Year: 2006
Journal: J Neurochem
Title: A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
Volume: 99
Issue: 6
Pages: 1456-69
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Publication
24268736 | J:206150
First Author: Ozcan L
Year: 2013
Journal: Cell Metab
Title: Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
Volume: 18
Issue: 6
Pages: 803-15
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Publication
33318509 | J:321020
First Author: Kapoor T
Year: 2020
Journal: Sci Rep
Title: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells.
Volume: 10
Issue: 1
Pages: 21626
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Publication
24370996 | J:217253
First Author: Hirsch I
Year: 2014
Journal: Apoptosis
Title: ERp29 deficiency affects sensitivity to apoptosis via impairment of the ATF6-CHOP pathway of stress response.
Volume: 19
Issue: 5
Pages: 801-15
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Publication
17991856 | J:127332
First Author: Lin JH
Year: 2007
Journal: Science
Title: IRE1 signaling affects cell fate during the unfolded protein response.
Volume: 318
Issue: 5852
Pages: 944-9
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Publication
31348885 | J:278341
First Author: Dvela-Levitt M
Year: 2019
Journal: Cell
Title: Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
Volume: 178
Issue: 3
Pages: 521-535.e23
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Publication
32065579 | J:290683
   
First Author: Hinte F
Year: 2020
Journal: Elife
Title: Repression of viral gene expression and replication by the unfolded protein response effector XBP1u.
Volume: 9
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Publication
17178827 | J:210912
First Author: Kondo S
Year: 2007
Journal: Mol Cell Biol
Title: BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer.
Volume: 27
Issue: 5
Pages: 1716-29
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Publication
35691375 | J:340542
 
First Author: Wu K
Year: 2022
Journal: Exp Eye Res
Title: TCF7L2 promotes ER stress signaling in diabetic retinopathy.
Volume: 221
Pages: 109142
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Publication
28972541 | J:252595
First Author: Doran AC
Year: 2017
Journal: J Clin Invest
Title: CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
Volume: 127
Issue: 11
Pages: 4075-4089
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Publication
27317663 | J:236170
First Author: Berthoud VM
Year: 2016
Journal: J Biol Chem
Title: The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.
Volume: 291
Issue: 34
Pages: 17569-78
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Publication
22713599 | J:203598
 
First Author: Alapure BV
Year: 2012
Journal: Exp Eye Res
Title: The unfolded protein response is activated in connexin 50 mutant mouse lenses.
Volume: 102
Pages: 28-37
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Publication
15899857 | J:99068
First Author: Baumeister P
Year: 2005
Journal: Mol Cell Biol
Title: Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.
Volume: 25
Issue: 11
Pages: 4529-40
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Publication
22354938 | J:314779
First Author: Zhang D
Year: 2012
Journal: Circ Res
Title: Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.
Volume: 110
Issue: 6
Pages: 808-17
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Publication
27514483 | J:240450
First Author: Kwanten WJ
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice.
Volume: 311
Issue: 4
Pages: G599-G609
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Publication
24623133 | J:210226
First Author: Miller M
Year: 2014
Journal: J Immunol
Title: ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
Volume: 192
Issue: 8
Pages: 3475-87
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Publication
21605081 | J:177894
First Author: Agouni A
Year: 2011
Journal: Biochem J
Title: Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.
Volume: 438
Issue: 2
Pages: 369-78
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Publication
18049481 | J:146385
First Author: Kudo T
Year: 2008
Journal: Cell Death Differ
Title: A molecular chaperone inducer protects neurons from ER stress.
Volume: 15
Issue: 2
Pages: 364-75
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Publication
23144714 | J:225075
First Author: Mann MJ
Year: 2012
Journal: PLoS One
Title: UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levels.
Volume: 7
Issue: 10
Pages: e47931
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Publication
20221394 | J:158673
First Author: Ghosh R
Year: 2010
Journal: PLoS One
Title: Transcriptional regulation of VEGF-A by the unfolded protein response pathway.
Volume: 5
Issue: 3
Pages: e9575
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Publication
17822768 | J:126349
First Author: Gass JN
Year: 2008
Journal: Mol Immunol
Title: The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells.
Volume: 45
Issue: 4
Pages: 1035-43
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Publication
26960794 | J:312639
First Author: Fusakio ME
Year: 2016
Journal: Mol Biol Cell
Title: Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
Volume: 27
Issue: 9
Pages: 1536-51
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Publication
24576409 | J:211577
First Author: Galán M
Year: 2014
Journal: Biochim Biophys Acta
Title: Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.
Volume: 1843
Issue: 6
Pages: 1063-75
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Publication
18559892 | J:139749
First Author: Cunha DA
Year: 2008
Journal: J Cell Sci
Title: Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Volume: 121
Issue: Pt 14
Pages: 2308-18
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Publication
19808896 | J:164169
First Author: Ye R
Year: 2010
Journal: Diabetes
Title: Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.
Volume: 59
Issue: 1
Pages: 6-16
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Publication
34544877 | J:311448
 
First Author: Liang W
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Necroptosis activates UPR sensors without disrupting their binding with GRP78.
Volume: 118
Issue: 39
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Publication
28439080 | J:275034
First Author: Sreenath TL
Year: 2017
Journal: Sci Rep
Title: ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.
Volume: 7
Issue: 1
Pages: 1109
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Publication
25387528 | J:221389
First Author: Rao J
Year: 2015
Journal: Biochem J
Title: C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure.
Volume: 466
Issue: 2
Pages: 369-78
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Publication
25151953 | J:225783
 
First Author: Brooks AC
Year: 2014
Journal: J Mol Cell Cardiol
Title: Endoplasmic reticulum stress-dependent activation of ATF3 mediates the late phase of ischemic preconditioning.
Volume: 76
Pages: 138-47
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Publication
34831079 | J:321030
 
First Author: Moore J
Year: 2021
Journal: Cells
Title: Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation.
Volume: 10
Issue: 11
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Publication
21981022 | J:333136
First Author: Liu Z
Year: 2012
Journal: Cell Microbiol
Title: The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
Volume: 14
Issue: 1
Pages: 133-46
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Publication
17030611 | J:117626
First Author: Ogata M
Year: 2006
Journal: Mol Cell Biol
Title: Autophagy is activated for cell survival after endoplasmic reticulum stress.
Volume: 26
Issue: 24
Pages: 9220-31
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Publication
16601230 | J:122232
First Author: Martindale JJ
Year: 2006
Journal: Circ Res
Title: Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.
Volume: 98
Issue: 9
Pages: 1186-93
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Publication
20616807 | J:186339
First Author: Kang YJ
Year: 2011
Journal: Cell Death Differ
Title: The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Volume: 18
Issue: 1
Pages: 133-44
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Publication
23517917 | J:202418
First Author: Nakamura Y
Year: 2013
Journal: Biochim Biophys Acta
Title: Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.
Volume: 1832
Issue: 8
Pages: 1117-28
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Publication
23933252 | J:211380
First Author: Tanaka K
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Advanced glycation end products suppress osteoblastic differentiation of stromal cells by activating endoplasmic reticulum stress.
Volume: 438
Issue: 3
Pages: 463-7
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Publication
31408662 | J:293563
 
First Author: Xue CD
Year: 2019
Journal: Peptides
Title: Endogenous intermedin protects against intimal hyperplasia by inhibiting endoplasmic reticulum stress.
Volume: 121
Pages: 170131
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Publication
32327487 | J:299875
First Author: Arrieta A
Year: 2020
Journal: J Biol Chem
Title: Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
Volume: 295
Issue: 22
Pages: 7566-7583
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Publication
22609432 | J:313306
First Author: Vekich JA
Year: 2012
Journal: J Mol Cell Cardiol
Title: Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death.
Volume: 53
Issue: 2
Pages: 259-67
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Publication
33586853 | J:321018
First Author: Poncet AF
Year: 2021
Journal: EMBO Rep
Title: The UPR sensor IRE1α promotes dendritic cell responses to control Toxoplasma gondii infection.
Volume: 22
Issue: 3
Pages: e49617
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Publication
34262465 | J:321024
 
First Author: Hao L
Year: 2021
Journal: Front Pharmacol
Title: TLR9 Signaling Protects Alcohol-Induced Hepatic Oxidative Stress but Worsens Liver Inflammation in Mice.
Volume: 12
Pages: 709002
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Publication
24242870 | -
First Author: Saito A
Year: 2014
Journal: Anat Sci Int
Title: Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system.
Volume: 89
Issue: 1
Pages: 11-20
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Protein
A0A0A0MQE2
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
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Publication
27907038 | J:254579
First Author: Zhang T
Year: 2016
Journal: PLoS One
Title: Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells.
Volume: 11
Issue: 12
Pages: e0167020
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Publication
37731512 | J:340793
 
First Author: Lu Y
Year: 2023
Journal: Front Immunol
Title: ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development.
Volume: 14
Pages: 1268916
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Publication
25147951 | J:221086
First Author: Patra D
Year: 2014
Journal: PLoS One
Title: Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Volume: 9
Issue: 8
Pages: e105674
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Publication
29961149 | J:321036
First Author: Kristensen CM
Year: 2018
Journal: Pflugers Arch
Title: PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice.
Volume: 470
Issue: 10
Pages: 1431-1447
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Publication
27941872 | J:243050
First Author: Dumartin L
Year: 2017
Journal: Oncogene
Title: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Volume: 36
Issue: 22
Pages: 3094-3103
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Publication
12871976 | J:217287
First Author: Luo S
Year: 2003
Journal: J Biol Chem
Title: Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements.
Volume: 278
Issue: 39
Pages: 37375-85
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Publication
27868197 | J:241803
First Author: Teng YC
Year: 2017
Journal: J Pathol
Title: Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice.
Volume: 241
Issue: 4
Pages: 463-474
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Publication
28611075 | J:267494
First Author: Bischoff FC
Year: 2017
Journal: Circ Res
Title: Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.
Volume: 121
Issue: 4
Pages: 368-375
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Publication
29909009 | J:270368
First Author: Pei SJ
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation.
Volume: 503
Issue: 2
Pages: 744-751
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Publication
30612139 | J:275494
First Author: Yang J
Year: 2019
Journal: Diabetologia
Title: Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes.
Volume: 62
Issue: 3
Pages: 531-543
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Publication
38352425 | J:361040
     
First Author: Touvier T
Year: 2024
Journal: bioRxiv
Title: Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B.
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Publication
32673694 | J:321007
First Author: Stengel ST
Year: 2020
Journal: Gastroenterology
Title: Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.
Volume: 159
Issue: 4
Pages: 1357-1374.e10
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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