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Search results 401 to 500 out of 877 for Atr

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1672828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799758
Specimen Label: JAX_1799758
Detected: true
Specimen Num: 26
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799739
Specimen Label: JAX_1799739
Detected: true
Specimen Num: 7
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799763
Specimen Label: JAX_1799763
Detected: true
Specimen Num: 31
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1860128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799757
Specimen Label: JAX_1799757
Detected: true
Specimen Num: 25
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3283428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799744
Specimen Label: JAX_1799744
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799764
Specimen Label: JAX_1799764
Detected: true
Specimen Num: 32
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1685328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799748
Specimen Label: JAX_1799748
Detected: true
Specimen Num: 16
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799756
Specimen Label: JAX_1799756
Detected: true
Specimen Num: 24
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799760
Specimen Label: JAX_1799760
Detected: true
Specimen Num: 28
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799759
Specimen Label: JAX_1799759
Detected: true
Specimen Num: 27
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1832128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799754
Specimen Label: JAX_1799754
Detected: true
Specimen Num: 22
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1754028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799733
Specimen Label: JAX_1799733
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799745
Specimen Label: JAX_1799745
Detected: true
Specimen Num: 13
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3590528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799752
Specimen Label: JAX_1799752
Detected: true
Specimen Num: 20
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799761
Specimen Label: JAX_1799761
Detected: true
Specimen Num: 29
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799749
Specimen Label: JAX_1799749
Detected: true
Specimen Num: 17
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799753
Specimen Label: JAX_1799753
Detected: true
Specimen Num: 21
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799742
Specimen Label: JAX_1799742
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799746
Specimen Label: JAX_1799746
Detected: true
Specimen Num: 14
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799751
Specimen Label: JAX_1799751
Detected: true
Specimen Num: 19
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692200
Age: postnatal adult
Image: JAX_1799735
Specimen Label: JAX_1799735
Detected: true
Specimen Num: 3
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Publication
20657549 | J:163624
First Author: Kenneth NS
Year: 2010
Journal: EMBO J
Title: IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.
Volume: 29
Issue: 17
Pages: 2966-78
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Publication
25344324 | J:217428
First Author: Zimmermann M
Year: 2014
Journal: Genes Dev
Title: TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
Volume: 28
Issue: 22
Pages: 2477-91
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Protein
Q9CZ52
Organism: Mus musculus/domesticus
Length: 562  
Fragment?: false
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Protein
Q9CZ52-2
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Allele
Atrip<tm1e(KOMP)Wtsi> | MGI:4419260
Name: ATR interacting protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Atrip<tm1a(KOMP)Wtsi> | MGI:4420066
Name: ATR interacting protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Atrip<tm1b(KOMP)Wtsi> | MGI:5473356
Name: ATR interacting protein; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Atrip<tm1.1Pof> | MGI:6501143
Name: ATR interacting protein; targeted mutation 1.1, Pierre-Olivier Frappart
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Atrip<em1Gpt> | MGI:7295708
Name: ATR interacting protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Atrip<em6Gpt> | MGI:7295709
Name: ATR interacting protein; endonuclease-mediated mutation 6, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Atr<em2Smoc> | MGI:7288403
Name: ataxia telangiectasia and Rad3 related; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
19364474 | J:148697
First Author: Kumamoto-Yonezawa Y
Year: 2009
Journal: Biochim Biophys Acta
Title: Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.
Volume: 1790
Issue: 5
Pages: 339-46
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UniProt Feature
UniProt Feature
Begin: 824
Description: Phosphoserine; by ATM and ATR and dsDNA kinase
Type: modified residue
End: 824
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Interaction Experiment
Takai H (2010)
Description: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
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Strain
MGI:6280381 | C57BL/6N-Atrip<tm1a(KOMP)Wtsi>/J
Attribute String: mutant strain, targeted mutation
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Strain
MGI:5763577 | C57BL/6N-Atrip<tm1b(KOMP)Wtsi>/J
Attribute String: targeted mutation, mutant strain
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Strain
MGI:5489718 | B6N(Cg)-Atrip<tm1b(KOMP)Wtsi>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Atrip/Atrip
Background: B6N(Cg)-Atrip/J
Zygosity: hm
Has Mutant Allele: true
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Publication
17525332 | -
First Author: Matsuoka S
Year: 2007
Journal: Science
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Volume: 316
Issue: 5828
Pages: 1160-6
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Publication
26854234 | -
First Author: Zhang H
Year: 2016
Journal: Cell Rep
Title: ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Volume: 14
Issue: 6
Pages: 1435-1447
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DO Term
DOID:0070007 | Seckel syndrome 1
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Interaction Experiment
Lim PX (2015)
Description: Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.
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Strain
MGI:6770577 | C57BL/6JSmoc-Atr<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Pathway
R-MMU-176187 | Activation of ATR in response to replication stress
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Allele
Atr<em1Smoc> | MGI:7288402
Name: ataxia telangiectasia and Rad3 related; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6343846 | C57BL/6N-A<tm1Brd> Atrip<tm1a(KOMP)Wtsi>/JMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6343847 | C57BL/6N-A<tm1Brd> Atrip<tm1b(KOMP)Wtsi>/JMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Atrip/Atrip Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atrip/Atrip Tg(Pax6-cre,GFP)1Pgr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atrip/Atrip Tg(Pax6-cre,GFP)2Pgr/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atrip/Atrip Tg(Rho-icre)1Ck/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atrip/Atrip<+>
Background: B6N(Cg)-Atrip/J
Zygosity: ht
Has Mutant Allele: true
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Publication
21659603 | -
First Author: Cotta-Ramusino C
Year: 2011
Journal: Science
Title: A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Volume: 332
Issue: 6035
Pages: 1313-7
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GO Term
GO:0070310 | ATR-ATRIP complex
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Publication
20810650 | -
First Author: Hurov KE
Year: 2010
Journal: Genes Dev
Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Volume: 24
Issue: 17
Pages: 1939-50
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Publication
24332808 | -
First Author: Maréchal A
Year: 2014
Journal: Mol Cell
Title: PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Volume: 53
Issue: 2
Pages: 235-246
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Publication
25911100 | -
First Author: Lim PX
Year: 2015
Journal: J Biol Chem
Title: Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.
Volume: 290
Issue: 24
Pages: 14826-40
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Protein
Q80YR7
Organism: Mus musculus/domesticus
Length: 1315  
Fragment?: false
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Genotype
Genotype
Symbol: Atrip/Atrip Tg(Nes-cre)1Kln/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atrip/Atrip Tg(Pax6-cre,GFP)2Pgr/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:6474828 | C57BL/6JSmoc-Atr<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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DO Term
DOID:0110029 | alpha thalassemia-intellectual disability syndrome type 1
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Protein
Q8BMG1
Organism: Mus musculus/domesticus
Length: 785  
Fragment?: false
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Publication
31974352 | J:284248
First Author: Wilson DH
Year: 2020
Journal: Nat Commun
Title: Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.
Volume: 11
Issue: 1
Pages: 445
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Protein Domain
IPR026568 | NEDD4-bind_pro_2-like_2
Type: Family
Description: Human NEDD4-binding protein 2-like 2 protein has been found phosphorylated upon DNA damage, probably by ATM or ATR [].
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Allele
Topbp1<tm1.1Zqw> | MGI:5544423
 
Name: topoisomerase (DNA) II binding protein 1; targeted mutation 1.1, Zhao-Qi Wang
Allele Type: Targeted
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Genotype
Genotype
Symbol: Topbp1/Topbp1
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor
Zygosity: hm
Has Mutant Allele: true
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Protein
Q8BI22
Organism: Mus musculus/domesticus
Length: 1102  
Fragment?: false
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Protein
B7ZNX8
Organism: Mus musculus/domesticus
Length: 1102  
Fragment?: false
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Protein
Q9D4Z7
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
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Protein
Q8BI33
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
Q8BI30
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
F7CIB0
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: true
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Protein
F6Q1Q5
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein Domain
IPR026652 | CEP128
Type: Family
Description: Centrosomal protein of 128kDa (CEP128) associates with the mother centriole []. It is phosphorylated upon DNA damage, probably by ATM or ATR [].
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Protein Coding Gene
MGI:1338073 | Cdc45
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917274 | Mcm10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351328 | Dbf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1309511 | Cdc7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9Z1X9
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q9Z0H0
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
Q9QZ41
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
Q0VBD2
Organism: Mus musculus/domesticus
Length: 885  
Fragment?: false
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Protein
Q9Z0F6
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q6WBX7
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Publication
28607084 | J:244584
First Author: Miosge LA
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.
Volume: 114
Issue: 26
Pages: E5216-E5225
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Protein
Q3TRR0
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
Q80XU3
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
A0A0A6YVR4
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
A0A0R4J2D7
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
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Protein
A0A0A6YXJ3
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: true
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Protein
A2A5Z4
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
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Protein
A0A087WRY3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
A0A0A6YVV4
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
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Publication
16049101 | -
First Author: Saffin JM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis.
Volume: 102
Issue: 32
Pages: 11302-7
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Publication
11298763 | J:68910
First Author: Ostvold AC
Year: 2001
Journal: Eur J Biochem
Title: Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo.
Volume: 268
Issue: 8
Pages: 2430-40
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Publication
15381070 | -
First Author: Grundt K
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species.
Volume: 323
Issue: 3
Pages: 796-801
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Protein Domain
IPR026106 | MAP9
Type: Family
Description: Human MAP9 is involved in organisation of the mitotic spindle []. Besides being required for mitosis progression and cytokinesis, it may stabilise interphase microtubules []. Upon DNA damage, it is phosphorylated probably by ATM or ATR [].
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Protein Domain
IPR026633 | NUCKS1
Type: Family
Description: Members of this vertebrate family of proteins are targets for phosphorylation by CDK1 and casein kinase [, ]. They are also phosphorylated upon DNA damage, probably by ATM or ATR [].
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