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Search results 401 to 500 out of 552 for Bace1

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Hits by Strain

Type Details Score
Strain
MGI:6144706 | C57BL/6J-Tg(CAG-BACE1)2Rbrc/Rbrc
Attribute String: mutant strain, coisogenic, transgenic
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Publication
25663301 | -
First Author: Mei Z
Year: 2015
Journal: Neurochem Res
Title: Transcriptional regulation of BACE1 by NFAT3 leads to enhanced amyloidogenic processing.
Volume: 40
Issue: 4
Pages: 829-36
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Publication
20854419 | -
First Author: Gong B
Year: 2010
Journal: Aging Cell
Title: SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.
Volume: 9
Issue: 6
Pages: 1018-31
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Publication
19251705 | -
First Author: Lakshmana MK
Year: 2009
Journal: J Biol Chem
Title: Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
Volume: 284
Issue: 18
Pages: 11863-72
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Allele
Bace1<tm1Bux> | MGI:3042562
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Joseph D Buxbaum
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Bace1<tm1.1Yanr> | MGI:6150902
Name: beta-site APP cleaving enzyme 1; targeted mutation 1.1, Riqiang Yan
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
18343582 | J:136861
First Author: Hirata-Fukae C
Year: 2008
Journal: Neurosci Lett
Title: Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo.
Volume: 435
Issue: 3
Pages: 186-9
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Publication
24373286 | -
First Author: Buggia-Prévot V
Year: 2013
Journal: Cell Rep
Title: A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.
Volume: 5
Issue: 6
Pages: 1552-63
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Publication
30496823 | J:271319
 
First Author: Pan X
Year: 2019
Journal: Neuroscience
Title: Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease.
Volume: 397
Pages: 138-146
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Allele
Tg(Thy1-BACE1)16Vln | MGI:3722132
Name: transgene insertion 16, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Hprt1<tm5(Camk2a-BACE1)Geno> | MGI:5607312
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 5, Genoway
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7539023 | C57BL/6-Bace1<tm1.1Yanr>
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: C57BL/6-Bace1
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:7539011 | B6.Cg-Bace1<tm1.1Yanr> Tg(Thy1-cre)1Vln
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Strain
MGI:5607329 | B6.129P2-Hprt1<tm5(Camk2a-BACE1)Geno>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Hprt1/?
Background: B6.129P2-Hprt1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/Hprt1
Background: B6.129P2-Hprt1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1 Tg(Thy1-cre)1Vln/?
Background: B6.Cg-Bace1 Tg(Thy1-cre)1Vln
Zygosity: cn
Has Mutant Allele: true
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Publication
10931940 | -
First Author: Farzan M
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Volume: 97
Issue: 17
Pages: 9712-7
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Publication
10749877 | -
First Author: Bennett BD
Year: 2000
Journal: J Biol Chem
Title: Expression analysis of BACE2 in brain and peripheral tissues.
Volume: 275
Issue: 27
Pages: 20647-51
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Protein Domain
IPR009121 | BACE2
Type: Family
Description: One of the major neuropathological hallmarks of Alzheimer's disease (AD) is the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of beta-amyloid protein (beta-APP) []. Production of beta-APP requires proteolytic cleavage of the large type-1 transmembrane (TM) protein amyloid precursor protein (APP) []. This process is performed by a variety of enzymes known as secretases. To initiate beta-APP formation, beta-secretase cleaves APP to release a soluble N-terminal fragment (APPsBeta) and a C-terminal fragment that remains membrane bound. This fragment is subsequently cleaved by gamma-secretase to liberate beta-APP.Several independent studies identified a novel TM aspartic protease as the major beta-secretase [, , ]. This protein, termed memapsin 2 or beta-site APP cleaving enzyme 1 (BACE1), shares 64% amino acid sequence similarity with a second enzyme, termed BACE2. Together, BACE1 and BACE2 define a novel family of aspartyl proteases []. Both enzymes share significant sequence similarity with other members of the pepsin family of aspartyl proteases and contain the two characteristic D(T/S)G(T/S) motifs that form the catalytic site. However, by contrast with other aspartyl proteases, BACE1 and BACE2 are type I TM proteins. Each protein comprises a large lumenal domain containing the active centre, a single TM domain and a small cytoplasmic tail.BACE2, also termed Asp1 and memapsin 1, was initially identified though Expressed Sequence Tag (EST) database searching. In vitro enzymaticassays with peptide substrates have demonstrated that BACE2 cleaves beta-secretase substrates in a similar fashion to BACE1 []. The BACE2 mRNA is expressed in the central nervous system and many peripheral tissues, although its expression level in neurons is substantially lower than that of BACE1 [].
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Publication
10591213 | -
First Author: Yan R
Year: 1999
Journal: Nature
Title: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Volume: 402
Issue: 6761
Pages: 533-7
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Publication
2881207 | -
First Author: Kang J
Year: 1987
Journal: Nature
Title: The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Volume: 325
Issue: 6106
Pages: 733-6
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Publication
6375662 | -
First Author: Glenner GG
Year: 1984
Journal: Biochem Biophys Res Commun
Title: Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
Volume: 120
Issue: 3
Pages: 885-90
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Publication
10656250 | -
First Author: Hussain I
Year: 1999
Journal: Mol Cell Neurosci
Title: Identification of a novel aspartic protease (Asp 2) as beta-secretase.
Volume: 14
Issue: 6
Pages: 419-27
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Publication
12391600 | -
First Author: Citron M
Year: 2002
Journal: J Neurosci Res
Title: Beta-secretase as a target for the treatment of Alzheimer's disease.
Volume: 70
Issue: 3
Pages: 373-9
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Protein
Q925B0
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Protein
Q3UWE8
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Publication
11585763 | -
First Author: Chakraborty M
Year: 2001
Journal: Cancer Res
Title: Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression.
Volume: 61
Issue: 19
Pages: 7255-63
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Publication
8943350 | -
First Author: Johnstone RW
Year: 1996
Journal: Mol Cell Biol
Title: A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.
Volume: 16
Issue: 12
Pages: 6945-56
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Publication
15671026 | -
First Author: Xie J
Year: 2005
Journal: J Biol Chem
Title: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Volume: 280
Issue: 14
Pages: 13824-32
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Protein Domain
IPR026117 | Par-4
Type: Family
Description: Prostate apoptosis response 4 (Par-4) induced apoptosis of selective prostate cancer cells PC-3, DU-145, and TSU-Pr and caused tumor regression by inhibition of NF-kappaB activity and cell membrane trafficking of Fas and FasL that leads to the activation of the Fas-Fas-associated death domain-caspase-8 pro-death pathway []. It modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. It down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1 []. Par-4 also regulates the amyloid precursor protein (APP) cleavage activity of BACE1 [].
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-BACE1)54/4Ppa/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR009119 | BACE
Type: Family
Description: One of the major neuropathological hallmarks of Alzheimer's disease (AD)is the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of beta-amyloid protein (beta-APP) [].Production of beta-APP requires proteolytic cleavage of the large type-1 transmembrane (TM) protein amyloid precursor protein (APP) []. This processis performed by a variety of enzymes known as secretases. To initiate beta-APP formation, beta-secretase cleaves APP to release a soluble N-terminal fragment (APPsBeta) and a C-terminal fragment that remains membrane bound. This fragment is subsequently cleaved by gamma-secretase to liberate beta-APP.Several independent studies identified a novel TM aspartic protease as themajor beta-secretase [, , ]. This protein, termed beta-site APP cleavingenzyme 1 (BACE1), shares 64% amino acid sequence similarity with a secondenzyme, termed BACE2. Together, BACE1 and BACE2 define a novel family of aspartyl proteases []. Both enzymes share significant sequence similaritywith other members of the pepsin family of aspartyl proteases and contain the two characteristic D(T/S)G(T/S) motifs that form the catalytic site.However, by contrast with other aspartyl proteases, BACE1 and BACE2 aretype I TM proteins. Each protein comprises a large lumenal domain containingthe active centre, a single TM domain and a small cytoplasmic tail.
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Publication
11948243 | J:75039
First Author: Bodendorf U
Year: 2002
Journal: J Neurochem
Title: Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
Volume: 80
Issue: 5
Pages: 799-806
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Genotype
Genotype
Symbol: Tg(Thy1-APPLon)2Vln/? Tg(Thy1-BACE1)16Vln/?
Background: involves: C57BL/6 * DBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
30858603 | J:277515
First Author: Park H
Year: 2019
Journal: Nat Neurosci
Title: In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease.
Volume: 22
Issue: 4
Pages: 524-528
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Publication
19416837 | J:148402
First Author: Bengoechea TG
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model.
Volume: 106
Issue: 19
Pages: 7870-5
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Publication
17724122 | J:134832
First Author: He P
Year: 2007
Journal: J Cell Biol
Title: Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.
Volume: 178
Issue: 5
Pages: 829-41
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Publication
18687504 | J:161837
First Author: Jo DG
Year: 2010
Journal: Neurobiol Aging
Title: Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.
Volume: 31
Issue: 6
Pages: 917-25
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Publication
22105352 | J:178937
First Author: Wen L
Year: 2011
Journal: J Cell Biol
Title: VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.
Volume: 195
Issue: 5
Pages: 765-79
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Publication
27447728 | J:249227
First Author: Whitehouse IJ
Year: 2016
Journal: PLoS One
Title: Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.
Volume: 11
Issue: 7
Pages: e0159119
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Publication
23133641 | J:195596
First Author: Yang SG
Year: 2012
Journal: PLoS One
Title: A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.
Volume: 7
Issue: 11
Pages: e48540
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Publication
32029735 | J:304213
First Author: Durrant CS
Year: 2020
Journal: Cell Death Dis
Title: Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.
Volume: 11
Issue: 2
Pages: 98
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Publication
19548013 | J:152747
First Author: Tong Y
Year: 2010
Journal: Neurogenetics
Title: COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo.
Volume: 11
Issue: 1
Pages: 41-52
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Publication
35579602 | J:332590
 
First Author: Ahmad T
Year: 2022
Journal: J Cell Biol
Title: Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.
Volume: 221
Issue: 7
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Publication
18936252 | J:140648
First Author: Sakurai T
Year: 2008
Journal: J Cell Biol
Title: Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.
Volume: 183
Issue: 2
Pages: 339-52
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Publication
25590804 | J:315368
 
First Author: Mouton-Liger F
Year: 2015
Journal: Cell Death Dis
Title: PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
Volume: 6
Pages: e1594
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Protein
A0A338P773
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Publication
21199326 | J:205664
First Author: Mishra M
Year: 2011
Journal: J Cell Mol Med
Title: P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis.
Volume: 15
Issue: 11
Pages: 2462-77
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Publication
34029592 | J:306268
   
First Author: Gaborit B
Year: 2021
Journal: J Biol Chem
Title: The aminosterol Claramine inhibits β-secretase 1-mediated insulin receptor cleavage.
Pages: 100818
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Publication
17255335 | J:117817
First Author: Yamamoto M
Year: 2007
Journal: Am J Pathol
Title: Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Volume: 170
Issue: 2
Pages: 680-92
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Publication
27796320 | J:271412
 
First Author: Ma Z
Year: 2016
Journal: Sci Rep
Title: Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer's disease-risk genes.
Volume: 6
Pages: 36035
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Publication
31055081 | J:283443
First Author: Fanaee-Danesh E
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells.
Volume: 1865
Issue: 9
Pages: 2224-2245
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Publication
26778963 | J:310589
 
First Author: Piedrahita D
Year: 2015
Journal: Front Cell Neurosci
Title: β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Volume: 9
Pages: 498
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Publication
36758468 | J:351246
 
First Author: Li YY
Year: 2023
Journal: Neurobiol Aging
Title: Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism.
Volume: 124
Pages: 71-84
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Publication
37171575 | J:351245
First Author: Ricciardi NR
Year: 2023
Journal: Mol Neurobiol
Title: Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer's Disease Models.
Volume: 60
Issue: 8
Pages: 4811-4827
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Publication
19183260 | J:146855
First Author: Kitazawa M
Year: 2009
Journal: J Neurochem
Title: Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD.
Volume: 108
Issue: 6
Pages: 1550-60
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Publication
39110781 | J:353793
First Author: Han J
Year: 2024
Journal: Sci Transl Med
Title: Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas-based epigenome editing in Alzheimer's disease.
Volume: 16
Issue: 759
Pages: eadi4830
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Publication
36241022 | J:348507
 
First Author: Valle ML
Year: 2022
Journal: Mol Cell Neurosci
Title: Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology.
Volume: 123
Pages: 103785
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Publication
35244207 | J:349610
First Author: Yu ZY
Year: 2022
Journal: J Neurochem
Title: Inhibiting α1-adrenergic receptor signaling pathway ameliorates AD-type pathologies and behavioral deficits in APPswe/PS1 mouse model.
Volume: 161
Issue: 3
Pages: 293-307
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Publication
30506868 | J:273251
First Author: Truong PH
Year: 2019
Journal: Glia
Title: Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
Volume: 67
Issue: 3
Pages: 525-538
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Publication
34958873 | J:351594
 
First Author: Wang ZH
Year: 2022
Journal: Prog Neurobiol
Title: Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model.
Volume: 209
Pages: 102212
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Publication
30506549 | J:327646
First Author: De Rossi P
Year: 2019
Journal: Brain Pathol
Title: Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
Volume: 29
Issue: 4
Pages: 485-501
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Publication
33848635 | J:306424
 
First Author: Janssens J
Year: 2021
Journal: Neurobiol Dis
Title: Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.
Volume: 154
Pages: 105365
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Publication
30692199 | J:275958
First Author: Andrew RJ
Year: 2019
Journal: J Biol Chem
Title: Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.
Volume: 294
Issue: 12
Pages: 4477-4487
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Publication
14701757 | J:285020
First Author: Christensen MA
Year: 2004
Journal: Mol Cell Biol
Title: Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Volume: 24
Issue: 2
Pages: 865-74
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Publication
15452128 | J:95174
First Author: Chiocco MJ
Year: 2004
Journal: J Biol Chem
Title: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Volume: 279
Issue: 50
Pages: 52535-42
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Publication
16387391 | J:117963
First Author: Chiocco MJ
Year: 2007
Journal: Neurobiol Aging
Title: Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice.
Volume: 28
Issue: 1
Pages: 75-84
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Publication
20384814 | J:159858
First Author: Zhang XM
Year: 2010
Journal: Eur J Neurosci
Title: Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex.
Volume: 31
Issue: 4
Pages: 710-21
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Publication
32455709 | J:304191
 
First Author: Park SY
Year: 2020
Journal: Cells
Title: SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model.
Volume: 9
Issue: 5
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Publication
23595759 | J:196964
First Author: Corbett BF
Year: 2013
Journal: J Neurosci
Title: Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.
Volume: 33
Issue: 16
Pages: 7020-6
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Publication
15465277 | J:100042
First Author: Apelt J
Year: 2004
Journal: Int J Dev Neurosci
Title: Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology.
Volume: 22
Issue: 7
Pages: 475-84
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Publication
15788759 | J:128887
First Author: Lim GP
Year: 2005
Journal: J Neurosci
Title: A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.
Volume: 25
Issue: 12
Pages: 3032-40
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Publication
23474306 | J:202423
First Author: Gerenu G
Year: 2013
Journal: Biochim Biophys Acta
Title: Early cognitive stimulation compensates for memory and pathological changes in Tg2576 mice.
Volume: 1832
Issue: 6
Pages: 837-47
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Publication
21435457 | J:169845
First Author: Chu J
Year: 2011
Journal: Am J Pathol
Title: Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
Volume: 178
Issue: 4
Pages: 1762-9
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Publication
22542680 | J:192436
 
First Author: Cai Y
Year: 2012
Journal: Neuroscience
Title: An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation.
Volume: 215
Pages: 160-73
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Publication
24824215 | J:214328
First Author: Jiang H
Year: 2014
Journal: Hum Mol Genet
Title: Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.
Volume: 23
Issue: 18
Pages: 4906-18
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Publication
23472157 | J:200200
First Author: He P
Year: 2013
Journal: PLoS One
Title: Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease.
Volume: 8
Issue: 3
Pages: e58181
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Publication
23405115 | J:197210
First Author: He P
Year: 2013
Journal: PLoS One
Title: Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease.
Volume: 8
Issue: 2
Pages: e55091
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Publication
14645205 | J:87691
First Author: Jankowsky JL
Year: 2004
Journal: Hum Mol Genet
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