| Type |
Details |
Score |
| Publication |
| First Author: |
Du A |
| Year: |
2009 |
| Journal: |
Diabetes |
| Title: |
Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. |
| Volume: |
58 |
| Issue: |
9 |
| Pages: |
2059-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang F |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. |
| Volume: |
8 |
|
| Pages: |
15182 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Breitwieser W |
| Year: |
2007 |
| Journal: |
Genes Dev |
| Title: |
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. |
| Volume: |
21 |
| Issue: |
16 |
| Pages: |
2069-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Soma S |
| Year: |
2024 |
| Journal: |
Stem Cells |
| Title: |
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. |
| Volume: |
42 |
| Issue: |
1 |
| Pages: |
55-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jones MR |
| Year: |
2018 |
| Journal: |
Front Genet |
| Title: |
A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. |
| Volume: |
9 |
|
| Pages: |
746 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu B |
| Year: |
2023 |
| Journal: |
J Am Heart Assoc |
| Title: |
Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. |
| Volume: |
12 |
| Issue: |
18 |
| Pages: |
e029683 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Freeman TC |
| Year: |
1998 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Expression Mapping of Mouse Genes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pagliarini DJ |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
| Volume: |
134 |
| Issue: |
1 |
| Pages: |
112-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
JAX BSS Panel Mapping Data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ko MS |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
| Volume: |
127 |
| Issue: |
8 |
| Pages: |
1737-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen J |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
| Issue: |
17 |
| Pages: |
9918-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedel RH |
| Year: |
2007 |
| Journal: |
Brief Funct Genomic Proteomic |
| Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
180-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao Q |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
The E2F-1 transcription factor promotes caspase-8 and bid expression, and enhances Fas signaling in T cells. |
| Volume: |
173 |
| Issue: |
2 |
| Pages: |
1111-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan KO |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
A novel BH3-like domain in BID is required for intramolecular interaction and autoinhibition of pro-apoptotic activity. |
| Volume: |
274 |
| Issue: |
34 |
| Pages: |
23687-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Casciola-Rosen L |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway. |
| Volume: |
282 |
| Issue: |
7 |
| Pages: |
4545-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kook S |
| Year: |
2014 |
| Journal: |
Cell Death Differ |
| Title: |
Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
172-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Viswanath V |
| Year: |
2001 |
| Journal: |
J Neurosci |
| Title: |
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. |
| Volume: |
21 |
| Issue: |
24 |
| Pages: |
9519-28 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
A stapled BID BH3 helix directly binds and activates BAX. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
A role for proapoptotic BID in the DNA-damage response. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Proapoptotic BID is an ATM effector in the DNA-damage response. |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kuriyama S |
| Year: |
2018 |
| Journal: |
Cell Death Discov |
| Title: |
PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. |
| Volume: |
4 |
|
| Pages: |
11 |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hsu SH |
| Year: |
2013 |
| Journal: |
Am J Pathol |
| Title: |
Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. |
| Volume: |
183 |
| Issue: |
6 |
| Pages: |
1719-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang B |
| Year: |
2014 |
| Journal: |
Hepatology |
| Title: |
Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. |
| Volume: |
59 |
| Issue: |
2 |
| Pages: |
555-66 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
247
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
496
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Pleckstrin homology domain-containing family N member 1 (PLEKHN1), also known as CLPABP, is a cardiolipin phosphatidic acid binding protein that associates with microtubules and accumulates in RNAgranules, which contain cytochrome-c mRNA []. It binds to Bid (a pro-apoptotic protein), removes Bid from transient Bid-Bax complexes, and promotes apoptosis []. |
|
•
•
•
•
•
|
| Allele |
| Name: |
BH3 interacting domain death agonist; targeted mutation 1, Andreas Strasser |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Bid/Bid |
| Background: |
involves: BALB/cJ * C57BL/6 * NZB |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Roy CR |
| Year: |
2009 |
| Journal: |
Sci Signal |
| Title: |
Bacterial FIC Proteins AMP Up Infection. |
| Volume: |
2 |
| Issue: |
62 |
| Pages: |
pe14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goepfert A |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with Fic fold. |
| Volume: |
8 |
| Issue: |
5 |
| Pages: |
e64901 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sano E |
| Year: |
2008 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule. |
| Volume: |
1783 |
| Issue: |
6 |
| Pages: |
1036-47 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
VbhT is a bacterial Fic protein of the mammalian pathogen B. schoenbuchensis. It is composed of an N-terminal FIC domain and a C-terminal BID domain. FIC domains are known to catalyse adenylylation (also called AMPylation). This entry represents VbhA, an antitoxin that binds FIC domain (filamentation induced by cyclic AMP) of VbhT and inhibits its activity. It inhibits the adenylylation activity of VbhT by positioning close to the putative ATP-binding site, hence competing with ATP binding []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
VbhA is the antitoxin to VbhT. VbhT is a toxin of the mammalian pathogen Bartonella schoenbuchensis responsible for the disruptive adenylation of host proteins []. VbhT is composed of an N-terminal FIC domain and a C-terminal BID domain. VbhT also induces FIC-domain-mediated growth arrest in bacteria. It is inhibited by this antitoxin which binds to block the ATP binding site of the VbhT FIC domain []. The antitoxin is related to an N-terminal domain in several Fic family proteins []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
VbhT is a bacterial Fic protein of the mammalian pathogen B. schoenbuchensis. It is composed of an N-terminal FIC domain and a C-terminal BID domain. FIC domains are known to catalyse adenylylation (also called AMPylation). This entry represents VbhA, an antitoxin that binds FIC domain (filamentation induced by cyclic AMP) of VbhT and inhibits its activity. It inhibits the adenylylation activity of VbhT by positioning close to the putative ATP-binding site, hence competing with ATP binding [].Structurally, VbhA consists of 3 alpha helices. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
PLEKHN1 (also known as CLPABP) is a cardiolipin phosphatidic acid binding protein that associates with microtubules and accumulates in RNA granules, which contain cytochrome-c mRNA []. It binds to Bid (a pro-apoptotic protein), removes Bid from transient Bid-Bax complexes, and promotes apoptosis []. This entry represents the PH domain of PLEKHN1. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner []. They share little sequence conservation, but all have a commonfold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity []. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes []. |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE54418 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Engel P |
| Year: |
2012 |
| Journal: |
Nature |
| Title: |
Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. |
| Volume: |
482 |
| Issue: |
7383 |
| Pages: |
107-10 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
480
 |
| Fragment?: |
false |
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| Publication |
| First Author: |
Papadakis ES |
| Year: |
2006 |
| Journal: |
FEBS Lett |
| Title: |
The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway. |
| Volume: |
580 |
| Issue: |
5 |
| Pages: |
1320-6 |
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| Publication |
| First Author: |
Vander Heiden MG |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. |
| Volume: |
276 |
| Issue: |
22 |
| Pages: |
19414-9 |
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| Publication |
| First Author: |
Malia TJ |
| Year: |
2007 |
| Journal: |
Biochemistry |
| Title: |
NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL. |
| Volume: |
46 |
| Issue: |
2 |
| Pages: |
514-25 |
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| Protein Domain |
| Type: |
Family |
| Description: |
VDAC-1 (outer mitochondrial membrane protein porin 1) is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. VDAC-1 appeares to be a pro-apoptotic protein through oligomerisation []. It is implicated in cell death induction for its ability to interact with BAX, a protein belonging to the BCL-2 protein family. BAX plays a role in apoptosis and mitochondrial function regulation via multiple protein-protein interactions with BCL-2, BAK, BID or other members of the family [, ]. Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ]. |
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| Publication |
| First Author: |
Lindemann RK |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. |
| Volume: |
104 |
| Issue: |
19 |
| Pages: |
8071-6 |
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| Publication |
| First Author: |
Mérino D |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. |
| Volume: |
186 |
| Issue: |
3 |
| Pages: |
355-62 |
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| Publication |
| First Author: |
Zheng JH |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. |
| Volume: |
23 |
| Issue: |
7 |
| Pages: |
2083-2094.e6 |
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| Publication |
| First Author: |
Namba T |
| Year: |
2013 |
| Journal: |
Cell Rep |
| Title: |
CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. |
| Volume: |
5 |
| Issue: |
2 |
| Pages: |
331-9 |
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| Publication |
| First Author: |
Hockings C |
| Year: |
2018 |
| Journal: |
Cell Death Differ |
| Title: |
Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins. |
| Volume: |
25 |
| Issue: |
4 |
| Pages: |
719-732 |
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| Publication |
| First Author: |
Tan CT |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
174-185 |
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| Publication |
| First Author: |
Sim GK |
| Year: |
1990 |
| Journal: |
Cell |
| Title: |
Dominantly inherited expression of BID, an invariant undiversified T cell receptor delta chain. |
| Volume: |
61 |
| Issue: |
3 |
| Pages: |
397-405 |
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| Publication |
| First Author: |
Luo X |
| Year: |
1998 |
| Journal: |
Cell |
| Title: |
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. |
| Volume: |
94 |
| Issue: |
4 |
| Pages: |
481-90 |
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| Publication |
| First Author: |
Kaiserman D |
| Year: |
2006 |
| Journal: |
J Cell Biol |
| Title: |
The major human and mouse granzymes are structurally and functionally divergent. |
| Volume: |
175 |
| Issue: |
4 |
| Pages: |
619-30 |
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| Publication |
| First Author: |
Lin CF |
| Year: |
2007 |
| Journal: |
J Cell Sci |
| Title: |
GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. |
| Volume: |
120 |
| Issue: |
Pt 16 |
| Pages: |
2935-43 |
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| Publication |
| First Author: |
Ott M |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release. |
| Volume: |
282 |
| Issue: |
38 |
| Pages: |
27633-9 |
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| Publication |
| First Author: |
Tobaben S |
| Year: |
2011 |
| Journal: |
Cell Death Differ |
| Title: |
Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
282-92 |
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| Publication |
| First Author: |
Weaver D |
| Year: |
2014 |
| Journal: |
Mol Cell |
| Title: |
Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. |
| Volume: |
54 |
| Issue: |
5 |
| Pages: |
870-8 |
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| Publication |
| First Author: |
Alsop AE |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis. |
| Volume: |
6 |
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| Pages: |
6841 |
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| Publication |
| First Author: |
Lim CL |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism. |
| Volume: |
9 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
610
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
611
 |
| Fragment?: |
false |
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