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Search results 401 to 500 out of 692 for Btk

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Type Details Score
Publication
18519649 | J:137039
First Author: Shimomura Y
Year: 2008
Journal: J Exp Med
Title: A unique B2 B cell subset in the intestine.
Volume: 205
Issue: 6
Pages: 1343-55
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Publication
26361887 | J:233734
First Author: Kilzheimer M
Year: 2015
Journal: Eur J Immunol
Title: NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells.
Volume: 45
Issue: 12
Pages: 3441-53
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Publication
22511754 | J:186204
First Author: Shao B
Year: 2012
Journal: J Biol Chem
Title: Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.
Volume: 287
Issue: 23
Pages: 19585-98
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Publication
17998397 | J:135554
First Author: Habib T
Year: 2007
Journal: J Cell Biol
Title: Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
Volume: 179
Issue: 4
Pages: 717-31
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Publication
23478294 | J:334006
First Author: Choi HK
Year: 2013
Journal: Cell Res
Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.
Volume: 23
Issue: 4
Pages: 524-36
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Publication
10358768 | J:55440
 
First Author: Kurosaki T
Year: 1999
Journal: Annu Rev Immunol
Title: Genetic analysis of B cell antigen receptor signaling.
Volume: 17
Pages: 555-92
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Publication
10611342 | J:119839
First Author: Ho LH
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.
Volume: 96
Issue: 26
Pages: 15086-90
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Publication
22542159 | J:185809
First Author: Akiyama K
Year: 2012
Journal: Cell Stem Cell
Title: Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis.
Volume: 10
Issue: 5
Pages: 544-55
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Publication
17982459 | J:127760
First Author: Takenaka K
Year: 2007
Journal: Nat Immunol
Title: Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.
Volume: 8
Issue: 12
Pages: 1313-23
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Publication
21464221 | J:177319
First Author: Bhattacharyya S
Year: 2011
Journal: J Exp Med
Title: NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.
Volume: 208
Issue: 4
Pages: 823-39
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Publication
3297105 | J:51094
 
First Author: Shultz LD
Year: 1987
Journal: Annu Rev Immunol
Title: Genetically determined murine models of immunodeficiency.
Volume: 5
Pages: 367-403
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Publication
10872802 | J:62510
First Author: Iseki M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Volume: 272
Issue: 1
Pages: 45-54
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Publication
20299514 | J:162825
First Author: Yago T
Year: 2010
Journal: Blood
Title: E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.
Volume: 116
Issue: 3
Pages: 485-94
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Publication
9143490 | J:39837
First Author: Holloway AJ
Year: 1997
Journal: Genomics
Title: Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.
Volume: 41
Issue: 2
Pages: 160-8
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Publication
16897342 | J:111669
First Author: Sollars VE
Year: 2006
Journal: Mamm Genome
Title: Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.
Volume: 17
Issue: 8
Pages: 808-21
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
15196959 | J:91443
First Author: Wilm B
Year: 2004
Journal: Dev Biol
Title: The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
Volume: 271
Issue: 1
Pages: 176-89
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Publication
9560157 | J:46940
First Author: Zambrowicz BP
Year: 1998
Journal: Nature
Title: Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.
Volume: 392
Issue: 6676
Pages: 608-11
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Publication
8530024 | J:25776
First Author: Steingrímsson E
Year: 1995
Journal: Genomics
Title: Murine chromosomal location of five bHLH-Zip transcription factor genes.
Volume: 28
Issue: 2
Pages: 179-83
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Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
F6W1T9
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Publication
8070576 | -
First Author: Vihinen M
Year: 1994
Journal: FEBS Lett
Title: Tec homology (TH) adjacent to the PH domain.
Volume: 350
Issue: 2-3
Pages: 263-5
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Publication
9280283 | -
First Author: Vihinen M
Year: 1997
Journal: FEBS Lett
Title: Missense mutations affecting a conserved cysteine pair in the TH domain of Btk.
Volume: 413
Issue: 2
Pages: 205-10
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Publication
9796816 | -
First Author: Jiang Y
Year: 1998
Journal: Nature
Title: The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.
Volume: 395
Issue: 6704
Pages: 808-13
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Publication
15661031 | -
 
First Author: Lindvall JM
Year: 2005
Journal: Immunol Rev
Title: Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.
Volume: 203
Pages: 200-15
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Protein Domain
IPR001562 | Znf_Btk_motif
Type: Conserved_site
Description: The Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice [, ]. Btk is a member of the Tec family of protein tyrosine kinases (PTK). These kinases contain a conserved Tec homology (TH) domain between the N-terminal pleckstrin homology (PH) domain () and the Src homology 3 (SH3) domain (). The N-terminal of the TH domain is highly conserved and known as the Btf motif, while the C-terminal region of the TH domain contains a proline-rich region (PRR). The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc finger topologies), while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins [, ]. The TH domain may be of functional importance in various signalling pathways in different species []. A complete TH domain, containing both the Btk and PRR regions, has not been found outside the Tec family; however, the Btk motif on its own does occur in other proteins, usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains are followed by a Btk motif).The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held together by a zinc ion, and that the Btk motif is packed against the PH domain []. The zinc-binding residues are a histidine and three cysteines, which are fully conserved in the Btk motif []. Proteins known to contain a Btk-type zinc finger include:Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase involved in modulation of diverse cellular processes. Mutations affecting Btk are the cause of X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein kinase Btk29A, which is required for the development of proper ring canals and of male genitalia and required for adult survival. Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to GTP.
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Allele
Btk<tm1Witt> | MGI:3612416
Name: Bruton agammaglobulinemia tyrosine kinase; targeted mutation 1, Owen N Witte
Allele Type: Targeted
Attribute String: Modified isoform(s)
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UniProt Feature
UniProt Feature
Begin: 2
Description: Tyrosine-protein kinase BTK
Type: chain
End: 659
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UniProt Feature
UniProt Feature
Begin: 248
Description: Phosphotyrosine; by BTK
Type: modified residue
End: 248
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UniProt Feature
UniProt Feature
Begin: 398
Description: Phosphotyrosine; by BTK
Type: modified residue
End: 398
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UniProt Feature
UniProt Feature
Begin: 503
Description: Phosphotyrosine; by BTK
Type: modified residue
End: 503
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UniProt Feature
UniProt Feature
Begin: 759
Description: Phosphotyrosine; by BTK
Type: modified residue
End: 759
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UniProt Feature
UniProt Feature
Begin: 753
Description: Phosphotyrosine; by BTK
Type: modified residue
End: 753
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UniProt Feature
UniProt Feature
Begin: 1197
Description: Phosphotyrosine; by BTK
Type: modified residue
End: 1197
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Publication
7538439 | J:26928
First Author: Li T
Year: 1995
Journal: Immunity
Title: Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Volume: 2
Issue: 5
Pages: 451-60
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Publication
16582106 | J:108508
First Author: Brunner C
Year: 2006
Journal: Nucleic Acids Res
Title: Btk expression is controlled by Oct and BOB.1/OBF.1.
Volume: 34
Issue: 6
Pages: 1807-15
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Publication
9751072 | -
First Author: Uckun FM
Year: 1998
Journal: Biochem Pharmacol
Title: Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis.
Volume: 56
Issue: 6
Pages: 683-91
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Publication
19290921 | -
First Author: Mohamed AJ
Year: 2009
Journal: Immunol Rev
Title: Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
Volume: 228
Issue: 1
Pages: 58-73
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Publication
24954503 | J:221259
First Author: Spaargaren M
Year: 2015
Journal: Oncogene
Title: BTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future.
Volume: 34
Issue: 19
Pages: 2426-36
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Publication
19687229 | J:152159
First Author: Kubo T
Year: 2009
Journal: J Exp Med
Title: Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.
Volume: 206
Issue: 9
Pages: 1971-82
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Publication
21482705 | J:174707
First Author: Janda E
Year: 2011
Journal: Blood
Title: Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ.
Volume: 117
Issue: 24
Pages: 6520-31
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Publication
30988116 | J:274631
First Author: Haselmayer P
Year: 2019
Journal: J Immunol
Title: Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.
Volume: 202
Issue: 10
Pages: 2888-2906
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Protein
Q3TQ19
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Pathway
R-MMU-8964315 | G beta:gamma signalling through BTK
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Publication
21518255 | J:190798
First Author: Hussain A
Year: 2011
Journal: FEBS J
Title: TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.
Volume: 278
Issue: 12
Pages: 2001-10
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Protein
D6RJM5
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
18292575 | J:131568
First Author: Semaan N
Year: 2008
Journal: J Immunol
Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.
Volume: 180
Issue: 5
Pages: 3485-91
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Publication
11598012 | -
First Author: Kang SW
Year: 2001
Journal: EMBO J
Title: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
Volume: 20
Issue: 20
Pages: 5692-702
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Publication
11114746 | -
First Author: Qiu Y
Year: 2000
Journal: Oncogene
Title: Signaling network of the Btk family kinases.
Volume: 19
Issue: 49
Pages: 5651-61
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Protein
Q8C6G4
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
F6W8M5
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q9Z131
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein
Q9Z131-2
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Protein
Q9Z131-3
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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Protein
Q8BNW5
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: true
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Protein
Q5STT7
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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DO Term
DOID:14179 | X-linked agammaglobulinemia
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Publication
7626884 | -
First Author: Oeltjen JC
Year: 1995
Journal: Mamm Genome
Title: Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci.
Volume: 6
Issue: 5
Pages: 334-8
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Publication
10327049 | -
First Author: Maeda A
Year: 1999
Journal: Oncogene
Title: Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1.
Volume: 18
Issue: 14
Pages: 2291-7
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Allele
Btk<em1Smoc> | MGI:7288537
Name: Bruton agammaglobulinemia tyrosine kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein
Q9Z268
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
Q6PFQ7
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Protein
P58069
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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Protein
Q60790
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q3UGJ5
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q3U405
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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