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Search results 401 to 500 out of 690 for Cast

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Srgap1/Srgap1 Six2/Six2<+>
Background: involves: 129 * C57BL/6J * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tnfaip2/Tnfaip2
Background: C.Cg-Tnfaip2
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6383983 | STOCK Sox2<em2.1(Snrpn-EGFP)Jae>/J
Attribute String: endonuclease-mediated mutation, mutant stock
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Strain
MGI:6383987 | STOCK Mir290a<em2.1(Snrpn-EGFP)Jae>/J
Attribute String: endonuclease-mediated mutation, mutant stock
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Protein Domain
IPR010050 | MTA_SAH_nuc_hyp
Type: Family
Description: This entry represents the enzyme 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, which acts on its two substrates at the same active site, from the Rhizobiales (alphaproteobacteria).This clade of sequences is sufficiently distinct from the characterised proteins [, ]which form as to cast some doubt on the accuracy of annotations based on sequence similarity alone. This enzyme is involved in the recycling of the components of S-adenosylmethionine after it has donated one of its two non-ribose sulphur ligands to an acceptor. In the case of 5'-methylthioadenosine this represents the first step of the methionine salvage pathway in bacteria [, ]. This enzyme is widely distributed in bacteria.
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Protein Coding Gene
MGI:1917329 | Golm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98446 | Med22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917483 | Cd2bp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Uox<tm1Bay> | MGI:1857266
Name: urate oxidase; targeted mutation 1, Baylor College of Medicine
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Col4a3<tm1Jhm> | MGI:1934893
Name: collagen, type IV, alpha 3; targeted mutation 1, Jeffrey H Miner
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Aprt<tm1Dwm> | MGI:2429961
Name: adenine phosphoribosyl transferase; targeted mutation 1, David W Melton
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tns1<tm1Efu> | MGI:2447792
Name: tensin 1; targeted mutation 1, Elaine Fuchs
Allele Type: Targeted
Attribute String: Null/knockout
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Transgene
MGI:2654007 | Tg(Neph1-Vegfa)1Seq
Type: transgene
Organism: mouse, laboratory
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Allele
Actn4<tm1Mrpk> | MGI:2664917
Name: actinin alpha 4; targeted mutation 1, Martin R Pollak
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Prdx6<tm1Pgn> | MGI:2668338
Name: peroxiredoxin 6; targeted mutation 1, Beverly Paigen
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Cd151<tm1Lka> | MGI:3050539
Name: CD151 antigen; targeted mutation 1, Leonie K Ashman
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Grm1<crv4> | MGI:3664783
 
Name: glutamate receptor, metabotropic 1; cervelet 4
Allele Type: Spontaneous
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Allele
Wt1<tm1Mlh> | MGI:3794650
 
Name: WT1 transcription factor; targeted mutation 1, Martin L Hooper
Allele Type: Targeted
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Allele
Nphs2<tm2.1Antc> | MGI:4360671
 
Name: nephrosis 2, podocin; targeted mutation 2.1, Corinne Antignac
Allele Type: Targeted
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Allele
Fasl<tm1.1Ast> | MGI:4366050
 
Name: Fas ligand; targeted mutation 1.1, Andreas Strasser
Allele Type: Targeted
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Allele
Myo1e<tm1.1Flv> | MGI:4441413
Name: myosin IE; targeted mutation 1.1, Richard A Flavell
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(Umod*C147W)958Lura | MGI:4819096
Name: transgene insertion 958, Luca Rampoldi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Magi2<tm1Key> | MGI:5508897
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2; targeted mutation 1, Charles L Sawyers
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tjp1<tm1.1Whun> | MGI:5749399
Name: tight junction protein 1; targeted mutation 1.1, Walter Hunziker
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Atp6ap2<tm1.1Ics> | MGI:5776594
Name: ATPase, H+ transporting, lysosomal accessory protein 2; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Coq6<tm1c(EUCOMM)Hmgu> | MGI:6451728
Name: coenzyme Q6 monooxygenase; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Col4a4<m1H> | MGI:6501795
Name: collagen, type IV, alpha 4; mutation 1, Harwell
Allele Type: Chemically induced (ENU)
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(Neph1-Vegfa)1Seq/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prdx6/Prdx6
Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ret/Ret<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aprt/Aprt
Background: 129P2/OlaHsd-Aprt
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aprt/Aprt
Background: involves: 129P2/OlaHsd * BALB/c
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Grm1/Grm1
Background: BALB/cPas-Grm1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: C1galt1/C1galt1
Background: C57BL/6-C1galt1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tusc2/Tusc2<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: A/a
Background: involves: KK
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Glis2/Glis2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Golm1/Golm1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col4a3/Col4a3
Background: 129-Col4a3/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd151/Cd151
Background: FVB.B6-CD151
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vhl/Vhl Tg(NPHS2-cre)295Lbh/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tjp1/Tjp1 Tg(Nphs1-cre)33Mska/?
Background: involves: C57BL/6 * C57BL/6N * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atp6ap2/? Tg(NPHS2-cre)295Lbh/?
Background: involves: C57BL/6 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rhpn1/Rhpn1
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Med22/Med22 Tg(Nphs1-cre)#Seq/?
Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR007481 | SspB
Type: Family
Description: Escherichia coli stringent starvation protein B (SspB), is thought to enhance the specificity of degradation of tmRNA-tagged proteins by the ClpXP protease. The tmRNA tag, also known as ssrA, is an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP. SspB is a cytoplasmic protein that specifically binds to residues 1-4 and 7 of the tag. Binding of SspB enhances degradation of tagged proteins by ClpX, and masks sequence elements important for ClpA interactions, inhibiting degradation by ClpA []. However, more recent work has cast doubt on the importance of SspB in wild-type cells []. SspB is encoded in an operon whose synthesis is stimulated by carbon, amino acid, and phosphate starvation. SspB may play a special role during nutrient stress, for example by ensuring rapid degradation of the products of stalled translation, without causing a global increase in degradation of all ClpXP substrates [].
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Publication
11009422 | -
First Author: Levchenko I
Year: 2000
Journal: Science
Title: A specificity-enhancing factor for the ClpXP degradation machine.
Volume: 289
Issue: 5488
Pages: 2354-6
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Publication
11535833 | -
First Author: Flynn JM
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis.
Volume: 98
Issue: 19
Pages: 10584-9
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Publication
11810257 | -
First Author: Bohn C
Year: 2002
Journal: Mol Genet Genomics
Title: Screening for stabilization of proteins with a trans-translation signature in Escherichia coli selects for inactivation of the ClpXP protease.
Volume: 266
Issue: 5
Pages: 827-31
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Protein Coding Gene
MGI:104552 | Tns1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098783 | Rhpn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1932535 | Glis2
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Pdss2<kd> | MGI:1856927
 
Name: prenyl (solanesyl) diphosphate synthase, subunit 2; kidney disease
Allele Type: Spontaneous
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Allele
Hmox1<tm1Poss> | MGI:2388322
Name: heme oxygenase 1; targeted mutation 1, Kenneth D Poss
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Nphs2<tm1Antc> | MGI:3028629
Name: nephrosis 2, podocin; targeted mutation 1, Corinne Antignac
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cd151<tm1Nki> | MGI:3691076
Name: CD151 antigen; targeted mutation 1, The Netherlands Cancer Institute
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
urehr1 | MGI:3712281
 
Name: urea phenotype 1
Allele Type: Chemically induced (ENU)
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Allele
Prkci<tm1Rfar> | MGI:3720810
Name: protein kinase C, iota; targeted mutation 1, Robert V Farese Sr
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(Pkd1)6Mtru | MGI:4437717
Name: transgene insertion 6, Marie Trudel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Transgene
MGI:4819112 | Tg(Umod*C147W)958Lura
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Vegfa/Vegfa<+> Tg(Nphs1-cre)1Seq/?
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tns1/Tns1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Actn4/Actn4
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col4a3/Col4a3
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pdss2/Pdss2
Background: CBA/H-Pdss2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Uox/Uox
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tlr4/Tlr4
Background: B6.129P2-Tlr4
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tusc2/Tusc2
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nphs2/Nphs2
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fasl/Fasl
Background: involves: BALB/cJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo1e/Myo1e
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Umod*C147W)958Lura/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nphs2/Nphs2 Tg(CAG-cre/Esr1*)86Lbgn/?
Background: involves: 129 * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itgb1/Itgb1 Tg(NPHS2-cre)295Lbh/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkci/Prkci Tg(Nphs1-cre)33Mska/?
Background: involves: C57BL/6 * C57BL/6N * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Magi2/Magi2
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Coq6/Coq6 Tg(NPHS2-cre)295Lbh/?
Background: involves: C57BL/6 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col4a4/Col4a4
Background: involves: C3H/HeH * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
E-GEOD-10493 | Novartis 12 Strain Diet Sex Survey
Series Id: GSE10493
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Protein Coding Gene
MGI:894320 | Prdx6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106621 | Myo1e
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Col4a3<tm1Dec> | MGI:1857432
Name: collagen, type IV, alpha 3; targeted mutation 1, Dominic Cosgrove
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tlr4<tm1Aki> | MGI:1860885
Name: toll-like receptor 4; targeted mutation 1, Shizuo Akira
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Arhgdia<tm1Ytk> | MGI:3613573
Name: Rho GDP dissociation inhibitor alpha; targeted mutation 1, Yoshimi Takai
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tusc2<tm1Avi> | MGI:3706236
Name: tumor suppressor 2, mitochondrial calcium regulator; targeted mutation 1, Alla Ivanova
Allele Type: Targeted
Attribute String: Null/knockout
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Heritable Phenotypic Marker
MGI:3712268 | urehr1
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Transgene
MGI:4437765 | Tg(Pkd1)6Mtru
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(Pkd1)26Mtru | MGI:4437718
Name: transgene insertion 26, Marie Trudel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Col4a1<tm1.1Ics> | MGI:5896437
Name: collagen, type IV, alpha 1; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Humanized sequence
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Genotype
Genotype
Symbol: Nphs2/Nphs2
Background: involves: 129 * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hmox1/Hmox1
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd151/Cd151
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: urehr1/urehr1
Background: C3HeB/FeJ-urehr1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pkd1)6Mtru/?
Background: involves: C57BL/6J * CBA/J
Zygosity: ot
Has Mutant Allele: true
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Publication
10574451 | -
First Author: Sekowska A
Year: 1999
Journal: DNA Res
Title: Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilis.
Volume: 6
Issue: 5
Pages: 255-64
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Publication
11591349 | -
First Author: Lee JE
Year: 2001
Journal: Structure
Title: Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.
Volume: 9
Issue: 10
Pages: 941-53
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Publication
12887894 | -
First Author: Song HK
Year: 2003
Journal: Mol Cell
Title: Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine.
Volume: 12
Issue: 1
Pages: 75-86
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Protein Domain
IPR036760 | SspB-like_sf
Type: Homologous_superfamily
Description: Escherichia coli stringent starvation protein B (SspB), is thought to enhance the specificity of degradation of tmRNA-tagged proteins by the ClpXP protease. The tmRNA tag, also known as ssrA, is an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP. SspB is a cytoplasmic protein that specifically binds to residues 1-4 and 7 of the tag. Binding of SspB enhances degradation of tagged proteins by ClpX, and masks sequence elements important for ClpA interactions, inhibiting degradation by ClpA []. However, more recent work has cast doubt on the importance of SspB in wild-type cells []. SspB is encoded in an operon whose synthesis is stimulated by carbon, amino acid, and phosphate starvation. SspB may play a special role during nutrient stress, for example by ensuring rapid degradation of the products of stalled translation, without causing a global increase in degradation of all ClpXP substrates [].The structure of SspB revealed an SH3-like topology, sharing some similarity with the Sm-like fold [].
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Publication
3917858 | J:7709
First Author: Hayday AC
Year: 1985
Journal: Cell
Title: Structure, organization, and somatic rearrangement of T cell gamma genes.
Volume: 40
Issue: 2
Pages: 259-69
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Publication
12359746 | J:79690
First Author: Koratkar R
Year: 2002
Journal: Cancer Res
Title: The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus.
Volume: 62
Issue: 19
Pages: 5413-7
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