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Search results 401 to 500 out of 580 for Ccr4

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:6369686
Assay Type: RT-PCR
Annotation Date: 2019-11-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752726
Stage: TS26
Assay Id: MGI:6369699
Age: embryonic day 19.5
Image: 4
Specimen Label: WTe Dermis
Specimen Num: 3
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•
GXD Expression
GXD Expression
   
Probe: MGI:6369686
Assay Type: RT-PCR
Annotation Date: 2019-11-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752726
Stage: TS26
Assay Id: MGI:6369699
Age: embryonic day 19.5
Image: 4
Specimen Label: KOe Dermis
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
   
Probe: MGI:7561939
Assay Type: RT-PCR
Annotation Date: 2023-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1829025
Stage: TS25
Assay Id: MGI:7562035
Age: embryonic day 17.5
Image: 7
Specimen Label: WT
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:7561939
Assay Type: RT-PCR
Annotation Date: 2023-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1829025
Stage: TS25
Assay Id: MGI:7562035
Age: embryonic day 17.5
Image: 7
Specimen Label: Irf6-null
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945772
Age: embryonic day 11.5
Image: g01478 E11.5
Specimen Label: g01478 E11.5
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
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•
GXD Expression
GXD Expression
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945772
Age: embryonic day 11.5
Image: g01478 E11.5
Specimen Label: g01478 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5000758
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2910624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5541318
Age: embryonic day 16.0
Image: GUDMAP:8375
Specimen Label: GUDMAP:8375
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945772
Age: embryonic day 11.5
Image: g01478 E11.5
Specimen Label: g01478 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Note: Expression was region specific and scattered.
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945772
Age: embryonic day 11.5
Image: g01478 E11.5
Specimen Label: g01478 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945772
Age: embryonic day 11.5
Image: g01478 E11.5
Specimen Label: g01478 E11.5
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945772
Age: embryonic day 15.5
Image: g01478 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01478 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 7
Image: g01478 P7
Specimen Label: g01478 P7
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884292
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945772
Age: postnatal day 42
Image: g01478 Adult
Specimen Label: g01478 Adult
Detected: true
Specimen Num: 4
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Protein
Q8K1C0
Organism: Mus musculus/domesticus
Length: 544  
Fragment?: false
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Protein Domain
IPR012270 | CCR4-NOT_su3/5
Type: Family
Description: The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 []. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress []. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex []. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [].This group represents CCR4-NOT complex, subunits 3 and 5.
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Protein Domain
IPR040168 | Not2/3/5
Type: Family
Description: The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 []. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress []. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex []. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [].This entry includes CCR4-NOT complex subunits Not2, Not3, Not5 and related proteins.
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Protein Domain
IPR024557 | CNOT1_dom_4
Type: Domain
Description: The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 []. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress []. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex []. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [].This entry represents a domain of unknown function found in the Not1 subunit of the CCR4-Not complex.
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Protein Domain
IPR007196 | CCR4-Not_Not1_C
Type: Domain
Description: The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 []. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress []. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex []. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [].The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [].
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Protein
F6YBV1
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: true
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Publication
19716330 | J:196089
First Author: Fabian MR
Year: 2009
Journal: Mol Cell
Title: Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
Volume: 35
Issue: 6
Pages: 868-80
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Publication
31756626 | J:307242
 
First Author: Kikuchi T
Year: 2019
Journal: iScience
Title: Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis.
Volume: 22
Pages: 81-96
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Publication
30910796 | J:275086
First Author: Rapp M
Year: 2019
Journal: J Exp Med
Title: CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
Volume: 216
Issue: 5
Pages: 1170-1181
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Publication
27195186 | J:236051
First Author: Rapp M
Year: 2016
Journal: Oncoimmunology
Title: C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer.
Volume: 5
Issue: 3
Pages: e1105428
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Publication
22593615 | J:188966
First Author: Shankar SP
Year: 2012
Journal: J Immunol
Title: RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Volume: 188
Issue: 12
Pages: 6347-56
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Publication
11696541 | -
First Author: Maillet L
Year: 2002
Journal: J Biol Chem
Title: Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.
Volume: 277
Issue: 4
Pages: 2835-42
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Publication
12957374 | -
 
First Author: Collart MA
Year: 2003
Journal: Gene
Title: Global control of gene expression in yeast by the Ccr4-Not complex.
Volume: 313
Pages: 1-16
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Publication
18430587 | -
First Author: Liu WF
Year: 2008
Journal: Protein Expr Purif
Title: Biophysical and biochemical characterization of recombinant human Pop2 deadenylase.
Volume: 60
Issue: 1
Pages: 46-52
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Protein
Q6ZQ08
Organism: Mus musculus/domesticus
Length: 2375  
Fragment?: false
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Protein
B2RXR3
Organism: Mus musculus/domesticus
Length: 2369  
Fragment?: false
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Protein
A0A1D5RMJ8
Organism: Mus musculus/domesticus
Length: 2369  
Fragment?: false
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•
Protein
B7ZWL1
Organism: Mus musculus/domesticus
Length: 2326  
Fragment?: false
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•
Protein
Q505C5
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
A0A1D5RMD8
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
A0A1L1STS0
Organism: Mus musculus/domesticus
Length: 32  
Fragment?: true
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Publication
10754297 | -
First Author: Inngjerdingen M
Year: 2000
Journal: J Immunol
Title: Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.
Volume: 164
Issue: 8
Pages: 4048-54
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Publication
10637271 | -
First Author: Lloyd CM
Year: 2000
Journal: J Exp Med
Title: CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo.
Volume: 191
Issue: 2
Pages: 265-74
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Publication
15683617 | -
First Author: Garcia G
Year: 2005
Journal: Curr Allergy Asthma Rep
Title: New chemokine targets for asthma therapy.
Volume: 5
Issue: 2
Pages: 155-60
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Publication
20148806 | -
First Author: Banfield G
Year: 2010
Journal: Allergy
Title: CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses.
Volume: 65
Issue: 9
Pages: 1126-33
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Protein Domain
IPR002239 | Chemokine_CCR4
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 4 (CCR4), it is expressed on T(h)2 cells []and is up-regulated by T cell receptor activation. CCR4 is also found in the brain microvascular and coronary artery endothelial cells []and in blood dentric cells []. It has been suggested the receptor is invloved in trafficking of dendritic cells []. CCR4 is noted as playing a role in allergic reactions, particularly in asthma [, , ].
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Protein
F6WUZ2
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
A0A0U1RNN8
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: true
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Publication
16971515 | -
First Author: DeBella LR
Year: 2006
Journal: Mol Biol Cell
Title: LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos.
Volume: 17
Issue: 11
Pages: 4911-24
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Publication
32553196 | -
First Author: Vissers LELM
Year: 2020
Journal: Am J Hum Genet
Title: De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay.
Volume: 107
Issue: 1
Pages: 164-172
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Publication
15549374 | -
First Author: Cao X
Year: 2005
Journal: Planta
Title: Molecular analysis of the CRINKLY4 gene family in Arabidopsis thaliana.
Volume: 220
Issue: 5
Pages: 645-57
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Publication
27100110 | -
First Author: Demko V
Year: 2016
Journal: Planta
Title: The phenotype of the CRINKLY4 deletion mutant of Physcomitrella patens suggests a broad role in developmental regulation in early land plants.
Volume: 244
Issue: 1
Pages: 275-84
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Publication
26557128 | -
 
First Author: Nikonorova N
Year: 2015
Journal: Front Plant Sci
Title: A phylogenetic approach to study the origin and evolution of the CRINKLY4 family.
Volume: 6
Pages: 880
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Protein Domain
IPR044815 | CCR3/4
Type: Family
Description: This family includes plant serine/threonine receptor-like kinases related to CRINKLY4 (CR4), a protein involved in developmental processes in plant and endosperm that was first isolated in maize [, ]. Mutations in this protein affects the cell wall thickness and structure, cuticle formation, and vesicle trafficking, and tumor like outgrowths, with similar effects seen in rice [, , ]. Arabidopsis thaliana contains an orthologue of CR4, ACR4, and four CRINKLY4-related proteins (CRR or CCR) AtCRR1, AtCRR2, AtCRR3 and AtCRR4 (also known as CRINKLY 4-related kinase 1, AtCRK1) []. Phylogenetic analysis showed that the CR4 family of receptor kinases can be divided in three clades, one including CR4, CCR1 and CCR2, a second including CCR3 and CCR4 family members, and a third and more distant clade including members from algae and Selaginella moellendorffii sequences with transmembrane and/or kinase domains []. Kinase assays showed that ACR4 is an active serine/threonine kinase, while CCR1 and CCR2 are nearly inactive in autophosphorylation assays []. CR4 family are characterised by the presence of seven 'crinkly' repeats in the extracellular part which is required both for signalling and normal protein internalisation, including a conserved C(X~10)CWG sequence motif. The Cys residues in the extracellular 'crinkly' repeat domain are likely to form stabilizing disulfide bridges []. Another feature of the CR4 family is that the extracellular domain shows homology to the three Cys-rich repeats of the TUMOR NECROSIS FACTOR RECEPTOR (TNFR) extracellular domain [].This family represents the CRINKLE4-related proteins CCR3 and CCR4.
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Protein Domain
IPR040398 | Not1
Type: Family
Description: Not1 is the core component of the CCR4/NOT complex, which plays roles in the negative regulation of gene expression at transcriptional and post-transcriptional levels. This entry includes Not1 (also known as Cdc39) and its homologues, such as LET-711 from Caenorhabditis elegans []. De novo variants in CNOT1 have been shown to cause neurodevelopmental delay []. The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 []. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress []. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex []. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [].
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Publication
10637334 | -
First Author: Albert TK
Year: 2000
Journal: Nucleic Acids Res
Title: Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.
Volume: 28
Issue: 3
Pages: 809-17
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Publication
22073225 | J:180997
First Author: Niu S
Year: 2011
Journal: PLoS One
Title: The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.
Volume: 6
Issue: 11
Pages: e26954
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Publication
21278420 | J:196260
First Author: Sandler H
Year: 2011
Journal: Nucleic Acids Res
Title: Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.
Volume: 39
Issue: 10
Pages: 4373-86
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Publication
30496701 | J:288001
First Author: Shi Q
Year: 2019
Journal: FASEB J
Title: Single-cell analyses reveal functional classification of dendritic cells and their potential roles in inflammatory disease.
Volume: 33
Issue: 3
Pages: 3784-3794
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Publication
15728489 | J:97710
First Author: Rodriguez-Galán MC
Year: 2005
Journal: J Immunol
Title: Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.
Volume: 174
Issue: 5
Pages: 2796-804
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Publication
20083666 | J:159480
First Author: Gregg RK
Year: 2010
Journal: J Immunol
Title: Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice.
Volume: 184
Issue: 4
Pages: 1909-17
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Publication
18523230 | J:138164
First Author: Thomas MS
Year: 2008
Journal: J Leukoc Biol
Title: The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites.
Volume: 84
Issue: 3
Pages: 814-23
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Publication
25201756 | J:230196
First Author: Hua C
Year: 2014
Journal: Exp Hematol
Title: Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.
Volume: 42
Issue: 12
Pages: 1031-40.e1-4
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Publication
20508071 | J:183352
First Author: Moriwaki A
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma.
Volume: 44
Issue: 4
Pages: 448-55
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Publication
25788530 | J:332285
First Author: Lerret NM
Year: 2015
Journal: J Am Soc Nephrol
Title: Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection.
Volume: 26
Issue: 11
Pages: 2753-64
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Publication
31653684 | J:282208
First Author: Snelgrove SL
Year: 2019
Journal: J Immunol
Title: Regulatory T Cell Transmigration and Intravascular Migration Undergo Mechanistically Distinct Regulation at Different Phases of the Inflammatory Response.
Volume: 203
Issue: 11
Pages: 2850-2861
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Publication
24550297 | J:206802
First Author: Watanabe C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Stability of mRNA influences osteoporotic bone mass via CNOT3.
Volume: 111
Issue: 7
Pages: 2692-7
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Publication
31879354 | J:283345
First Author: Laothamatas I
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response.
Volume: 117
Issue: 2
Pages: 993-999
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Publication
19841169 | J:157196
First Author: Kimpfler S
Year: 2009
Journal: J Immunol
Title: Skin melanoma development in ret transgenic mice despite the depletion of CD25+Foxp3+ regulatory T cells in lymphoid organs.
Volume: 183
Issue: 10
Pages: 6330-7
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Publication
31962142 | J:285693
 
First Author: Flores-Guzmán F
Year: 2020
Journal: Cancer Lett
Title: Dormant tumor cells interact with memory CD8+ T cells in RET transgenic mouse melanoma model.
Volume: 474
Pages: 74-81
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Publication
24591636 | J:207385
First Author: Ravishankar B
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance.
Volume: 111
Issue: 11
Pages: 4215-20
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Publication
31796596 | J:282793
First Author: Valente M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells.
Volume: 116
Issue: 51
Pages: 25816-25827
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Publication
27197194 | J:234851
First Author: Beziaud L
Year: 2016
Journal: Cancer Res
Title: Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity.
Volume: 76
Issue: 14
Pages: 4100-12
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Publication
28615693 | J:261080
First Author: Rodríguez-Gil A
Year: 2017
Journal: Sci Rep
Title: The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.
Volume: 7
Issue: 1
Pages: 3547
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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