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Search results 401 to 500 out of 3124 for Ccr5

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Type Details Score
Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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HT Experiment
E-GEOD-47029 | CCR5 controls neuronal damage in an in vivo model of HIV glycoprotein 120-induced brain injury
Series Id: GSE47029
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
10486970 | J:57081
First Author: Zhang YW
Year: 1999
Journal: Mol Biol Evol
Title: Sequence evolution of the CCR5 chemokine receptor gene in primates.
Volume: 16
Issue: 9
Pages: 1145-54
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Allele
Ccr5<tm1Kuz> | MGI:1861911
Name: C-C motif chemokine receptor 5; targeted mutation 1, William A Kuziel
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
30794775 | J:271340
First Author: Joy MT
Year: 2019
Journal: Cell
Title: CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.
Volume: 176
Issue: 5
Pages: 1143-1157.e13
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Publication
31292161 | J:279993
First Author: Jiao X
Year: 2019
Journal: Cancer Res
Title: Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology.
Volume: 79
Issue: 19
Pages: 4801-4807
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Allele
Ccr5<tm1(CCR5)Pfi> | MGI:5774771
Name: C-C motif chemokine receptor 5; targeted mutation 1, Pfizer, Ltd
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Publication
20601939 | J:162607
First Author: Holt N
Year: 2010
Journal: Nat Biotechnol
Title: Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo.
Volume: 28
Issue: 8
Pages: 839-47
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Publication
23326556 | J:195710
First Author: Ochoa-Callejero L
Year: 2013
Journal: PLoS One
Title: Maraviroc, a CCR5 antagonist, prevents development of hepatocellular carcinoma in a mouse model.
Volume: 8
Issue: 1
Pages: e53992
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Publication
9405665 | J:54611
First Author: Browning J
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection.
Volume: 94
Issue: 26
Pages: 14637-41
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Publication
10878389 | J:120456
First Author: Cameron MJ
Year: 2000
Journal: J Immunol
Title: Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes.
Volume: 165
Issue: 2
Pages: 1102-10
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Strain
MGI:4838609 | B6.129P2-Ccr5<tm1Kuz>/Tac
Attribute String: congenic, mutant strain, targeted mutation
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Publication
11543653 | J:102561
First Author: Glass WG
Year: 2001
Journal: Virology
Title: Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus.
Volume: 288
Issue: 1
Pages: 8-17
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Publication
10975845 | J:104242
First Author: Unutmaz D
Year: 2000
Journal: J Immunol
Title: The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse.
Volume: 165
Issue: 6
Pages: 3284-92
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Allele
Ccr5<tm1(CCR5)Smoc> | MGI:7288741
Name: C-C motif chemokine receptor 5; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Ccr5/Ccr5
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
36430701 | J:332993
 
First Author: Chan PC
Year: 2022
Journal: Int J Mol Sci
Title: Adipose Tissue-Derived CCL5 Enhances Local Pro-Inflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice.
Volume: 23
Issue: 22
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DO Term
DOID:0110759 | type 1 diabetes mellitus 22
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Publication
33705493 | J:313250
First Author: Smith LK
Year: 2021
Journal: PLoS One
Title: Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.
Volume: 16
Issue: 3
Pages: e0248309
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Publication
12682253 | -
First Author: Ng-Cashin J
Year: 2003
Journal: J Immunol
Title: Host absence of CCR5 potentiates dendritic cell vaccination.
Volume: 170
Issue: 8
Pages: 4201-8
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Publication
23691059 | J:200852
First Author: Seay K
Year: 2013
Journal: PLoS One
Title: Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy.
Volume: 8
Issue: 5
Pages: e63537
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Protein Coding Gene
MGI:1925828 | Cnih4
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Ccr5<em1Smoc> | MGI:7288740
Name: C-C motif chemokine receptor 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428331 | C57BL/6JSmoc-Ccr5<tm1(CCR5)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
11994538 | -
First Author: Habasque C
Year: 2002
Journal: Mol Hum Reprod
Title: Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.
Volume: 8
Issue: 5
Pages: 419-25
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Publication
15572394 | -
First Author: Brühl H
Year: 2005
Journal: Rheumatology (Oxford)
Title: Expression of DARC, CXCR3 and CCR5 in giant cell arteritis.
Volume: 44
Issue: 3
Pages: 309-13
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Strain
MGI:6354597 | C57BL/6JSmoc-Ccr5<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
9261347 | -
First Author: Doranz BJ
Year: 1997
Journal: J Virol
Title: Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
Volume: 71
Issue: 9
Pages: 6305-14
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Publication
9466968 | -
First Author: Qin S
Year: 1998
Journal: J Clin Invest
Title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume: 101
Issue: 4
Pages: 746-54
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Publication
10816381 | -
First Author: Xiao X
Year: 2000
Journal: Exp Mol Pathol
Title: Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Volume: 68
Issue: 3
Pages: 133-8
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Protein Coding Gene
MGI:101784 | Nes
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98261 | Ccl4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18439751 | -
First Author: Soria G
Year: 2008
Journal: Cancer Lett
Title: The inflammatory chemokines CCL2 and CCL5 in breast cancer.
Volume: 267
Issue: 2
Pages: 271-85
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Publication
24523569 | -
 
First Author: Aldinucci D
Year: 2014
Journal: Mediators Inflamm
Title: The inflammatory chemokine CCL5 and cancer progression.
Volume: 2014
Pages: 292376
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Publication
16791620 | -
First Author: Capoulade-Métay C
Year: 2006
Journal: Immunogenetics
Title: A natural CCL5/RANTES variant antagonist for CCR1 and CCR3.
Volume: 58
Issue: 7
Pages: 533-41
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Publication
25114130 | -
First Author: Secchi M
Year: 2014
Journal: Antimicrob Agents Chemother
Title: Combination of the CCL5-derived peptide R4.0 with different HIV-1 blockers reveals wide target compatibility and synergic cobinding to CCR5.
Volume: 58
Issue: 10
Pages: 6215-23
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Publication
18243436 | -
First Author: Vangelista L
Year: 2008
Journal: Vaccine
Title: Rational design of novel HIV-1 entry inhibitors by RANTES engineering.
Volume: 26
Issue: 24
Pages: 3008-15
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Protein Domain
IPR030595 | CCL5
Type: Family
Description: C-C chemokine ligand 5 (CCL5), also known as RANTES, is a target gene of NF-kappaB, and is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumour cells [, ]. CCL5 plays a role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils. CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5 [, ].CCR5 is a G-protein-coupled receptor for CCL3, CCL4 and CCL5. CCR5 is also the major coreceptor for HIV-1 entry into target cells and is thought to be a suitable therapeutic target for HIV-1 blockade []. However, the affinity between CCR5 and natural CCL5 is low and has limited viral entry inhibiting activity. Therefore, several CCL5 derivatives with high anti-HIV-1 potency have been produced to act as entry inhibitors and CCR5 antagonists [, ].
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Allele
Tg(UBC-CCR5,-CD4)19Mnz | MGI:5509007
Name: transgene insertion 19, Michel C Nussenzweig
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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MP Term
MP:0031250 | decreased circulating CCL3 level
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MP Term
MP:0031247 | decreased CCL3 level
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MP Term
MP:0031246 | abnormal CCL3 level
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MP Term
MP:0031248 | increased CCL3 level
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MP Term
MP:0031249 | abnormal circulating CCL3 level
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MP Term
MP:0031251 | increased circulating CCL3 level
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Protein Coding Gene
MGI:96628 | Jak1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8663314 | J:45024
First Author: Raport CJ
Year: 1996
Journal: J Biol Chem
Title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
Volume: 271
Issue: 29
Pages: 17161-6
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Allele
Ptgs2os<tm1Scrp> | MGI:7314907
Name: prostaglandin-endoperoxide synthase 2, opposite strand; targeted mutation 1, Susan Carpenter
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Protein Coding Gene
MGI:98260 | Ccl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24855645 | -
First Author: Jin J
Year: 2014
Journal: J Biol Chem
Title: Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.
Volume: 289
Issue: 27
Pages: 19042-52
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ncRNA Gene
MGI:2443180 | Ptgs2os
Type: lncRNA_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Ptgs2os/Ptgs2os
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:5509008 | STOCK Gt(ROSA)26Sor<tm1(Luc)Kael> Tg(UBC-CCR5,-CD4)19Mnz/J
Attribute String: mutant stock, targeted mutation, transgenic
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HT Experiment
GSE256440 | Transcriptome analyses reveal key features of mouse seminal vesicle during aging
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein Coding Gene
MGI:103063 | Stat1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98262 | Ccl5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23720722 | J:200013
First Author: Gruell H
Year: 2013
Journal: J Virol
Title: Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model.
Volume: 87
Issue: 15
Pages: 8535-44
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Publication
9655467 | -
First Author: Jiang Y
Year: 1998
Journal: J Neuroimmunol
Title: Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis.
Volume: 86
Issue: 1
Pages: 1-12
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Protein Domain
IPR002240 | Chemokine_CCR5
Type: Family
Description: CC chemokine receptor 5 (CCR5) is found on the surface of white blood cells, such as macrophages [], T cells []and dendritic cells [, ], and expressed in lymphoid organs []. Transfected cells expressing CCR5 receptor bind CCL5 (RANTES), CCL4 (MIP-1beta) and CCL3 (MIP-1alpha), and generate inositol phosphates in response to these chemokines. The same combination of chemokines has been shown to potently inhibit human immunodeficiency virus replication in human peripheral blood leukocytes []. CCR5 is the major coreceptor for HIV-1 entry into target cells and is thought to be a suitable therapeutic target for HIV-1 blockade [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.
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Protein Coding Gene
MGI:103038 | Stat3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12554737 | -
First Author: Lüttichau HR
Year: 2003
Journal: J Biol Chem
Title: A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
Volume: 278
Issue: 13
Pages: 10928-33
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Publication
25355130 | -
First Author: Tweedy J
Year: 2015
Journal: J Gen Virol
Title: Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators.
Volume: 96
Issue: Pt 2
Pages: 370-89
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Protein Domain
IPR035347 | Putative_chemo_U83
Type: Family
Description: Human herpesvirus 6A (HHV-6A) and HHV-6B are classified as roseoloviruses and are highly prevalent in the human population. Roseolovirus reactivation in an immunocompromised host can cause severe pathologies []. HHV6 A/B encode two putative chemokine receptors and a chemokine-like protein. The HHV6 U83 gene encodes a CC chemokine, which functions as a highly selective and efficacious agonist for the human CCR2 receptor, both in respect of signal transduction and the ability to induce chemotaxis. Homologues of the U83 gene products are found in Human cytomegalovirus encoded chemokines vCXC1 and vCXC2.HHV-6 U83, also known as vCCL4, contains a region with the CC/CX3C chemokine motif and a glycosaminoglycan (GAG)-binding epitope, BBXB (B being a basic residue), found right before the third Cys residue, which very likely forms a disulfide bridge back to the first Cys of the protein []. This gene is the only HHV-6A/B divergent gene that is specific for these viruses. The U83 chemokine gene is distinct between HHV-6A and HHV-6B strains, encoding up to 13 amino acid differences. The HHV-6A (U83A) and HHV-6B (U83B) chemokines have distinct specificities which determine chemoattraction or diversion of different leukocyte subsets for infection or immune evasion, thus an early component of cellular tropism as well as mediator of innate immunity. U83 also has a varied gene structure, with N-terminal length variation determining production of the encoded mature secreted chemokine, coupled with control by cell-directed splicing which truncates the chemokine gene early in replication to encode an antagonist. The 'long' active form of U83A has a unique broad specificity for receptors CCR1, CCR4, CCR5, CCR6 and CCR8 present on plasmacytoid and myeloid dendritic and monocyte/macrophage antigen presenting cells, as well as both TH1 and TH2 skin homing lymphocytes and NK cells; it is also amongst the highest affinity ligands for CCR5 and inhibits HIV-1 binding at this coreceptor. U83A can both block and divert human chemokine action while occupying the human chemokine receptors [].
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Publication
38579682 | J:349695
First Author: Dudek AM
Year: 2024
Journal: Cell Stem Cell
Title: A simultaneous knockout knockin genome editing strategy in HSPCs potently inhibits CCR5- and CXCR4-tropic HIV-1 infection.
Volume: 31
Issue: 4
Pages: 499-518.e6
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Publication
20190758 | J:158986
First Author: Semmling V
Year: 2010
Journal: Nat Immunol
Title: Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.
Volume: 11
Issue: 4
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