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Search results 401 to 500 out of 530 for Cd22

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0.021s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene Segment
MGI:4439558 | Igkv1-110
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439722 | Igkv1-122
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644894 | Igkv2-112
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:2685913 | Igkv16-104
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:96513 | Igkv15-103
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:5009884 | Igkv20-101-2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439828 | Igkv1-88
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:1330840 | Igkv8-21
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3647134 | Ighv6-5
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439734 | Ighv8-13
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644475 | Ighv8-9
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645823 | Ighv8-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3643819 | Ighv16-1
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439516 | Ighv5-12
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439815 | Ighv5-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645478 | Ighv8-5
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3815333 | Ighv8-8
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644925 | Ighv8-11
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:5313039 | Gm20730
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3819952 | Igkv1-135
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3642626 | Igkv2-109
Type: gene_segment
Organism: mouse, laboratory
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Protein
P18531
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
P01650
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
P01844
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
P18533
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Protein
P01845
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
P20764
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
P01627
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Protein
P29351
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
A0A075B5Y0
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
A0A075B5Q9
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
A0A075B5K3
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
J3QK03
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
A0A0G2JDU3
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Protein
A0A075B693
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
A0A0B4J1H9
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A140T8P7
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A075B5Q6
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
A0A075B5W4
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
A0A0A6YW58
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A0B4J1H8
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A140T8M9
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A075B5T2
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
A0A0A6YWG4
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A075B5X1
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
A0A075B5N0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
A0A0B4J1I1
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
A0A075B5S4
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
A0A140T8P3
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
A0A075B5X8
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
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Protein
A0A0A6YWU3
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A075B5S6
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
A0A075B5T3
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A075B5T1
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A140T8M8
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A075B5J6
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
A0A075B5Q2
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A075B5K8
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
A0A0B4J1H6
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A0B4J1H7
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A075B5T0
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
A0A0B4J1I0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A0G2JE99
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
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Protein
A0A087WPN7
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
A0A075B5R0
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
A0A075B5R3
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
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Protein
A0A075B5S5
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Protein
J3QNN6
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
A0A075B5R2
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A075B5R1
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A140T8M0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A0A6YXF1
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A075B5M9
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
A0A075B5Q0
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A075B5X4
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A075B5P9
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A075B5P7
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
A0A0A6YXQ0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A075B5S0
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
A0A075B5Q4
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A075B5K6
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A0A6YY60
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A140T8N1
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Publication
12496284 | J:85392
First Author: Briscoe CP
Year: 2003
Journal: J Biol Chem
Title: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Volume: 278
Issue: 13
Pages: 11303-11
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Publication
12629551 | -
First Author: Itoh Y
Year: 2003
Journal: Nature
Title: Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Volume: 422
Issue: 6928
Pages: 173-6
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Protein Domain
IPR013313 | GPR40_recept_FA
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ]. A cluster of four intronless GPCR genes, sharing significant sequence similarity with one another, have been identified on human chromosome 19q13.1, downstream from the CD22 gene []. The receptors have been named GPR40, GPR41, GPR42 and GPR43. The GPR42 protein sequence shares more than 98% amino acid identity with GPR41 and is located on a possible polymorphic insert []. GPR40 has recently been shown to bind long-chain free fatty acids, molecules that have a role in various cellular processes, including regulation of insulin secretion [, ]. Expression of GPR40 is restricted to the pancreas, with high levels in the islets and pancreatic beta cell lines []. Upon activation, GPR40 appears to couple predominantly to Gq and partially to Gi proteins, and has been shown to amplify glucose-stimulated insulin secretion from pancreatic beta cells. The receptor may therefore be a potential target for anti-diabetic drugs [].
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Publication
23836061 | J:205703
First Author: Pfrengle F
Year: 2013
Journal: J Immunol
Title: Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.
Volume: 191
Issue: 4
Pages: 1724-31
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Publication
24790146 | J:265415
First Author: Hutzler S
Year: 2014
Journal: J Immunol
Title: The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.
Volume: 192
Issue: 11
Pages: 5406-14
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Publication
7925291 | J:20831
First Author: Crocker PR
Year: 1994
Journal: EMBO J
Title: Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.
Volume: 13
Issue: 19
Pages: 4490-503
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Publication
24600033 | J:210020
First Author: Bökers S
Year: 2014
Journal: J Immunol
Title: Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.
Volume: 192
Issue: 7
Pages: 2994-3002
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Publication
20422398 | J:163562
First Author: Lim AK
Year: 2010
Journal: Diabetologia
Title: Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury.
Volume: 53
Issue: 8
Pages: 1772-82
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Publication
34470858 | J:327008
First Author: Zhou M
Year: 2021
Journal: J Immunol
Title: Integrin CD11b Negatively Regulates B Cell Receptor Signaling to Shape Humoral Response during Immunization and Autoimmunity.
Volume: 207
Issue: 7
Pages: 1785-1797
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Publication
12471124 | J:118420
First Author: Xu Y
Year: 2002
Journal: J Immunol
Title: The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent.
Volume: 169
Issue: 12
Pages: 6910-8
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Publication
11207264 | J:126693
First Author: Li X
Year: 2001
Journal: J Immunol
Title: Antigen receptor proximal signaling in splenic B-2 cell subsets.
Volume: 166
Issue: 5
Pages: 3122-9
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Publication
32391003 | J:306684
 
First Author: Irons EE
Year: 2020
Journal: Front Immunol
Title: Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
Volume: 11
Pages: 617
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Publication
17296732 | J:121365
First Author: Naito Y
Year: 2007
Journal: Mol Cell Biol
Title: Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation.
Volume: 27
Issue: 8
Pages: 3008-22
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Publication
37276426 | J:357342
First Author: Ennerfelt H
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer's disease mouse model.
Volume: 120
Issue: 24
Pages: e2303760120
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Publication
23486472 | J:354401
First Author: Wei H
Year: 2013
Journal: J Biol Chem
Title: A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene.
Volume: 288
Issue: 17
Pages: 12305-12
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Publication
11584010 | J:72917
First Author: Fujimoto M
Year: 2001
Journal: J Biol Chem
Title: CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
Volume: 276
Issue: 48
Pages: 44820-7
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Publication
12221241 | J:78937
First Author: Manzano M
Year: 2002
Journal: J Nutr
Title: Absolute counts and distribution of lymphocyte subsets in small intestine of BALB/c mice change during weaning.
Volume: 132
Issue: 9
Pages: 2757-62
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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