Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MartÃn-Fontecha A |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
Triggering of murine NK cells by CD40 and CD86 (B7-2). |
Volume: |
162 |
Issue: |
10 |
Pages: |
5910-6 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Maeda K |
Year: |
1997 |
Journal: |
Int Immunol |
Title: |
Characterization of rat CD80 and CD86 by molecular cloning and mAb. |
Volume: |
9 |
Issue: |
7 |
Pages: |
993-1000 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agadjanyan MG |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. |
Volume: |
162 |
Issue: |
6 |
Pages: |
3417-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
1997 |
Journal: |
Cell Immunol |
Title: |
Molecular cloning and comparative analysis of the rhesus macaque costimulatory molecules CD80 (B7-1) and CD86 (B7-2). |
Volume: |
177 |
Issue: |
1 |
Pages: |
9-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Girard T |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation. |
Volume: |
423 |
Issue: |
2 |
Pages: |
301-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathur M |
Year: |
1999 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice. |
Volume: |
21 |
Issue: |
4 |
Pages: |
498-509 |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin BK |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
Combination gene therapy with CD86 and the MHC class II transactivator in the control of lung tumor growth. |
Volume: |
162 |
Issue: |
11 |
Pages: |
6663-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moser EK |
Year: |
2014 |
Journal: |
PLoS Pathog |
Title: |
Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. |
Volume: |
10 |
Issue: |
8 |
Pages: |
e1004315 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; targeted mutation 2, Arlene H Sharpe |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; wild type |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaspari AA |
Year: |
1998 |
Journal: |
Infect Immun |
Title: |
CD86 (B7-2), but not CD80 (B7-1), expression in the epidermis of transgenic mice enhances the immunogenicity of primary cutaneous Candida albicans infections. |
Volume: |
66 |
Issue: |
9 |
Pages: |
4440-9 |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 expression in activated macrophages; B10.RIII |
Allele Type: |
QTL |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD86 expression in activated macrophages; RIIIS/J |
Allele Type: |
QTL |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; gene trap OST137097, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; endonuclease-mediated mutation 2, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; targeted mutation 1, Arlene H Sharpe |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; endonuclease-mediated mutation 6, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Karlsson J |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. |
Volume: |
174 |
Issue: |
1 |
Pages: |
533-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vandenborre K |
Year: |
1999 |
Journal: |
Immunology |
Title: |
Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. |
Volume: |
98 |
Issue: |
3 |
Pages: |
413-21 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, coisogenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
involves: 129S4/SvJae |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
involves: 129S4/SvJae * NOD |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
129.SJL-Cd86 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
involves: 129S4/SvJae * C57BL/6J * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
involves: 129S4/SvJae * BALB/c |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
C.129S4(B6)-Cd80 Cd86 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd86/Cd86 Icos/Icos |
Background: |
involves: 129S1/Sv * 129S4/SvJaeSor |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Allele |
Name: |
CD86 antigen; gene trap IST14957D5, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd86/Cd86 |
Background: |
NOD.129S4-Cd86 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd86/Cd86 |
Background: |
involves: 129S4/SvJae |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd86/Cd86 |
Background: |
B6.129S4-Cd86 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 Tg(Ighm-Ctla4Ig/Cd80)1Jbs/? |
Background: |
involves: 129S4/SvJae * FVB/N * NOD |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 Ctla4/Ctla4 |
Background: |
involves: 129S4/SvJae * BALB/c |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd80/Cd80 Cd86/Cd86 |
Background: |
B6.129S4-Cd80 Cd86 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 12B70, Richard Flavell |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd86/Cd86 Marchf1/Marchf1 |
Background: |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 27, James P Allison |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 31, James P Allison |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 7, James P Allison |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Abul K Abbas |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Ins2-CD86)12B70Flv/? |
Background: |
involves: C57BL/6 * CBA/Ca |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, coisogenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(H2-K-Cd86)27All/? |
Background: |
involves: C57BL/6J * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(H2-K-Cd86)31All/? |
Background: |
involves: C57BL/6J * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(H2-K-Cd86)7All/? |
Background: |
involves: C57BL/6J * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(H2-K-Cd86)7All/? |
Background: |
B6.Cg-Tg(H2-K-Cd86)7All |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(H2-K-Cd86)7All/? |
Background: |
involves: BALB/c * C57BL/6 * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Igh-6-Cd86)1Akab/? |
Background: |
involves: FVB |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-73077 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Guerder S |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes. |
Volume: |
161 |
Issue: |
5 |
Pages: |
2128-40 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, spontaneous mutation, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
B2m/B2m Tg(H2-K-Cd86)27All/? |
Background: |
involves: 129S2/SvPas * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Mombaerts P |
Year: |
1991 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. |
Volume: |
88 |
Issue: |
8 |
Pages: |
3084-7 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcrb/Tcrb Tg(H2-K-Cd86)7All/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tcrb/Tcrb Tg(H2-K-Cd86)27All/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd28/Cd28 Tg(H2-K-Cd86)7All/? |
Background: |
involves: BALB/c * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Ins2-CD86)12B70Flv/? Tg(Ins2-Tnf)17Flv/? |
Background: |
involves: C57BL/6 * CBA/Ca |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zehntner SP |
Year: |
2003 |
Journal: |
FASEB J |
Title: |
Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease. |
Volume: |
17 |
Issue: |
13 |
Pages: |
1910-2 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd28/Cd28 Tg(H2-K-Cd86)27All/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Ins2-CD86)12B70Flv/? Tg(Ins2-H2-Ea,Ins2-H2-Eb1)187-7Bri/? |
Background: |
involves: C57BL/6 * CBA/Ca * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Wing K |
Year: |
2008 |
Journal: |
Science |
Title: |
CTLA-4 control over Foxp3+ regulatory T cell function. |
Volume: |
322 |
Issue: |
5899 |
Pages: |
271-5 |
|
•
•
•
•
•
|