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Search results 401 to 481 out of 481 for Cdk6

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Type Details Score
Publication
32294430 | J:306324
First Author: Romero-Pozuelo J
Year: 2020
Journal: Cell Rep
Title: Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1.
Volume: 31
Issue: 2
Pages: 107504
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Interaction Experiment
Chan FK (1995)
Description: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
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DO Term
DOID:0070284 | primary autosomal recessive microcephaly 12
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Publication
21734724 | J:174617
First Author: Musgrove EA
Year: 2011
Journal: Nat Rev Cancer
Title: Cyclin D as a therapeutic target in cancer.
Volume: 11
Issue: 8
Pages: 558-72
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Publication
8078588 | J:20317
First Author: Hannon GJ
Year: 1994
Journal: Nature
Title: p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.
Volume: 371
Issue: 6494
Pages: 257-61
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Publication
8521522 | J:41563
First Author: Quelle DE
Year: 1995
Journal: Cell
Title: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.
Volume: 83
Issue: 6
Pages: 993-1000
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Publication
23871778 | J:201910
 
First Author: Zhu P
Year: 2013
Journal: Gen Comp Endocrinol
Title: GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion.
Volume: 193
Pages: 19-26
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Publication
34520734 | J:355252
First Author: Freeman-Cook K
Year: 2021
Journal: Cancer Cell
Title: Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Volume: 39
Issue: 10
Pages: 1404-1421.e11
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Publication
29202464 | J:258389
First Author: Raleigh DR
Year: 2018
Journal: J Clin Invest
Title: Hedgehog signaling drives medulloblastoma growth via CDK6.
Volume: 128
Issue: 1
Pages: 120-124
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Publication
22355113 | J:182141
First Author: Diril MK
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.
Volume: 109
Issue: 10
Pages: 3826-31
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Publication
11544316 | J:118562
First Author: Kovalev GI
Year: 2001
Journal: J Immunol
Title: An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation.
Volume: 167
Issue: 6
Pages: 3285-92
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Publication
12556487 | J:81540
First Author: Bai F
Year: 2003
Journal: Mol Cell Biol
Title: Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.
Volume: 23
Issue: 4
Pages: 1269-77
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Publication
19383288 | J:125217
First Author: Barrière C
Year: 2007
Journal: Mol Oncol
Title: Mice thrive without Cdk4 and Cdk2.
Volume: 1
Issue: 1
Pages: 72-83
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Publication
30926782 | J:273283
First Author: Krimpenfort P
Year: 2019
Journal: Nat Commun
Title: A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis.
Volume: 10
Issue: 1
Pages: 1425
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Publication
32109375 | J:285842
First Author: Salvador-Barbero B
Year: 2020
Journal: Cancer Cell
Title: CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma.
Volume: 37
Issue: 3
Pages: 340-353.e6
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Publication
10437914 | J:122911
First Author: Rodriguez-Puebla ML
Year: 1999
Journal: Cell Growth Differ
Title: Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development.
Volume: 10
Issue: 7
Pages: 467-72
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Publication
16236519 | J:106087
First Author: Malumbres M
Year: 2005
Journal: Trends Biochem Sci
Title: Mammalian cyclin-dependent kinases.
Volume: 30
Issue: 11
Pages: 630-41
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Publication
10229815 | J:133539
First Author: Brunner MC
Year: 1999
Journal: J Immunol
Title: CTLA-4-Mediated inhibition of early events of T cell proliferation.
Volume: 162
Issue: 10
Pages: 5813-20
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Publication
24604117 | J:210828
First Author: Liu G
Year: 2014
Journal: J Pathol
Title: MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.
Volume: 233
Issue: 3
Pages: 308-18
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Publication
10368294 | -
First Author: Schulze-Gahmen U
Year: 1999
Journal: Structure
Title: Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Volume: 7
Issue: 3
Pages: 245-54
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Protein Domain
IPR015322 | Cyclin_dom_herpesvir
Type: Domain
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].This entry represents a domain found in a family of viral cyclins that specifically activate CDK6 of host cells to a very high degree []. This domain adopts a helical structure consisting of five α-helices, with one helix surrounded by the others.
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Publication
8887674 | J:51744
First Author: Hirai H
Year: 1996
Journal: Mol Cell Biol
Title: Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1.
Volume: 16
Issue: 11
Pages: 6457-67
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Publication
33854235 | J:305916
First Author: Simoneschi D
Year: 2021
Journal: Nature
Title: CRL4AMBRA1 is a master regulator of D-type cyclins.
Volume: 592
Issue: 7856
Pages: 789-793
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Publication
17297445 | J:125545
First Author: Ott RG
Year: 2007
Journal: Oncogene
Title: JunB is a gatekeeper for B-lymphoid leukemia.
Volume: 26
Issue: 33
Pages: 4863-71
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Publication
17442339 | J:238540
First Author: Tallack MR
Year: 2007
Journal: J Mol Biol
Title: Erythroid Kruppel-like factor regulates the G1 cyclin dependent kinase inhibitor p18INK4c.
Volume: 369
Issue: 2
Pages: 313-21
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Publication
18311721 | J:131845
First Author: Ciemerych MA
Year: 2008
Journal: Int J Dev Biol
Title: CDK4 activity in mouse embryos expressing a single D-type cyclin.
Volume: 52
Issue: 2-3
Pages: 299-305
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Publication
23664366 | J:197441
First Author: Nakles RE
Year: 2013
Journal: Am J Pathol
Title: The PPARγ agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency.
Volume: 182
Issue: 6
Pages: 1976-85
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Publication
19147556 | J:143711
First Author: Saab R
Year: 2009
Journal: Cancer Res
Title: p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor.
Volume: 69
Issue: 2
Pages: 440-8
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Publication
24687853 | J:221632
First Author: Bai F
Year: 2014
Journal: Mol Cell Biol
Title: p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation.
Volume: 34
Issue: 12
Pages: 2121-34
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Publication
15254233 | J:92146
First Author: Pei XH
Year: 2004
Journal: Mol Cell Biol
Title: Genetic evidence for functional dependency of p18Ink4c on Cdk4.
Volume: 24
Issue: 15
Pages: 6653-64
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Publication
12163365 | J:78458
First Author: Rodriguez-Puebla ML
Year: 2002
Journal: Am J Pathol
Title: Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.
Volume: 161
Issue: 2
Pages: 405-11
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Publication
15456744 | J:95201
First Author: Jirawatnotai S
Year: 2004
Journal: J Biol Chem
Title: Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.
Volume: 279
Issue: 49
Pages: 51100-6
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Publication
12538879 | J:81833
First Author: Kannan K
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Volume: 100
Issue: 3
Pages: 1221-5
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Publication
30143714 | J:279146
First Author: Giannattasio S
Year: 2018
Journal: Sci Rep
Title: Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism.
Volume: 8
Issue: 1
Pages: 12792
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Publication
22367880 | J:183774
First Author: Adhikari D
Year: 2012
Journal: Hum Mol Genet
Title: Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes.
Volume: 21
Issue: 11
Pages: 2476-84
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Publication
23010077 | J:192878
First Author: Qian X
Year: 2012
Journal: Cancer Res
Title: Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.
Volume: 72
Issue: 22
Pages: 5900-11
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Publication
22210897 | J:197728
First Author: Zhu Y
Year: 2012
Journal: Nucleic Acids Res
Title: MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.
Volume: 40
Issue: 10
Pages: 4615-25
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Publication
18356297 | J:133577
First Author: Peng Y
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer.
Volume: 105
Issue: 13
Pages: 5236-41
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Publication
16477001 | J:107316
First Author: Prathapam T
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.
Volume: 103
Issue: 8
Pages: 2695-700
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Publication
19001083 | J:145571
First Author: Joshi I
Year: 2009
Journal: Blood
Title: Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
Volume: 113
Issue: 8
Pages: 1689-98
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Publication
26466808 | J:228887
First Author: Wang Z
Year: 2015
Journal: Stem Cells
Title: CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1.
Volume: 33
Issue: 12
Pages: 3437-51
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Publication
26090669 | J:233802
First Author: Ruppender N
Year: 2015
Journal: PLoS One
Title: Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy.
Volume: 10
Issue: 6
Pages: e0130565
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Publication
26974154 | J:234662
First Author: Palanichamy JK
Year: 2016
Journal: J Clin Invest
Title: RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.
Volume: 126
Issue: 4
Pages: 1495-511
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Publication
29160310 | J:255535
First Author: Zhang J
Year: 2018
Journal: Nature
Title: Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Volume: 553
Issue: 7686
Pages: 91-95
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Publication
38975874 | J:357844
First Author: Dilly J
Year: 2024
Journal: Cancer Discov
Title: Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer.
Volume: 14
Issue: 11
Pages: 2135-2161
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Publication
25901736 | J:233472
First Author: Vaillant C
Year: 2015
Journal: PLoS One
Title: Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.
Volume: 10
Issue: 4
Pages: e0124870
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Publication
12185599 | J:78497
First Author: Zhang Z
Year: 2002
Journal: Oncogene
Title: A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression.
Volume: 21
Issue: 38
Pages: 5960-6
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Publication
31043741 | J:282963
First Author: Walter DM
Year: 2019
Journal: Nature
Title: RB constrains lineage fidelity and multiple stages of tumour progression and metastasis.
Volume: 569
Issue: 7756
Pages: 423-427
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Publication
12657672 | J:82675
First Author: Nguyen MD
Year: 2003
Journal: J Neurosci
Title: Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.
Volume: 23
Issue: 6
Pages: 2131-40
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Publication
31592235 | J:286949
First Author: Li T
Year: 2019
Journal: Int J Biol Sci
Title: P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.
Volume: 15
Issue: 10
Pages: 2198-2210
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Publication
10022811 | J:53213
First Author: Balasubramanian S
Year: 1999
Journal: Oncogene
Title: Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse.
Volume: 18
Issue: 6
Pages: 1297-302
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Publication
10365910 | J:55837
First Author: Herzog CR
Year: 1999
Journal: Mol Carcinog
Title: Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis.
Volume: 25
Issue: 2
Pages: 92-8
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Publication
10475236 | J:56941
First Author: Lukas C
Year: 1999
Journal: Hybridoma
Title: Immunohistochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies.
Volume: 18
Issue: 3
Pages: 225-34
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Publication
25087568 | J:215381
First Author: Liu HX
Year: 2014
Journal: Biochem Pharmacol
Title: Retinoic acid regulates cell cycle genes and accelerates normal mouse liver regeneration.
Volume: 91
Issue: 2
Pages: 256-65
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Publication
1827757 | J:14776
First Author: Matsushime H
Year: 1991
Journal: Cell
Title: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.
Volume: 65
Issue: 4
Pages: 701-13
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Publication
8712071 | -
 
First Author: Hall M
Year: 1996
Journal: Adv Cancer Res
Title: Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer.
Volume: 68
Pages: 67-108
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Publication
1827756 | -
First Author: Xiong Y
Year: 1991
Journal: Cell
Title: Human D-type cyclin.
Volume: 65
Issue: 4
Pages: 691-9
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Publication
10577389 | -
 
First Author: Kato J
Year: 1999
Journal: Front Biosci
Title: Induction of S phase by G1 regulatory factors.
Volume: 4
Pages: D787-92
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Publication
7791752 | -
First Author: Resnitzky D
Year: 1995
Journal: Mol Cell Biol
Title: Different roles for cyclins D1 and E in regulation of the G1-to-S transition.
Volume: 15
Issue: 7
Pages: 3463-9
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Protein Domain
IPR015451 | Cyclin_D
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Among G1 regulators, D-type cyclins serve as targets of growth factors to integrate extracellular signals into the core cell cycle regulators. D-type cyclins were identified in three independent approaches; (I) a target gene of chromosomal translocations in a variety of cancers [], (II) a mammalian cyclin gene that can complement yeast G1 cyclin deficiency [], and (III) a delayed early growth factor inducible gene []. D-type cyclins are composed of three different but closely related subfamilies (D1, D2, and D3), all differentially expressed in a wide variety of organs and in a tissue-specific manner. Expression of D-type cyclins is induced in response to a variety of mitogenic signals and they function as a regulatory subunit of cyclin-dependent kinases (Cdk).D-type cyclins can interact with 4 different Cdks (Cdk2, 4, 5, and 6), among which Cdk4 and Cdk6 are apparently the major functional catalytic partners in proliferating cells. When cells are exposed to growth factor stimulation, the expression of cyclin D is maintained regardless of the point in the cell cycle. However, accumulation of active cyclin D/Cdk4 (or Cdk6) complex is rate-limiting and is required for cells to progress through G1 and to commit to entering S phase. The over expression of D-type cyclins shortens the length of G1 without affecting remainder of the cell cycle. This event is clearly different from phenotype of the cells over expressing another G1 cyclin, cyclin E, in which G1 is shortened but elongation of the S phase compensates this shortening and as a result, doubling time of the cell remains unchanged. Thus, the cyclin D/Cdk4 complex largely exerts effects on commitment of cells for the S phase entry during the G1 phase, while functions of cyclin E/Cdk2 kinase are more directly involved in the initiation of chromosomal DNA synthesis [, ].This entry is comprised of D-type cyclins that are evolutionarily conserved across a variety of species.
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Protein
S4R2N1
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
S4R1C8
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
S4R275
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Protein
S4R1R1
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
S4R216
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein
A0A0J9YU51
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
Q9D8L9
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P25322
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
P30280
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
P30282
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q3TC96
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
S4R240
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
S4R2N5
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Protein
S4R1D9
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q3TWY0
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
B2M0W7
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
Q790L7
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q3TSW4
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q4FK45
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Publication
11056549 | -
First Author: Hardwick JM
Year: 2000
Journal: Nat Cell Biol
Title: Cyclin' on the viral path to destruction.
Volume: 2
Issue: 11
Pages: E203-4
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Publication
12910258 | -
First Author: Galderisi U
Year: 2003
Journal: Oncogene
Title: Cell cycle regulation and neural differentiation.
Volume: 22
Issue: 33
Pages: 5208-19
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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