Type |
Details |
Score |
Publication |
First Author: |
Shan J |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation. |
Volume: |
44 |
Issue: |
20 |
Pages: |
9719-9732 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. |
Volume: |
119 |
Issue: |
17 |
Pages: |
e2110557119 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
351
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Guen VJ |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. |
Volume: |
110 |
Issue: |
48 |
Pages: |
19525-30 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [].This entry represents several Cyclin families (C, L, Q, T1, T2, and H/Ccl1) and yeast RNA polymerase II holoenzyme cyclin-like subunit (also known as Ssn8/Srb11).Cyclin C can regulate both cell cycle progression and gene transcription. The Cdk8-cyclin C complex is a component of the RNA polymerase II holoenzyme [].Cyclin L is a transcriptional regulator involved in the regulation of RNA polymerase II transcription and participating in regulating the pre-mRNA splicing process [, ].Cyclin Q (also known as Cyclin M) consists of cyclin-related protein FAM58A [].Cyclin-T2 is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex [].Cyclin-H from vertebrates, mcs2 from fission yeast and Ccl1 from budding yeasts are cyclins that play a role in cell cycle [].Cyclin-T associates with CDK9 which are subunits of the positive-transcription elongation factor (P-TEFb) [].Ssn8/Srb11 is a component of the SRB8-11 complex (consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11), which is a regulatory module of the mediator complex that is involved in regulation of basal and activated RNA polymerase II-dependent transcription [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
He M |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy. |
Volume: |
10 |
Issue: |
12 |
Pages: |
e0145112 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
184
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
80
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaillard E |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7. |
Volume: |
103 |
Issue: |
25 |
Pages: |
9548-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bieniasz PD |
Year: |
1999 |
Journal: |
J Virol |
Title: |
Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. |
Volume: |
73 |
Issue: |
7 |
Pages: |
5777-86 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson LA |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Cyclin L is an RS domain protein involved in pre-mRNA splicing. |
Volume: |
277 |
Issue: |
28 |
Pages: |
25465-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herrmann A |
Year: |
2007 |
Journal: |
FASEB J |
Title: |
Characterization of cyclin L1 as an immobile component of the splicing factor compartment. |
Volume: |
21 |
Issue: |
12 |
Pages: |
3142-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akoulitchev S |
Year: |
2000 |
Journal: |
Nature |
Title: |
TFIIH is negatively regulated by cdk8-containing mediator complexes. |
Volume: |
407 |
Issue: |
6800 |
Pages: |
102-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao SM |
Year: |
1995 |
Journal: |
Nature |
Title: |
A kinase-cyclin pair in the RNA polymerase II holoenzyme. |
Volume: |
374 |
Issue: |
6518 |
Pages: |
193-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hengartner CJ |
Year: |
1998 |
Journal: |
Mol Cell |
Title: |
Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. |
Volume: |
2 |
Issue: |
1 |
Pages: |
43-53 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
250
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
335
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
320
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
311
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
287
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
723
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
191
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
173
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
327
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1400
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
956
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
331
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1401
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
582
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Galderisi U |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
Cell cycle regulation and neural differentiation. |
Volume: |
22 |
Issue: |
33 |
Pages: |
5208-19 |
|
•
•
•
•
•
|