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Search results 401 to 500 out of 518 for Cga

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:6369614 | B6(SJL)-Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj>/J
Attribute String: endonuclease-mediated mutation, mutant strain, targeted mutation
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Publication
31250150 | J:299347
First Author: Benítez J
Year: 2020
Journal: Gastric Cancer
Title: A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.
Volume: 23
Issue: 1
Pages: 52-63
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Strain
MGI:7541260 | B6.Cg-Tc(HSA17)2Mdk App<em1Adiuj>/J
Attribute String: congenic, mutant strain, targeted mutation, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Ercc3/Ercc3 Xpa/Xpa
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nlrp3/Nlrp3<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myd88/Myd88 Sh3bp2/Sh3bp2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atp4a/Atp4a
Background: involves: 129S6/SvEv * C57BL/6J * C57BL/6NCrl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atp4a/Atp4a<+>
Background: involves: 129S6/SvEv * C57BL/6J * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
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Publication
11302742 | J:337081
First Author: Ichida K
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II.
Volume: 282
Issue: 5
Pages: 1194-200
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Publication
20807312 | J:168609
First Author: Ezzi SA
Year: 2010
Journal: J Neurochem
Title: Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS.
Volume: 115
Issue: 5
Pages: 1102-11
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Publication
18565323 | J:138020
First Author: Cai Y
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Single-stranded DNA-binding proteins regulate the abundance and function of the LIM-homeodomain transcription factor LHX2 in pituitary cells.
Volume: 373
Issue: 2
Pages: 303-8
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Protein
P16014
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q3UZU8
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
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Protein
Q3TY66
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q3UN28
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
Q3UZP2
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q9CTW1
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
Q8BP91
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Publication
2053134 | -
First Author: Huttner WB
Year: 1991
Journal: Trends Biochem Sci
Title: The granin (chromogranin/secretogranin) family.
Volume: 16
Issue: 1
Pages: 27-30
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Publication
19501001 | J:150053
First Author: Meng G
Year: 2009
Journal: Immunity
Title: A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Volume: 30
Issue: 6
Pages: 860-74
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Publication
28039299 | J:247871
First Author: Lu A
Year: 2017
Journal: J Immunol
Title: Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus.
Volume: 198
Issue: 3
Pages: 1119-1129
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Publication
26119741 | J:224854
First Author: Wang H
Year: 2015
Journal: Cell Rep
Title: Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome.
Volume: 12
Issue: 1
Pages: 42-48
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Publication
25705883 | J:221901
First Author: Prod'Homme V
Year: 2015
Journal: J Clin Invest
Title: Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages.
Volume: 125
Issue: 4
Pages: 1396-400
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Publication
34257294 | J:322211
First Author: Yamazawa T
Year: 2021
Journal: Nat Commun
Title: A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke.
Volume: 12
Issue: 1
Pages: 4293
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Publication
24478101 | J:209805
First Author: Mao L
Year: 2014
Journal: Infect Immun
Title: Pathogenic fungus Microsporum canis activates the NLRP3 inflammasome.
Volume: 82
Issue: 2
Pages: 882-92
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Publication
23809161 | J:207576
First Author: Muñoz-Planillo R
Year: 2013
Journal: Immunity
Title: K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
Volume: 38
Issue: 6
Pages: 1142-53
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Strain
MGI:6164023 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, targeted mutation, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6508534 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Abca7<em2Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:6444738 | B6.Cg-Pilra<em1Adiuj> Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
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Strain
MGI:6444731 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Il1rap<em2Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: mutant strain, congenic, targeted mutation, endonuclease-mediated mutation
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Publication
38735056 | J:351102
First Author: Kotredes KP
Year: 2024
Journal: Alzheimers Dement
Title: Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology.
Volume: 20
Issue: 6
Pages: 4126-4146
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Publication
31177033 | J:351561
 
First Author: Chen Y
Year: 2019
Journal: J Neuroimmunol
Title: Oxymatrine can attenuate pathological deficits of Alzheimer's disease mice through regulation of neuroinflammation.
Volume: 334
Pages: 576978
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Strain
MGI:6369613 | B6(SJL)-Apoe<em2(APOE*)Adiuj> Tc(HSA17)1Mdk App<em1Adiuj>/AdiujJ
Attribute String: endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Ercc2/Ercc2 Ercc3/Ercc3
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cga-icre)961Sac/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
12388744 | -
First Author: Hosaka M
Year: 2002
Journal: Mol Biol Cell
Title: Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells.
Volume: 13
Issue: 10
Pages: 3388-99
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Publication
17200173 | -
First Author: Tanabe A
Year: 2007
Journal: J Clin Endocrinol Metab
Title: Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.
Volume: 92
Issue: 3
Pages: 1145-54
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Protein
P47867
Organism: Mus musculus/domesticus
Length: 471  
Fragment?: false
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Protein
A0A1Y7VLI5
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein
A0A1L1SV66
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
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Publication
14597614 | -
First Author: Hosaka M
Year: 2004
Journal: J Biol Chem
Title: Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.
Volume: 279
Issue: 5
Pages: 3627-34
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Protein Domain
IPR026197 | SCG3
Type: Family
Description: Secretogranin-3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells []. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells []. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion [].Secretogranin-3 interacts with cromogranin A; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2) [].
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Protein Domain
IPR001990 | Granin
Type: Family
Description: Granins (chromogranins or secretogranins) []are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. The exact function(s) of these proteins is not yet known but they seem to be the precursors of biologically active peptides and/or they may act as helper proteins in the packaging of peptide hormones and neuropeptides. Apart from their subcellular location and the abundance of acidic residues (Asp and Glu), these proteins do not share many structural similarities. Only one short region, located in the C-terminal section, is conserved in all these proteins, such as:Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly inhibits glucose- induced insulin release from the pancreas.Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.Secretogranin 2 (chromogranin C): A sulfated protein of about 650 residues.Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high similarity in their N-terminal section; this region includes two cysteine residues involved in a disulphide bond.
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Protein Domain
IPR018054 | Chromogranin_CS
Type: Conserved_site
Description: Granins (chromogranins or secretogranins) []are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. The exact function(s) of these proteins is not yet known but they seem to be the precursors of biologically active peptides and/or they may act as helper proteins in the packaging of peptide hormones and neuropeptides. Apart from their subcellular location and the abundance of acidic residues (Asp and Glu), these proteins do not share many structural similarities. Only one short region, located in the C-terminal section, is conserved in all these proteins, such as:Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly inhibits glucose- induced insulin release from the pancreas.Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.Secretogranin 2 (chromogranin C): A sulfated protein of about 650 residues.Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high similarity in their N-terminal section; this region includes two cysteine residues involved in a disulphide bond.
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Publication
16219686 | J:102191
First Author: Hosaka M
Year: 2005
Journal: J Cell Sci
Title: Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.
Volume: 118
Issue: Pt 20
Pages: 4785-95
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Publication
25673877 | J:231502
First Author: Hao Z
Year: 2015
Journal: J Cell Sci
Title: Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells.
Volume: 128
Issue: 7
Pages: 1365-74
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Publication
29281094 | J:256077
First Author: Maeda Y
Year: 2018
Journal: Endocrinology
Title: Impaired Processing of Prohormones in Secretogranin III-Null Mice Causes Maladaptation to an Inadequate Diet and Stress.
Volume: 159
Issue: 2
Pages: 1213-1227
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Publication
22895716 | J:187721
First Author: Sun L
Year: 2012
Journal: J Neurosci
Title: Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
Volume: 32
Issue: 33
Pages: 11330-42
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Publication
23831373 | J:327393
First Author: Wu Z
Year: 2013
Journal: Neurobiol Aging
Title: Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia.
Volume: 34
Issue: 12
Pages: 2715-25
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Publication
25100706 | J:215750
First Author: Stilley JA
Year: 2014
Journal: Biol Reprod
Title: FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice.
Volume: 91
Issue: 3
Pages: 74
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Publication
19620250 | J:191261
First Author: Harding B
Year: 2009
Journal: Endocr Relat Cancer
Title: Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.
Volume: 16
Issue: 4
Pages: 1313-27
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Publication
19015516 | J:142219
First Author: Ono H
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Involvement of thyrotropin in photoperiodic signal transduction in mice.
Volume: 105
Issue: 47
Pages: 18238-42
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Publication
28220294 | J:274443
First Author: Wollam J
Year: 2017
Journal: Cell Tissue Res
Title: Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion.
Volume: 368
Issue: 3
Pages: 487-501
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Publication
36440192 | J:332079
 
First Author: Liu MA
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes.
Volume: 13
Pages: 1037465
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Publication
26472536 | J:236356
 
First Author: Wang H
Year: 2016
Journal: Mol Cell Endocrinol
Title: Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage.
Volume: 419
Pages: 124-38
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Publication
16556729 | J:111025
First Author: Hendy GN
Year: 2006
Journal: Mol Endocrinol
Title: Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins.
Volume: 20
Issue: 8
Pages: 1935-47
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Publication
20089903 | J:157697
First Author: Díaz-Vera J
Year: 2010
Journal: J Neurosci
Title: Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles.
Volume: 30
Issue: 3
Pages: 950-7
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Publication
26869462 | J:231620
First Author: Bianco M
Year: 2016
Journal: Cancer Res
Title: Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients.
Volume: 76
Issue: 7
Pages: 1781-91
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Publication
16319172 | J:111754
First Author: Kim T
Year: 2006
Journal: Mol Biol Cell
Title: Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation.
Volume: 17
Issue: 2
Pages: 789-98
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Publication
11152972 | J:67126
First Author: McKenna IM
Year: 2001
Journal: Mutat Res
Title: K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
Volume: 490
Issue: 1
Pages: 57-65
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Publication
11560247 | J:71718
First Author: Hayashi S
Year: 2001
Journal: Toxicol Pathol
Title: High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
Volume: 29
Issue: 4
Pages: 422-9
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Publication
11746253 | J:73548
First Author: Nakanishi Y
Year: 2001
Journal: Teratog Carcinog Mutagen
Title: Polychlorinated biphenyls promote 1-nitropyrene-induced lung tumorigenesis without the induction of K-ras gene mutation in A/J mice.
Volume: 21
Issue: 6
Pages: 395-403
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Publication
10930038 | J:64651
First Author: Hong HH
Year: 2000
Journal: Toxicol Pathol
Title: Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Volume: 28
Issue: 4
Pages: 529-34
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Publication
1617214 | J:1582
First Author: Dietz AB
Year: 1992
Journal: Mamm Genome
Title: Assignment of eight loci to bovine syntenic groups by use of PCR: extension of a comparative gene map.
Volume: 3
Issue: 2
Pages: 106-11
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Publication
8120054 | J:17109
First Author: Mouland AJ
Year: 1994
Journal: J Biol Chem
Title: Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression.
Volume: 269
Issue: 9
Pages: 6918-26
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Publication
7522983 | J:20675
First Author: Sutter C
Year: 1994
Journal: Carcinogenesis
Title: SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.
Volume: 15
Issue: 9
Pages: 1975-8
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Publication
8994386 | J:37041
First Author: Gleeson CM
Year: 1996
Journal: J Endocrinol
Title: Occurrence of WE-14 and chromogranin A-derived peptides in tissues of the human and bovine gastro-entero-pancreatic system and in human neuroendocrine neoplasia.
Volume: 151
Issue: 3
Pages: 409-20
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Publication
12746566 | J:84220
First Author: Hill GD
Year: 2003
Journal: Endocr Pathol
Title: A comparative immunohistochemical study of spontaneous and chemically induced pheochromocytomas in B6C3F1 mice.
Volume: 14
Issue: 1
Pages: 81-91
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Publication
16049171 | J:100057
First Author: Kim T
Year: 2005
Journal: J Neurosci
Title: Chromogranin A deficiency in transgenic mice leads to aberrant chromaffin granule biogenesis.
Volume: 25
Issue: 30
Pages: 6958-61
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Publication
19131506 | J:145698
First Author: Salisbury TB
Year: 2009
Journal: Mol Endocrinol
Title: GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin.
Volume: 23
Issue: 3
Pages: 402-11
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Publication
18973469 | J:147918
First Author: Stettler H
Year: 2009
Journal: Biochem J
Title: Determinants for chromogranin A sorting into the regulated secretory pathway are also sufficient to generate granule-like structures in non-endocrine cells.
Volume: 418
Issue: 1
Pages: 81-91
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Publication
16093275 | J:196573
First Author: Freyer G
Year: 2005
Journal: Ann Oncol
Title: Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study.
Volume: 16
Issue: 11
Pages: 1795-800
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Publication
22529686 | J:196820
First Author: Roy SA
Year: 2012
Journal: World J Gastroenterol
Title: Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes.
Volume: 18
Issue: 14
Pages: 1579-89
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Publication
27653784 | J:242175
 
First Author: Rudnizky S
Year: 2016
Journal: Nat Commun
Title: H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes.
Volume: 7
Pages: 12958
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Publication
28430903 | J:248484
First Author: Fothergill LJ
Year: 2017
Journal: Endocrinology
Title: Costorage of Enteroendocrine Hormones Evaluated at the Cell and Subcellular Levels in Male Mice.
Volume: 158
Issue: 7
Pages: 2113-2123
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Protein
Q03517
Organism: Mus musculus/domesticus
Length: 617  
Fragment?: false
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Protein
Q4W8U9
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Publication
22819042 | J:187396
First Author: Nakamura Y
Year: 2012
Journal: Immunity
Title: Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein.
Volume: 37
Issue: 1
Pages: 85-95
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Publication
19114557 | J:145759
First Author: Andressoo JO
Year: 2009
Journal: Mol Cell Biol
Title: An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Volume: 29
Issue: 5
Pages: 1276-90
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Publication
28790324 | J:271852
First Author: Ren R
Year: 2017
Journal: Sci Rep
Title: The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-caspase-1 inflammasome.
Volume: 7
Issue: 1
Pages: 7625
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Publication
25060364 | J:218337
First Author: Hoffmann HM
Year: 2014
Journal: Endocrinology
Title: Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice.
Volume: 155
Issue: 10
Pages: 4043-53
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Publication
36064300 | J:350549
First Author: Bocharova OV
Year: 2023
Journal: Brain Pathol
Title: Aβ plaques do not protect against HSV-1 infection in a mouse model of familial Alzheimer's disease, and HSV-1 does not induce Aβ pathology in a model of late onset Alzheimer's disease.
Volume: 33
Issue: 1
Pages: e13116
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Publication
29098359 | J:309376
First Author: Ding M
Year: 2018
Journal: Calcif Tissue Int
Title: A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development.
Volume: 102
Issue: 3
Pages: 348-357
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Publication
37041148 | J:336768
First Author: Mao K
Year: 2023
Journal: Nat Commun
Title: FOXI3 pathogenic variants cause one form of craniofacial microsomia.
Volume: 14
Issue: 1
Pages: 2026
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Strain
MGI:6446948 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Il34<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: endonuclease-mediated mutation, congenic, mutant strain, targeted mutation
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Strain
MGI:6446962 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj> Bin1<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:6446958 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Ptk2b<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:6446960 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Ptprb<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
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Strain
MGI:6446956 | B6.Cg-Epha1<em1Adiuj> Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
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Strain
MGI:6446950 | B6.Cg-Adamts4<em1Adiuj> Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
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Strain
MGI:6446953 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Cd2ap<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:6508535 | B6.Cg-Mthfr<em1Adiuj> Apoe<tm1.1(APOE*4)Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
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Strain
MGI:6369607 | B6(SJL)-Apoe<tm1.1(APOE*4)Adiuj> Plcg2<em3Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: mutant strain, targeted mutation, endonuclease-mediated mutation
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Strain
MGI:6444736 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Scimp<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:7544905 | B6(SJL)-Apoe<tm1.1(APOE*4)Adiuj> Tc(HSA17)2Mdk App<em1Adiuj>/J
Attribute String: endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:6369611 | B6(SJL)-Apoe<tm1.1(APOE*4)Adiuj> Tc(HSA17)1Mdk App<em1Adiuj>/AdiujJ
Attribute String: endonuclease-mediated mutation, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cga-icre)961Sac/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cga-icre)961Sac/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
21436258 | J:219078
First Author: Koshimizu H
Year: 2011
Journal: Mol Endocrinol
Title: Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells.
Volume: 25
Issue: 5
Pages: 732-44
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Publication
25849026 | J:233416
First Author: Jin S
Year: 2015
Journal: PLoS One
Title: Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice.
Volume: 10
Issue: 4
Pages: e0120842
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