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Search results 401 to 500 out of 532 for Cpe

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Type Details Score
Publication
19745193 | J:177975
First Author: Shore SA
Year: 2009
Journal: J Appl Physiol (1985)
Title: Pulmonary responses to subacute ozone exposure in obese vs. lean mice.
Volume: 107
Issue: 5
Pages: 1445-52
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Publication
8621612 | J:33332
First Author: Collins S
Year: 1996
Journal: J Biol Chem
Title: Pharmacologic manipulation of ob expression in a dietary model of obesity.
Volume: 271
Issue: 16
Pages: 9437-40
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Publication
27128821 | J:253810
First Author: Ubags ND
Year: 2016
Journal: Am J Respir Cell Mol Biol
Title: A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function.
Volume: 55
Issue: 2
Pages: 188-200
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Publication
23736543 | J:203210
First Author: Nakahara K
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia.
Volume: 305
Issue: 3
Pages: E451-63
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Publication
15289464 | J:91840
First Author: Chiu CH
Year: 2004
Journal: Genes Dev
Title: Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
Volume: 18
Issue: 16
Pages: 1970-5
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Publication
12439655 | J:81517
First Author: Suto J
Year: 2002
Journal: Int J Obes Relat Metab Disord
Title: A quantitative trait locus that accounts for glucose intolerance maps to chromosome 8 in hereditary obese KK-A(y) mice.
Volume: 26
Issue: 11
Pages: 1517-9
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Publication
9405382 | J:44740
First Author: Leibel RL
Year: 1997
Journal: J Biol Chem
Title: The molecular genetics of rodent single gene obesities.
Volume: 272
Issue: 51
Pages: 31937-40
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Publication
10218993 | J:54849
First Author: Wilson BD
Year: 1999
Journal: Endocrinology
Title: Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.
Volume: 140
Issue: 5
Pages: 2387-97
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Publication
9207125 | J:41751
First Author: Dong ZM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A new class of obesity genes encodes leukocyte adhesion receptors.
Volume: 94
Issue: 14
Pages: 7526-30
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Publication
18463231 | J:138523
First Author: Wang F
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation.
Volume: 295
Issue: 1
Pages: C213-20
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Publication
8177042 | J:18161
First Author: Nishina PM
Year: 1994
Journal: Metabolism
Title: Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
Volume: 43
Issue: 5
Pages: 549-53
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Publication
8177043 | J:19043
First Author: Nishina PM
Year: 1994
Journal: Metabolism
Title: Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
Volume: 43
Issue: 5
Pages: 554-8
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Publication
14701919 | J:88732
First Author: Lyons MA
Year: 2004
Journal: Physiol Genomics
Title: Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice.
Volume: 17
Issue: 1
Pages: 60-8
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Publication
9885188 | J:51538
 
First Author: Keightley PD
Year: 1998
Journal: Heredity (Edinb)
Title: Test of candidate gene--quantitative trait locus association applied to fatness in mice.
Volume: 81 ( Pt 6)
Pages: 630-7
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Publication
27709799 | J:237213
First Author: Selvaraj P
Year: 2017
Journal: Stem Cells
Title: Neurotrophic Factor-α1: A Key Wnt-β-Catenin Dependent Anti-Proliferation Factor and ERK-Sox9 Activated Inducer of Embryonic Neural Stem Cell Differentiation to Astrocytes in Neurodevelopment.
Volume: 35
Issue: 3
Pages: 557-571
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Publication
10395190 | J:56197
First Author: Schalling M
Year: 1999
Journal: J Intern Med
Title: Genes involved in animal models of obesity and anorexia.
Volume: 245
Issue: 6
Pages: 613-9
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Publication
10395195 | J:56198
First Author: Echwald SM
Year: 1999
Journal: J Intern Med
Title: Genetics of human obesity: lessons from mouse models and candidate genes.
Volume: 245
Issue: 6
Pages: 653-66
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Publication
14974682 | J:87328
First Author: Suto J
Year: 2003
Journal: Biochem Genet
Title: Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice.
Volume: 41
Issue: 9-10
Pages: 325-41
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Publication
15210844 | J:93243
First Author: Ishimori N
Year: 2004
Journal: J Lipid Res
Title: Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice.
Volume: 45
Issue: 9
Pages: 1624-32
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Publication
15917267 | J:99793
First Author: Mazón Peláez I
Year: 2005
Journal: Hum Mol Genet
Title: Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
Volume: 14
Issue: 14
Pages: 1977-89
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Publication
8009369 | J:18405
First Author: Milatovich A
Year: 1994
Journal: Somat Cell Mol Genet
Title: Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.
Volume: 20
Issue: 2
Pages: 75-86
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Publication
9229117 | J:41474
First Author: Naggert J
Year: 1997
Journal: Curr Opin Genet Dev
Title: The genetics of obesity.
Volume: 7
Issue: 3
Pages: 398-404
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Publication
16163737 | J:104961
First Author: St Germain C
Year: 2005
Journal: Mol Reprod Dev
Title: Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Volume: 72
Issue: 4
Pages: 483-93
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Publication
9680377 | J:48971
First Author: Grewal PK
Year: 1998
Journal: Mamm Genome
Title: High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint.
Volume: 9
Issue: 8
Pages: 603-7
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Publication
18256137 | J:133509
First Author: Stratigopoulos G
Year: 2008
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Regulation of Fto/Ftm gene expression in mice and humans.
Volume: 294
Issue: 4
Pages: R1185-96
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Publication
8973143 | J:36583
First Author: Chagnon YC
Year: 1996
Journal: Trends Genet
Title: Genetics of obesity: advances from rodent studies.
Volume: 12
Issue: 11
Pages: 441-4
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Publication
16247769 | J:102850
First Author: Singh U
Year: 2005
Journal: Dev Dyn
Title: Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
Volume: 234
Issue: 4
Pages: 1034-45
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Publication
37689751 | J:340404
First Author: Bohuslavova R
Year: 2023
Journal: Nat Commun
Title: NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.
Volume: 14
Issue: 1
Pages: 5554
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Publication
32694784 | J:310126
First Author: Quarta C
Year: 2019
Journal: Nat Metab
Title: Functional identity of hypothalamic melanocortin neurons depends on Tbx3.
Volume: 1
Issue: 2
Pages: 222-235
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Publication
12652657 | J:106181
First Author: Chiellini C
Year: 2003
Journal: J Cell Physiol
Title: Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Volume: 195
Issue: 2
Pages: 309-21
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Publication
37168577 | J:335566
First Author: Lu C
Year: 2023
Journal: iScience
Title: Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.
Volume: 26
Issue: 5
Pages: 106670
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Publication
9403069 | J:36973
First Author: Taketo MM
Year: 1997
Journal: Genomics
Title: Mapping of eight testis-specific genes to mouse chromosomes.
Volume: 46
Issue: 1
Pages: 138-42
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Publication
14651920 | J:86843
First Author: Easterday MC
Year: 2003
Journal: Dev Biol
Title: Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Volume: 264
Issue: 2
Pages: 309-22
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Publication
11172053 | J:67552
First Author: Jiang CH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The effects of aging on gene expression in the hypothalamus and cortex of mice.
Volume: 98
Issue: 4
Pages: 1930-4
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
24006456 | J:221550
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Cpe<tm1Yplo> | MGI:3527901
Name: carboxypeptidase E; targeted mutation 1, Y Peng Loh
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
9878248 | J:52002
First Author: Paperna T
Year: 1998
Journal: Genomics
Title: Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion.
Volume: 54
Issue: 3
Pages: 453-9
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Protein
Q00493
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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GO Term
GO:0017131 | uridine-rich cytoplasmic polyadenylylation element binding
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Allele
Cpe<em2Smoc> | MGI:7289118
Name: carboxypeptidase E; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:2136809
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136855
Age: embryonic day 12.5
Image: 1D
Note: Expression marks the cortical hem; abuts the CPe dorsally.
Specimen Label: 1D
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:2136809
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136855
Age: embryonic day 12.5
Image: 1F
Note: Expression marks the cortical hem; abuts the CPe caudally.
Specimen Label: 1F
Detected: true
Specimen Num: 11
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Strain
MGI:6428479 | C57BL/6JSmoc-Cpe<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
Q9DA37
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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HT Experiment
E-GEOD-49973 | Gene expression of the mouse choroid plexus epithelium (CPE)
Series Id: GSE49973
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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GXD Expression
GXD Expression
Probe: MGI:2136809
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136855
Age: embryonic day 12.5
Image: 1E
Note: Expression marks the cortical hem; no expression in the junctional epithelium between the hem and CPe; abuts the CPe dorsally and caudoventrally.
Specimen Label: 1E
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:512808
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136862
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2136852
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136863
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1275942
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136864
Age: embryonic day 12.5
Image: 3G
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: 3G
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:512808
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136862
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2136852
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136863
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1275942
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136864
Age: embryonic day 12.5
Image: 3G
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: 3G
Detected: true
Specimen Num: 2
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Publication
10966857 | -
First Author: Goodge KA
Year: 2000
Journal: Semin Cell Dev Biol
Title: Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
Volume: 11
Issue: 4
Pages: 235-42
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Protein Domain
IPR034232 | M14_CPE_CPD
Type: Domain
Description: This entry represents the carboxypeptidase domain found in carboxypeptidase (CP) E (CPE, also known as carboxypeptidase H, and enkephalin convertase;(); MEROPS identifier M14.005). CPE belongs to subfamily M14B (N/E subfamily) of the M14 family of metallocarboxypeptidases (MCPs) []. It is an important enzyme responsible for the proteolytic processing of prohormone intermediates (such as pro-insulin, pro-opiomelanocortin, or pro-gonadotropin-releasing hormone) by specifically removing C-terminal basic residues []. In addition, it has been proposed that the regulated secretory pathway (RSP) of the nervous and endocrine systems utilizes membrane-bound CPE as a sorting receptor. A naturally occurring point mutation in CPE reduces the stability of the enzyme and causes its degradation, leading to an accumulation of numerous neuroendocrine peptides that result in obesity and hyperglycemia [, ]. Reduced CPE enzyme and receptor activity could underlie abnormal placental phenotypes from the observation that CPE is down-regulated in enlarged placentas of interspecific hybrid (interspecies hybrid placental dysplasia, IHPD) and cloned mice [].The carboxypeptidase A family can be divided into four subfamilies: M14A(carboxypeptidase A or digestive), M14B (carboxypeptidase H or regulatory), M14C (gamma-D-glutamyl-L-diamino acid peptidase I) and M14D (AGTPBP-1/Nna1-like proteins) [, ]. Members of subfamily M14B have longer C-termini than those of subfamily M14A [], and carboxypeptidase M (a member of the H family) is bound to the membrane by a glycosylphosphatidylinositol anchor, unlike the majority of the M14 family, which are soluble []. The zinc ligands have been determined as two histidines and a glutamate,and the catalytic residue has been identified as a C-terminal glutamate,but these do not form the characteristic metalloprotease HEXXH motif [, ]. Members of the carboxypeptidase A family are synthesised as inactive molecules with propeptides that must be cleaved to activate the enzyme. Structural studies of carboxypeptidases A and B reveal the propeptide to exist as a globular domain, followed by an extended α-helix; this shields the catalytic site, without specifically binding to it, while the substrate-binding site is blocked by making specific contacts [, ].
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Publication
9334247 | J:43620
First Author: Katahira J
Year: 1997
Journal: J Biol Chem
Title: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.
Volume: 272
Issue: 42
Pages: 26652-8
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Publication
26120850 | J:233788
First Author: Alsters SI
Year: 2015
Journal: PLoS One
Title: Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.
Volume: 10
Issue: 6
Pages: e0131417
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Protein
Q543R4
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Publication
10635326 | J:59157
First Author: Stebbins-Boaz B
Year: 1999
Journal: Mol Cell
Title: Maskin is a CPEB-associated factor that transiently interacts with elF-4E.
Volume: 4
Issue: 6
Pages: 1017-27
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Publication
28699639 | J:250382
 
First Author: Blandino-Rosano M
Year: 2017
Journal: Nat Commun
Title: Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Volume: 8
Pages: 16014
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Publication
20219456 | J:159995
First Author: Murai S
Year: 2010
Journal: Dev Biol
Title: Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos.
Volume: 341
Issue: 1
Pages: 205-12
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Publication
8335373 | -
First Author: Czeczulin JR
Year: 1993
Journal: Infect Immun
Title: Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli.
Volume: 61
Issue: 8
Pages: 3429-39
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Publication
9087440 | -
First Author: Katahira J
Year: 1997
Journal: J Cell Biol
Title: Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin.
Volume: 136
Issue: 6
Pages: 1239-47
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Publication
17581814 | -
First Author: Hasegawa K
Year: 2007
Journal: J Biol Chem
Title: A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms.
Volume: 282
Issue: 34
Pages: 24777-83
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