|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 500 out of 737 for Crk

<< First    < Previous  |  Next >    Last >>
0.04s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
7883800 | -
 
First Author: Marengere LE
Year: 1994
Journal: J Cell Sci Suppl
Title: Structure and function of SH2 domains.
Volume: 18
Pages: 97-104
•
•
•
•
•
Publication
3025655 | -
First Author: Sadowski I
Year: 1986
Journal: Mol Cell Biol
Title: A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.
Volume: 6
Issue: 12
Pages: 4396-408
•
•
•
•
•
Publication
11911873 | -
First Author: Pawson T
Year: 2002
Journal: FEBS Lett
Title: Interaction domains: from simple binding events to complex cellular behavior.
Volume: 513
Issue: 1
Pages: 2-10
•
•
•
•
•
Protein
B2RWI0
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
•
•
•
•
•
Protein
B1AUF8
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
•
•
•
•
•
Protein
F7BZA7
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR000980 | SH2
Type: Domain
Description: The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps []. Similar sequences were later found in many other intracellular signal-transducing proteins []. SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine-containing target peptides in a sequence-specific, SH2 domains recognise between 3-6 residues C-terminal to the phosphorylated tyrosine in a fashion that differs from one SH2 domain to another, and strictly phosphorylation-dependent manner [, , , ]. They are found in a wide variety of protein contexts e.g., in association with catalytic domains of phospholipase Cy (PLCy) and the non-receptor protein tyrosine kinases; within structural proteins such as fodrin and tensin; and in a group of small adaptor molecules, i.e Crk and Nck. The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. The structure of the SH2 domain belongs to the α+β class, its overall shape forming a compact flattened hemisphere. The core structural elements comprise a central hydrophobic anti-parallel β-sheet, flanked by 2 short α-helices. The loop between strands 2 and 3 provides many of the binding interactions with the phosphate group of its phosphopeptide ligand, and is hence designated the phosphate binding loop, the phosphorylated ligand binds perpendicular to the β-sheet and typically interacts with the phosphate binding loop and a hydrophobic binding pocket that interacts with a pY+3 side chain. The N- and C-termini of the domain are close together in space and on the opposite face from the phosphopeptide binding surface and it has been speculated that this has facilitated their integration into surface-exposed regions of host proteins [].
•
•
•
•
•
Protein Domain
IPR036860 | SH2_dom_sf
Type: Homologous_superfamily
Description: The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps []. Similar sequences were later found in many other intracellular signal-transducing proteins []. SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine-containing target peptides in a sequence-specific, SH2 domains recognise between 3-6 residues C-terminal to the phosphorylated tyrosine in a fashion that differs from one SH2 domain to another, and strictly phosphorylation-dependent manner [, , , ]. They are found in a wide variety of protein contexts e.g., in association with catalytic domains of phospholipase Cy (PLCy) and the non-receptor protein tyrosine kinases; within structural proteins such as fodrin and tensin; and in a group of small adaptor molecules, i.e Crk and Nck. The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. The structure of the SH2 domain belongs to the α+β class, its overall shape forming a compact flattened hemisphere. The core structural elements comprise a central hydrophobic anti-parallel β-sheet, flanked by 2 short α-helices. The loop between strands 2 and 3 provides many of the binding interactions with the phosphate group of its phosphopeptide ligand, and is hence designated the phosphate binding loop, the phosphorylated ligand binds perpendicular to the β-sheet and typically interacts with the phosphate binding loop and a hydrophobic binding pocket that interacts with a pY+3 side chain. The N- and C-termini of the domain are close together in space and on the opposite face from the phosphopeptide binding surface and it has been speculated that this has facilitated their integration into surface-exposed regions of host proteins [].
•
•
•
•
•
Protein
D3Z355
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
•
•
•
•
•
Protein
Q8JZW5
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
•
•
•
•
•
Protein
Q9ES52
Organism: Mus musculus/domesticus
Length: 1191  
Fragment?: false
•
•
•
•
•
Protein
Q6PD21
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
•
•
•
•
•
Protein
O88890
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
•
•
•
•
•
Protein
Q8CG80
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
•
•
•
•
•
Protein
O88834
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
•
•
•
•
•
Protein
Q45HK4
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
•
•
•
•
•
Protein
O35324
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JDR4
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
•
•
•
•
•
Protein
Q149T1
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
•
•
•
•
•
Protein
Q544F1
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
•
•
•
•
•
Protein
B7ZP01
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
•
•
•
•
•
Protein
Q8CCG3
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
•
•
•
•
•
Protein
Q3TP23
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
•
•
•
•
•
Protein
Q6A021
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
•
•
•
•
•
Protein
A2AM67
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
•
•
•
•
•
Protein
B7ZWB7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
•
•
•
•
•
Protein
A2AQ87
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: true
•
•
•
•
•
Protein
D3YZ26
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
•
•
•
•
•
Protein
A2ASX4
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
•
•
•
•
•
Protein
M0QWP8
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: false
•
•
•
•
•
Protein
A0A087WPT7
Organism: Mus musculus/domesticus
Length: 1166  
Fragment?: true
•
•
•
•
•
Protein
Q8C3F4
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
•
•
•
•
•
Protein
Q6P0X5
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
•
•
•
•
•
Protein
A2AQ89
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JDE7
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
•
•
•
•
•
Protein
A0A0H2UKC0
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
•
•
•
•
•
Protein
E9Q2F4
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
•
•
•
•
•
Protein
Q45GR7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
•
•
•
•
•
Protein
Q3UZ87
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
•
•
•
•
•
Protein
Q8C1J7
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
•
•
•
•
•
Protein
A2ASX3
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
•
•
•
•
•
Protein
Q62225
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
•
•
•
•
•
Protein
Q60787
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
•
•
•
•
•
Protein
Q9QXT1
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
•
•
•
•
•
Protein
Q91ZA6
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
•
•
•
•
•
Protein
O09039
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
•
•
•
•
•
Protein
O35718
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
•
•
•
•
•
Protein
O35717
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
•
•
•
•
•
Protein
Q6P549
Organism: Mus musculus/domesticus
Length: 1257  
Fragment?: false
•
•
•
•
•
Protein
Q9JLY0
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
•
•
•
•
•
Protein
Q8R0L1
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
•
•
•
•
•
Protein
O35716
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
•
•
•
•
•
Protein
Q8BZ33
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
•
•
•
•
•
Protein
O54928
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
•
•
•
•
•
Protein
Q8VHQ2
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
•
•
•
•
•
Protein
Q3V3Q2
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
•
•
•
•
•
Protein
A0A087WRI1
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
•
•
•
•
•
Protein
Q3U5Y3
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
•
•
•
•
•
Protein
Q3UK44
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
•
•
•
•
•
Protein
Q3UL29
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SR46
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
•
•
•
•
•
Protein
D6RGA0
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
•
•
•
•
•
Protein
Q5U469
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
•
•
•
•
•
Protein
F6RVG2
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
•
•
•
•
•
Protein
A0A571BEJ5
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
•
•
•
•
•
Protein
D3Z3Y5
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
•
•
•
•
•
Protein
B1ATD1
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1STA1
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
•
•
•
•
•
Protein
Q8CAS1
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
•
•
•
•
•
Protein
A0A087WQM2
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
•
•
•
•
•
Protein
A0A338P675
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
•
•
•
•
•
Protein
Q3U9J8
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
•
•
•
•
•
Protein
A7VK13
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
•
•
•
•
•
Protein
Q548Q7
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
•
•
•
•
•
Protein
Q91V57
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
•
•
•
•
•
Protein
O89100
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
•
•
•
•
•
Protein
Q9CX99
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
•
•
•
•
•
Protein
Q06649
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
•
•
•
•
•
Protein
Q9QZK2
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
•
•
•
•
•
Protein
Q60631
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
•
•
•
•
•
Protein
Q64143
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
•
•
•
•
•
Protein
Q9JM90
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
•
•
•
•
•
Protein
Q9D684
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
•
•
•
•
•
Protein
Q8R4L0
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
•
•
•
•
•
Protein
Q9JID9
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
•
•
•
•
•
Protein
Q9QZS8
Organism: Mus musculus/domesticus
Length: 854  
Fragment?: false
•
•
•
•
•
Protein
Q60898
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
•
•
•
•
•
Protein
Q61120
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
•
•
•
•
•
Protein
Q921Q7
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
•
•
•
•
•
Protein
Q91ZM2
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
•
•
•
•
•
Protein
P98083
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
•
•
•
•
•
Protein
Q6S5L9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
•
•
•
•
•
Protein
Q8BMC3
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
•
•
•
•
•
Protein
Q5SUW3
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
•
•
•
•
•
Protein
Q3U1H0
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
•
•
•
•
•
Protein
Q80UI5
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
•
•
•
•
•
Protein
Q91Z52
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
•
•
•
•
•
Protein
Q9DBT6
Organism: Mus musculus/domesticus
Length: 624  
Fragment?: false
•
•
•
•
•
Protein
Q3UZ79
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: true
•
•
•
•
•
Protein
Q3U0E8
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom