|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 500 out of 524 for Cry1

<< First    < Previous  |  Next >    Last >>
0.032s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Allele
Cry1<em1Liga> | MGI:7314236
Name: cryptochrome circadian regulator 1; endonuclease-mediated mutation 1, Gang Li
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
Rr471<em1Rits> | MGI:7610640
Name: regulatory region 471; endonuclease-mediated mutation 1, Makoto Akashi
Allele Type: Transgenic
Attribute String: Modified regulatory region
•
•
•
•
•
Allele
Rr471<em2Rits> | MGI:7610641
Name: regulatory region 471; endonuclease-mediated mutation 2, Makoto Akashi
Allele Type: Transgenic
Attribute String: Modified regulatory region
•
•
•
•
•
Publication
28388406 | J:282602
First Author: Patke A
Year: 2017
Journal: Cell
Title: Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.
Volume: 169
Issue: 2
Pages: 203-215.e13
•
•
•
•
•
Regulatory Region
MGI:7610581 | Rr471
Type: enhancer
Organism: mouse, laboratory
•
•
•
•
•
Publication
16703358 | -
First Author: Canamero RC
Year: 2006
Journal: Planta
Title: Cryptochrome photoreceptors cry1 and cry2 antagonistically regulate primary root elongation in Arabidopsis thaliana.
Volume: 224
Issue: 5
Pages: 995-1003
•
•
•
•
•
Publication
32538895 | -
First Author: Onat OE
Year: 2020
Journal: J Clin Invest
Title: Human CRY1 variants associate with attention deficit/hyperactivity disorder.
Volume: 130
Issue: 7
Pages: 3885-3900
•
•
•
•
•
Allele
Tg(tetO-Cry1)1Jt | MGI:4950913
Name: transgene insertion 1, Joseph S Takahashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Regulatory Region
MGI:7117395 | Rr229173
Type: enhancer
Organism: mouse, laboratory
•
•
•
•
•
Allele
Rr229173<em1Fena> | MGI:7432343
Name: regulatory region 229173; endonuclease-mediated mutation 1, Felix Naef
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
•
•
•
•
•
Genotype
Genotype
Symbol: Rr229173/Rr229173
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
HT Experiment
GSE199061 | Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and delta-RRE Liver Transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
- | J:321631
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2022
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Regulatory Build.
•
•
•
•
•
Publication
20133010 | -
First Author: Zeng J
Year: 2010
Journal: J Plant Physiol
Title: Arabidopsis cryptochrome-1 restrains lateral roots growth by inhibiting auxin transport.
Volume: 167
Issue: 8
Pages: 670-3
•
•
•
•
•
Publication
18988809 | -
First Author: Liu H
Year: 2008
Journal: Science
Title: Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis.
Volume: 322
Issue: 5907
Pages: 1535-9
•
•
•
•
•
Protein Domain
IPR014134 | Cryptochrome_pln
Type: Family
Description: The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ].Members of this subfamily are from plants; they appear mostly to be regulatory proteins that respond to blue light. For instance, Arabidopsis cryptochromes Cry1 and Cry2 antagonistically regulate primary root elongation [, ]. Cry2 is also reported to interact with CIB1 and regulate transcription and floral initiation [].
•
•
•
•
•
Publication
17041588 | -
First Author: Higa LA
Year: 2006
Journal: Nat Cell Biol
Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Volume: 8
Issue: 11
Pages: 1277-83
•
•
•
•
•
Publication
16024659 | -
First Author: Horn PJ
Year: 2005
Journal: Genes Dev
Title: A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation.
Volume: 19
Issue: 14
Pages: 1705-14
•
•
•
•
•
Publication
21959250 | -
First Author: Iovine B
Year: 2011
Journal: Int J Biochem Cell Biol
Title: Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions.
Volume: 43
Issue: 12
Pages: 1664-7
•
•
•
•
•
Publication
18551167 | -
First Author: Molinier J
Year: 2008
Journal: PLoS Genet
Title: Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stress.
Volume: 4
Issue: 6
Pages: e1000093
•
•
•
•
•
Protein Domain
IPR031297 | DDB1
Type: Family
Description: This entry represents the DNA damage-binding protein 1 (DDB1) family, whose members are involved in DNA repair.The fission yeast members in this family includes Rik1 and Ddb1. Rik1 is a component of the Rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation []. Ddb1 is a component of cullin 4A ubiquitin ligases, which regulates the selective proteolysis of key proteins in DNA repair, replication and transcription [, ].Mammalian Ddb1 is apart of the CUL4-DDB1 ubiquitin E3 ligase that regulates cell-cycle progression, replication and DNA damage response. The CUL4-DDB1 ubiquitin E3 ligase interacts with multiple WD40-repeat proteins and regulates histone methylation []. This complex also regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 [].The plant Ddb1 is part of the CUL4-DDB1-DDB2 E3 ligase involved in maintaining genome integrity upon UV stress [].
•
•
•
•
•
Publication
36347873 | J:347090
First Author: Gul S
Year: 2022
Journal: Nat Commun
Title: Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice.
Volume: 13
Issue: 1
Pages: 6742
•
•
•
•
•
Publication
17996461 | J:132601
First Author: Feillet CA
Year: 2008
Journal: Mol Cell Neurosci
Title: Forebrain oscillators ticking with different clock hands.
Volume: 37
Issue: 2
Pages: 209-21
•
•
•
•
•
Publication
27840026 | J:249123
First Author: Huber AL
Year: 2016
Journal: Mol Cell
Title: CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Volume: 64
Issue: 4
Pages: 774-789
•
•
•
•
•
Publication
35999195 | J:336593
First Author: Abe YO
Year: 2022
Journal: Nat Commun
Title: Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals.
Volume: 13
Issue: 1
Pages: 4652
•
•
•
•
•
Publication
17726112 | J:124947
First Author: Komatsu M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration.
Volume: 104
Issue: 36
Pages: 14489-94
•
•
•
•
•
Publication
19910529 | J:154736
First Author: Zhang Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis.
Volume: 106
Issue: 47
Pages: 19860-5
•
•
•
•
•
Publication
21339326 | J:176843
First Author: Mortensen M
Year: 2011
Journal: J Exp Med
Title: The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Volume: 208
Issue: 3
Pages: 455-67
•
•
•
•
•
Publication
18794354 | -
First Author: Fukumoto Y
Year: 2008
Journal: Mol Cell Biol
Title: Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
Volume: 28
Issue: 22
Pages: 6746-56
•
•
•
•
•
Publication
15308756 | -
First Author: Laubinger S
Year: 2004
Journal: Plant Cell
Title: The SPA quartet: a family of WD-repeat proteins with a central role in suppression of photomorphogenesis in arabidopsis.
Volume: 16
Issue: 9
Pages: 2293-306
•
•
•
•
•
Publication
27444995 | -
First Author: Chen S
Year: 2016
Journal: BMC Plant Biol
Title: The functional divergence between SPA1 and SPA2 in Arabidopsis photomorphogenesis maps primarily to the respective N-terminal kinase-like domain.
Volume: 16
Issue: 1
Pages: 165
•
•
•
•
•
Publication
28433946 | -
 
First Author: Hoecker U
Year: 2017
Journal: Curr Opin Plant Biol
Title: The activities of the E3 ubiquitin ligase COP1/SPA, a key repressor in light signaling.
Volume: 37
Pages: 63-69
•
•
•
•
•
Publication
12887588 | -
First Author: Laubinger S
Year: 2003
Journal: Plant J
Title: The SPA1-like proteins SPA3 and SPA4 repress photomorphogenesis in the light.
Volume: 35
Issue: 3
Pages: 373-85
•
•
•
•
•
Publication
32994167 | -
 
First Author: Lee S
Year: 2020
Journal: Development
Title: SPAs promote thermomorphogenesis by regulating the phyB-PIF4 module in Arabidopsis.
Volume: 147
Issue: 19
•
•
•
•
•
Protein Domain
IPR044630 | SPA1/2/3/4
Type: Family
Description: In Arabidopsis, SPA1/2/3/4 play a central role in suppression of photomorphogenesis. SPA1 and SPA2 predominate in dark-grown seedlings, whereas SPA3 and SPA4 prevalently regulate the elongation growth in adult plants []. SPAs contain a kinase-like domain, a coiled-coil domain and the WD-repeats. SPAs and COP1 (a ring finger E3 ubiquitin ligase) can form homo- and heterodimers via their respective coiled-coil domains, and the COP1/SPA complex forms a tetramer of two COP1 and two SPA proteins []. The SPA proteins can self-associate or interact with each other, forming a heterogeneous group of SPA-COP1 complexes []. Besides recognizing substrates, both COP1 and SPA bind DDB1 in the CUL4 complex through their C-terminal WD-repeat domains. They serve as DDB1-CUL4-associated factors (DCAFs) similar to other substrate adaptors in CUL4-based E3 ligases. SPA1 interacts with photoreceptor cry2 via its kinase-like domain, with cry1 via its WD-repeat domain and with phytochromes possibly via both []. SPAs have also been shown to regulate the phyB-PIF4 module at high ambient temperature [].
•
•
•
•
•
Protein Domain
IPR006285 | Atg7
Type: Family
Description: This is a family of eukaryotic proteins found in animals, plants, and yeasts that includes Atg7p (YHR171W) from Saccharomyces cerevisiae (Baker's yeast) and ATG7 from Pichia angusta. Members are about 650 to 700 residues in length and include a central domain of about 150 residues shared with the ThiF/MoeB/HesA family of proteins. A low level of similarity toubiquitin-activating enzyme E1 is described in a paper on peroxisome autophagy mediated by ATG7 [], and is the basis of the name ubiquitin activating enzyme E1-like protein. Members of the family are involved in protein lipidation events analogous to ubiquitination and required for membrane fusion events during autophagy.This protein is important for several processes. It plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration [], the maintenance of hematopoietic stem cells [], the formation of Paneth cell granules [[cite22291845]], as well as in adipose differentiation []. It is involved in circadian clock regulation in the liver and glucose metabolism through the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner [].
•
•
•
•
•
Publication
20153195 | J:158600
First Author: Shi S
Year: 2010
Journal: Curr Biol
Title: Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.
Volume: 20
Issue: 4
Pages: 316-21
•
•
•
•
•
Publication
18411297 | J:137262
First Author: Nakashima A
Year: 2008
Journal: Mol Cell Biol
Title: DEC1 modulates the circadian phase of clock gene expression.
Volume: 28
Issue: 12
Pages: 4080-92
•
•
•
•
•
Publication
20123978 | J:161722
First Author: Kurabayashi N
Year: 2010
Journal: Mol Cell Biol
Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.
Volume: 30
Issue: 7
Pages: 1757-68
•
•
•
•
•
Publication
18454201 | J:319841
First Author: Liu AC
Year: 2008
Journal: PLoS Genet
Title: Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms.
Volume: 4
Issue: 2
Pages: e1000023
•
•
•
•
•
Publication
29750810 | J:263234
First Author: Ramanathan C
Year: 2018
Journal: PLoS Genet
Title: mTOR signaling regulates central and peripheral circadian clock function.
Volume: 14
Issue: 5
Pages: e1007369
•
•
•
•
•
Publication
19401184 | J:148090
 
First Author: Kaneko K
Year: 2009
Journal: Brain Res
Title: Obesity alters circadian expressions of molecular clock genes in the brainstem.
Volume: 1263
Pages: 58-68
•
•
•
•
•
Publication
10938103 | J:63933
First Author: Shearman LP
Year: 2000
Journal: Mol Cell Biol
Title: Targeted disruption of the mPer3 gene: subtle effects on circadian clock function.
Volume: 20
Issue: 17
Pages: 6269-75
•
•
•
•
•
Publication
20668203 | J:162853
First Author: Maywood ES
Year: 2010
Journal: J Neurosci
Title: Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.
Volume: 30
Issue: 30
Pages: 10199-204
•
•
•
•
•
Publication
28973913 | J:252914
First Author: Yoo SH
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Volume: 114
Issue: 42
Pages: E8855-E8864
•
•
•
•
•
Publication
34668266 | J:351698
First Author: Niu L
Year: 2022
Journal: Brain Pathol
Title: Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology.
Volume: 32
Issue: 3
Pages: e13028
•
•
•
•
•
Publication
34807912 | J:350938
First Author: Shen Y
Year: 2021
Journal: PLoS Genet
Title: NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.
Volume: 17
Issue: 11
Pages: e1009933
•
•
•
•
•
Publication
23771028 | J:202149
First Author: Powell WT
Year: 2013
Journal: Hum Mol Genet
Title: A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure.
Volume: 22
Issue: 21
Pages: 4318-28
•
•
•
•
•
Publication
11804325 | J:74040
First Author: Eun BK
Year: 2001
Journal: Mol Cells
Title: Cloning and expression of cryptochrome2 cDNA in the rat.
Volume: 12
Issue: 3
Pages: 286-91
•
•
•
•
•
Publication
12483227 | J:81183
First Author: Etchegaray JP
Year: 2003
Journal: Nature
Title: Rhythmic histone acetylation underlies transcription in the mammalian circadian clock.
Volume: 421
Issue: 6919
Pages: 177-82
•
•
•
•
•
Publication
17660446 | J:127130
First Author: Chen-Goodspeed M
Year: 2007
Journal: J Biol Rhythms
Title: Tumor suppression and circadian function.
Volume: 22
Issue: 4
Pages: 291-8
•
•
•
•
•
Publication
31515273 | J:283068
First Author: Garg A
Year: 2019
Journal: J Biol Chem
Title: Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein.
Volume: 294
Issue: 45
Pages: 16604-16619
•
•
•
•
•
Publication
24085301 | J:205916
First Author: Yumimoto K
Year: 2013
Journal: J Biol Chem
Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Volume: 288
Issue: 45
Pages: 32766-76
•
•
•
•
•
Publication
32700769 | J:298817
First Author: Hassan SA
Year: 2021
Journal: Int J Cancer
Title: Time-dependent changes in proliferation, DNA damage and clock gene expression in hepatocellular carcinoma and healthy liver of a transgenic mouse model.
Volume: 148
Issue: 1
Pages: 226-237
•
•
•
•
•
Publication
23292171 | J:333593
First Author: Hashinaga T
Year: 2013
Journal: Endocr J
Title: Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome.
Volume: 60
Issue: 4
Pages: 483-92
•
•
•
•
•
Publication
34954114 | J:319806
 
First Author: Oda Y
Year: 2022
Journal: Neurosci Lett
Title: Role of heterozygous and homozygous alleles in cryptochrome-deficient mice.
Volume: 772
Pages: 136415
•
•
•
•
•
Protein
A0A494BBJ6
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
•
•
•
•
•
Publication
23443664 | J:197826
First Author: Zmrzljak UP
Year: 2013
Journal: J Biol Chem
Title: Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.
Volume: 288
Issue: 15
Pages: 10318-27
•
•
•
•
•
Publication
22039518 | J:179726
First Author: Mongrain V
Year: 2011
Journal: PLoS One
Title: Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
Volume: 6
Issue: 10
Pages: e26622
•
•
•
•
•
Publication
36687679 | J:356175
 
First Author: Yan L
Year: 2022
Journal: Front Nutr
Title: Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pubertal mice.
Volume: 9
Pages: 1068350
•
•
•
•
•
Protein
A0A494B987
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
•
•
•
•
•
Protein
Q3U1J4
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
•
•
•
•
•
Protein
Q9D906
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
•
•
•
•
•
Protein
A0A0A0MQN4
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
•
•
•
•
•
Protein
Q3ULS8
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: true
•
•
•
•
•
Protein
S4R2T5
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
•
•
•
•
•
Protein
Q3TM87
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
•
•
•
•
•
Protein
Q3TAB9
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
•
•
•
•
•
Protein
Q91YC8
Organism: Mus musculus/domesticus
Length: 994  
Fragment?: false
•
•
•
•
•
Publication
17204848 | -
First Author: Meijer WH
Year: 2007
Journal: Autophagy
Title: ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes.
Volume: 3
Issue: 2
Pages: 106-16
•
•
•
•
•
Publication
14706636 | -
First Author: Fujiwara H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases.
Volume: 313
Issue: 4
Pages: 962-8
•
•
•
•
•
Publication
19819873 | -
First Author: Maruyama M
Year: 2009
Journal: J Biol Chem
Title: Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties.
Volume: 284
Issue: 50
Pages: 34692-702
•
•
•
•
•
Publication
20531381 | -
First Author: Haroon N
Year: 2010
Journal: Nat Rev Rheumatol
Title: Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.
Volume: 6
Issue: 8
Pages: 461-7
•
•
•
•
•
Publication
17525158 | -
First Author: Maruyama M
Year: 2007
Journal: J Biol Chem
Title: Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.
Volume: 282
Issue: 28
Pages: 20088-96
•
•
•
•
•
Publication
17346152 | -
First Author: Luan Y
Year: 2007
Journal: Curr Med Chem
Title: The structure and main functions of aminopeptidase N.
Volume: 14
Issue: 6
Pages: 639-47
•
•
•
•
•
Publication
21205077 | -
First Author: Wickström M
Year: 2011
Journal: Cancer Sci
Title: Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Volume: 102
Issue: 3
Pages: 501-8
•
•
•
•
•
Publication
21210704 | -
First Author: Likitvivatanavong S
Year: 2011
Journal: J Agric Food Chem
Title: Multiple receptors as targets of Cry toxins in mosquitoes.
Volume: 59
Issue: 7
Pages: 2829-38
•
•
•
•
•
Protein Domain
IPR034016 | M1_APN-typ
Type: Family
Description: This M1 peptidase family includes eukaryotic and bacterial members: aminopeptidase N (APN; MEROPS identifier M01.001), aminopeptidase Q (APQ, laeverin; MEROPS identifier M01.026) [, ], endoplasmic reticulum aminopeptidase 1 (ERAP1; MEROPS identifier M01.018) []as well as tricorn interacting factor F3 (MEROPS identifier M01.021).Aminopeptidase N (APN; CD13; Alanyl aminopeptidase; ), a type II integral membrane protease, consists of a small N-terminal cytoplasmic domain, a single transmembrane domain, and a large extracellular ectodomain that contains the active site. It preferentially cleaves neutral amino acids from the N terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs [, ].ERAP1 also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP) or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2 (MEROPS identifier M01.024), for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors [].The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position [].APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation []. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities.APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection []. Insect APNs (MEROPS identifiers M01.013 and M01.030) are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established [].
•
•
•
•
•
Publication
15893768 | -
First Author: Kyrieleis OJ
Year: 2005
Journal: J Mol Biol
Title: Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.
Volume: 349
Issue: 4
Pages: 787-800
•
•
•
•
•
Protein
P97449
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
•
•
•
•
•
Protein
Q2KHK3
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
•
•
•
•
•
Protein
P16406
Organism: Mus musculus/domesticus
Length: 945  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom