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Search results 401 to 498 out of 498 for Cx3cl1

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0.029s
Type Details Score
Publication  
First Author: Lehner C
Year: 2019
Journal: Dis Model Mech
Title: Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1.
Volume: 12
Issue: 12
Publication
First Author: Wang SK
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa.
Volume: 116
Issue: 20
Pages: 10140-10149
Publication
First Author: Shimoyama S
Year: 2021
Journal: Eur J Immunol
Title: Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis.
Volume: 51
Issue: 6
Pages: 1519-1530
Publication
First Author: Fu R
Year: 2020
Journal: Sci Rep
Title: Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model.
Volume: 10
Issue: 1
Pages: 1455
Publication
First Author: Xin H
Year: 2005
Journal: Eur J Immunol
Title: Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells.
Volume: 35
Issue: 5
Pages: 1371-80
Allele
Name: C-X3-C motif chemokine ligand 1; endonuclease-mediated mutation 1, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
GO Term
GO Term
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Wojdasiewicz P
Year: 2014
Journal: Arch Immunol Ther Exp (Warsz)
Title: The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1: occurrence and potential role in osteoarthritis.
Volume: 62
Issue: 5
Pages: 395-403
Allele
Name: C-X3-C motif chemokine ligand 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
GO Term
Allele
Name: transgene insertion RA63, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 1, Steffen Jung
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion ES26, Nathaniel Heintz
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant strain, transgenic, congenic
Allele
Name: transgene insertion 1, Steffen Jung
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: transgenic, mutant strain, congenic
Publication
First Author: Old EA
Year: 2014
Journal: J Clin Invest
Title: Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain.
Volume: 124
Issue: 5
Pages: 2023-36
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cx3cl1-cre)RA63Gsat/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Combadiere C
Year: 1998
Journal: J Biol Chem
Title: Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.
Volume: 273
Issue: 37
Pages: 23799-804
Publication
First Author: Sbrana S
Year: 2005
Journal: Cytometry B Clin Cytom
Title: Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation.
Volume: 65
Issue: 1
Pages: 14-21
Publication
First Author: Raport CJ
Year: 1995
Journal: Gene
Title: The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.
Volume: 163
Issue: 2
Pages: 295-9
Protein Domain
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. It is a transmembrane molecule containing a chemokine domain on an extended mucin-like stalk []. Both the adhesive and chemotactic effects of CX3CL1 are mediated through CX3C chemokine receptor type 1 (CX3CR1), also known as fractalkine receptor []. The receptor is expressed specifically on T cells, natural killer cells and monocytes [, ]. Coupling of the receptor to pertussis toxin-sensitive Gi proteins leads to calcium mobilisation and chemotaxis []. In contrast, adhesion mediated by the receptor is insensitive to pertussis toxin and does not appear to involve calcium mobilisation. CX3CR1 has also been found to act as a weak fusion cofactor for some HIV-1 strains, an interaction that can be potently and specifically blocked by CX3CL1 [].
Publication
First Author: Mionnet C
Year: 2010
Journal: Nat Med
Title: CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung.
Volume: 16
Issue: 11
Pages: 1305-12
Publication
First Author: Okuma A
Year: 2017
Journal: Nat Commun
Title: p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Volume: 8
Issue: 1
Pages: 2050
Publication  
First Author: Lauro C
Year: 2014
Journal: Front Cell Neurosci
Title: Fractalkine/CX3CL1 engages different neuroprotective responses upon selective glutamate receptor overactivation.
Volume: 8
Pages: 472
Publication
First Author: Thierry GR
Year: 2024
Journal: Immunity
Title: Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis.
Volume: 57
Issue: 9
Pages: 2108-2121.e6
Publication
First Author: Chen D
Year: 2024
Journal: Nat Commun
Title: Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice.
Volume: 15
Issue: 1
Pages: 449
Publication  
First Author: Dorfman MD
Year: 2017
Journal: Nat Commun
Title: Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.
Volume: 8
Pages: 14556
Publication
First Author: Ishida Y
Year: 2017
Journal: Sci Rep
Title: Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration.
Volume: 7
Issue: 1
Pages: 16833
Publication
First Author: Das Sarma J
Year: 2020
Journal: PLoS Pathog
Title: Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection.
Volume: 16
Issue: 11
Pages: e1009034
Publication
First Author: Gesuita L
Year: 2022
Journal: Cell Rep
Title: Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity.
Volume: 40
Issue: 7
Pages: 111209
Publication
First Author: Klapproth E
Year: 2022
Journal: Nat Commun
Title: Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
Volume: 13
Issue: 1
Pages: 7648
Publication
First Author: Striebel JF
Year: 2016
Journal: J Gen Virol
Title: Knockout of fractalkine receptor Cx3cr1 does not alter disease or microglial activation in prion-infected mice.
Volume: 97
Issue: 6
Pages: 1481-1487
Publication
First Author: Peng X
Year: 2015
Journal: J Immunol
Title: CX3CL1-CX3CR1 Interaction Increases the Population of Ly6C(-)CX3CR1(hi) Macrophages Contributing to Unilateral Ureteral Obstruction-Induced Fibrosis.
Volume: 195
Issue: 6
Pages: 2797-805
Publication
First Author: Marelli G
Year: 2017
Journal: Cancer Res
Title: Heme-oxygenase-1 Production by Intestinal CX3CR1+ Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.
Volume: 77
Issue: 16
Pages: 4472-4485
Publication  
First Author: Ashraf M
Year: 2023
Journal: Cells
Title: Chemokine/ITGA4 Interaction Directs iPSC-Derived Myogenic Progenitor Migration to Injury Sites in Aging Muscle for Regeneration.
Volume: 12
Issue: 14
Publication    
First Author: Jeong D
Year: 2021
Journal: Elife
Title: Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.
Volume: 10
Publication
First Author: Dobrian AD
Year: 2015
Journal: J Endocrinol
Title: STAT4 contributes to adipose tissue inflammation and atherosclerosis.
Volume: 227
Issue: 1
Pages: 13-24
Publication
First Author: Cardona AE
Year: 2008
Journal: Blood
Title: Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues.
Volume: 112
Issue: 2
Pages: 256-63
Publication
First Author: Herlea-Pana O
Year: 2015
Journal: Cardiovasc Res
Title: Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression.
Volume: 106
Issue: 2
Pages: 324-37
Publication
First Author: Wang H
Year: 2015
Journal: Cell Res
Title: P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy.
Volume: 25
Issue: 6
Pages: 674-90
Publication
First Author: Roy-Chowdhury E
Year: 2021
Journal: Cardiovasc Res
Title: Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.
Volume: 117
Issue: 6
Pages: 1510-1522
Publication
First Author: Herbin O
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Volume: 36
Issue: 9
Pages: 1791-801
Publication
First Author: Morari J
Year: 2014
Journal: Diabetes
Title: Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity.
Volume: 63
Issue: 11
Pages: 3770-84
Publication
First Author: Park H
Year: 2014
Journal: J Biol Chem
Title: Tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) by Hck regulates macrophage function.
Volume: 289
Issue: 11
Pages: 7897-906
Publication
First Author: Jung K
Year: 2017
Journal: J Clin Invest
Title: Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
Volume: 127
Issue: 8
Pages: 3039-3051
Publication
First Author: Chen M
Year: 2012
Journal: Glia
Title: Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent.
Volume: 60
Issue: 5
Pages: 833-42
Publication
First Author: Larsen KO
Year: 2011
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation.
Volume: 301
Issue: 1
Pages: L50-9
Publication  
First Author: Xu K
Year: 2020
Journal: Front Cell Dev Biol
Title: Local Macrophage-Related Immune Response Is Involved in Cochlear Epithelial Damage in Distinct Gjb2-Related Hereditary Deafness Models.
Volume: 8
Pages: 597769
Publication  
First Author: Sarikidi A
Year: 2022
Journal: Biomedicines
Title: Altered Immunomodulatory Responses in the CX3CL1/CX3CR1 Axis Mediated by hMSCs in an Early In Vitro SOD1(G93A) Model of ALS.
Volume: 10
Issue: 11
Publication
First Author: Lubos N
Year: 2020
Journal: Basic Res Cardiol
Title: Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.
Volume: 115
Issue: 4
Pages: 42
Publication
First Author: Lee S
Year: 2020
Journal: Neuro Oncol
Title: Role of CX3CR1 signaling in malignant transformation of gliomas.
Volume: 22
Issue: 10
Pages: 1463-1473
Publication
First Author: Florentin J
Year: 2018
Journal: J Immunol
Title: Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes.
Volume: 200
Issue: 10
Pages: 3612-3625
Publication
First Author: Lee YS
Year: 2018
Journal: Sci Rep
Title: CX3CR1 differentiates F4/80low monocytes into pro-inflammatory F4/80high macrophages in the liver.
Volume: 8
Issue: 1
Pages: 15076
Publication  
First Author: Chaudhri A
Year: 2023
Journal: Front Immunol
Title: The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy.
Volume: 14
Pages: 1237715
Publication
First Author: Xiong Z
Year: 2011
Journal: J Immunol
Title: CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-α and IL-6 and promote cigarette smoke-induced emphysema.
Volume: 186
Issue: 5
Pages: 3206-14
Publication
First Author: Rogers JT
Year: 2011
Journal: J Neurosci
Title: CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.
Volume: 31
Issue: 45
Pages: 16241-50
Publication
First Author: Hoshino A
Year: 2013
Journal: J Cell Sci
Title: Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts.
Volume: 126
Issue: Pt 4
Pages: 1032-45
Publication
First Author: Getzin T
Year: 2018
Journal: EMBO Mol Med
Title: The chemokine receptor CX3CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury.
Volume: 10
Issue: 2
Pages: 151-159
Publication  
First Author: Zhu Q
Year: 2022
Journal: Front Immunol
Title: Analysis of Mononuclear Phagocytes Disclosed the Establishment Processes of Two Macrophage Subsets in the Adult Murine Kidney.
Volume: 13
Pages: 805420
Publication
First Author: Dworzak J
Year: 2015
Journal: PLoS One
Title: Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity.
Volume: 10
Issue: 6
Pages: e0127730
Publication
First Author: Liang KJ
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling.
Volume: 50
Issue: 9
Pages: 4444-51
Publication  
First Author: Li A
Year: 2020
Journal: Neurobiol Aging
Title: Delivery of exogenous proteins by mesenchymal stem cells attenuates early memory deficits in a murine model of Alzheimer's disease.
Volume: 86
Pages: 81-91
Publication
First Author: Ishida Y
Year: 2008
Journal: J Immunol
Title: Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis.
Volume: 181
Issue: 6
Pages: 4208-18
Publication
First Author: Flamant M
Year: 2021
Journal: Sci Rep
Title: Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Volume: 11
Issue: 1
Pages: 17982
Publication
First Author: Ghatnekar A
Year: 2013
Journal: Am J Pathol
Title: Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension.
Volume: 182
Issue: 6
Pages: 2391-406
Publication
First Author: González-Prieto M
Year: 2021
Journal: Glia
Title: Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline.
Volume: 69
Issue: 1
Pages: 73-90
Publication  
First Author: Lonskaya I
Year: 2015
Journal: Neuroscience
Title: Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models.
Volume: 304
Pages: 316-27
Publication
First Author: Lou ZY
Year: 2011
Journal: Mol Immunol
Title: Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis.
Volume: 49
Issue: 3
Pages: 453-61
Publication
First Author: Borsig L
Year: 2014
Journal: Oncogene
Title: Inflammatory chemokines and metastasis--tracing the accessory.
Volume: 33
Issue: 25
Pages: 3217-24
Publication
First Author: Koenen A
Year: 2017
Journal: PLoS One
Title: The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
Volume: 12
Issue: 3
Pages: e0173486
Publication
First Author: Ishida Y
Year: 2020
Journal: J Invest Dermatol
Title: Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis.
Volume: 140
Issue: 10
Pages: 1951-1961.e6
Publication
First Author: Celesti G
Year: 2013
Journal: Br J Cancer
Title: Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis.
Volume: 109
Issue: 9
Pages: 2424-33
Publication  
First Author: Barbosa-Silva MC
Year: 2022
Journal: Brain Behav Immun
Title: Mice lacking 5-lipoxygenase display motor deficits associated with cortical and hippocampal synapse abnormalities.
Volume: 100
Pages: 183-193
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Publication
First Author: Zhang D
Year: 2008
Journal: J Biol Chem
Title: G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.
Volume: 283
Issue: 13
Pages: 8580-90
Publication
First Author: Ebrahimian T
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice.
Volume: 35
Issue: 5
Pages: 1190-7
Publication
First Author: Doddapattar P
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Cell-Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice.
Volume: 38
Issue: 3
Pages: 520-528
Publication  
First Author: Zhang J
Year: 2018
Journal: Transl Neurodegener
Title: Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model.
Volume: 7
Pages: 35
Publication
First Author: Castro-Sánchez S
Year: 2018
Journal: Glia
Title: Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.
Volume: 66
Issue: 8
Pages: 1752-1762
Publication
First Author: Erreni M
Year: 2016
Journal: J Immunol
Title: The Fractalkine-Receptor Axis Improves Human Colorectal Cancer Prognosis by Limiting Tumor Metastatic Dissemination.
Volume: 196
Issue: 2
Pages: 902-14
Publication
First Author: Fang X
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Effects of n-3PUFAs on autophagy and inflammation of hypothalamus and body weight in mice.
Volume: 501
Issue: 4
Pages: 927-932
Publication  
First Author: García-García E
Year: 2023
Journal: Neurobiol Dis
Title: VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis.
Volume: 187
Pages: 106292
Publication
First Author: Reed JR
Year: 2012
Journal: PLoS One
Title: Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner.
Volume: 7
Issue: 9
Pages: e45877
Publication
First Author: Zhao L
Year: 2009
Journal: Exp Eye Res
Title: Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy.
Volume: 88
Issue: 6
Pages: 1004-13
Publication  
First Author: Wang X
Year: 2023
Journal: Front Cell Neurosci
Title: CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting.
Volume: 17
Pages: 1189348
Publication
First Author: Ding XM
Year: 2016
Journal: Int J Mol Med
Title: Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice.
Volume: 37
Issue: 3
Pages: 703-15
Publication
First Author: Ensan S
Year: 2016
Journal: Nat Immunol
Title: Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth.
Volume: 17
Issue: 2
Pages: 159-68
Publication
First Author: Gerfen CR
Year: 2013
Journal: Neuron
Title: GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits.
Volume: 80
Issue: 6
Pages: 1368-83
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data