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Search results 401 to 468 out of 468 for Cyp51

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:6842968
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-05
Strength: Weak
Sex: Female
Emaps: EMAPS:1796222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6845039
Age: embryonic day 14.5
Image: 1Ab
Note: Expression is in the somatic cells around the cysts.
Specimen Label: 1Ab
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5309467
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422835
Age: embryonic day 14.5
Image: MH2907; Specimen C3979
Note: Expression was strong in the skull (base and vault).
Specimen Label: MH2907; Specimen C3979
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4416687
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824180
Age: embryonic day 14.5
Image: euxassay_010645_12
Specimen Label: euxassay_010645_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4416687
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824180
Age: embryonic day 14.5
Image: euxassay_010645_13
Specimen Label: euxassay_010645_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4416687
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824180
Age: embryonic day 14.5
Image: euxassay_010645_16
Specimen Label: euxassay_010645_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
Probe: MGI:5309467
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422835
Age: embryonic day 14.5
Image: MH2907; Specimen C3979
Note: Expression was strong in whisker follicle.
Specimen Label: MH2907; Specimen C3979
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6842968
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-05
Strength: Present
Sex: Female
Emaps: EMAPS:3792826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6845039
Age: embryonic day 19.5
Image: 1Ae
Note: Expression is in the oocyte cytoplasm of the primordial follicles in the medulla.
Specimen Label: 1Ae
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:6842968
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-05
Strength: Present
Sex: Female
Emaps: EMAPS:3792726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6845039
Age: embryonic day 19.5
Image: 1Ae
Note: Expression is in the nucleus of oocytes within the cysts in the cortex of the ovary.
Specimen Label: 1Ae
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6441933
Assay Type: Immunohistochemistry
Annotation Date: 2020-07-20
Strength: Absent
Sex: Female
Emaps: EMAPS:3803228
Stage: TS28
Assay Id: MGI:6442555
Age: postnatal adult
Specimen Label: 2b
Detected: false
Specimen Num: 2
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
8619637 | J:32721
First Author: Strömstedt M
Year: 1996
Journal: Arch Biochem Biophys
Title: The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.
Volume: 329
Issue: 1
Pages: 73-81
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Publication
24353279 | J:208360
First Author: Zhu J
Year: 2014
Journal: J Lipid Res
Title: FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
Volume: 55
Issue: 3
Pages: 431-42
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HT Experiment
E-GEOD-58271 | Effect of dietary fat and cholesterol on hepatic gene expression of liver-specific Cyp51 knockout male and female mice
Series Id: GSE58271
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
8809088 | J:35548
First Author: Rozman D
Year: 1996
Journal: Arch Biochem Biophys
Title: The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family.
Volume: 333
Issue: 2
Pages: 466-74
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Publication
10653123 | -
First Author: Debeljak N
Year: 2000
Journal: Pflugers Arch
Title: Molecular cloning and partial characterisation of the mouse Cyp51 cDNA.
Volume: 439
Issue: 3 Suppl
Pages: R7-8
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Protein
Q8K0C4
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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GO Term
GO:0008398 | sterol 14-demethylase activity
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Publication
19005074 | J:142399
First Author: Tamboli IY
Year: 2008
Journal: J Neurosci
Title: Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
Volume: 28
Issue: 46
Pages: 12097-106
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Publication
33330474 | J:341883
 
First Author: Gatticchi L
Year: 2020
Journal: Front Cell Dev Biol
Title: Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics.
Volume: 8
Pages: 592573
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Publication
30566610 | J:357025
First Author: Shu L
Year: 2019
Journal: Endocrinology
Title: Prenatal Bisphenol A Exposure in Mice Induces Multitissue Multiomics Disruptions Linking to Cardiometabolic Disorders.
Volume: 160
Issue: 2
Pages: 409-429
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Publication
8845856 | J:32996
First Author: Nelson DR
Year: 1996
Journal: Pharmacogenetics
Title: P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
Volume: 6
Issue: 1
Pages: 1-42
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Publication
8975714 | J:37709
First Author: Rozman D
Year: 1996
Journal: Genomics
Title: Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes.
Volume: 38
Issue: 3
Pages: 371-81
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Publication
23486184 | J:304036
First Author: Leamy LJ
Year: 2013
Journal: Bone
Title: Quantitative trait loci for bone mineral density and femoral morphology in an advanced intercross population of mice.
Volume: 55
Issue: 1
Pages: 222-9
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Publication
8051072 | -
First Author: Hara S
Year: 1994
Journal: J Biol Chem
Title: Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells.
Volume: 269
Issue: 31
Pages: 19897-903
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Protein Domain
IPR002403 | Cyt_P450_E_grp-IV
Type: Family
Description: Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea (Streptomyces erythraeus).Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so a single atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium [], which has haem and flavin domains.Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) - a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) - NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [, , ]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I). The divergence of the cytochrome P450 superfamily into B- and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.This entry represents class E cytochrome P450 proteins that fall into sequence cluster group IV. Group IV comprises the CYP7 (cholesterol 7-alpha-hydroxylase) and CYP51 (lanosterol 14-alpha-demethylase) families, which show significant sequence similarity even though there is no apparent functional resemblance. The CYP8 (prostacyclin synthase) family also falls into this group, and shows high sequence similarity to CYP7 members []. Proteins required in the biosynthesis of fungal mycotoxins are also included: cytochrome P450 monooxygenases gloO and gloP from Glarea lozoyensis are required for synthesis of lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase [].
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Publication
27705900 | -
First Author: Hüttel W
Year: 2017
Journal: Z Naturforsch C
Title: Structural diversity in echinocandin biosynthesis: the impact of oxidation steps and approaches toward an evolutionary explanation.
Volume: 72
Issue: 1-2
Pages: 1-20
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Protein
Q9JKJ9
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
O88962
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
Q60991
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
O35074
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q8BXC0
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
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Protein
Q544S6
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
Q3USU4
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q3TA21
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q7TSX2
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
Q05CS3
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q8CHV7
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
A0A0R4J0N7
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
A0A3B2W4C8
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q64505
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q811W2
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
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Protein
O55127
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Protein
G3UW78
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
A0A0R4J061
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Protein
A0A0N4SV88
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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Protein
D3YTX0
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
A0A1D5RLD0
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Protein
A0A0N4SUV4
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
A0A1C7CYU8
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
A1L3S6
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Publication
16042601 | -
First Author: McLean KJ
Year: 2005
Journal: Biochem Soc Trans
Title: Biodiversity of cytochrome P450 redox systems.
Volume: 33
Issue: Pt 4
Pages: 796-801
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Publication
17023115 | -
First Author: Munro AW
Year: 2007
Journal: Biochim Biophys Acta
Title: Cytochrome P450--redox partner fusion enzymes.
Volume: 1770
Issue: 3
Pages: 345-59
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Publication
15128046 | J:87417
First Author: Nelson DR
Year: 2004
Journal: Pharmacogenetics
Title: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Volume: 14
Issue: 1
Pages: 1-18
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Publication
8637843 | -
First Author: Degtyarenko KN
Year: 1995
Journal: Protein Eng
Title: Structural domains of P450-containing monooxygenase systems.
Volume: 8
Issue: 8
Pages: 737-47
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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