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Search results 401 to 440 out of 440 for Dad1

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Type Details Score
Publication
15640796 | -
First Author: Miranda JJ
Year: 2005
Journal: Nat Struct Mol Biol
Title: The yeast DASH complex forms closed rings on microtubules.
Volume: 12
Issue: 2
Pages: 138-43
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Publication
15664196 | -
First Author: Westermann S
Year: 2005
Journal: Mol Cell
Title: Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.
Volume: 17
Issue: 2
Pages: 277-90
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Publication
11799062 | -
First Author: Li Y
Year: 2002
Journal: Genes Dev
Title: The mitotic spindle is required for loading of the DASH complex onto the kinetochore.
Volume: 16
Issue: 2
Pages: 183-97
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Allele
Dad1<tm1Wnt> | MGI:2183460
Name: defender against cell death 1; targeted mutation 1, Astar Winoto
Allele Type: Targeted
Attribute String: Modified regulatory region, Null/knockout
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Genotype
Genotype
Symbol: Dad1/Dad1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dad1/Dad1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR013966 | Spc34
Type: Family
Description: The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis []. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [, ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [].
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Protein Domain
IPR013964 | DASH_Ask1
Type: Family
Description: The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis []. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [, ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [].
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Protein Domain
IPR013962 | DASH_Dam1
Type: Family
Description: The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis []. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [, ]. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [].
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Protein Domain
IPR025213 | Sim4_Fta2
Type: Family
Description: Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1 [].This entry represents Fta2.
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Protein Domain
IPR025207 | Sim4_Fta4
Type: Family
Description: Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1 [].This entry represents Fta4.
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Genotype
Genotype
Symbol: Dad1/Dad1<+> Tcrd/Tcrd<+>
Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)
Zygosity: cx
Has Mutant Allele: true
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Publication
32853367 | J:296383
First Author: Zhao H
Year: 2020
Journal: Nucleic Acids Res
Title: A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.
Volume: 48
Issue: 17
Pages: 9621-9636
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Publication
9097408 | J:39946
First Author: Halberda JP
Year: 1997
Journal: Synapse
Title: DAD1- and DAD2-like agonist effects on motor activity of C57 mice: differences compared to rats.
Volume: 26
Issue: 1
Pages: 81-92
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Publication
17617601 | J:149398
First Author: Gomos-Klein J
Year: 2007
Journal: J Immunol
Title: CTCF-independent, but not CTCF-dependent, elements significantly contribute to TCR-alpha locus control region activity.
Volume: 179
Issue: 2
Pages: 1088-95
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Publication
21124935 | J:167312
First Author: Knirr S
Year: 2010
Journal: PLoS One
Title: Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.
Volume: 5
Issue: 11
Pages: e15527
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Protein
Q8K015
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
Q9CZW2
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
B8JK51
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
A0A1D5RM33
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
Q8BI07
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
B8JK52
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Publication
12589047 | -
First Author: Pot I
Year: 2003
Journal: Mol Biol Cell
Title: Chl4p and iml3p are two new members of the budding yeast outer kinetochore.
Volume: 14
Issue: 2
Pages: 460-76
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Publication
19543270 | -
First Author: Carroll CW
Year: 2009
Journal: Nat Cell Biol
Title: Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.
Volume: 11
Issue: 7
Pages: 896-902
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Publication
9339342 | -
First Author: Roy N
Year: 1997
Journal: Curr Genet
Title: The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome.
Volume: 32
Issue: 3
Pages: 182-9
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Publication
16855021 | -
First Author: Kerres A
Year: 2006
Journal: Mol Biol Cell
Title: Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.
Volume: 17
Issue: 10
Pages: 4167-78
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Publication
21445296 | -
First Author: Shiroiwa Y
Year: 2011
Journal: PLoS One
Title: Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.
Volume: 6
Issue: 3
Pages: e17761
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Publication
12242294 | -
First Author: Jin QW
Year: 2002
Journal: Mol Cell Biol
Title: The mal2p protein is an essential component of the fission yeast centromere.
Volume: 22
Issue: 20
Pages: 7168-83
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Protein Domain
IPR018464 | CENP-O
Type: Family
Description: This entry represents centromere protein O (CENP-O) and its homologues in yeasts, Mcm21 and Mal2. In humans, centromere protein O (CENP-O) is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation []. CENP-O mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. CENP-O modulates the kinetochore-bound levels of NDC80 complex []. It may be involved in incorporation of newly synthesized CENP-A into centromeres via its interaction with the CENPA-NAC complex [].In Saccharomyces cerevisiae, Mcm21 is a component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p), which links kinetochore subunits with subunits bound to microtubules during kinetochore assembly [, ]. In Schizosaccharomyces pombe, Mal2 is a component of the Sim4 complex, which is required for loading the DASH complex onto the kinetochore via interaction with Dad1 []. It plays a role in the maintenance of core chromatin structure and kinetochore function [].
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Protein Domain
IPR007902 | Chl4/mis15/CENP-N
Type: Family
Description: This family includes Chl4 from budding yeasts, mis15 from fission yeasts and centromere protein N (CENP-N) from animals. In Saccharomyces cerevisiae, Chl4 is an outer kinetochore structural component required for chromosome stability []. Chl4 is a component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p []. It is required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation []. In Schizosaccharomyces pombe, mis15 is a subunit of the Sim4 complex, which is required for loading the DASH complex onto the kinetochore via interaction with dad1 []. It is required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialised chromatin at the centromere []. In humans, centromere protein N (CENP-N) is a component of the CENPA-NAC (nucleosome-associated) complex, which plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation []. CENP-N localises exclusively in the kinetochore domain of centromeres []. It is required for chromosome congression and efficiently align the chromosomes on a metaphase plate [].
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Publication
35082160 | J:322743
First Author: Rodríguez-Caparrós A
Year: 2022
Journal: J Immunol
Title: Differently Regulated Gene-Specific Activity of Enhancers Located at the Boundary of Subtopologically Associated Domains: TCRα Enhancer.
Volume: 208
Issue: 4
Pages: 910-928
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Publication
16716197 | -
First Author: Izuta H
Year: 2006
Journal: Genes Cells
Title: Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.
Volume: 11
Issue: 6
Pages: 673-84
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Publication
18007590 | -
First Author: McClelland SE
Year: 2007
Journal: EMBO J
Title: The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity.
Volume: 26
Issue: 24
Pages: 5033-47
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Publication
16079914 | -
First Author: Liu X
Year: 2005
Journal: EMBO J
Title: Molecular analysis of kinetochore architecture in fission yeast.
Volume: 24
Issue: 16
Pages: 2919-30
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Publication
14633972 | -
First Author: De Wulf P
Year: 2003
Journal: Genes Dev
Title: Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.
Volume: 17
Issue: 23
Pages: 2902-21
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Publication
22561346 | -
First Author: Schleiffer A
Year: 2012
Journal: Nat Cell Biol
Title: CENP-T proteins are conserved centromere receptors of the Ndc80 complex.
Volume: 14
Issue: 6
Pages: 604-13
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Publication
16622419 | -
First Author: Foltz DR
Year: 2006
Journal: Nat Cell Biol
Title: The human CENP-A centromeric nucleosome-associated complex.
Volume: 8
Issue: 5
Pages: 458-69
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Publication
16622420 | -
First Author: Okada M
Year: 2006
Journal: Nat Cell Biol
Title: The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.
Volume: 8
Issue: 5
Pages: 446-57
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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