|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 451 out of 451 for Ddr2

<< First    < Previous  |  Next >    Last >>
0.027s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
HT Experiment
GSE212281 | Single-cell RNA sequencing of Ddr2 slie/slie and littermate control
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
37527178 | J:343638
First Author: Schab AM
Year: 2023
Journal: Mol Cancer Res
Title: Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins.
Volume: 21
Issue: 11
Pages: 1234-1248
•
•
•
•
•
Publication
34477203 | J:318713
 
First Author: Barcus CE
Year: 2021
Journal: J Cell Sci
Title: Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis.
Volume: 134
Issue: 19
•
•
•
•
•
Publication
22328973 | -
First Author: Hammerman PS
Year: 2011
Journal: Cancer Discov
Title: Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
Volume: 1
Issue: 1
Pages: 78-89
•
•
•
•
•
Allele
Ddr2<em2Smoc> | MGI:7289302
Name: discoidin domain receptor family, member 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6428525 | C57BL/6JSmoc-Ddr2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Allele
Ddr2<em1Smoc> | MGI:7289301
Name: discoidin domain receptor family, member 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Tg(tetO-DDR2)#Yeli | MGI:6270427
Name: transgene insertion, Yefu Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
•
•
•
•
•
DO Term
DOID:0112196 | spondylometaepiphyseal dysplasia, short limb-hand type
•
•
•
•
•
Allele
Ddr2<slie> | MGI:3640081
 
Name: discoidin domain receptor family, member 2; smallie
Allele Type: Spontaneous
•
•
•
•
•
Strain
MGI:6475110 | C57BL/6JSmoc-Ddr2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:7781344 | C57BL/6JSmoc-Ddr2<em1Smoc> Scx<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
•
•
•
•
•
Publication
21855682 | J:176308
First Author: Xu L
Year: 2011
Journal: Am J Pathol
Title: Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model.
Volume: 179
Issue: 3
Pages: 1338-46
•
•
•
•
•
Strain
MGI:3785261 | BKS(HRS)-Ddr2<slie>/JngJ
Attribute String: spontaneous mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Ddr2/Ddr2
Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpe/LtJng
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Ddr2/Ddr2
Background: involves: C57BLKS/J * HRS/J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
12065315 | J:109760
First Author: Hou G
Year: 2002
Journal: Circ Res
Title: Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression.
Volume: 90
Issue: 11
Pages: 1147-9
•
•
•
•
•
Publication
9659900 | -
First Author: Shrivastava A
Year: 1997
Journal: Mol Cell
Title: An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.
Volume: 1
Issue: 1
Pages: 25-34
•
•
•
•
•
Publication
17665456 | -
First Author: Xu L
Year: 2007
Journal: Arthritis Rheum
Title: Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis.
Volume: 56
Issue: 8
Pages: 2663-73
•
•
•
•
•
Publication
24781958 | -
First Author: Márquez J
Year: 2014
Journal: Histol Histopathol
Title: Role of discoidin domain receptor 2 in wound healing.
Volume: 29
Issue: 11
Pages: 1355-64
•
•
•
•
•
Publication
20884741 | -
First Author: Roberts ME
Year: 2011
Journal: Eur Respir J
Title: Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production.
Volume: 37
Issue: 6
Pages: 1482-93
•
•
•
•
•
Publication
16234985 | -
First Author: Ram R
Year: 2006
Journal: J Neurooncol
Title: Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.
Volume: 76
Issue: 3
Pages: 239-48
•
•
•
•
•
Publication
24768818 | -
First Author: Canning P
Year: 2014
Journal: J Mol Biol
Title: Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
Volume: 426
Issue: 13
Pages: 2457-70
•
•
•
•
•
Protein Domain
IPR034299 | DDR1/DDR2
Type: Family
Description: The discoidin domain-containing receptor (DDR) family includes DDR1 and DDR2. DDR family members are receptor tyrosine kinases (RTKs) whose activating ligands are various collagens []. The proteins contain an extracellular discoidin domain, which binds various collagen proteins, and an intracellular tyrosine kinase domain.DDR2 may have a role in wound healing; DDR2 signalling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing []. Increased expression of DDR2 may also be important in the pathogenesis of osteoarthritis [], and there is evidence that the receptor could be implicated in certain forms of cancer - mutations in the DDR2 kinase gene have been detected in ~ 4% of squamous cell lung cancers [].Epithelial discoidin domain-containing receptor 1 (also known as DDR1) is involved in smooth muscle cell migration and matrix metalloproteinase expression []. It is responsible for maintaining the normal structure of skin and kidney epithelia []. The receptor may play a critical role in inducing tumour cell adhesion and invasion []. Itsstructure has been solved [].
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Comp-tTA)#Yeli/? Tg(tetO-DDR2)#Yeli/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
9659899 | J:47333
First Author: Vogel W
Year: 1997
Journal: Mol Cell
Title: The discoidin domain receptor tyrosine kinases are activated by collagen.
Volume: 1
Issue: 1
Pages: 13-23
•
•
•
•
•
Protein
G3UXE5
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: true
•
•
•
•
•
Protein
Q6NZR6
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
•
•
•
•
•
Protein
B0V2H8
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
•
•
•
•
•
Protein
D6RII6
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
•
•
•
•
•
Publication
22019896 | J:180270
First Author: Olaso E
Year: 2011
Journal: Am J Pathol
Title: Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages.
Volume: 179
Issue: 6
Pages: 2894-904
•
•
•
•
•
Publication
24787381 | J:217038
First Author: Yan Z
Year: 2014
Journal: Biochim Biophys Acta
Title: Discoidin domain receptor 2 facilitates prostate cancer bone metastasis via regulating parathyroid hormone-related protein.
Volume: 1842
Issue: 9
Pages: 1350-63
•
•
•
•
•
Publication
25130389 | J:216173
First Author: Ren T
Year: 2014
Journal: J Pathol
Title: Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia.
Volume: 234
Issue: 4
Pages: 526-37
•
•
•
•
•
Protein
Q62371
Organism: Mus musculus/domesticus
Length: 854  
Fragment?: false
•
•
•
•
•
Protein
Q03146
Organism: Mus musculus/domesticus
Length: 911  
Fragment?: false
•
•
•
•
•
Protein
Q544T2
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
•
•
•
•
•
Protein
Q05BN5
Organism: Mus musculus/domesticus
Length: 891  
Fragment?: true
•
•
•
•
•
Protein
O35407
Organism: Mus musculus/domesticus
Length: 911  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom