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Search results 401 to 500 out of 540 for Disc1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:6504887
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-04
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3525628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6504894
Age: postnatal adult
Note: Expression particularly high in layers II/III and V/VI. Expression colocalized with Map2 indicating expression in neurons,.
Specimen Label: 3a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3689097
Age: embryonic day 16.0
Specimen Label: 1 Antisense E16
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3689097
Age: postnatal day 1
Specimen Label: 1 Antisense P1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3689097
Age: postnatal day 21
Specimen Label: 1 Antisense P21
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3689097
Age: postnatal day 21
Specimen Label: 4B
Detected: true
Specimen Num: 27
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3689097
Age: postnatal day 21
Specimen Label: 4C
Detected: true
Specimen Num: 28
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GXD Expression
GXD Expression
Probe: MGI:6860640
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6860643
Age: postnatal adult
Image: S5
Note: Expression is in astrocytes.
Specimen Label: S5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Patchy
Stage: TS28
Assay Id: MGI:3689097
Age: postnatal day 21
Note: Expression was detected in scattered cells of the granule cell layer of the cerebellum.
Specimen Label: 4H
Detected: true
Specimen Num: 33
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3689097
Age: postnatal day 1
Specimen Label: 6G
Detected: true
Specimen Num: 45
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3689097
Age: postnatal day 21
Specimen Label: 6H
Detected: true
Specimen Num: 46
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GXD Expression
GXD Expression
   
Probe: MGI:3689076
Assay Type: RNA in situ
Annotation Date: 2006-11-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3689097
Age: postnatal day 21
Specimen Label: 6I
Detected: true
Specimen Num: 47
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GXD Expression
GXD Expression
   
Probe: MGI:6504887
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6504893
Age: postnatal adult
Specimen Label: 2g
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:6504887
Assay Type: Immunohistochemistry
Annotation Date: 2021-02-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Single cells
Stage: TS28
Assay Id: MGI:6504893
Age: postnatal adult
Note: Some expression in other small cells in molecular layer and granule layer.
Specimen Label: 2h
Detected: true
Specimen Num: 11
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Publication
- | J:80968
   
First Author: Taylor MS
Year: 2002
Journal: GenBank Submission
Title: Mus musculus partial mRNA for disrupted in schizophrenia 1 (Disc1 gene)
Pages: AJ506179
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Publication
- | J:80969
   
First Author: Taylor MS
Year: 2002
Journal: GenBank Submission
Title: Evolutionary constraints on the Disrupted in Schizophrenia locus
Pages: AJ506180
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Publication
12506198 | J:81177
First Author: Ozeki Y
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
Volume: 100
Issue: 1
Pages: 289-94
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Publication
21632933 | J:173379
First Author: Wang Y
Year: 2011
Journal: J Neurosci
Title: Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.
Volume: 31
Issue: 22
Pages: 8109-22
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Publication
37294752 | J:338039
First Author: Obi-Nagata K
Year: 2023
Journal: Sci Adv
Title: Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.
Volume: 9
Issue: 23
Pages: eade5973
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Publication
27515175 | J:248584
First Author: Baan M
Year: 2016
Journal: Transgenic Res
Title: Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice.
Volume: 25
Issue: 6
Pages: 847-854
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Publication
38642554 | J:348662
     
First Author: Zhou X
Year: 2024
Journal: Neuron
Title: Astrocyte-mediated regulation of BLA(WFS1) neurons alleviates risk-assessment deficits in DISC1-N mice.
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Publication
22153077 | J:190270
First Author: Guettler S
Year: 2011
Journal: Cell
Title: Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
Volume: 147
Issue: 6
Pages: 1340-54
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Publication
23796137 | J:216563
First Author: Cole AR
Year: 2013
Journal: FEBS J
Title: Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia.
Volume: 280
Issue: 21
Pages: 5213-27
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Publication
36002185 | J:352634
 
First Author: Potluri HK
Year: 2022
Journal: J Immunother Cancer
Title: Antitumor efficacy of (90)Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors.
Volume: 10
Issue: 8
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Publication
23826333 | J:203731
First Author: Arguello A
Year: 2013
Journal: PLoS One
Title: Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons.
Volume: 8
Issue: 6
Pages: e67679
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Publication
22124272 | J:217297
First Author: Cheah PS
Year: 2012
Journal: Mol Psychiatry
Title: Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
Volume: 17
Issue: 4
Pages: 451-66
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Publication
29330412 | J:260136
First Author: Cipriani C
Year: 2018
Journal: Sci Rep
Title: High expression of Endogenous Retroviruses from intrauterine life to adulthood in two mouse models of Autism Spectrum Disorders.
Volume: 8
Issue: 1
Pages: 629
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Publication
22031837 | J:179756
First Author: Mühlhans J
Year: 2011
Journal: PLoS One
Title: The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors.
Volume: 6
Issue: 10
Pages: e26496
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Allele
Disc1<em1Kwt> | MGI:6833988
Name: disrupted in schizophrenia 1; endonuclease-mediated mutation 1, Kazuo Kuwata
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Publication
18055216 | J:132688
First Author: Wang Q
Year: 2008
Journal: Mol Cell Neurosci
Title: How has DISC1 enabled drug discovery?
Volume: 37
Issue: 2
Pages: 187-95
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Publication
21315744 | J:183592
First Author: Pogorelov VM
Year: 2012
Journal: Neuropharmacology
Title: Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model.
Volume: 62
Issue: 3
Pages: 1242-51
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Publication
24481677 | J:207476
First Author: Shimizu S
Year: 2014
Journal: Glia
Title: DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation.
Volume: 62
Issue: 5
Pages: 709-24
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Allele
Tg(tetO-DISC1*)70Plet | MGI:6287122
Name: transgene insertion 70, Mikhail Pletnikov
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inducible, Inserted expressed sequence
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Publication
17675407 | J:124683
First Author: Hikida T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Volume: 104
Issue: 36
Pages: 14501-6
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Allele
Tg(tetO-DISC1*)1001Plet | MGI:3838645
Name: transgene insertion 1001, Mikhail Pletnikov
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inducible, Inserted expressed sequence
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Publication
22832659 | J:222364
 
First Author: Kivimäe S
Year: 2011
Journal: Transl Psychiatry
Title: Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.
Volume: 1
Pages: e43
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Publication
29103808 | J:256159
First Author: Ye F
Year: 2017
Journal: Neuron
Title: DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.
Volume: 96
Issue: 5
Pages: 1041-1054.e5
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Publication
21835207 | J:176068
First Author: Nagai T
Year: 2011
Journal: Behav Brain Res
Title: Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.
Volume: 225
Issue: 1
Pages: 305-10
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Publication
17848917 | J:146881
First Author: Pletnikov MV
Year: 2008
Journal: Mol Psychiatry
Title: Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
Volume: 13
Issue: 2
Pages: 173-86, 115
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Publication
29156684 | J:255536
First Author: Deng D
Year: 2017
Journal: Oncotarget
Title: A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development.
Volume: 8
Issue: 49
Pages: 84798-84817
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Publication
20048751 | J:273095
First Author: Ayhan Y
Year: 2011
Journal: Mol Psychiatry
Title: Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.
Volume: 16
Issue: 3
Pages: 293-306
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Publication
23716713 | J:273094
First Author: Abazyan B
Year: 2014
Journal: Schizophr Bull
Title: Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study.
Volume: 40
Issue: 3
Pages: 575-84
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Protein
A2AST1
Organism: Mus musculus/domesticus
Length: 1451  
Fragment?: false
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-DISC1*)1001Plet/?
Background: involves: C57BL/6 * CBA * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(tetO-DISC1*)70Plet/? Tg(Camk2a-tTA)1Mmay/?
Background: involves: C57BL/6 * CBA * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
22072671 | J:177836
First Author: Carlisle HJ
Year: 2011
Journal: J Neurosci
Title: Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
Volume: 31
Issue: 45
Pages: 16194-207
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Allele
Disc1<Rgsc1390> | MGI:3707421
 
Name: disrupted in schizophrenia 1; RIKEN Genomic Sciences Center (GSC), 1390
Allele Type: Chemically induced (ENU)
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Allele
Disc1<Rgsc1393> | MGI:3707419
 
Name: disrupted in schizophrenia 1; RIKEN Genomic Sciences Center (GSC), 1393
Allele Type: Chemically induced (ENU)
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Transgene
MGI:3838644 | Tg(tetO-DISC1*)1001Plet
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:6287120 | Tg(tetO-DISC1*)70Plet
Type: transgene
Organism: mouse, laboratory
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DO Term
DOID:0070085 | schizophrenia 9
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Strain
MGI:6353895 | D2JJcl;B6JJcl-Disc1<Rgsc01390>/Rbrc
Attribute String: mutant strain, spontaneous mutation
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Strain
MGI:6146786 | B6(D2)-Disc1<Rgsc1390>/RodRbrc
Attribute String: chemically induced mutation, mutant strain
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Strain
MGI:3708178 | B6.Cg-Disc1<Rgsc1390>
Attribute String: mutant strain, congenic, chemically induced mutation
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Genotype
Genotype
Symbol: Disc1/Disc1
Background: B6.Cg-Disc1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Disc1/Disc1<+>
Background: B6.Cg-Disc1
Zygosity: ht
Has Mutant Allele: true
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Publication
12812986 | -
First Author: Morris JA
Year: 2003
Journal: Hum Mol Genet
Title: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Volume: 12
Issue: 13
Pages: 1591-608
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Strain
MGI:6146787 | B6(D2)-Disc1<Rgsc1393>/RodRbrc
Attribute String: chemically induced mutation, mutant strain
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Strain
MGI:3708175 | B6.Cg-Disc1<Rgsc1393>
Attribute String: mutant strain, congenic, chemically induced mutation
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Strain
MGI:6353897 | D2JJcl;B6JJcl-Disc1<Rgsc01393>/Rbrc
Attribute String: mutant strain, spontaneous mutation
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Genotype
Genotype
Symbol: Disc1/Disc1
Background: B6.Cg-Disc1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Disc1/Disc1<+>
Background: B6.Cg-Disc1
Zygosity: ht
Has Mutant Allele: true
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Publication
15797709 | -
First Author: Brandon NJ
Year: 2005
Journal: Mol Cell Neurosci
Title: Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.
Volume: 28
Issue: 4
Pages: 613-24
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Publication
32493513 | -
First Author: Su P
Year: 2020
Journal: Mol Brain
Title: The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity.
Volume: 13
Issue: 1
Pages: 87
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Publication
25735038 | J:269482
   
First Author: Sauer JF
Year: 2015
Journal: Elife
Title: Impaired fast-spiking interneuron function in a genetic mouse model of depression.
Volume: 4
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Publication
31444471 | -
     
First Author: Wang X
Year: 2019
Journal: Mol Psychiatry
Title: Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.
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Strain
MGI:3708177 | B6.Cg-Disc1<Rgsc1390>/Disc1<Rgsc1393>
Attribute String: chemically induced mutation, congenic, mutant strain
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Genotype
Genotype
Symbol: Disc1/Disc1
Background: B6.Cg-Disc1/Disc1
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(Disc1/EGFP)M19Sshe | MGI:5428215
Name: transgene insertion M19, Sanbing Shen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Disc1<tm1Asaw> | MGI:5910355
Name: disrupted in schizophrenia 1; targeted mutation 1, Akira Sawa
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
26206934 | J:226037
First Author: Greenhill SD
Year: 2015
Journal: Science
Title: NEURODEVELOPMENT. Adult cortical plasticity depends on an early postnatal critical period.
Volume: 349
Issue: 6246
Pages: 424-7
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Allele
Disc1<tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho> | MGI:5648808
Name: disrupted in schizophrenia 1; targeted mutation 1, Xianjin Zhou
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout
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Allele
Tg(tetO-DISC1*)1302BPlet | MGI:6287123
Name: transgene insertion 1302B, Mikhail Pletnikov
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Disc1/EGFP)M19Sshe/?
Background: involves: C57BL/6JCrl * CBA/CaCrl
Zygosity: ot
Has Mutant Allele: true
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Publication
30911039 | J:277089
First Author: Sullivan CR
Year: 2019
Journal: Sci Rep
Title: Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia.
Volume: 9
Issue: 1
Pages: 5087
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Publication
38320995 | J:352329
First Author: Wu Q
Year: 2024
Journal: Transl Psychiatry
Title: Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia.
Volume: 14
Issue: 1
Pages: 79
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Allele
Tg(Camk2a-DISC1)10Asaw | MGI:3758077
Name: transgene insertion 10, Akira Sawa
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
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Strain
MGI:3758638 | C57BL/6-Tg(Camk2a-DISC1)10Asaw
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:3840612 | STOCK Tg(tetO-DISC1*)1001Plet/J
Attribute String: mutant stock, transgenic
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