|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 500 out of 512 for Dscam

<< First    < Previous  |  Next >    Last >>
0.035s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:2149733
Assay Type: Immunohistochemistry
Annotation Date: 2019-02-25
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1698921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6279949
Age: embryonic day 13.5
Image: 4B
Note: Authors report ectopias occurred very rarely in Dscam mutant embryos.
Specimen Label: 4B
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2149733
Assay Type: Immunohistochemistry
Annotation Date: 2019-02-25
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1698921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6279959
Age: embryonic day 13.5
Image: 4B
Note: Authors report ectopias occurred very rarely in Dscam mutant embryos.
Specimen Label: 4B
Specimen Num: 8
•
•
•
•
•
Publication
18216854 | -
First Author: Yamagata M
Year: 2008
Journal: Nature
Title: Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina.
Volume: 451
Issue: 7177
Pages: 465-9
•
•
•
•
•
Publication
19171779 | -
First Author: Schmucker D
Year: 2009
Journal: Genes Dev
Title: Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes.
Volume: 23
Issue: 2
Pages: 147-56
•
•
•
•
•
Publication
18403399 | -
First Author: Brites D
Year: 2008
Journal: Mol Biol Evol
Title: The Dscam homologue of the crustacean Daphnia is diversified by alternative splicing like in insects.
Volume: 25
Issue: 7
Pages: 1429-39
•
•
•
•
•
Protein
Q9ERC8
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: false
•
•
•
•
•
Protein
Q4VA61
Organism: Mus musculus/domesticus
Length: 2053  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:2150309 | Dscaml1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Allele
Tg(Myh6-Dscam)26Rsd | MGI:6160092
Name: transgene insertion 26, Michael G Rosenfeld
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:6160095 | B6N.Cg-Tg(Myh6-Dscam)26Rsd/J
Attribute String: congenic, mutant strain, transgenic
•
•
•
•
•
Publication
11453658 | J:70662
First Author: Agarwala KL
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion.
Volume: 285
Issue: 3
Pages: 760-72
•
•
•
•
•
Publication
24084194 | J:207869
 
First Author: Cui S
Year: 2013
Journal: Neurosci Lett
Title: Tyrosine phosphorylation is essential for DSCAML1 to promote dendrite arborization of mouse cortical neurons.
Volume: 555
Pages: 193-7
•
•
•
•
•
Protein Domain
IPR033029 | DSCAML1
Type: Family
Description: DSCAM and DSCAM-like (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance [, , ]. DSCAML1 is a paralogue of DSCAM that has been identified in vertebrates [].
•
•
•
•
•
Publication
26930660 | J:342561
First Author: Li S
Year: 2016
Journal: PLoS One
Title: Morphological Diversity of the Rod Spherule: A Study of Serially Reconstructed Electron Micrographs.
Volume: 11
Issue: 3
Pages: e0150024
•
•
•
•
•
Allele
Tg(CAG-RFP*,-Dscam,-EGFP)1Pfu | MGI:5584100
Name: transgene insertion 1, Peter Fuerst
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
Strain
MGI:5584099 | STOCK Tg(CAG-RFP*,-Dscam,-EGFP)1Pfu/J
Attribute String: mutant stock, transgenic
•
•
•
•
•
Publication
25175881 | -
First Author: Lah GJ
Year: 2014
Journal: Neuron
Title: Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring.
Volume: 83
Issue: 6
Pages: 1376-88
•
•
•
•
•
Protein Domain
IPR033027 | DSCAM_metazoan
Type: Family
Description: Cell adhesion molecule DSCAM is a cell adhesion molecule that plays a role in axon guidance, self-avoidance and synaptic formation [, , , , ]. It is a receptor for netrin, acting independently of and in collaboration with DCC []. DSCAM is one of the largest Immunoglobulin (Ig) superfamily CAMs, containing 10 Ig domains and six fibronectin type III (FN) repeats [], and contributes to defects in the central nervous system in Down syndrome patients []. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene []. Drosophila Dscam2 is also alternatively spliced and plays a crucial role in the development of two visual system neurons, monopolar cells L1 and L2 [].
•
•
•
•
•
Protein Domain
IPR021012 | Dscam_C
Type: Domain
Description: This entry is specific to the insecta, predominantly Drosophila spp. This entry is found in association with , and . The Down syndrome cell adhesion molecule (Dscam) belongs to a family of cell membrane molecules involved in the differentiation of the nervous system. This is the C-terminal cytoplasmic tail region of Dscam. In Drosophila melanogaster (Fruit fly) the gene has at least 59 different transcripts. Dscam may play a role in the nervous and immune systems [].
•
•
•
•
•
Publication
21957262 | J:176120
First Author: Ahmed G
Year: 2011
Journal: J Neurosci
Title: Draxin inhibits axonal outgrowth through the netrin receptor DCC.
Volume: 31
Issue: 39
Pages: 14018-23
•
•
•
•
•
Publication
21490218 | J:170968
First Author: Blank M
Year: 2011
Journal: J Neurosci
Title: The Down syndrome critical region regulates retinogeniculate refinement.
Volume: 31
Issue: 15
Pages: 5764-76
•
•
•
•
•
Publication
20558441 | J:182114
First Author: Dunlevy L
Year: 2010
Journal: Cardiovasc Res
Title: Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.
Volume: 88
Issue: 2
Pages: 287-95
•
•
•
•
•
Publication
39341334 | J:354984
 
First Author: Emili M
Year: 2024
Journal: Neuropharmacology
Title: Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model.
Volume: 261
Pages: 110170
•
•
•
•
•
Publication
26092713 | J:227314
 
First Author: Xue Y
Year: 2015
Journal: Behav Brain Res
Title: Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains.
Volume: 292
Pages: 83-94
•
•
•
•
•
Publication
21270903 | -
First Author: Zhu K
Year: 2011
Journal: Neurosci Bull
Title: Down syndrome cell adhesion molecule and its functions in neural development.
Volume: 27
Issue: 1
Pages: 45-52
•
•
•
•
•
Publication
28483977 | J:242688
First Author: Shao Q
Year: 2017
Journal: J Neurosci
Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
Volume: 37
Issue: 23
Pages: 5620-5633
•
•
•
•
•
Publication
22842903 | J:186772
First Author: Lefebvre JL
Year: 2012
Journal: Nature
Title: Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.
Volume: 488
Issue: 7412
Pages: 517-21
•
•
•
•
•
Publication
23223444 | J:314652
First Author: Qu C
Year: 2013
Journal: J Biol Chem
Title: c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance.
Volume: 288
Issue: 3
Pages: 1883-95
•
•
•
•
•
Protein
Q8BLW1
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
•
•
•
•
•
Protein
A0A1W2P6Z1
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JDZ8
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JFT2
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
•
•
•
•
•
Protein
A2AK24
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JDZ3
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JDY6
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JFI0
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
•
•
•
•
•
Protein
Q6QRP1
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
•
•
•
•
•
Protein
J3QNK9
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
•
•
•
•
•
Protein
D6RJ38
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
•
•
•
•
•
Protein
Q8BUK9
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
•
•
•
•
•
Publication
10759566 | -
First Author: Smalla KH
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses.
Volume: 97
Issue: 8
Pages: 4327-32
•
•
•
•
•
Publication
16925595 | -
First Author: Empson RM
Year: 2006
Journal: J Neurochem
Title: The cell adhesion molecule neuroplastin-65 inhibits hippocampal long-term potentiation via a mitogen-activated protein kinase p38-dependent reduction in surface expression of GluR1-containing glutamate receptors.
Volume: 99
Issue: 3
Pages: 850-60
•
•
•
•
•
Publication
19952283 | -
First Author: Owczarek S
Year: 2010
Journal: FASEB J
Title: Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor.
Volume: 24
Issue: 4
Pages: 1139-50
•
•
•
•
•
Protein Domain
IPR043204 | Basigin-like
Type: Family
Description: Neuroplastin and basigin are members of the immunoglobulin (Ig) superfamily. They have two Ig domains that project into the extracellular space. They are also present as isoforms containing an additional N-terminal Ig domain. They contain a glutamate (E) at exactly the same position in the transmembrane domain, which may be important for molecular interactions within the membrane region [].Basigin is present on the surface of tumour cells and stimulate nearby fibroblasts to synthesise matrix metalloproteases (MMPs), which play an important role in tumour invasiveness and metastasis []. Basigin has also been repeatedly implicated in the proper function of the blood brain barrier [, ]. In addition, the protein is essential for fertility in both males and females[]. In males, it is required for the completion of spermatogenesis, while in females, it is needed for maintaining normal reproductive functions. Basigins are highly glycosylated membrane proteins, the degree of glycosylation varying with tissue type. The extracellular region of basigin contains two randomly arranged Ig domains: an Ig-like C2-type domain and an Ig-like V-domain [].Neuroplastin is a probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK []. It may also regulate neurite outgrowth by activating the FGFR1 signaling pathway []. It may play a role in synaptic plasticity [].Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development []. Contactin-2 (CNTN2/axonin-1/TAG-1/TAX-1) is highly expressed at the axon growth cone and plays an important role in regulating axon guidance and path finding, as well as in neuron migration. Contactin-6 (CNTN6/NB-3) binds Notch and and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells.Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays a role in axon guidance, self-avoidance and synaptic formation []. DSCAM is one of the largest Immunoglobulin (Ig) superfamily CAMs [], and contributes to defects in the central nervous system in Down syndrome patients [].This entry represents a family of neuronal cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development.
•
•
•
•
•
Publication
2361961 | J:10584
First Author: Miyauchi T
Year: 1990
Journal: J Biochem
Title: Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class II antigen.
Volume: 107
Issue: 2
Pages: 316-23
•
•
•
•
•
Protein
Q8BLD3
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: true
•
•
•
•
•
Protein
Q9D003
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
•
•
•
•
•
Publication
25040546 | -
First Author: Beesley PW
Year: 2014
Journal: J Neurochem
Title: The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function.
Volume: 131
Issue: 3
Pages: 268-83
•
•
•
•
•
Publication
11992541 | -
First Author: Kanekura T
Year: 2002
Journal: Int J Cancer
Title: Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts.
Volume: 99
Issue: 4
Pages: 520-8
•
•
•
•
•
Publication
2357963 | -
First Author: Seulberger H
Year: 1990
Journal: EMBO J
Title: The inducible blood--brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein.
Volume: 9
Issue: 7
Pages: 2151-8
•
•
•
•
•
Publication
1383894 | -
First Author: Seulberger H
Year: 1992
Journal: Neurosci Lett
Title: HT7, Neurothelin, Basigin, gp42 and OX-47--many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons.
Volume: 140
Issue: 1
Pages: 93-7
•
•
•
•
•
Publication
9559645 | J:46952
First Author: Kuno N
Year: 1998
Journal: FEBS Lett
Title: Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily.
Volume: 425
Issue: 2
Pages: 191-4
•
•
•
•
•
Protein
Q3V3B0
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: true
•
•
•
•
•
Protein
Q8R4B4
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: true
•
•
•
•
•
Protein
Q8R4B3
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: true
•
•
•
•
•
Protein
Q8R4B5
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: true
•
•
•
•
•
Protein
A0A1W2P7R6
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
•
•
•
•
•
Publication
25300137 | -
 
First Author: Mohebiany AN
Year: 2014
Journal: Adv Neurobiol
Title: New insights into the roles of the contactin cell adhesion molecules in neural development.
Volume: 8
Pages: 165-94
•
•
•
•
•
Protein
Q8CHB2
Organism: Mus musculus/domesticus
Length: 1723  
Fragment?: true
•
•
•
•
•
Protein
Q91ZY7
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: true
•
•
•
•
•
Protein
E9QPR7
Organism: Mus musculus/domesticus
Length: 2111  
Fragment?: false
•
•
•
•
•
Protein
A0A0A0MQN8
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
•
•
•
•
•
Protein
A2AST1
Organism: Mus musculus/domesticus
Length: 1451  
Fragment?: false
•
•
•
•
•
Protein
Q6P6Q1
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
•
•
•
•
•
Protein
Q6P9Y5
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
•
•
•
•
•
Protein
A0A1W2P7X4
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
•
•
•
•
•
Protein
Q8R4B2
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: true
•
•
•
•
•
Protein
A0A0N4SUM4
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SQZ7
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: true
•
•
•
•
•
Protein
Q3UY89
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: true
•
•
•
•
•
Protein
J3QP71
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
•
•
•
•
•
Protein
A0A1W2P6P3
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
•
•
•
•
•
Protein
P18572
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
•
•
•
•
•
Protein
P21995
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
•
•
•
•
•
Protein
Q7TPW1
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
•
•
•
•
•
Protein
P97300
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
•
•
•
•
•
Protein
Q3TSZ8
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
•
•
•
•
•
Protein
Q3TQK2
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JG59
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: true
•
•
•
•
•
Protein
O55107
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
•
•
•
•
•
Protein
G4W8R3
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
•
•
•
•
•
Protein
Z4YLB7
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JFD8
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
•
•
•
•
•
Protein
O55108
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JEX1
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
•
•
•
•
•
Protein
G4W8R2
Organism: Mus musculus/domesticus
Length: 671  
Fragment?: false
•
•
•
•
•
Protein
H3BKA7
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JGI1
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
•
•
•
•
•
Protein
A0A1W2P814
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
•
•
•
•
•
Protein
H3BIX4
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
•
•
•
•
•
Protein
G4W8R4
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
E9Q8Q6
Organism: Mus musculus/domesticus
Length: 1531  
Fragment?: false
•
•
•
•
•
Protein
Q3UFK0
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
•
•
•
•
•
Protein
K3W4Q8
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
•
•
•
•
•
Protein
Q3TI59
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
•
•
•
•
•
Protein
Q69Z26
Organism: Mus musculus/domesticus
Length: 1026  
Fragment?: false
•
•
•
•
•
Protein
P70232
Organism: Mus musculus/domesticus
Length: 1209  
Fragment?: false
•
•
•
•
•
Protein
Q2EY15
Organism: Mus musculus/domesticus
Length: 1191  
Fragment?: false
•
•
•
•
•
Protein
Q810U3
Organism: Mus musculus/domesticus
Length: 1240  
Fragment?: false
•
•
•
•
•
Protein
A0A087WPX3
Organism: Mus musculus/domesticus
Length: 1347  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom