Type |
Details |
Score |
Publication |
First Author: |
Kim Y |
Year: |
2013 |
Journal: |
Dev Neurobiol |
Title: |
Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development. |
Volume: |
73 |
Issue: |
9 |
Pages: |
702-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frisén J |
Year: |
1997 |
Journal: |
Cell Tissue Res |
Title: |
Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. |
Volume: |
290 |
Issue: |
2 |
Pages: |
209-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masinde GL |
Year: |
2006 |
Journal: |
Funct Integr Genomics |
Title: |
New quantitative trait loci that regulate wound healing in an intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of mice. |
Volume: |
6 |
Issue: |
2 |
Pages: |
157-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buensuceso AV |
Year: |
2013 |
Journal: |
Biol Reprod |
Title: |
The ephrin signaling pathway regulates morphology and adhesion of mouse granulosa cells in vitro. |
Volume: |
88 |
Issue: |
1 |
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noberini R |
Year: |
2012 |
Journal: |
Cell Adh Migr |
Title: |
Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. |
Volume: |
6 |
Issue: |
2 |
Pages: |
102-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
1997 |
Journal: |
Oncogene |
Title: |
The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. |
Volume: |
14 |
Issue: |
5 |
Pages: |
533-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agrawal P |
Year: |
2014 |
Journal: |
Dev Dyn |
Title: |
Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. |
Volume: |
243 |
Issue: |
11 |
Pages: |
1470-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teng T |
Year: |
2017 |
Journal: |
eNeuro |
Title: |
EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain. |
Volume: |
4 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ebisu H |
Year: |
2017 |
Journal: |
Cereb Cortex |
Title: |
Foxp2 Regulates Identities and Projection Patterns of Thalamic Nuclei During Development. |
Volume: |
27 |
Issue: |
7 |
Pages: |
3648-3659 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stark DA |
Year: |
2015 |
Journal: |
J Cell Biol |
Title: |
Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. |
Volume: |
211 |
Issue: |
5 |
Pages: |
1077-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freywald A |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. |
Volume: |
176 |
Issue: |
7 |
Pages: |
4066-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yue Y |
Year: |
1999 |
Journal: |
J Neurosci |
Title: |
Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5. |
Volume: |
19 |
Issue: |
22 |
Pages: |
10026-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Son AI |
Year: |
2014 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice. |
Volume: |
55 |
Issue: |
3 |
Pages: |
1594-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buenaventura DF |
Year: |
2019 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors. |
Volume: |
60 |
Issue: |
8 |
Pages: |
2787-2799 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yun ME |
Year: |
2003 |
Journal: |
J Comp Neurol |
Title: |
EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence. |
Volume: |
456 |
Issue: |
3 |
Pages: |
203-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujii H |
Year: |
2006 |
Journal: |
Dev Dyn |
Title: |
Eph-ephrin A system regulates murine blastocyst attachment and spreading. |
Volume: |
235 |
Issue: |
12 |
Pages: |
3250-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdul-Aziz NM |
Year: |
2009 |
Journal: |
Int J Dev Biol |
Title: |
EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion. |
Volume: |
53 |
Issue: |
4 |
Pages: |
559-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xavier GM |
Year: |
2016 |
Journal: |
Front Physiol |
Title: |
Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. |
Volume: |
7 |
|
Pages: |
60 |
|
•
•
•
•
•
|
Publication |
|
Year: |
1997 |
Journal: |
Cell |
Title: |
Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |
Volume: |
90 |
Issue: |
3 |
Pages: |
403-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pickles JO |
Year: |
2003 |
Journal: |
Hear Res |
Title: |
Expression of Ephs and ephrins in developing mouse inner ear. |
Volume: |
178 |
Issue: |
1-2 |
Pages: |
44-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Islam S |
Year: |
2010 |
Journal: |
Dig Dis Sci |
Title: |
Developmental expression of Eph and ephrin family genes in mammalian small intestine. |
Volume: |
55 |
Issue: |
9 |
Pages: |
2478-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerstmann K |
Year: |
2015 |
Journal: |
Development |
Title: |
Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. |
Volume: |
142 |
Issue: |
1 |
Pages: |
140-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Eyll JM |
Year: |
2006 |
Journal: |
Gene Expr Patterns |
Title: |
Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. |
Volume: |
6 |
Issue: |
4 |
Pages: |
353-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata M |
Year: |
2021 |
Journal: |
Nature |
Title: |
Regulation of prefrontal patterning and connectivity by retinoic acid. |
Volume: |
598 |
Issue: |
7881 |
Pages: |
483-488 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida S |
Year: |
2004 |
Journal: |
Hum Mol Genet |
Title: |
Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. |
Volume: |
13 |
Issue: |
14 |
Pages: |
1487-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graef IA |
Year: |
2001 |
Journal: |
Cell |
Title: |
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. |
Volume: |
105 |
Issue: |
7 |
Pages: |
863-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki-Hirano A |
Year: |
2011 |
Journal: |
J Comp Neurol |
Title: |
Dynamic spatiotemporal gene expression in embryonic mouse thalamus. |
Volume: |
519 |
Issue: |
3 |
Pages: |
528-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weiss AC |
Year: |
2019 |
Journal: |
J Pathol |
Title: |
Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. |
Volume: |
248 |
Issue: |
4 |
Pages: |
452-463 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bibollet-Bahena O |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. |
Volume: |
12 |
Issue: |
5 |
Pages: |
e0177977 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2006 |
Journal: |
Neuron |
Title: |
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. |
Volume: |
52 |
Issue: |
5 |
Pages: |
775-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robinson DR |
Year: |
2000 |
Journal: |
Oncogene |
Title: |
The protein tyrosine kinase family of the human genome. |
Volume: |
19 |
Issue: |
49 |
Pages: |
5548-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimogori T |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
A genomic atlas of mouse hypothalamic development. |
Volume: |
13 |
Issue: |
6 |
Pages: |
767-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Liu X |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
EphA8 is a prognostic marker for epithelial ovarian cancer. |
Volume: |
7 |
Issue: |
15 |
Pages: |
20801-9 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion GK250, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Pandey A |
Year: |
2002 |
Journal: |
Oncogene |
Title: |
Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. |
Volume: |
21 |
Issue: |
52 |
Pages: |
8029-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhong J |
Year: |
2011 |
Journal: |
J Proteomics |
Title: |
The interactome of a PTB domain-containing adapter protein, Odin, revealed by SILAC. |
Volume: |
74 |
Issue: |
3 |
Pages: |
294-303 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
ANKS1A, also known as Odin, functions as an effector of epidermal derived growth factor receptor (EGFR) recycling [], interacts with 14-3-3 proteins []and restricts platelet-derived growth factor (PDGF)-mediated cell proliferation [].Structurally, it consist of N-terminal ankyrin motifs followed by tandem sterile alpha motif (SAM) domains and a carboxyl phosphotyrosine binding (PTB) domain []. The PTB domain has been shown to be crucial for association with the juxtamembrane domain of ephrin receptor EphA8 [], and the SAM domain is involved in modulating its degradation [], thereby regulating EphA signalling. |
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•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the ligand-binding domain found in ephrin type-A receptor 8 (EphA8), also known as EEK. EphA8 has been suggested to play a role in axonal pathfinding during nervous system development in mammals [], as well as being implicated in cancer [].Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) []. |
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•
•
•
•
•
|
Publication |
First Author: |
Arpke RW |
Year: |
2023 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Normal muscle fiber type distribution is recapitulated in aged ephrin-A3(-/-) mice that previously lacked most slow myofibers. |
Volume: |
324 |
Issue: |
3 |
Pages: |
C718-C727 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukushima K |
Year: |
2006 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes. |
Volume: |
291 |
Issue: |
5 |
Pages: |
G812-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong J |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Odin (ANKS1A) modulates EGF receptor recycling and stability. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e64817 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
110
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
496
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
433
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
593
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lackmann M |
Year: |
2008 |
Journal: |
Sci Signal |
Title: |
Eph, a protein family coming of age: more confusion, insight, or complexity? |
Volume: |
1 |
Issue: |
15 |
Pages: |
re2 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1150
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1189
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1129
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Himanen JP |
Year: |
2003 |
Journal: |
Trends Neurosci |
Title: |
Eph signaling: a structural view. |
Volume: |
26 |
Issue: |
1 |
Pages: |
46-51 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1004
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|