Type |
Details |
Score |
Publication |
First Author: |
Tan J |
Year: |
2017 |
Journal: |
Neural Dev |
Title: |
Lacking of palladin leads to multiple cellular events changes which contribute to NTD. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tarantino C |
Year: |
2010 |
Journal: |
FASEB J |
Title: |
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. |
Volume: |
24 |
Issue: |
9 |
Pages: |
3255-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elliott R |
Year: |
2000 |
Journal: |
Personal Communication |
Title: |
Chromosome Locations Based on RH mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Miller JA |
Year: |
2013 |
Journal: |
Development |
Title: |
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. |
Volume: |
140 |
Issue: |
22 |
Pages: |
4633-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Araki K |
Year: |
1999 |
Journal: |
Cell Mol Biol (Noisy-le-grand) |
Title: |
Exchangeable gene trap using the Cre/mutated lox system. |
Volume: |
45 |
Issue: |
5 |
Pages: |
737-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniwaki T |
Year: |
2005 |
Journal: |
Dev Growth Differ |
Title: |
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. |
Volume: |
47 |
Issue: |
3 |
Pages: |
163-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Goicoechea S |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. |
Volume: |
119 |
Issue: |
Pt 16 |
Pages: |
3316-24 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE14454 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Logue JS |
Year: |
2015 |
Journal: |
Elife |
Title: |
Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration. |
Volume: |
4 |
|
Pages: |
e08314 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sudhaharan T |
Year: |
2016 |
Journal: |
J Cell Sci |
Title: |
The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia. |
Volume: |
129 |
Issue: |
14 |
Pages: |
2829-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Fiore PP |
Year: |
2002 |
Journal: |
Int J Biochem Cell Biol |
Title: |
Eps8 in the midst of GTPases. |
Volume: |
34 |
Issue: |
10 |
Pages: |
1178-83 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Kishan KV |
Year: |
1997 |
Journal: |
Nat Struct Biol |
Title: |
The SH3 domain of Eps8 exists as a novel intertwined dimer. |
Volume: |
4 |
Issue: |
9 |
Pages: |
739-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lanzetti L |
Year: |
2000 |
Journal: |
Nature |
Title: |
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. |
Volume: |
408 |
Issue: |
6810 |
Pages: |
374-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
481
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
388
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
476
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
446
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
475
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Saksela K |
Year: |
2012 |
Journal: |
FEBS Lett |
Title: |
SH3 domain ligand binding: What's the consensus and where's the specificity? |
Volume: |
586 |
Issue: |
17 |
Pages: |
2609-14 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH3 domain found in Eps8 and Eps8-like proteins including Eps8-like 1-3. These proteins contain N-terminal phosphotyrosine-binding (PTB), central SH3, and C-terminal effector domains. The SH3 domains of Eps8 and similar proteins recognize peptides containing a PxxDY motif, instead of the classical PxxP motif []. Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Boukhelifa M |
Year: |
2004 |
Journal: |
Cell Motil Cytoskeleton |
Title: |
Palladin is a novel binding partner for Ena/VASP family members. |
Volume: |
58 |
Issue: |
1 |
Pages: |
17-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo H |
Year: |
2005 |
Journal: |
Mol Cell Neurosci |
Title: |
Disruption of palladin results in neural tube closure defects in mice. |
Volume: |
29 |
Issue: |
4 |
Pages: |
507-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rachlin AS |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin. |
Volume: |
119 |
Issue: |
Pt 6 |
Pages: |
995-1004 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dixon RD |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. |
Volume: |
283 |
Issue: |
10 |
Pages: |
6222-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beck MR |
Year: |
2013 |
Journal: |
J Mol Biol |
Title: |
Structure and function of palladin's actin binding domain. |
Volume: |
425 |
Issue: |
18 |
Pages: |
3325-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rönty M |
Year: |
2007 |
Journal: |
Exp Cell Res |
Title: |
Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling. |
Volume: |
313 |
Issue: |
12 |
Pages: |
2575-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chin YR |
Year: |
2010 |
Journal: |
Mol Cell |
Title: |
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. |
Volume: |
38 |
Issue: |
3 |
Pages: |
333-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mykkänen OM |
Year: |
2001 |
Journal: |
Mol Biol Cell |
Title: |
Characterization of human palladin, a microfilament-associated protein. |
Volume: |
12 |
Issue: |
10 |
Pages: |
3060-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boukhelifa M |
Year: |
2006 |
Journal: |
FEBS J |
Title: |
The proline-rich protein palladin is a binding partner for profilin. |
Volume: |
273 |
Issue: |
1 |
Pages: |
26-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen NU |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e0124762 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen NU |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells. |
Volume: |
452 |
Issue: |
3 |
Pages: |
728-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin L |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
The actin associated protein palladin is important for the early smooth muscle cell differentiation. |
Volume: |
5 |
Issue: |
9 |
Pages: |
e12823 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin L |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies. |
Volume: |
284 |
Issue: |
4 |
Pages: |
2121-30 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes EPS8 and EPS8L1-3 from animals.Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].Similarly to EPS8, EPSLs interact with Abi1 and Sos-1. However, only EPS8L1 and EPS8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo []. Eps8L2 null-mutant mice has been shown to exhibit a late-onset, progressive hearing loss that is directly linked to a gradual deterioration in hair bundle morphology []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Palladin is a cytoskeletal actin scaffold protein that regulates actin dynamics. The immunoglobulin-like domain of palladin is directly responsible for both actin binding and bundling [, ]. Palladin also interacts with different actin binding proteins and signalling intermediaries required for regulation of cytoskeleton organisation, including profilin [], VASP [], Eps8 [], ezrin [], Lasp-1 [], and Src []. Palladin plays an important role in smooth and skeletal muscle differentiation [, , ], contraction []and cell migration [, , ].Palladin is expressed as several alternatively spliced isoforms, having various combinations of Ig-like domains, in a cell-type-specific manner. It has been suggested that palladin's different Ig-like domains may be specialized for distinct functions []. This entry represents the C-terminal immunoglobulin-like domain (Ig5). |
|
•
•
•
•
•
|
Publication |
First Author: |
Krugmann S |
Year: |
2001 |
Journal: |
Curr Biol |
Title: |
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. |
Volume: |
11 |
Issue: |
21 |
Pages: |
1645-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmed S |
Year: |
2010 |
Journal: |
Semin Cell Dev Biol |
Title: |
I-BAR domains, IRSp53 and filopodium formation. |
Volume: |
21 |
Issue: |
4 |
Pages: |
350-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferrari I |
Year: |
2012 |
Journal: |
Commun Integr Biol |
Title: |
LIN7-IRSp53: A novel pathway for filopodia and neurite formation? |
Volume: |
5 |
Issue: |
6 |
Pages: |
631-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lorente-Cánovas B |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells. |
Volume: |
17 |
Issue: |
3 |
Pages: |
e0261530 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krey JF |
Year: |
2020 |
Journal: |
Curr Biol |
Title: |
Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells. |
Volume: |
30 |
Issue: |
3 |
Pages: |
442-454.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weiss SM |
Year: |
2009 |
Journal: |
Cell Host Microbe |
Title: |
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. |
Volume: |
5 |
Issue: |
3 |
Pages: |
244-58 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP []. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH3 domain of IRSp53. The SH3 domain of IRSp53 has been shown to bind the proline-rich C terminus of EspFu (E. coli secreted protein F-like from prophage U) [].IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
52
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
80
 |
Fragment?: |
true |
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Publication |
First Author: |
Krey JF |
Year: |
2023 |
Journal: |
PLoS Biol |
Title: |
Control of stereocilia length during development of hair bundles. |
Volume: |
21 |
Issue: |
4 |
Pages: |
e3001964 |
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Publication |
First Author: |
Zhang Y |
Year: |
2019 |
Journal: |
BMC Biol |
Title: |
SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation. |
Volume: |
17 |
Issue: |
1 |
Pages: |
104 |
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Publication |
First Author: |
Carlton AJ |
Year: |
2021 |
Journal: |
J Physiol |
Title: |
Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. |
Volume: |
599 |
Issue: |
4 |
Pages: |
1173-1198 |
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Publication |
First Author: |
Zhao H |
Year: |
2011 |
Journal: |
Curr Opin Cell Biol |
Title: |
I-BAR domain proteins: linking actin and plasma membrane dynamics. |
Volume: |
23 |
Issue: |
1 |
Pages: |
14-21 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
600
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
152
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
109
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
729
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
716
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
777
 |
Fragment?: |
false |
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Publication |
First Author: |
Pykäläinen A |
Year: |
2011 |
Journal: |
Nat Struct Mol Biol |
Title: |
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. |
Volume: |
18 |
Issue: |
8 |
Pages: |
902-7 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
535
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
521
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
522
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1408
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1002
 |
Fragment?: |
false |
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