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Search results 401 to 500 out of 593 for Fastkd3

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Type Details Score
Publication  
First Author: Braun H
Year: 2022
Journal: Free Radic Biol Med
Title: The F2-isoprostane 8-iso-PGF(2α) attenuates atherosclerotic lesion formation in Ldlr-deficient mice - Potential role of vascular thromboxane A(2) receptors.
Volume: 185
Pages: 36-45
Publication
First Author: Rateri DL
Year: 2012
Journal: PLoS One
Title: Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice.
Volume: 7
Issue: 12
Pages: e51483
Publication  
First Author: Choudhury TZ
Year: 2024
Journal: JCI Insight
Title: Impact of genetic factors on antioxidant rescue of maternal diabetes-associated congenital heart disease.
Volume: 9
Issue: 23
Publication
First Author: Zhao M
Year: 2012
Journal: Blood
Title: FGF signaling facilitates postinjury recovery of mouse hematopoietic system.
Volume: 120
Issue: 9
Pages: 1831-42
Publication
First Author: Lasater EA
Year: 2010
Journal: J Clin Invest
Title: Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.
Volume: 120
Issue: 3
Pages: 859-70
Publication
First Author: Feng X
Year: 2010
Journal: Development
Title: Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion.
Volume: 137
Issue: 24
Pages: 4191-9
Publication
First Author: Chen L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function.
Volume: 107
Issue: 23
Pages: 10555-60
Publication
First Author: Banerjee ER
Year: 2007
Journal: Exp Hematol
Title: Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical.
Volume: 35
Issue: 4
Pages: 605-17
Publication
First Author: Li Z
Year: 2006
Journal: Blood
Title: Runx1 function in hematopoiesis is required in cells that express Tek.
Volume: 107
Issue: 1
Pages: 106-10
Publication
First Author: Westgate EJ
Year: 2008
Journal: Circulation
Title: Genetic components of the circadian clock regulate thrombogenesis in vivo.
Volume: 117
Issue: 16
Pages: 2087-95
Publication
First Author: Ridder K
Year: 2014
Journal: PLoS Biol
Title: Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation.
Volume: 12
Issue: 6
Pages: e1001874
Publication
First Author: Sweet DT
Year: 2012
Journal: Blood
Title: The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis.
Volume: 119
Issue: 8
Pages: 1946-55
Publication  
First Author: Copeland JN
Year: 2011
Journal: BMC Dev Biol
Title: Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.
Volume: 11
Pages: 12
Publication
First Author: Jiao K
Year: 2006
Journal: Development
Title: Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development.
Volume: 133
Issue: 22
Pages: 4585-93
Publication
First Author: Leu NA
Year: 2009
Journal: PLoS One
Title: Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice.
Volume: 4
Issue: 11
Pages: e7734
Publication
First Author: Hasapis S
Year: 2023
Journal: Sci Rep
Title: Characterizing the role of Phlda3 in the development of acute toxicity and malignant transformation of hematopoietic cells induced by total-body irradiation in mice.
Volume: 13
Issue: 1
Pages: 12916
Publication
First Author: Li W
Year: 2013
Journal: Dev Cell
Title: Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin.
Volume: 24
Issue: 4
Pages: 359-71
Publication  
First Author: Chan MP
Year: 2015
Journal: Nat Commun
Title: DNase II-dependent DNA digestion is required for DNA sensing by TLR9.
Volume: 6
Pages: 5853
Publication
First Author: Krause DS
Year: 2014
Journal: Blood
Title: Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche.
Volume: 123
Issue: 9
Pages: 1361-71
Publication
First Author: Rantakari P
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury.
Volume: 113
Issue: 33
Pages: 9298-303
Publication
First Author: Liu X
Year: 2015
Journal: J Neurosci
Title: Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.
Volume: 35
Issue: 7
Pages: 2860-70
Publication
First Author: White TA
Year: 2010
Journal: Blood
Title: Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis.
Volume: 116
Issue: 10
Pages: 1787-94
Publication
First Author: Abdel Malik R
Year: 2017
Journal: Circ Res
Title: AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.
Volume: 120
Issue: 1
Pages: 99-109
Publication
First Author: Tărlungeanu DC
Year: 2016
Journal: Cell
Title: Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.
Volume: 167
Issue: 6
Pages: 1481-1494.e18
Publication
First Author: Smirnova NF
Year: 2015
Journal: Circ Res
Title: The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.
Volume: 117
Issue: 9
Pages: 770-8
Publication
First Author: Zhang B
Year: 2018
Journal: Nat Med
Title: Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.
Volume: 24
Issue: 4
Pages: 450-462
Publication
First Author: Lin SC
Year: 2023
Journal: iScience
Title: Endothelial-to-osteoblast transition in normal mouse bone development.
Volume: 26
Issue: 2
Pages: 105994
Publication
First Author: Griffin CT
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels.
Volume: 108
Issue: 6
Pages: 2282-7
Publication
First Author: Refaeli I
Year: 2020
Journal: Sci Rep
Title: Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease.
Volume: 10
Issue: 1
Pages: 9419
Publication
First Author: Goyama S
Year: 2008
Journal: Cell Stem Cell
Title: Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
Volume: 3
Issue: 2
Pages: 207-20
Publication
First Author: Koh BH
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma.
Volume: 107
Issue: 23
Pages: 10614-9
Publication
First Author: Mahmoud MM
Year: 2016
Journal: Circ Res
Title: TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis.
Volume: 119
Issue: 3
Pages: 450-62
Publication
First Author: Nanba D
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.
Volume: 350
Issue: 2
Pages: 315-21
Publication
First Author: Yu Z
Year: 2022
Journal: Blood
Title: Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
Volume: 139
Issue: 10
Pages: 1529-1540
Publication
First Author: Ma L
Year: 2022
Journal: Sci Adv
Title: Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Volume: 8
Issue: 9
Pages: eabm3470
Publication
First Author: Davis NM
Year: 2021
Journal: mBio
Title: Metabolomic Analysis of Diverse Mice Reveals Hepatic Arginase-1 as Source of Plasma Arginase in Plasmodium chabaudi Infection.
Volume: 12
Issue: 5
Pages: e0242421
Publication
First Author: Li J
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Endothelial TWIST1 promotes pathological ocular angiogenesis.
Volume: 55
Issue: 12
Pages: 8267-77
Publication
First Author: Rajderkar S
Year: 2019
Journal: Dev Biol
Title: Trim33 is required for appropriate development of pre-cardiogenic mesoderm.
Volume: 450
Issue: 2
Pages: 101-114
Publication
First Author: Aziz Q
Year: 2017
Journal: J Biol Chem
Title: Molecular and functional characterization of the endothelial ATP-sensitive potassium channel.
Volume: 292
Issue: 43
Pages: 17587-17597
Publication
First Author: Aziz Q
Year: 2020
Journal: J Mol Med (Berl)
Title: Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia.
Volume: 98
Issue: 8
Pages: 1149-1160
Publication
First Author: Majumder S
Year: 2016
Journal: Cell Rep
Title: G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.
Volume: 17
Issue: 10
Pages: 2532-2541
Publication
First Author: Wheeler JL
Year: 2013
Journal: J Immunol
Title: Novel cellular targets of AhR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection.
Volume: 190
Issue: 2
Pages: 659-68
Publication
First Author: Wang Z
Year: 2018
Journal: J Immunol
Title: Differential Roles of LTβR in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation.
Volume: 201
Issue: 1
Pages: 69-76
Publication
First Author: Ulvmar MH
Year: 2016
Journal: Genesis
Title: Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins.
Volume: 54
Issue: 6
Pages: 350-8
Publication
First Author: Weisberg SP
Year: 2014
Journal: Cell Rep
Title: ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.
Volume: 6
Issue: 3
Pages: 528-40
Publication
First Author: Krenz M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.
Volume: 105
Issue: 48
Pages: 18930-5
Publication
First Author: Walisser JA
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types.
Volume: 102
Issue: 49
Pages: 17858-63
Publication
First Author: Honig G
Year: 2016
Journal: PLoS One
Title: Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve.
Volume: 11
Issue: 1
Pages: e0144215
Publication
First Author: Radu M
Year: 2015
Journal: Mol Cell Biol
Title: p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.
Volume: 35
Issue: 23
Pages: 3990-4005
Publication
First Author: Phillips HM
Year: 2013
Journal: Cardiovasc Res
Title: Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets.
Volume: 99
Issue: 3
Pages: 452-60
Publication
First Author: Lakshmikanthan S
Year: 2011
Journal: Blood
Title: Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.
Volume: 118
Issue: 7
Pages: 2015-26
Publication
First Author: Lu YW
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Myocyte Enhancer Factor 2c Inhibits Migration of Smooth Muscle Cells Through Fenestrations in the Internal Elastic Lamina.
Volume: 37
Issue: 7
Pages: 1380-1390
Publication
First Author: Okyere B
Year: 2016
Journal: PLoS One
Title: Endothelial-Specific EphA4 Negatively Regulates Native Pial Collateral Formation and Re-Perfusion following Hindlimb Ischemia.
Volume: 11
Issue: 7
Pages: e0159930
Publication
First Author: Komatsu K
Year: 2007
Journal: Dev Biol
Title: Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart.
Volume: 303
Issue: 1
Pages: 82-92
Publication
First Author: O'Reilly VC
Year: 2014
Journal: Dev Biol
Title: Gene-environment interaction demonstrates the vulnerability of the embryonic heart.
Volume: 391
Issue: 1
Pages: 99-110
Publication
First Author: Singh SK
Year: 2018
Journal: Cell Stem Cell
Title: Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging.
Volume: 23
Issue: 2
Pages: 252-265.e8
Publication
First Author: Ge S
Year: 2009
Journal: J Mol Neurosci
Title: Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation.
Volume: 39
Issue: 1-2
Pages: 269-83
Publication
First Author: Guarani V
Year: 2011
Journal: Nature
Title: Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Volume: 473
Issue: 7346
Pages: 234-8
Publication
First Author: Ehninger A
Year: 2014
Journal: Blood
Title: Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence.
Volume: 123
Issue: 26
Pages: 4054-63
Publication
First Author: Forte E
Year: 2020
Journal: Cell Rep
Title: Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice.
Volume: 30
Issue: 9
Pages: 3149-3163.e6
Publication
First Author: Lin SC
Year: 2017
Journal: Dev Cell
Title: Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer.
Volume: 41
Issue: 5
Pages: 467-480.e3
Publication
First Author: Yang MY
Year: 2013
Journal: Cell Rep
Title: Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.
Volume: 3
Issue: 5
Pages: 1457-64
Publication
First Author: Yamazaki T
Year: 2008
Journal: J Immunol
Title: CCR6 regulates the migration of inflammatory and regulatory T cells.
Volume: 181
Issue: 12
Pages: 8391-401
Publication
First Author: Chang SH
Year: 2011
Journal: Immunity
Title: Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.
Volume: 35
Issue: 4
Pages: 611-21
Publication
First Author: He Y
Year: 2010
Journal: Sci Signal
Title: Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.
Volume: 3
Issue: 116
Pages: ra26
Publication
First Author: Hayashi M
Year: 2004
Journal: J Clin Invest
Title: Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.
Volume: 113
Issue: 8
Pages: 1138-48
Publication
First Author: Kim I
Year: 2007
Journal: Cell
Title: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells.
Volume: 130
Issue: 3
Pages: 470-83
Publication
First Author: Li J
Year: 2014
Journal: Nature
Title: Piezo1 integration of vascular architecture with physiological force.
Volume: 515
Issue: 7526
Pages: 279-282
Publication
First Author: Wei X
Year: 2020
Journal: Circ Res
Title: Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.
Volume: 127
Issue: 2
Pages: 249-265
Publication
First Author: Sawada N
Year: 2014
Journal: Cell Metab
Title: Endothelial PGC-1α mediates vascular dysfunction in diabetes.
Volume: 19
Issue: 2
Pages: 246-58
Publication  
First Author: Breasson L
Year: 2017
Journal: Sci Signal
Title: PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity.
Volume: 10
Issue: 488
Publication
First Author: Chung Y
Year: 2009
Journal: Immunity
Title: Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.
Volume: 30
Issue: 4
Pages: 576-87
Publication
First Author: Lee CL
Year: 2021
Journal: Cancer Res
Title: Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma.
Volume: 81
Issue: 14
Pages: 3777-3790
Publication
First Author: Jia W
Year: 2021
Journal: Nat Commun
Title: Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells.
Volume: 12
Issue: 1
Pages: 2118
Publication
First Author: Doan PL
Year: 2013
Journal: Nat Med
Title: Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
Volume: 19
Issue: 3
Pages: 295-304
Publication
First Author: Lee CL
Year: 2012
Journal: Sci Signal
Title: p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.
Volume: 5
Issue: 234
Pages: ra52
Publication
First Author: Kirsch DG
Year: 2010
Journal: Science
Title: p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Volume: 327
Issue: 5965
Pages: 593-6
Publication
First Author: Rateri DL
Year: 2011
Journal: Circ Res
Title: Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice.
Volume: 108
Issue: 5
Pages: 574-81
Publication  
First Author: Nishii K
Year: 2016
Journal: Mech Dev
Title: Connexin45 contributes to global cardiovascular development by establishing myocardial impulse propagation.
Volume: 140
Pages: 41-52
Publication
First Author: Chen X
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report.
Volume: 36
Issue: 6
Pages: 1085-9
Publication
First Author: Takeshita K
Year: 2007
Journal: Circ Res
Title: Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
Volume: 100
Issue: 1
Pages: 70-8
Publication
First Author: Bonasio R
Year: 2006
Journal: Nat Immunol
Title: Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus.
Volume: 7
Issue: 10
Pages: 1092-100
Publication
First Author: Chojnowski JL
Year: 2014
Journal: Development
Title: Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Volume: 141
Issue: 19
Pages: 3697-708
Publication
First Author: Xie J
Year: 2009
Journal: Am J Pathol
Title: Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.
Volume: 175
Issue: 3
Pages: 1315-27
Publication
First Author: Odelin G
Year: 2023
Journal: Nat Commun
Title: Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish.
Volume: 14
Issue: 1
Pages: 1543
Publication
First Author: Zeidler JD
Year: 2022
Journal: iScience
Title: Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
Volume: 25
Issue: 11
Pages: 105431
Publication  
First Author: Zhu L
Year: 2019
Journal: Brain Behav Immun
Title: Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling.
Volume: 81
Pages: 292-304
Publication  
First Author: Fisher OS
Year: 2015
Journal: Nat Commun
Title: Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.
Volume: 6
Pages: 7937
Publication
First Author: Appelbe OK
Year: 2013
Journal: Mech Dev
Title: Conditional deletions refine the embryonic requirement for Dlk1.
Volume: 130
Issue: 2-3
Pages: 143-59
Publication
First Author: Yoon MJ
Year: 2008
Journal: Mol Cell Biol
Title: Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.
Volume: 28
Issue: 15
Pages: 4794-804
Publication
First Author: Beppu H
Year: 2009
Journal: Dev Biol
Title: BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis.
Volume: 331
Issue: 2
Pages: 167-75
Publication
First Author: Bao X
Year: 2010
Journal: Immunity
Title: Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes.
Volume: 33
Issue: 5
Pages: 817-29
Publication
First Author: Koni PA
Year: 2001
Journal: J Exp Med
Title: Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow.
Volume: 193
Issue: 6
Pages: 741-54
Publication
First Author: Griffin CT
Year: 2008
Journal: Development
Title: The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.
Volume: 135
Issue: 3
Pages: 493-500
Publication
First Author: Poduri A
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta.
Volume: 35
Issue: 9
Pages: 1995-2002
Publication  
First Author: Nemeth DP
Year: 2022
Journal: J Inflamm Res
Title: Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS.
Volume: 15
Pages: 1575-1590
Publication
First Author: Abe H
Year: 2019
Journal: Nat Commun
Title: Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.
Volume: 10
Issue: 1
Pages: 2824
Publication
First Author: Lauriol J
Year: 2016
Journal: J Clin Invest
Title: Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
Volume: 126
Issue: 8
Pages: 2989-3005
Publication
First Author: Lee JS
Year: 2006
Journal: Dev Cell
Title: Klf2 is an essential regulator of vascular hemodynamic forces in vivo.
Volume: 11
Issue: 6
Pages: 845-57
Publication    
First Author: Favre J
Year: 2021
Journal: Elife
Title: Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner.
Volume: 10