Type |
Details |
Score |
Genotype |
Symbol: |
Tg(Acp5-Fhl2)#Rosc/? |
Background: |
FVB/N-Tg(Acp5-Fhl2)#Rosc |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Johannessen M |
Year: |
2006 |
Journal: |
Cell Mol Life Sci |
Title: |
The multifunctional roles of the four-and-a-half-LIM only protein FHL2. |
Volume: |
63 |
Issue: |
3 |
Pages: |
268-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huss S |
Year: |
2013 |
Journal: |
BMC Gastroenterol |
Title: |
Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. |
Volume: |
13 |
|
Pages: |
8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of four and a half LIM domains proteins (FHLs), including FHL2/3/5. The LIM domain is a conserved cysteine-rich module that provides protein-protein binding interfaces. FHL2 is one of the best studied FHL proteins. It is involved in a wide range of cellular processes, such as transcriptional regulation, signal transduction, and cell survival by binding to various protein partners [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Dierck F |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling. |
Volume: |
292 |
Issue: |
37 |
Pages: |
15180-15191 |
|
•
•
•
•
•
|
Publication |
First Author: |
Granzier HL |
Year: |
2009 |
Journal: |
Circ Res |
Title: |
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction. |
Volume: |
105 |
Issue: |
6 |
Pages: |
557-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radke MH |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. |
Volume: |
104 |
Issue: |
9 |
Pages: |
3444-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strom J |
Year: |
2024 |
Journal: |
J Mol Cell Cardiol |
Title: |
Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart. |
Volume: |
191 |
|
Pages: |
40-49 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
279
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
289
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
279
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
280
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
120
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Radke MH |
Year: |
2019 |
Journal: |
Circulation |
Title: |
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes. |
Volume: |
139 |
Issue: |
15 |
Pages: |
1813-1827 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
 |
Fragment?: |
false |
|
•
•
•
•
•
|