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Search results 401 to 500 out of 543 for Flrt3

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_06
Specimen Label: euxassay_006295_06
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_07
Specimen Label: euxassay_006295_07
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_08
Specimen Label: euxassay_006295_08
Detected: true
Specimen Num: 8
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_09
Specimen Label: euxassay_006295_09
Detected: true
Specimen Num: 9
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•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_10
Specimen Label: euxassay_006295_10
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_11
Specimen Label: euxassay_006295_11
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_12
Specimen Label: euxassay_006295_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_13
Specimen Label: euxassay_006295_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_14
Specimen Label: euxassay_006295_14
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_15
Specimen Label: euxassay_006295_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_16
Specimen Label: euxassay_006295_16
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_17
Specimen Label: euxassay_006295_17
Detected: true
Specimen Num: 17
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618412
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:3689513
Age: embryonic day 8.0
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618412
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:3689513
Age: embryonic day 8.0
Image: 2B
Note: Expression is in the earliest forming somites at the dorsal lip with expression extending ventrally along the rostral and caudal lips.
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3689513
Age: embryonic day 9.5
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618415
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:3689513
Age: embryonic day 9.5
Image: 3A
Note: Expression in the earliest somites occurred throughout the inner edge of the somitic epithelium and was stronger dorsally. In slightly more mature somites, expression had decreased throughout the epithelium and increased at the somitic lips.
Specimen Label: 3A
Detected: true
Specimen Num: 9
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•
GXD Expression
GXD Expression
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3689513
Age: embryonic day 10.5
Image: 3B
Note: Expression in the earliest somites occurred throughout the inner edge of the somitic epithelium and was stronger dorsally. In slightly more mature somites, expression had decreased throughout the epithelium and increased at the somitic lips.
Specimen Label: 3B
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3689513
Age: embryonic day 10.5
Image: 3Bi
Note: Expression in the earliest somites occurred throughout the inner edge of the somitic epithelium and was stronger dorsally.
Specimen Label: 3Bi
Detected: true
Specimen Num: 13
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•
GXD Expression
GXD Expression
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3689513
Age: embryonic day 10.5
Image: 3Bii
Note: In slightly more mature somites, expression had decreased throughout the epithelium and increased at the somitic lips.
Specimen Label: 3Bii
Detected: true
Specimen Num: 14
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3689513
Age: embryonic day 10.5
Image: 3Biii
Specimen Label: 3Biii
Detected: true
Specimen Num: 15
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•
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•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2020-01-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1654015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6386964
Age: embryonic day 9.5
Image: 3F
Specimen Label: 3F
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2020-01-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1654015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6386964
Age: embryonic day 9.5
Image: 3F'
Specimen Label: 3F'
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3689513
Age: embryonic day 10.5
Image: 2Dii
Specimen Label: 2Dii
Detected: true
Specimen Num: 7
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3689565
Assay Type: RNA in situ
Annotation Date: 2006-12-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609818
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3689513
Age: embryonic day 11.0
Image: 2E
Specimen Label: 2E
Detected: true
Specimen Num: 5
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_05
Specimen Label: euxassay_006295_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_06
Specimen Label: euxassay_006295_06
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_13
Specimen Label: euxassay_006295_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_14
Specimen Label: euxassay_006295_14
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_15
Specimen Label: euxassay_006295_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1984983
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824881
Age: embryonic day 14.5
Image: euxassay_006295_18
Specimen Label: euxassay_006295_18
Detected: true
Specimen Num: 18
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Publication
17804484 | J:126352
First Author: Sheehan S
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice.
Volume: 293
Issue: 5
Pages: F1649-56
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Publication
26960425 | J:269561
First Author: Yu Y
Year: 2016
Journal: Neurosci Bull
Title: Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.
Volume: 32
Issue: 2
Pages: 171-6
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Publication
38020907 | J:343098
 
First Author: Zhou Z
Year: 2023
Journal: Front Cell Dev Biol
Title: Single-cell analysis reveals specific neuronal transition during mouse corticogenesis.
Volume: 11
Pages: 1209320
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Publication
14573547 | J:86309
First Author: Tanabe K
Year: 2003
Journal: J Neurosci
Title: Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth.
Volume: 23
Issue: 29
Pages: 9675-86
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
39198421 | J:353553
First Author: Despin-Guitard E
Year: 2024
Journal: Nat Commun
Title: Non-apical mitoses contribute to cell delamination during mouse gastrulation.
Volume: 15
Issue: 1
Pages: 7364
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Publication
38713721 | J:348278
First Author: Liakath-Ali K
Year: 2024
Journal: PLoS Biol
Title: Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.
Volume: 22
Issue: 5
Pages: e3002599
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Publication
23312517 | J:197638
First Author: van den Berghe V
Year: 2013
Journal: Neuron
Title: Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.
Volume: 77
Issue: 1
Pages: 70-82
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Publication
33597191 | J:303701
 
First Author: He L
Year: 2021
Journal: Development
Title: PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.
Volume: 148
Issue: 6
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Publication
34433966 | J:325905
First Author: Willnow D
Year: 2021
Journal: Nature
Title: Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Volume: 597
Issue: 7874
Pages: 87-91
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Publication
17614941 | J:125931
First Author: Mühlfriedel S
Year: 2007
Journal: Eur J Neurosci
Title: Novel genes differentially expressed in cortical regions during late neurogenesis.
Volume: 26
Issue: 1
Pages: 33-50
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Publication
16782087 | J:112633
First Author: Jukkola T
Year: 2006
Journal: Dev Biol
Title: FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region.
Volume: 297
Issue: 1
Pages: 141-57
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Publication
24613359 | J:211830
First Author: Um JW
Year: 2014
Journal: Cell Rep
Title: Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Volume: 6
Issue: 6
Pages: 1096-1109
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Publication
21862448 | J:198109
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
29031500 | J:257654
First Author: Memic F
Year: 2018
Journal: Gastroenterology
Title: Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Volume: 154
Issue: 3
Pages: 624-636
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 29
Description: Leucine-rich repeat transmembrane protein FLRT3
Type: chain
End: 649
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Publication
19492039 | -
First Author: Karaulanov E
Year: 2009
Journal: PLoS One
Title: Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos.
Volume: 4
Issue: 5
Pages: e5742
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Protein
Q8BGT1
Organism: Mus musculus/domesticus
Length: 649  
Fragment?: false
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Allele
Flrt3<tm4(cre/ERT2)Kln> | MGI:7467420
Name: fibronectin leucine rich transmembrane protein 3; targeted mutation 3, Rudiger Klein
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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DO Term
DOID:0090093 | hypogonadotropic hypogonadism 21 with or without anosmia
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Genotype
Genotype
Symbol: Flrt3/Flrt3<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
24739570 | J:211177
 
First Author: O'Sullivan ML
Year: 2014
Journal: Neural Dev
Title: LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5.
Volume: 9
Pages: 7
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Genotype
Genotype
Symbol: Flrt3/Flrt3<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
26235030 | J:224830
First Author: Lu YC
Year: 2015
Journal: Structure
Title: Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Volume: 23
Issue: 9
Pages: 1678-91
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Protein Domain
IPR031234 | Latrophilin-1
Type: Family
Description: Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: Latrophilin-1 (LPH1), -2 (LPH2), and -3 (LPH3). LPH1 is a brain-specific calcium independent receptor of alpha-latrotoxin (LTX), a neurotoxin present in black widow spider venom which triggers massive exocytosis from presynaptic nerve terminals [, ]. It is the affinity of this form of the receptor for LTX that gives the family its name.Two endogenous ligands for latrophilins have been described, teneurin-2 []and FLRT3 []. LPH1 has been shown to bind Lasso (a splice variant of teneurin-2). LPH1 and Lasso interact across intercellular and synaptic junctions, suggesting an involvement in synaptic functions []. Latrophilins are potential synaptic cell-adhesion molecules that interact trans-synaptically with teneurins and FLRTs [].
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Publication
24273166 | -
First Author: Boucard AA
Year: 2014
Journal: J Biol Chem
Title: Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing.
Volume: 289
Issue: 1
Pages: 387-402
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Publication
11520923 | -
 
First Author: Südhof TC
Year: 2001
Journal: Annu Rev Neurosci
Title: alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.
Volume: 24
Pages: 933-62
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Publication
9208860 | -
First Author: Krasnoperov VG
Year: 1997
Journal: Neuron
Title: alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor.
Volume: 18
Issue: 6
Pages: 925-37
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Publication
21724987 | -
First Author: Silva JP
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
Volume: 108
Issue: 29
Pages: 12113-8
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Publication
20157310 | -
First Author: Arcos-Burgos M
Year: 2010
Journal: Mol Psychiatry
Title: A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.
Volume: 15
Issue: 11
Pages: 1053-66
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Publication
17016846 | -
First Author: Doyle SE
Year: 2006
Journal: Dev Dyn
Title: Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.
Volume: 235
Issue: 12
Pages: 3213-21
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Publication
21618826 | -
 
First Author: Silva JP
Year: 2010
Journal: Adv Exp Med Biol
Title: The latrophilins, "split-personality" receptors.
Volume: 706
Pages: 59-75
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Protein Domain
IPR015630 | Latrophilin-3
Type: Family
Description: Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: LPH1, LPH2 and LPH3. LPH1 is a brain-specific calciumindependent receptor of alpha-latrotoxin (LTX), a neurotoxin. It is the affinity of this form of the receptor for LTX that gives the family its name. LPH2 and LPH3, whilst sharing extensive sequence similarity to LPH1, do not bind LTX. LPH2 is distributed throughout most tissues, whereas LPH3 is also brain-specific []. The endogenous ligand(s) for these receptors are at present unknown. Binding of LTX to LPH1 stimulates exocytosis and the subsequent release of large amounts of neurotransmitters from neuronal and endocrine cells. The latrophilins possess up to 7 sites of alternative splicing; the resulting number of possible splice variants leads to a highly variable family of proteins.Structurally, these proteins have a seven-transmembrane region and a large extracellular N-terminal region which consists of several domains: a rhamnose binding lectin (RBL) domain, an olfactomedin-like (OLF) domain followed by a Serine/Threonine rich domain that is O-linked glycosylated, a hormone binding (HR) domain; and a GPCR Autoproteolysis INducing (GAIN) domain [].This entry represents latrophilin-3 (LPH3). It plays a role in cell-cell adhesion, neuron guidance and in the development of glutamatergic synapses in the cortex through interaction with FLRT3 []. A common variant of the latrophilin 3 gene confers susceptibility to Attention-Deficit/Hyperactivity Disorder (ADHD) [].
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Protein Domain
IPR031240 | Latrophilin-2
Type: Family
Description: Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: Latrophilin-1 (LPH1), -2 (LPH2), and -3 (LPH3). LPH1 is a brain-specific calcium independent receptor of alpha-latrotoxin (LTX), a neurotoxin present in black widow spider venom which triggers massive exocytosis from presynaptic nerve terminals [, ]. It is the affinity of this form of the receptor for LTX that gives the family its name.Two endogenous ligands for latrophilins have been described, teneurin-2 []and FLRT3 []. LPH1 has been shown to bind Lasso (a splice variant of teneurin-2). LPH1 and Lasso interact across intercellular and synaptic junctions, suggesting an involvement in synaptic functions []. Latrophilins are potential synaptic cell-adhesion molecules that interact trans-synaptically with teneurins and FLRTs []. LPH2 and LPH3, whilst sharing extensive sequence similarity to LPH1, do not bind LTX. LPH1 and LPH3 are expressed in neurons, while LPH2 is ubiquitous []. LPH2 is a component of the epithelial-mesenchymal transition in the heart []and may be involved in breast cancer []. This entry refers to both latrophilin-2.
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