| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3526169 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-02-13 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747020 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:3526175 |
| Age: |
embryonic day 12.5 |
| Image: |
2C |
|
| Specimen Label: |
2C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3526169 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-02-13 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747022 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:3526175 |
| Age: |
embryonic day 14.5 |
| Image: |
2D |
|
| Specimen Label: |
2D |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3526169 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-02-13 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747120 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:3526175 |
| Age: |
embryonic day 12.5 |
| Image: |
2C |
|
| Specimen Label: |
2C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3526169 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-02-13 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747122 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:3526175 |
| Age: |
embryonic day 14.5 |
| Image: |
2D |
|
| Specimen Label: |
2D |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Z |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. |
| Volume: |
7 |
|
| Pages: |
12603 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tubb B |
| Year: |
2002 |
| Journal: |
Exp Cell Res |
| Title: |
Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. |
| Volume: |
275 |
| Issue: |
1 |
| Pages: |
92-109 |
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•
•
•
•
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| Journal: |
J Biol Chem |
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Cloning and expression of a murine fascin homolog from mouse brain. |
| Volume: |
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| Issue: |
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| Pages: |
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•
•
•
•
•
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| Publication |
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Li X |
| Year: |
2012 |
| Journal: |
Oncogene |
| Title: |
Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. |
| Volume: |
31 |
| Issue: |
5 |
| Pages: |
595-610 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma Y |
| Year: |
2013 |
| Journal: |
Development |
| Title: |
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation. |
| Volume: |
140 |
| Issue: |
10 |
| Pages: |
2203-11 |
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•
•
•
•
•
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| Publication |
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Huang J |
| Year: |
2024 |
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J Neuroinflammation |
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Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. |
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21 |
| Issue: |
1 |
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88 |
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•
•
•
•
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| Publication |
| First Author: |
De Arcangelis A |
| Year: |
2004 |
| Journal: |
Gene Expr Patterns |
| Title: |
Expression of fascin-1, the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis. |
| Volume: |
4 |
| Issue: |
6 |
| Pages: |
637-43 |
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•
•
•
•
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| Publication |
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| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex. |
| Volume: |
9 |
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•
•
•
•
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| Publication |
| First Author: |
Yamakita Y |
| Year: |
2009 |
| Journal: |
Cell Motil Cytoskeleton |
| Title: |
Fascin1 is dispensable for mouse development but is favorable for neonatal survival. |
| Volume: |
66 |
| Issue: |
8 |
| Pages: |
524-34 |
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•
•
•
•
•
|
| Publication |
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Ma Y |
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2013 |
| Journal: |
Biol Open |
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Fascin 1 is dispensable for developmental and tumour angiogenesis. |
| Volume: |
2 |
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11 |
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•
•
•
•
•
|
| Publication |
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| Year: |
2021 |
| Journal: |
J Immunol |
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Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis. |
| Volume: |
207 |
| Issue: |
3 |
| Pages: |
938-949 |
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•
•
•
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Suzuki S |
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2015 |
| Journal: |
Exp Anim |
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Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice. |
| Volume: |
64 |
| Issue: |
3 |
| Pages: |
241-51 |
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•
•
•
•
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J Immunol |
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| Volume: |
187 |
| Issue: |
12 |
| Pages: |
6327-34 |
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•
•
•
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| Publication |
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Wei Z |
| Year: |
2014 |
| Journal: |
J Neurochem |
| Title: |
Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons. |
| Volume: |
130 |
| Issue: |
5 |
| Pages: |
678-92 |
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•
•
•
•
•
|
| Publication |
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Mejillano MR |
| Year: |
2004 |
| Journal: |
Cell |
| Title: |
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. |
| Volume: |
118 |
| Issue: |
3 |
| Pages: |
363-73 |
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•
•
•
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2019 |
| Journal: |
Nat Commun |
| Title: |
SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. |
| Volume: |
10 |
| Issue: |
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| Journal: |
Dev Genes Evol |
| Title: |
A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. |
| Volume: |
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| Issue: |
5 |
| Pages: |
330-339 |
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| Journal: |
Mech Dev |
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Proc Natl Acad Sci U S A |
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Nucleic Acids Res |
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The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
| Volume: |
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•
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Mouse Genome Informatics Scientific Curators |
| Year: |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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2014 |
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MGI download of germline transmission data for alleles from IMSR strain data |
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Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? |
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|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents fascin (FSCN) and its homologues, including FSCN1/2/3 from mammals and protein singed from fruit flies. Fascin is a globular actin cross-linking protein, which functions in forming parallel actin bundles in cell protrusions that are key specialisations of the plasma membrane for environmental guidance and cell migration []. Human FSCN1 organises filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Overexpression of fascin has been linked to a more aggressive clinical course of cancer []. |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE5510 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng Y |
| Year: |
2007 |
| Journal: |
Mol Cell Biol |
| Title: |
Abnormal sperm in mice lacking the Taf7l gene. |
| Volume: |
27 |
| Issue: |
7 |
| Pages: |
2582-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bros M |
| Year: |
2011 |
| Journal: |
Gene |
| Title: |
Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation. |
| Volume: |
472 |
| Issue: |
1-2 |
| Pages: |
18-27 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
498
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
492
 |
| Fragment?: |
false |
|
•
•
•
•
•
|