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Search results 401 to 500 out of 511 for Gpc3

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:3527506
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:3527507
Age: embryonic day 11.5
Specimen Label: E11.5 genital ridge
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2018-04-27
Strength: Present
Sex: Male
Emaps: EMAPS:3567625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6153842
Age: embryonic day 17.5
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6174227
Assay Type: RNA in situ
Annotation Date: 2021-12-01
Strength: Present
Sex: Male
Emaps: EMAPS:3288723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6828871
Age: embryonic day 15.5
Image: 5 S1
Note: Expression is seen in the dense mesenchyme near the boney otic capsule.
Specimen Label: 5 S1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3527506
Assay Type: RNA in situ
Annotation Date: 2005-02-25
Strength: Absent
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:3527507
Age: embryonic day 14.5
Specimen Label: E14.5 ovary
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5001354
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:5541909
Age: embryonic day 12.5
Image: GUDMAP:7856
Specimen Label: GUDMAP:7856
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5000854
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541413
Age: embryonic day 15.5
Image: GUDMAP:9626
Specimen Label: GUDMAP:9626
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6148292
Assay Type: RNA in situ
Annotation Date: 2018-04-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6149137
Age: embryonic day 10.5
Specimen Label: 4 top
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3061159
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2772123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5538961
Age: embryonic day 15.5
Image: GUDMAP:8814
Specimen Label: GUDMAP:8814
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6148292
Assay Type: RNA in situ
Annotation Date: 2018-04-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:6149137
Age: embryonic day 8.5
Specimen Label: 2B bottom
Detected: true
Specimen Num: 3
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Publication
- | J:63808
   
First Author: Veugelers M
Year: 1999
Journal: GenBank Submission
Title: Mus musculus glypican-3 (Gpc3) mRNA, complete cds
Pages: AF185614
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Publication
26616051 | J:233182
First Author: Iwama T
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Vaccination with liposome-coupled glypican-3-derived epitope peptide stimulates cytotoxic T lymphocytes and inhibits GPC3-expressing tumor growth in mice.
Volume: 469
Issue: 1
Pages: 138-143
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Publication
26517809 | J:317005
First Author: De Robertis M
Year: 2015
Journal: Oncotarget
Title: Novel insights into Notum and glypicans regulation in colorectal cancer.
Volume: 6
Issue: 38
Pages: 41237-57
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Publication
25789613 | J:221247
First Author: Zhang T
Year: 2015
Journal: PLoS One
Title: Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer.
Volume: 10
Issue: 3
Pages: e0118448
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Publication
23911103 | J:201656
First Author: de Wit J
Year: 2013
Journal: Neuron
Title: Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.
Volume: 79
Issue: 4
Pages: 696-711
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Publication
25624497 | J:219796
First Author: Ko JS
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Volume: 112
Issue: 6
Pages: 1874-9
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Publication
32201259 | J:297226
First Author: Lu H
Year: 2020
Journal: Am J Pathol
Title: Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice.
Volume: 190
Issue: 6
Pages: 1175-1187
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Publication
15665292 | J:95511
First Author: Reichling T
Year: 2005
Journal: Cancer Res
Title: Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors.
Volume: 65
Issue: 1
Pages: 166-76
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Publication
17339267 | J:121765
First Author: Duselis AR
Year: 2007
Journal: Hum Mol Genet
Title: Assessment and disease comparisons of hybrid developmental defects.
Volume: 16
Issue: 7
Pages: 808-19
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Publication
28178526 | J:254519
First Author: Li G
Year: 2017
Journal: Cell Rep
Title: CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.
Volume: 18
Issue: 6
Pages: 1499-1511
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Publication
17873295 | J:128588
First Author: Raefski AS
Year: 2007
Journal: J Mol Neurosci
Title: Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice.
Volume: 32
Issue: 2
Pages: 111-9
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Publication
17107664 | J:116479
First Author: Luxardi G
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain.
Volume: 352
Issue: 1
Pages: 55-60
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Publication
12761845 | J:83696
First Author: Ford-Perriss M
Year: 2003
Journal: Dev Dyn
Title: Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development.
Volume: 227
Issue: 2
Pages: 170-84
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Publication
22497843 | J:187541
First Author: Schievenbusch S
Year: 2012
Journal: Stem Cells Dev
Title: Neighbor of Punc E 11: expression pattern of the new hepatic stem/progenitor cell marker during murine liver development.
Volume: 21
Issue: 14
Pages: 2656-66
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Publication
25127920 | J:220108
First Author: Marotta P
Year: 2014
Journal: Mol Cell Endocrinol
Title: The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Volume: 396
Issue: 1-2
Pages: 26-36
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Publication
10668924 | J:59331
First Author: Piscione TD
Year: 1999
Journal: Clin Genet
Title: The malformed kidney: disruption of glomerular and tubular development.
Volume: 56
Issue: 5
Pages: 341-56
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Publication
29183737 | J:257917
First Author: Magella B
Year: 2018
Journal: Dev Biol
Title: Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.
Volume: 434
Issue: 1
Pages: 36-47
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Publication
37408198 | J:337768
 
First Author: Wishart TFL
Year: 2023
Journal: Cells
Title: Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis.
Volume: 12
Issue: 10
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Publication
16844427 | J:116022
First Author: Coveney D
Year: 2007
Journal: Gene Expr Patterns
Title: A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.
Volume: 7
Issue: 1-2
Pages: 82-92
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Publication
25515659 | J:219210
First Author: Nikolaou KC
Year: 2015
Journal: EMBO J
Title: Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.
Volume: 34
Issue: 4
Pages: 430-47
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Publication
26116392 | J:230611
 
First Author: Dierker T
Year: 2016
Journal: Matrix Biol
Title: Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.
Volume: 49
Pages: 82-92
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Publication
26393505 | J:296619
First Author: Fan Y
Year: 2015
Journal: PLoS Genet
Title: Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.
Volume: 11
Issue: 9
Pages: e1005533
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Publication
11431694 | J:70273
First Author: Mitchell KJ
Year: 2001
Journal: Nat Genet
Title: Functional analysis of secreted and transmembrane proteins critical to mouse development.
Volume: 28
Issue: 3
Pages: 241-9
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Publication
19762422 | J:153618
First Author: Ahrens MJ
Year: 2009
Journal: Development
Title: Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.
Volume: 136
Issue: 20
Pages: 3463-74
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Publication
26222436 | J:228828
First Author: Hamazaki J
Year: 2015
Journal: PLoS Genet
Title: Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
Volume: 11
Issue: 7
Pages: e1005401
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Publication
32201365 | J:297362
 
First Author: Bachvarova V
Year: 2020
Journal: Matrix Biol
Title: Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Volume: 93
Pages: 43-59
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Publication
32220631 | J:286311
 
First Author: Wu J
Year: 2020
Journal: Gene Expr Patterns
Title: The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.
Volume: 36
Pages: 119109
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Publication
23754746 | J:204566
First Author: Gendrel AV
Year: 2013
Journal: Mol Cell Biol
Title: Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.
Volume: 33
Issue: 16
Pages: 3150-65
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Publication
38011284 | J:343286
First Author: Queen R
Year: 2023
Journal: PLoS Genet
Title: Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves.
Volume: 19
Issue: 11
Pages: e1010777
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Publication
35831318 | J:326547
First Author: Lu P
Year: 2022
Journal: Nat Commun
Title: A SOX17-PDGFB signaling axis regulates aortic root development.
Volume: 13
Issue: 1
Pages: 4065
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Publication
37279265 | J:343328
First Author: Xie Z
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ZBTB20 is essential for cochlear maturation and hearing in mice.
Volume: 120
Issue: 24
Pages: e2220867120
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Publication
34003106 | J:307862
   
First Author: Wilkerson BA
Year: 2021
Journal: Elife
Title: Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris.
Volume: 10
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Publication
21491433 | J:174459
First Author: Boyle MP
Year: 2011
Journal: J Comp Neurol
Title: Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.
Volume: 519
Issue: 11
Pages: 2061-89
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Publication
19501082 | J:152865
First Author: Georgas K
Year: 2009
Journal: Dev Biol
Title: Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Volume: 332
Issue: 2
Pages: 273-86
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Publication
39217171 | J:353621
First Author: Patel VN
Year: 2024
Journal: Nat Commun
Title: Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.
Volume: 15
Issue: 1
Pages: 7584
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Publication
30228991 | J:283457
 
First Author: Uijtdewilligen PJE
Year: 2018
Journal: Biomed Res Int
Title: Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.
Volume: 2018
Pages: 9873471
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Publication
33932339 | J:306023
First Author: Dani N
Year: 2021
Journal: Cell
Title: A cellular and spatial map of the choroid plexus across brain ventricles and ages.
Volume: 184
Issue: 11
Pages: 3056-3074.e21
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Publication
11044607 | J:65653
First Author: Wertz K
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes involved in gonad development.
Volume: 98
Issue: 1-2
Pages: 51-70
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Publication
28558017 | J:245526
First Author: Bibollet-Bahena O
Year: 2017
Journal: PLoS One
Title: A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
Volume: 12
Issue: 5
Pages: e0177977
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Publication
35084365 | J:326026
First Author: Prokopuk L
Year: 2022
Journal: Reproduction
Title: An essential role for Polycomb Repressive Complex 2 in the mouse ovary.
Volume: 163
Issue: 3
Pages: 167-182
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Publication
28705898 | J:243411
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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Publication
18973680 | J:141291
 
First Author: Tamplin OJ
Year: 2008
Journal: BMC Genomics
Title: Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Volume: 9
Pages: 511
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Gpc3<tm1Fil> | MGI:2159356
Name: glypican 3; targeted mutation 1, Jorge Filmus
Allele Type: Targeted
Attribute String: Null/knockout
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Regulatory Region
MGI:7328750 | Rr217
Type: enhancer
Organism: mouse, laboratory
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Publication
9192268 | -
First Author: Lindsay S
Year: 1997
Journal: J Med Genet
Title: Large scale deletions in the GPC3 gene may account for a minority of cases of Simpson-Golabi-Behmel syndrome.
Volume: 34
Issue: 6
Pages: 480-3
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Allele
Gpc3<em1Smoc> | MGI:7289951
Name: glypican 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475403 | C57BL/6JSmoc-Gpc3<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
8589713 | -
First Author: Pilia G
Year: 1996
Journal: Nat Genet
Title: Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.
Volume: 12
Issue: 3
Pages: 241-7
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Publication
3185547 | -
First Author: Filmus J
Year: 1988
Journal: Mol Cell Biol
Title: Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine.
Volume: 8
Issue: 10
Pages: 4243-9
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Protein Domain
IPR015501 | Glypican-3
Type: Family
Description: Glypicans [, ]are a group of heparan sulphate proteoglycans which are anchored to cell membranes by a glycosylphosphatidylinositol (GPI) linkage. Structurally, these proteins consist of three separate domains:a) A signal sequence;b) An extracellular domain of about 500 residues that contains 12 conserved cysteines probably involved in disulphide bonds and also contains the sites of attachment of the heparan sulphate glycosaminoglycan side chains;c) A C-terminal hydrophobic region that is post-translationally removed after formation of the GPI-anchor. Six members (GPC1-6) are known in vertebrates []. GPC3 encodes a putative extracellular proteoglycan, glypican 3 that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. Initial western- and ligand-blotting experiments suggest that glypican 3 forms a complex with insulin-like growth factor 2 (IGF2), and might thereby modulate IGF2 action []. GPC3 gene defects in a wider range of overgrowth disorders []. GPC3 shares a number of features with the GPC1 [].
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Allele
Et(cre)TFC.09Lois | MGI:5443915
Name: enhancer trap TFC.09, Carlos Lois
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5638414 | STOCK Et(cre)TFC.09Lois/J
Attribute String: mutant stock, enhancer trap
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Genotype
Genotype
Symbol: Et(cre)TFC.09Lois/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Protein
Q8CFZ4
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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