Type |
Details |
Score |
Publication |
First Author: |
Kollman JM |
Year: |
2011 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Microtubule nucleation by γ-tubulin complexes. |
Volume: |
12 |
Issue: |
11 |
Pages: |
709-21 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The microtubule organizing centres (MTOCs) of eukaryotic cells are the sites of nucleation of microtubules, and are known as the centrosome in animal cells and the spindle pole body in yeast. Gamma-tubulin, which is 30% identical to alpha and beta tubulins that form microtubules, appears to be a key protein involved in nucleation of microtubules.Gamma tubulin can assemble into complexes of various sizes with members of the GCP family. In budding yeast, the gamma tubulin-containing small complex (gammaTuSC) contains gamma tubulin, GCP2 and GCP3 (also known as Spc97 and Spc98). In Drosophila and vertebrates, gamma tubulin forms much larger assemblies, termed gamma-tubulin ring complexes (gammaTuRCs), with gamma tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6. The purified gammaTuSC and gammaTuRC complexes exhibit a 'lock washer' shape []. However, the purified gammaTuSC has been shown to have a much lower microtubule-nucleating activity than intact gammaTuRC []. Several models have been proposed to explain their assembly and nucleation mechanism []. This entry represents the GCP family, whose members include GCP2/3/4/5/6 and Spc97/98 []. They contain the GRIP1 and GRIP2 motifs, which are predicted to participate in protein-protein interactions []. They are gamma tubulin binding proteins that have similar protein structures []. |
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•
•
•
•
•
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Publication |
First Author: |
Lee YH |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. |
Volume: |
24 |
Issue: |
5 |
Pages: |
2103-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teyssier C |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Characterization of the physical interaction between estrogen receptor alpha and JUN proteins. |
Volume: |
276 |
Issue: |
39 |
Pages: |
36361-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia J |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. |
Volume: |
280 |
Issue: |
8 |
Pages: |
7285-93 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1042
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1001
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
821
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
174
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
591
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalsotra A |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. |
Volume: |
105 |
Issue: |
51 |
Pages: |
20333-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
302
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
364
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
341
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
905
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
905
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
667
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1024
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1769
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
666
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
667
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
900
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
690
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
676
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
564
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
905
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1761
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
905
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
905
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
580
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
666
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
620
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
666
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gunawardane RN |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits. |
Volume: |
151 |
Issue: |
7 |
Pages: |
1513-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
•
•
•
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