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Search results 401 to 436 out of 436 for Grm5

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0.022s

Type

Details

Score

Allele

Grm5<tm1.1Ito> | MGI:7523172

Name:	glutamate receptor, metabotropic 5; targeted mutation 1.1, Shigeyoshi Itohara
Allele Type:	Targeted
Attribute String:	Conditional ready, Epitope tag, No functional change, Reporter

•

Strain

MGI:6353640 | C57BL/6-Grm5<tm1.1Ito>/ItoRbrc

Attribute String:

coisogenic, mutant strain, targeted mutation

•

Publication

36671524 | J:339543

First Author:	Leembruggen AJL
Year:	2023
Journal:	Biomolecules
Title:	Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon.
Volume:	13
Issue:	1

•

Publication

27513819 | J:237215

First Author:	Martin S
Year:	2016
Journal:	J Neurochem
Title:	Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum.
Volume:	139
Issue:	3
Pages:	349-368

•

Publication

34339538 | J:326974

First Author:	Tanaka M
Year:	2021
Journal:	Glia
Title:	Adenosine A_2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
Volume:	69
Issue:	11
Pages:	2546-2558

•

Publication

7908515 | -

First Author:	Minakami R
Year:	1994
Journal:	Biochem Biophys Res Commun
Title:	Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.
Volume:	199
Issue:	3
Pages:	1136-43

•

Publication

25042998 | -

First Author:	Doré AS
Year:	2014
Journal:	Nature
Title:	Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Volume:	511
Issue:	7511
Pages:	557-62

•

Publication

34469715 | -

First Author:	Nasrallah C
Year:	2021
Journal:	Cell Rep
Title:	Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Volume:	36
Issue:	9
Pages:	109648

•

Protein Domain

IPR000202 | GPCR_3_mGluR5

Type:

Family

Description:

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drugtargets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.mRNA for GRM5 is widespread in the brain, with a unique distribution; it is found in highlevels in the striatum, cerebral cortex, hippocampus and olfactory bulb.GRM5 activates the phosphoinositide pathway. It plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity []. Like GRM1 [], it is a potential therapeutic target for several diseases []with a similar structure to this seen in the entire GPCR superfamily [, ].

•

Publication

20055706 | -

First Author:	Niswender CM
Year:	2010
Journal:	Annu Rev Pharmacol Toxicol
Title:	Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Volume:	50

Pages:	295-322

•

Protein

Q8BJY3

Organism:	Mus musculus/domesticus
Length:	324
Fragment?:	true

•

Publication

7476890 | -

First Author:	Desai MA
Year:	1995
Journal:	Mol Pharmacol
Title:	Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.
Volume:	48
Issue:	4
Pages:	648-57

•

Publication

28886343 | -

First Author:	Watson LM
Year:	2017
Journal:	Am J Hum Genet
Title:	Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44.
Volume:	101
Issue:	3
Pages:	451-458

•

Publication

24603153 | -

First Author:	Wu H
Year:	2014
Journal:	Science
Title:	Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Volume:	344
Issue:	6179
Pages:	58-64

•

Protein Domain

IPR001256 | GPCR_3_mGluR1

Type:

Family

Description:

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.mRNA for GRM1 is widespread in the brain and is abundant in neuronal cells in hippocampaldentate gyrus and CA2-3 regions, cerebellum Purkinje cells, olfactory bulband thalamic nuclei. GRM1 activates the phophoinositide pathway. It is thought to participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum [, ]. Like GRM5 [], it is a potential therapeutic target for several diseases []. Crystallisation of its seven transmembrane domain shows a similar structure to this seen in the entire GPCR protein family [].

•

Publication

1320017 | -

First Author:	Abe T
Year:	1992
Journal:	J Biol Chem
Title:	Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume:	267
Issue:	19
Pages:	13361-8

•

Publication

1847995 | -

First Author:	Masu M
Year:	1991
Journal:	Nature
Title:	Sequence and expression of a metabotropic glutamate receptor.
Volume:	349
Issue:	6312
Pages:	760-5

•

Publication

1656524 | -

First Author:	Houamed KM
Year:	1991
Journal:	Science
Title:	Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Volume:	252
Issue:	5010
Pages:	1318-21

•

Publication

10773016 | -

First Author:	Sullivan R
Year:	2000
Journal:	J Pharmacol Exp Ther
Title:	Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
Volume:	293
Issue:	2
Pages:	460-7

•

Publication

9292726 | J:42626

First Author:	Ryba NJ
Year:	1997
Journal:	Neuron
Title:	A new multigene family of putative pheromone receptors.
Volume:	19
Issue:	2
Pages:	371-9

•

Publication

17266540 | -

First Author:	Bräuner-Osborne H
Year:	2007
Journal:	Curr Drug Targets
Title:	Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Volume:	8
Issue:	1
Pages:	169-84

•

Protein

Q3UVX5

Organism:	Mus musculus/domesticus
Length:	1203
Fragment?:	false

•

Protein

P97772

Organism:	Mus musculus/domesticus
Length:	1199
Fragment?:	false

•

Protein

E9QMC2

Organism:	Mus musculus/domesticus
Length:	1171
Fragment?:	false

•

Protein

Q3V0U2

Organism:	Mus musculus/domesticus
Length:	742
Fragment?:	true

•

Protein

B2BH30

Organism:	Mus musculus/domesticus
Length:	1203
Fragment?:	false

•

Publication

8255296 | -

First Author:	Brown EM
Year:	1993
Journal:	Nature
Title:	Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Volume:	366
Issue:	6455
Pages:	575-80

•

Publication

1309649 | -

First Author:	Tanabe Y
Year:	1992
Journal:	Neuron
Title:	A family of metabotropic glutamate receptors.
Volume:	8
Issue:	1
Pages:	169-79

•

Publication

12679517 | J:83410

First Author:	Vassilatis DK
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	The G protein-coupled receptor repertoires of human and mouse.
Volume:	100
Issue:	8
Pages:	4903-8

•

Publication

8170923 | -

First Author:	Attwood TK
Year:	1994
Journal:	Protein Eng
Title:	Fingerprinting G-protein-coupled receptors.
Volume:	7
Issue:	2
Pages:	195-203

•

Publication

8081729 | -

First Author:	Kolakowski LF Jr
Year:	1994
Journal:	Receptors Channels
Title:	GCRDb: a G-protein-coupled receptor database.
Volume:	2
Issue:	1
Pages:	1-7

•

Publication

15914470 | -

First Author:	Foord SM
Year:	2005
Journal:	Pharmacol Rev
Title:	International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume:	57
Issue:	2
Pages:	279-88

•

Publication

18948278 | -

First Author:	Harmar AJ
Year:	2009
Journal:	Nucleic Acids Res
Title:	IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume:	37
Issue:	Database issue
Pages:	D680-5

•

Publication

16753280 | J:115055

First Author:	Bjarnadóttir TK
Year:	2006
Journal:	Genomics
Title:	Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume:	88
Issue:	3
Pages:	263-73

•

Publication

23020293 | -

First Author:	Civelli O
Year:	2013
Journal:	Annu Rev Pharmacol Toxicol
Title:	G protein-coupled receptor deorphanizations.
Volume:	53

Pages:	127-46

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

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