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Search results 401 to 417 out of 417 for Has3

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0.009s

Type

Details

Score

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Allele

Has3<tm1.1(HAS3)Geno> | MGI:6201738

Name:	hyaluronan synthase 3; targeted mutation 1.1, Genoway
Allele Type:	Targeted
Attribute String:	Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout

•

Allele

Has3<tm1.2Geno> | MGI:6201739

Name:	hyaluronan synthase 3; targeted mutation 1.2, Genoway
Allele Type:	Targeted
Attribute String:	Null/knockout

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Protein Domain

IPR028371 | HAS2

Type:

Family

Description:

This entry represents the hyaluronan synthase 2 (HAS2), which plays a role in hyaluronan/hyaluronic acid (HA) synthesis []. There are three different, but related hyaluronan synthases - HAS1, HAS2 and HAS3. They are multipass transmembrane enzymes, the active sites of which protrude from the inner face of the plasma membrane. HA is an unbranched disaccharide glucuronic acid/N-acetylglucosamine polymer and is one of the main components of the extracellular matrix []. High level of HA in humans is associated with cancer progression [, ]. In vertebrates, different HA polymer length can trigger different biological responses. High-molecular-mass HA represses mitogenic signalling and has anti-inflammatory properties, while low-molecular-mass HA promotes proliferation and inflammation [, ]. A study of the naked mole rat showed that HAS2 is overexpressed in naked mole rat fibroblasts, while the expression levels of HAS1 and HAS3 are similar between mouse, human and naked mole-rat cells []. HAS2 is responsible for the synthesis of the high-molecular-mass HA (HMM-HA), which triggers ECI (early contact inhibition) via the CD44 receptor and plays a key role in mediating the cancer resistance of the naked mole rat [].

•

Protein

P70312

Organism:	Mus musculus/domesticus
Length:	552
Fragment?:	false

•

Publication

23783513 | -

First Author:	Tian X
Year:	2013
Journal:	Nature
Title:	High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.
Volume:	499
Issue:	7458
Pages:	346-9

•

Publication

15229478 | -

First Author:	Toole BP
Year:	2004
Journal:	Nat Rev Cancer
Title:	Hyaluronan: from extracellular glue to pericellular cue.
Volume:	4
Issue:	7
Pages:	528-39

•

Publication

11313172 | -

First Author:	Lipponen P
Year:	2001
Journal:	Eur J Cancer
Title:	High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer.
Volume:	37
Issue:	7
Pages:	849-56

•

Publication

17296798 | J:119716

First Author:	Kothapalli D
Year:	2007
Journal:	J Cell Biol
Title:	Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells.
Volume:	176
Issue:	4
Pages:	535-44

•

Publication

31036697 | J:276891

First Author:	Collum SD
Year:	2019
Journal:	Dis Model Mech
Title:	Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.
Volume:	12
Issue:	5

•

Publication

30858465 | J:276653

First Author:	Sukowati CHC
Year:	2019
Journal:	Sci Rep
Title:	Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis.
Volume:	9
Issue:	1
Pages:	4026

•

Publication

28234253 | J:355617

First Author:	Li Y
Year:	2017
Journal:	J Alzheimers Dis
Title:	Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases.
Volume:	57
Issue:	2
Pages:	395-409

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