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Search results 401 to 421 out of 421 for Homer2

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Type Details Score
Protein
E9Q0I8
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein Domain
IPR044100 | Homer_EVH1
Type: Domain
Description: Homer (also known as Vesl) family members, including Homer1/2/3, are synaptic scaffolding proteins that regulate localisation of group 1 metabotropic glutamate receptors (mGluRs), which are known to play major roles in neural signal transduction. Homer family members contain the EVH1 domain at the N terminus for receptor binding, two leucine zipper motifs at the C terminus for clustering, and a linking region whose function is unclear. Besides binding to mGluR, Homer family members also recognise the PPXXF motif found in other binding partners []. Homer2 and Homer3, but not Homer1, have been shown to bind to nuclear factor of activated T cells (NFAT) and serve as negative regulators of NFAT-dependent signaling in T cells [].This entry represents the N-terminal EVH1 domain found in the Homer family members [, ].
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Protein Domain
IPR045027 | Homer
Type: Family
Description: Homer (also known as Vesl) family members, including Homer1/2/3, are synaptic scaffolding proteins that regulate localisation of group 1 metabotropic glutamate receptors (mGluRs), which are known to play major roles in neural signal transduction. Homer family members contain the EVH1 domain at the N terminus for receptor binding, two leucine zipper motifs at the C terminus for clustering, and a linking region whose function is unclear. Besides binding to mGluR, Homer family members also recognise the PPXXF motif found in other binding partners []. Homer2 and Homer3, but not Homer1, have been shown to bind to nuclear factor of activated T cells (NFAT) and serve as negative regulators of NFAT-dependent signaling in T cells [].
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Publication
19587272 | J:151084
First Author: Cozzoli DK
Year: 2009
Journal: J Neurosci
Title: Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism.
Volume: 29
Issue: 27
Pages: 8655-68
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Publication
23966068 | J:319009
First Author: Cozzoli DK
Year: 2014
Journal: Neuropsychopharmacology
Title: Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala.
Volume: 39
Issue: 2
Pages: 435-44
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Publication
17355963 | J:122552
First Author: Huang G
Year: 2007
Journal: J Biol Chem
Title: Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling.
Volume: 282
Issue: 19
Pages: 14283-90
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Protein
Q9Z2Y3
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Protein
Q99JP6
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
Q9QWW1
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
D3Z6A9
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
D3Z6A7
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
D3Z6A8
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
Q5D052
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
Q3UVL6
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
Q501M9
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Publication
9808459 | -
First Author: Tu JC
Year: 1998
Journal: Neuron
Title: Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.
Volume: 21
Issue: 4
Pages: 717-26
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Publication
30737312 | J:274392
First Author: Campbell RR
Year: 2019
Journal: J Neurosci
Title: Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.
Volume: 39
Issue: 14
Pages: 2745-2761
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Protein
A0A140LHR9
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
A0A140LJ06
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Protein
E9Q4F9
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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