Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dayalan Naidu S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Transcription factors NRF2 and HSF1 have opposing functions in autophagy. |
Volume: |
7 |
Issue: |
1 |
Pages: |
11023 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu W |
Year: |
2019 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury. |
Volume: |
60 |
Issue: |
4 |
Pages: |
965-977 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gomez-Pastor R |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease. |
Volume: |
8 |
|
Pages: |
14405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santagata S |
Year: |
2013 |
Journal: |
Science |
Title: |
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. |
Volume: |
341 |
Issue: |
6143 |
Pages: |
1238303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kubota H |
Year: |
1999 |
Journal: |
FEBS Lett |
Title: |
Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2. |
Volume: |
461 |
Issue: |
1-2 |
Pages: |
125-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waldhart AN |
Year: |
2023 |
Journal: |
iScience |
Title: |
Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP. |
Volume: |
26 |
Issue: |
5 |
Pages: |
106538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green M |
Year: |
1995 |
Journal: |
Mol Cell Biol |
Title: |
A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. |
Volume: |
15 |
Issue: |
6 |
Pages: |
3354-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan K |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity. |
Volume: |
6 |
|
Pages: |
6580 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE26240 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Isermann T |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4019 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schulz R |
Year: |
2014 |
Journal: |
Cell Death Dis |
Title: |
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer. |
Volume: |
5 |
|
Pages: |
e980 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice. |
Volume: |
34 |
Issue: |
21 |
Pages: |
7253-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin YH |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress. |
Volume: |
464 |
Issue: |
2 |
Pages: |
561-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zou Y |
Year: |
2003 |
Journal: |
Circulation |
Title: |
Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. |
Volume: |
108 |
Issue: |
24 |
Pages: |
3024-30 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Akira Nakai |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka K |
Year: |
2010 |
Journal: |
Biochem Pharmacol |
Title: |
Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. |
Volume: |
80 |
Issue: |
6 |
Pages: |
920-31 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(ACTB-HSF1)1Anak/? |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2017 |
Journal: |
Oncotarget |
Title: |
FAM3C activates HSF1 to suppress hepatic gluconeogenesis and attenuate hyperglycemia of type 1 diabetic mice. |
Volume: |
8 |
Issue: |
62 |
Pages: |
106038-106049 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raitt DC |
Year: |
2000 |
Journal: |
Mol Biol Cell |
Title: |
The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress. |
Volume: |
11 |
Issue: |
7 |
Pages: |
2335-47 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hsf1/Hsf1 Tg(ACTB-HSF1)1Anak/? |
Background: |
involves: C57BL/6 * CBA * ICR |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
462
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
525
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1149
 |
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
160
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheldon LA |
Year: |
1993 |
Journal: |
Genes Dev |
Title: |
Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. |
Volume: |
7 |
Issue: |
8 |
Pages: |
1549-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abane R |
Year: |
2010 |
Journal: |
FEBS J |
Title: |
Roles of heat shock factors in gametogenesis and development. |
Volume: |
277 |
Issue: |
20 |
Pages: |
4150-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakurai H |
Year: |
2010 |
Journal: |
FEBS J |
Title: |
Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression. |
Volume: |
277 |
Issue: |
20 |
Pages: |
4140-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sandqvist A |
Year: |
2009 |
Journal: |
Mol Biol Cell |
Title: |
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. |
Volume: |
20 |
Issue: |
5 |
Pages: |
1340-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Four heat shock factor proteins (HSFs) have been identified in vertebrates (HSF1-4) []. HSF2 is localised to the cytoplasm duringnormal growth and moves to the nucleus upon activation [], where it specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 may not be directly involved in the stress response, but rather in cell differentiation and development [, ]. HSF1 and HSF2 can form heterotrimers, which could be a mechanism regulating transcription []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
806
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakai A |
Year: |
1999 |
Journal: |
Cell Stress Chaperones |
Title: |
New aspects in the vertebrate heat shock factor system: Hsf3 and Hsf4. |
Volume: |
4 |
Issue: |
2 |
Pages: |
86-93 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
724
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Solimini NL |
Year: |
2007 |
Journal: |
Cell |
Title: |
Non-oncogene addiction and the stress phenotype of cancer cells. |
Volume: |
130 |
Issue: |
6 |
Pages: |
986-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wooten MW |
Year: |
1999 |
Journal: |
Cell Death Differ |
Title: |
Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway. |
Volume: |
6 |
Issue: |
8 |
Pages: |
753-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki A |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. |
Volume: |
152 |
Issue: |
6 |
Pages: |
1183-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boellmann F |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
The identification of protein kinase C iota as a regulator of the Mammalian heat shock response using functional genomic screens. |
Volume: |
5 |
Issue: |
7 |
Pages: |
e11850 |
|
•
•
•
•
•
|
Publication |
First Author: |
Regala RP |
Year: |
2009 |
Journal: |
Cancer Res |
Title: |
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. |
Volume: |
69 |
Issue: |
19 |
Pages: |
7603-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kikuchi K |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. |
Volume: |
32 |
Issue: |
3 |
Pages: |
286-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohno S |
Year: |
2001 |
Journal: |
Curr Opin Cell Biol |
Title: |
Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. |
Volume: |
13 |
Issue: |
5 |
Pages: |
641-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Monick MM |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. |
Volume: |
165 |
Issue: |
8 |
Pages: |
4632-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wodarz A |
Year: |
2000 |
Journal: |
J Cell Biol |
Title: |
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. |
Volume: |
150 |
Issue: |
6 |
Pages: |
1361-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu SL |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism. |
Volume: |
273 |
Issue: |
2 |
Pages: |
1130-43 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This group represents protein kinase C (KPC), including zeta/iota types from mammals, protein kinase C-like 3 from round worms []and atypical protein kinase C (aPKC) from fruit flies []. Protein kinase C iota type (PRKCI) is a calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway [, , ]. It is an indirect co-regulator of the stress-activated transcription factor HSF1 and the heat shock response []. It has been linked to cancers [, ].Protein kinase C zeta type is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP) []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
255
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
733
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu D |
Year: |
2008 |
Journal: |
EMBO Rep |
Title: |
A transcription cofactor required for the heat-shock response. |
Volume: |
9 |
Issue: |
7 |
Pages: |
662-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee JH |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice. |
Volume: |
430 |
Issue: |
3 |
Pages: |
1109-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elsing AN |
Year: |
2014 |
Journal: |
J Cell Biol |
Title: |
Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. |
Volume: |
206 |
Issue: |
6 |
Pages: |
735-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maheshwari M |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease. |
Volume: |
23 |
Issue: |
10 |
Pages: |
2737-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
McMillan DR |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice. |
Volume: |
22 |
Issue: |
22 |
Pages: |
8005-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui D |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy. |
Volume: |
14 |
Issue: |
1 |
Pages: |
7032 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sebag SC |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. |
Volume: |
37 |
Issue: |
7 |
Pages: |
110003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ling X |
Year: |
2022 |
Journal: |
iScience |
Title: |
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis. |
Volume: |
25 |
Issue: |
11 |
Pages: |
105363 |
|
•
•
•
•
•
|
Publication |
First Author: |
Michel D |
Year: |
1997 |
Journal: |
Biochem J |
Title: |
Stress-induced transcription of the clusterin/apoJ gene. |
Volume: |
328 ( Pt 1) |
|
Pages: |
45-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donmez G |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. |
Volume: |
32 |
Issue: |
1 |
Pages: |
124-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mahat DB |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation. |
Volume: |
62 |
Issue: |
1 |
Pages: |
63-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Das S |
Year: |
2020 |
Journal: |
Elife |
Title: |
Serotonin signaling by maternal neurons upon stress ensures progeny survival. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Grunberg N |
Year: |
2021 |
Journal: |
Cancer Res |
Title: |
Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles. |
Volume: |
81 |
Issue: |
7 |
Pages: |
1639-1653 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li G |
Year: |
2021 |
Journal: |
Nat Cell Biol |
Title: |
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy. |
Volume: |
23 |
Issue: |
5 |
Pages: |
526-537 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collins CB |
Year: |
2013 |
Journal: |
Mucosal Immunol |
Title: |
Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. |
Volume: |
6 |
Issue: |
5 |
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