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Search results 401 to 500 out of 633 for Icos

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Type Details Score
Allele
Icosl<em5Smoc> | MGI:7626511
Name: icos ligand; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Icosl/Icosl
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Icosl/Icosl
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Publication
23578385 | J:198478
First Author: Riella LV
Year: 2013
Journal: Am J Pathol
Title: B7h (ICOS-L) maintains tolerance at the fetomaternal interface.
Volume: 182
Issue: 6
Pages: 2204-13
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Publication
31131325 | J:288087
First Author: Hong SW
Year: 2019
Journal: Sci Adv
Title: Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota.
Volume: 5
Issue: 5
Pages: eaaw1507
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Publication
24510964 | J:209925
First Author: White AJ
Year: 2014
Journal: J Immunol
Title: An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Volume: 192
Issue: 6
Pages: 2659-66
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Publication
19204112 | J:146450
First Author: Maynard CL
Year: 2009
Journal: J Exp Med
Title: Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells.
Volume: 206
Issue: 2
Pages: 343-57
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Publication
27183569 | J:299354
First Author: Smith C
Year: 2016
Journal: J Immunol
Title: CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.
Volume: 196
Issue: 12
Pages: 4935-46
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Interaction Experiment
Leavenworth JW (2015)
Description: A p85-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells.
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Publication
30814730 | J:276513
First Author: Liu X
Year: 2019
Journal: Nature
Title: Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.
Volume: 567
Issue: 7749
Pages: 525-529
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Publication
28978473 | J:254230
First Author: Kim BS
Year: 2017
Journal: Cell Rep
Title: Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity.
Volume: 21
Issue: 1
Pages: 195-207
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Publication
16887997 | J:138390
First Author: Logue EC
Year: 2006
Journal: J Immunol
Title: ICOS-induced B7h shedding on B cells is inhibited by TLR7/8 and TLR9.
Volume: 177
Issue: 4
Pages: 2356-64
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Allele
Icos<em3Smoc> | MGI:7290299
Name: inducible T cell co-stimulator; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Icos<em5(ICOS)Smoc> | MGI:7643468
Name: inducible T cell co-stimulator; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence, Null/knockout
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Strain
MGI:6354868 | C57BL/6JSmoc-Icos<em6(ICOS)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
35301301 | J:322874
First Author: Kwon DI
Year: 2022
Journal: Nat Commun
Title: Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival.
Volume: 13
Issue: 1
Pages: 1418
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Strain
MGI:2682594 | B6.129P2-Icosl<tm1Mak>/J
Attribute String: mutant strain, targeted mutation
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Strain
MGI:6770869 | C57BL/6JSmoc-Icosl<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6354869 | C57BL/6JSmoc-Icosl<em2(ICOSLG)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6428879 | C57BL/6JSmoc-Icosl<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7718098 | C57BL/6JSmoc-Icosl<em4Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7381702 | C57BL/6JGpt-Icosl<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7853843 | C57BL/6N-Icosl<em1(IMPC)Ics>/Ics
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6428880 | C57BL/6JSmoc-Icosl<tm3(ICOSLG)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6475528 | C57BL/6JSmoc-Icosl<em5Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Icosl/Icosl
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
20574047 | J:164496
First Author: Fukaya T
Year: 2010
Journal: Blood
Title: Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Volume: 116
Issue: 13
Pages: 2266-76
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Allele
Icos<em2(ICOS)Smoc> | MGI:7290298
Name: inducible T cell co-stimulator; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6354867 | C57BL/6JSmoc-Icos<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
11283156 | J:68616
First Author: Tseng SY
Year: 2001
Journal: J Exp Med
Title: B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
Volume: 193
Issue: 7
Pages: 839-46
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Publication
25552357 | J:234140
First Author: Clement M
Year: 2015
Journal: Circulation
Title: Control of the T follicular helper-germinal center B-cell axis by CD8⁺ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development.
Volume: 131
Issue: 6
Pages: 560-70
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Strain
MGI:6475972 | C57BL/6JSmoc-Pdcd1<em1(PDCD1)Smoc> Icos<em5(ICOS)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Icos<em1Smoc> | MGI:7290297
Name: inducible T cell co-stimulator; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6354866 | C57BL/6JSmoc-Icos<em2(ICOS)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
11015443 | J:64991
First Author: Freeman GJ
Year: 2000
Journal: J Exp Med
Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Volume: 192
Issue: 7
Pages: 1027-34
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Publication
11036763 | J:68971
 
First Author: Aurrand-Lions MA
Year: 2000
Journal: Curr Top Microbiol Immunol
Title: Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?
Volume: 251
Pages: 91-8
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Publication
21768353 | J:176027
First Author: Hu H
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development.
Volume: 108
Issue: 31
Pages: 12827-32
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Publication
20639877 | J:162534
First Author: Glasmacher E
Year: 2010
Journal: Nat Immunol
Title: Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.
Volume: 11
Issue: 8
Pages: 725-33
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Publication
25002484 | J:212264
First Author: Xin L
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.
Volume: 111
Issue: 29
Pages: 10672-7
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Publication
23583642 | J:196137
First Author: Pratama A
Year: 2013
Journal: Immunity
Title: Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.
Volume: 38
Issue: 4
Pages: 669-80
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Publication
17182586 | J:141924
First Author: Zhang P
Year: 2007
Journal: J Immunol
Title: The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Volume: 178
Issue: 1
Pages: 474-9
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MP Term
MP:0010187 | decreased T follicular helper cell number
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MP Term
MP:0010186 | increased T follicular helper cell number
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MP Term
MP:0010189 | abnormal T follicular helper cell physiology
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MP Term
MP:0010184 | abnormal T follicular helper cell morphology
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MP Term
MP:0010185 | abnormal T follicular helper cell number
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Publication
15917799 | J:98938
First Author: Vinuesa CG
Year: 2005
Journal: Nature
Title: A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
Volume: 435
Issue: 7041
Pages: 452-8
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Publication
25261207 | -
 
First Author: Qi H
Year: 2014
Journal: Adv Exp Med Biol
Title: Tfh cell differentiation and their function in promoting B-cell responses.
Volume: 841
Pages: 153-80
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Protein Domain
IPR032671 | RC3H1
Type: Family
Description: Roquin-1 (RC3H1) is a post-transcriptional repressor required to repress follicular helper T cells (Tfh) and autoimmunity []. It binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. For instance, it controls ICOS (inducible costimulator) expression through binding to the 3' UTR of ICOS mRNA and by interacting with proteins that confer post-transcriptional repression []. Besides ICOS, it also represses Ox40 and interferon-gamma in T cells, and this helps to prevent inappropriate T cell activation and Tfh cell differentiation [, ].Roquin-1 and its paralogue, Roquin-2 (Rc3h2), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [, ]. Tfhs are helper T-cells specialised in facilitating B-cell responses [].
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Genotype
Genotype
Symbol: Rinl/Rinl Tg(TcraTcrb)425Cbn/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Allele
Pnp<bata> | MGI:5468722
 
Name: purine-nucleoside phosphorylase; bata
Allele Type: Chemically induced (ENU)
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Allele
Rhoa<tm1.1Tpal> | MGI:6401218
Name: ras homolog family member A; targeted mutation 1.1, Teresa Palomero
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Tox2<em1Cdon> | MGI:7738442
Name: TOX high mobility group box family member 2; endonuclease-mediated mutation 1, Chen Dong
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1
Background: involves: C57BL/6 * C57BL/6JSfdAnu
Zygosity: ht
Has Mutant Allele: true
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MP Term
MP:0010188 | abnormal T follicular helper cell differentiation
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Protein Coding Gene
MGI:1098211 | Pik3cd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2443588 | Pik3r5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2144613 | Pik3r6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1353576 | Pik3cg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q5SW28
Organism: Mus musculus/domesticus
Length: 871  
Fragment?: false
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Protein
Q9JHG7
Organism: Mus musculus/domesticus
Length: 1102  
Fragment?: false
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Protein
Q3U6Q4
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
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Allele
Bcl6<tm1.1Dent> | MGI:5518542
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Alexander Dent
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Id3<tm2.1Cmu> | MGI:5305600
Name: inhibitor of DNA binding 3; targeted mutation 2.1, Cornelis Murre
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Il1r2<tm1.1Mchc> | MGI:7643172
Name: interleukin 1 receptor, type II; targeted mutation 1.1, Murray CH Clarke
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Mir146/Mir146 Ighg1/Ighg1<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir146/Mir146 Tg(CD2-icre)4Kio/?
Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Il1r2/Il1r2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:109277 | Pik3r3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q64143
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
O35904
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: false
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Allele
Bcl6<tm1.1Toka> | MGI:5140802
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Takaharu Okada
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Pten/Pten Tnfrsf4/Tnfrsf4<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Id3/Id3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pnp/Pnp
Background: C57BL/6JSfdAnu-Pnp
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40<+> Mir146/Mir146 Tg(Cr2-cre)3Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir146/Mir146 Mir146b/Mir146b Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rhoa/Rhoa<+> Tg(Cd4-cre/ERT2)11Gnri/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tox2/Tox2
Background: C57BL/6J-Tox2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1<+>
Background: involves: C57BL/6JSfdAnu
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl6/Bcl6 Tg(Cd4-cre)1Cwi/?
Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Allele
Mir146<tm1.1Lfl> | MGI:6359885
Name: microRNA 146; targeted mutation 1.1, Li-Fan Lu
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Bcl6/Bcl6
Background: involves: C57BL/6 * NZB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1 Rc3h2/Rc3h2
Background: involves: C57BL/6 * C57BL/6JSfdAnu
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir146/Mir146 Tg(Cr2-cre)3Cgn/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Foxp3/Foxp3<+> Il1r2/Il1r2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:1922019 | Pik3cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BTI9
Organism: Mus musculus/domesticus
Length: 1064  
Fragment?: false
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Publication
25697406 | J:221791
 
First Author: Srivastava M
Year: 2015
Journal: Nat Commun
Title: Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Volume: 6
Pages: 6253
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Publication
31636135 | J:285064
 
First Author: Long X
Year: 2020
Journal: J Exp Med
Title: Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation.
Volume: 217
Issue: 1
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Publication
24859450 | J:215934
First Author: Wang H
Year: 2014
Journal: Nat Immunol
Title: The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells.
Volume: 15
Issue: 7
Pages: 667-75
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Publication
18599325 | J:137869
First Author: Nurieva RI
Year: 2008
Journal: Immunity
Title: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
Volume: 29
Issue: 1
Pages: 138-49
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Publication
16878136 | J:112657
First Author: Croxford JL
Year: 2006
Journal: Nat Immunol
Title: Invariant V(alpha)19i T cells regulate autoimmune inflammation.
Volume: 7
Issue: 9
Pages: 987-94
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Publication
30082831 | J:301723
First Author: Takatsuka S
Year: 2018
Journal: Nat Immunol
Title: IL-9 receptor signaling in memory B cells regulates humoral recall responses.
Volume: 19
Issue: 9
Pages: 1025-1034
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Publication
35021053 | J:335798
First Author: Chaurio RA
Year: 2022
Journal: Immunity
Title: TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.
Volume: 55
Issue: 1
Pages: 115-128.e9
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Publication
33207246 | J:300245
First Author: Su W
Year: 2020
Journal: Cell Metab
Title: Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.
Volume: 32
Issue: 6
Pages: 996-1011.e7
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Publication
37590141 | J:339618
First Author: Cohen GS
Year: 2023
Journal: Cell Rep
Title: Transplantation elicits a clonally diverse CD8(+) T cell response that is comprised of potent CD43(+) effectors.
Volume: 42
Issue: 8
Pages: 112993
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Publication
30559442 | J:268329
First Author: Koizumi SI
Year: 2018
Journal: Nat Commun
Title: JunB regulates homeostasis and suppressive functions of effector regulatory T cells.
Volume: 9
Issue: 1
Pages: 5344
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Publication
23159227 | J:190440
First Author: Lee SK
Year: 2012
Journal: Immunity
Title: Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers.
Volume: 37
Issue: 5
Pages: 880-92
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Publication
26214741 | J:241194
First Author: Choi YS
Year: 2015
Journal: Nat Immunol
Title: LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Volume: 16
Issue: 9
Pages: 980-90
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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