| Type |
Details |
Score |
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The interferon-alpha/beta receptor 1 family of proteins associates with IFNAR2 to form the type I interferon receptor. Binding of interferons alpha and beta to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Fung KY |
| Year: |
2013 |
| Journal: |
Science |
| Title: |
Interferon-ε protects the female reproductive tract from viral and bacterial infection. |
| Volume: |
339 |
| Issue: |
6123 |
| Pages: |
1088-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang P |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
4700 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arimoto KI |
| Year: |
2017 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
279-289 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pfeffer LM |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
The short form of the interferon alpha/beta receptor chain 2 acts as a dominant negative for type I interferon action. |
| Volume: |
272 |
| Issue: |
17 |
| Pages: |
11002-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malakhova OA |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. |
| Volume: |
25 |
| Issue: |
11 |
| Pages: |
2358-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zuo Y |
| Year: |
2022 |
| Journal: |
Sci Adv |
| Title: |
LATS1 is a central signal transmitter for achieving full type-I interferon activity. |
| Volume: |
8 |
| Issue: |
14 |
| Pages: |
eabj3887 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar KG |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. |
| Volume: |
22 |
| Issue: |
20 |
| Pages: |
5480-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blomberg E |
| Year: |
2023 |
| Journal: |
Transl Oncol |
| Title: |
Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models. |
| Volume: |
28 |
|
| Pages: |
101607 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McCormack R |
| Year: |
2020 |
| Journal: |
J Immunol |
| Title: |
An Essential Role for Perforin-2 in Type I IFN Signaling. |
| Volume: |
204 |
| Issue: |
8 |
| Pages: |
2242-2256 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harari D |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Bridging the species divide: transgenic mice humanized for type-I interferon response. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e84259 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han CS |
| Year: |
1997 |
| Journal: |
Endocrinology |
| Title: |
Molecular cloning of ovine and bovine type I interferon receptor subunits from uteri, and endometrial expression of messenger ribonucleic acid for ovine receptors during the estrous cycle and pregnancy. |
| Volume: |
138 |
| Issue: |
11 |
| Pages: |
4757-67 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
590
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
590
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
590
 |
| Fragment?: |
false |
|
•
•
•
•
•
|