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Search results 401 to 418 out of 418 for Igf2bp1

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Type

Details

Score

Publication

39353395 | J:358419

First Author:	Jiang H
Year:	2024
Journal:	Int Immunopharmacol
Title:	GSDMB interacts with IGF2BP1 to suppress colorectal cancer progression by modulating DUSP6-ERK pathway.
Volume:	143
Issue:	Pt 1
Pages:	113280

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Allele

Igf2bp1<em1Smoc> | MGI:7290356

Name:	insulin-like growth factor 2 mRNA binding protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Strain

MGI:7623398 | C57BL/6JSmoc-Igf2bp1<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

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Publication

22465430 | -

First Author:	Manieri NA
Year:	2012
Journal:	Gastroenterology
Title:	Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.
Volume:	143
Issue:	1
Pages:	110-21.e10

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Protein Domain

IPR034837 | IGF2BP1_RRM1

Type:

Domain

Description:

This entry represents the RNA recognition motif 1 (RRM1) of IGF2BP1 (insulin-like growth factor 2 mRNA-binding protein 1 or IMP-1).IGF2BP1 (also known as ZBP-1 or IMP1) is a multi-functional regulator of RNA metabolism that has been implicated in the control of aspects of localization, stability, and translation for many mRNAs []. It is predominantly located in cytoplasm and was initially identified as a trans-acting factor that interacts with the zipcode in the 3'- untranslated region (UTR) of the beta-actin mRNA, which is important for its localization and translational regulation [, ]. IGF2BP1 also acts as human immunodeficiency virus type 1 (HIV-1) Gag-binding factor that interacts with HIV-1 Gag protein and blocks the formation of infectious HIV-1 particles []. It has also been linked to tumour growth []. IGF2BP1 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain. It also contains two putative nuclear export signals (NESs) and a putative nuclear localization signal (NLS).

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Protein Domain

IPR034842 | IGF2BP1_RRM2

Type:

Domain

Description:

This entry represents the RNA recognition motif 2 (RRM2) of IGF2BP1 (insulin-like growth factor 2 mRNA-binding protein 1 or IMP-1).IGF2BP1 (also known as ZBP-1 or IMP1) is a multi-functional regulator of RNA metabolism that has been implicated in the control of aspects of localization, stability, and translation for many mRNAs []. It is predominantly located in cytoplasm and was initially identified as a trans-acting factor that interacts with the zipcode in the 3'- untranslated region (UTR) of the beta-actin mRNA, which is important for its localization and translational regulation [, ]. IGF2BP1 also acts as human immunodeficiency virus type 1 (HIV-1) Gag-binding factor that interacts with HIV-1 Gag protein and blocks the formation of infectious HIV-1 particles []. It has also been linked to tumour growth []. IGF2BP1 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain. It also contains two putative nuclear export signals (NESs) and a putative nuclear localization signal (NLS).

•

Publication

18385235 | -

First Author:	Zhou Y
Year:	2008
Journal:	J Virol
Title:	Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly.
Volume:	82
Issue:	12
Pages:	5683-92

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Publication

20080952 | -

First Author:	Chao JA
Year:	2010
Journal:	Genes Dev
Title:	ZBP1 recognition of beta-actin zipcode induces RNA looping.
Volume:	24
Issue:	2
Pages:	148-58

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Publication

27940961 | -

First Author:	Degrauwe N
Year:	2016
Journal:	Genes Dev
Title:	IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.
Volume:	30
Issue:	22
Pages:	2459-2474

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Publication

17893325 | -

First Author:	Pan F
Year:	2007
Journal:	Mol Cell Biol
Title:	ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription.
Volume:	27
Issue:	23
Pages:	8340-51

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Publication

30581152 | J:270032

First Author:	Karras P
Year:	2019
Journal:	Cancer Cell
Title:	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Volume:	35
Issue:	1
Pages:	46-63.e10

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Publication

20512147 | J:166568

First Author:	Zhu H
Year:	2010
Journal:	Nat Genet
Title:	Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.
Volume:	42
Issue:	7
Pages:	626-30

•

Publication

38052926 | J:343459

First Author:	Krumbein M
Year:	2023
Journal:	Commun Biol
Title:	RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy.
Volume:	6
Issue:	1
Pages:	1229

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Publication

30739785 | J:300638

First Author:	Li J
Year:	2019
Journal:	Biochem Biophys Res Commun
Title:	Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE^-/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage.
Volume:	510
Issue:	4
Pages:	565-572

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Publication

37524872 | J:340510

First Author:	Ye G
Year:	2023
Journal:	Exp Mol Med
Title:	ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.
Volume:	55
Issue:	8
Pages:	1743-1756

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Protein

O88477

Organism:	Mus musculus/domesticus
Length:	577
Fragment?:	false

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Publication

37169182 | J:339252

First Author:	Zhai J
Year:	2023
Journal:	Gastroenterology
Title:	ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
Volume:	165
Issue:	2
Pages:	445-462

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Publication

36587923 | J:344512

First Author:	Tang Z
Year:	2023
Journal:	Free Radic Biol Med
Title:	KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1.
Volume:	195

Pages:	343-358

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