Type |
Details |
Score |
Publication |
First Author: |
Osterholzer JJ |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans. |
Volume: |
181 |
Issue: |
1 |
Pages: |
610-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Farrand KJ |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. |
Volume: |
183 |
Issue: |
12 |
Pages: |
7732-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leibundgut-Landmann S |
Year: |
2008 |
Journal: |
Blood |
Title: |
Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. |
Volume: |
112 |
Issue: |
13 |
Pages: |
4971-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iborra S |
Year: |
2011 |
Journal: |
Blood |
Title: |
H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity. |
Volume: |
117 |
Issue: |
19 |
Pages: |
5102-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Badalová J |
Year: |
2002 |
Journal: |
Genes Immun |
Title: |
Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. |
Volume: |
3 |
Issue: |
4 |
Pages: |
187-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ploemacher RE |
Year: |
1993 |
Journal: |
Leukemia |
Title: |
Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. |
Volume: |
7 |
Issue: |
9 |
Pages: |
1374-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu CR |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling. |
Volume: |
173 |
Issue: |
2 |
Pages: |
737-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kollet JI |
Year: |
2006 |
Journal: |
Mol Immunol |
Title: |
IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS. |
Volume: |
43 |
Issue: |
6 |
Pages: |
623-33 |
|
•
•
•
•
•
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Publication |
First Author: |
Nembrini C |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cells. |
Volume: |
176 |
Issue: |
12 |
Pages: |
7180-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brady J |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
The interactions of multiple cytokines control NK cell maturation. |
Volume: |
185 |
Issue: |
11 |
Pages: |
6679-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pillai MR |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
The plasticity of regulatory T cell function. |
Volume: |
187 |
Issue: |
10 |
Pages: |
4987-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oppmann B |
Year: |
2000 |
Journal: |
Immunity |
Title: |
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. |
Volume: |
13 |
Issue: |
5 |
Pages: |
715-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho JS |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. |
Volume: |
120 |
Issue: |
5 |
Pages: |
1762-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaur K |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation. |
Volume: |
37 |
Issue: |
13 |
Pages: |
110178 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shafiani S |
Year: |
2013 |
Journal: |
Immunity |
Title: |
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. |
Volume: |
38 |
Issue: |
6 |
Pages: |
1261-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernández PP |
Year: |
2015 |
Journal: |
Nat Immunol |
Title: |
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. |
Volume: |
16 |
Issue: |
7 |
Pages: |
698-707 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mullarky IK |
Year: |
2006 |
Journal: |
Infect Immun |
Title: |
Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection. |
Volume: |
74 |
Issue: |
2 |
Pages: |
1181-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bitsaktsis C |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. |
Volume: |
172 |
Issue: |
11 |
Pages: |
6894-901 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Alpha tumor necrosis factor contributes to CD8(+) T cell survival in the transition phase. |
Volume: |
360 |
Issue: |
3 |
Pages: |
702-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun J |
Year: |
2011 |
Journal: |
Nat Immunol |
Title: |
CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. |
Volume: |
12 |
Issue: |
4 |
Pages: |
327-34 |
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•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2022 |
Journal: |
Nature |
Title: |
STING-induced regulatory B cells compromise NK function in cancer immunity. |
Volume: |
610 |
Issue: |
7931 |
Pages: |
373-380 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mirlekar B |
Year: |
2020 |
Journal: |
Cancer Immunol Res |
Title: |
B cell-Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer. |
Volume: |
8 |
Issue: |
3 |
Pages: |
292-308 |
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•
•
•
•
•
|
Publication |
First Author: |
Sanders CJ |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. |
Volume: |
180 |
Issue: |
11 |
Pages: |
7184-92 |
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•
•
•
•
•
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Publication |
First Author: |
Ohtani M |
Year: |
2008 |
Journal: |
Blood |
Title: |
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. |
Volume: |
112 |
Issue: |
3 |
Pages: |
635-43 |
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•
•
•
•
•
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Publication |
First Author: |
Yen JH |
Year: |
2015 |
Journal: |
J Leukoc Biol |
Title: |
Differential effects of IFN-β on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells. |
Volume: |
98 |
Issue: |
5 |
Pages: |
689-702 |
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•
•
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•
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Publication |
First Author: |
Gajdasik DW |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues. |
Volume: |
11 |
Issue: |
1 |
Pages: |
3421 |
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•
•
•
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Publication |
First Author: |
Koyama M |
Year: |
2019 |
Journal: |
Immunity |
Title: |
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota. |
Volume: |
51 |
Issue: |
5 |
Pages: |
885-898.e7 |
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Publication |
First Author: |
Chan YR |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. |
Volume: |
182 |
Issue: |
8 |
Pages: |
4947-56 |
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•
•
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•
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Publication |
First Author: |
Lindsay RW |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling. |
Volume: |
185 |
Issue: |
3 |
Pages: |
1513-21 |
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Publication |
First Author: |
Eftychi C |
Year: |
2019 |
Journal: |
Immunity |
Title: |
Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment. |
Volume: |
51 |
Issue: |
2 |
Pages: |
367-380.e4 |
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Publication |
First Author: |
Shalaby KH |
Year: |
2018 |
Journal: |
J Allergy Clin Immunol |
Title: |
Pathogenic TH17 inflammation is sustained in the lungs by conventional dendritic cells and Toll-like receptor 4 signaling. |
Volume: |
142 |
Issue: |
4 |
Pages: |
1229-1242.e6 |
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Publication |
First Author: |
van de Wetering D |
Year: |
2009 |
Journal: |
Int Immunol |
Title: |
IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. |
Volume: |
21 |
Issue: |
2 |
Pages: |
145-53 |
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Publication |
First Author: |
Tang H |
Year: |
1998 |
Journal: |
J Autoimmun |
Title: |
The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis. |
Volume: |
11 |
Issue: |
6 |
Pages: |
581-9 |
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First Author: |
Desai SB |
Year: |
1999 |
Journal: |
J Immunother |
Title: |
Tumor angiogenesis and endothelial cell modulatory factors. |
Volume: |
22 |
Issue: |
3 |
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186-211 |
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First Author: |
Freeman BE |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Regulation of innate CD8+ T-cell activation mediated by cytokines. |
Volume: |
109 |
Issue: |
25 |
Pages: |
9971-6 |
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Publication |
First Author: |
Shaw MH |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. |
Volume: |
176 |
Issue: |
12 |
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7263-71 |
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First Author: |
Zanoni I |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions. |
Volume: |
4 |
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1235-49 |
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First Author: |
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Year: |
2018 |
Journal: |
Nature |
Title: |
Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. |
Volume: |
558 |
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First Author: |
Zandian M |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination. |
Volume: |
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e16820 |
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First Author: |
Vitry MA |
Year: |
2012 |
Journal: |
Infect Immun |
Title: |
Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. |
Volume: |
80 |
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First Author: |
Blake SJ |
Year: |
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Journal: |
Cancer Discov |
Title: |
Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy. |
Volume: |
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First Author: |
Wüthrich M |
Year: |
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Journal: |
J Clin Invest |
Title: |
Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. |
Volume: |
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First Author: |
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Year: |
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Nature |
Title: |
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. |
Volume: |
452 |
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First Author: |
Yoon J |
Year: |
2016 |
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J Exp Med |
Title: |
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. |
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J Invest Dermatol |
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Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation. |
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Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. |
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PLoS One |
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The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade. |
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J Immunol |
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Accessory protein-like is essential for IL-18-mediated signaling. |
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CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. |
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Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state. |
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Nat Immunol |
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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. |
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Nat Immunol |
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Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells. |
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International Committee on Standardized Genetic Nomenclature for Mice |
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Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols |
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The Gene Ontology Consortium |
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Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
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First Author: |
International Knockout Mouse Consortium |
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Database Download |
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MGI download of modified allele data from IKMC and creation of new knockout alleles |
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First Author: |
Velocigene |
Year: |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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International Mouse Strain Resource |
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Database Download |
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MGI download of germline transmission data for alleles from IMSR strain data |
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Helmholtz Zentrum Muenchen GmbH |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
215
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
116
 |
Fragment?: |
false |
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DO Term |
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Allele |
Name: |
interleukin 12a; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
interleukin 12a; targeted mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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Allele |
Name: |
interleukin 12a; endonuclease-mediated mutation 2, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
interleukin 12a; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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