|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 472 out of 472 for Il3

<< First    < Previous  |  Next >    Last >>
0.014s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
MP Term
MP:0008696 | increased interleukin-3 secretion
•
•
•
•
•
MP Term
MP:0008622 | abnormal circulating interleukin-3 level
•
•
•
•
•
MP Term
MP:0008695 | abnormal interleukin-3 secretion
•
•
•
•
•
Publication
3497843 | -
First Author: Dorssers L
Year: 1987
Journal: Gene
Title: Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3.
Volume: 55
Issue: 1
Pages: 115-24
•
•
•
•
•
Protein Domain
IPR002183 | IL-3
Type: Family
Description: Interleukin-3 (IL3) is a cytokine that regulates blood-cell production by controlling the production, differentiation and function of granulocytes and macrophages [, ]. The protein, which exists in vivo as a monomer, is produced in activated T-cells and mast cells [, ], and is activated by the cleavage of an N-terminal signal sequence [].IL3 is produced by T-lymphocytes and T-lymphomas only after stimulation with antigens, mitogens, or chemical activators such as phorbol esters. However, IL3 is constitutively expressed in the myelomonocytic leukaemia cell line WEHI-3B []. It is thought that the genetic change of the cell line to constitutive production of IL3 is the key event in development of this leukaemia [].
•
•
•
•
•
Publication
10679099 | J:60608
First Author: Paine R 3rd
Year: 2000
Journal: J Immunol
Title: Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice.
Volume: 164
Issue: 5
Pages: 2602-9
•
•
•
•
•
Publication
12169573 | J:108268
First Author: Frossard JL
Year: 2002
Journal: Am J Physiol Lung Cell Mol Physiol
Title: In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury.
Volume: 283
Issue: 3
Pages: L541-8
•
•
•
•
•
Publication
21900947 | J:180638
First Author: Kobayashi C
Year: 2012
Journal: J Invest Dermatol
Title: GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice.
Volume: 132
Issue: 1
Pages: 241-4
•
•
•
•
•
Allele
Csf2/Il3<tm1.1(CSF2,IL3)Flv> | MGI:4887879
Name: colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1.1, Richard A Flavell
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Allele
Csf2/Il3<tm1.1(CSF2,IL3)Flv> | MGI:4887881
Name: interleukin 3; targeted mutation 1.1, Richard A Flavell
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Strain
MGI:7718108 | C57BL/6JSmoc-Csf2<tm1(CSF2)Smoc> Csf1<tm2(CSF1)Smoc> Il3<tm1(IL3)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain, targeted mutation
•
•
•
•
•
MP Term
MP:0008697 | decreased interleukin-3 secretion
•
•
•
•
•
MP Term
MP:0008624 | decreased circulating interleukin-3 level
•
•
•
•
•
Strain
MGI:6429834 | NOD.Cg-Prkdc<scid> Il2rg<em1Smoc> Il3<em1Smoc>/Smoc
Attribute String: mutant strain, endonuclease-mediated mutation, spontaneous mutation, congenic
•
•
•
•
•
Strain
MGI:3586502 | B6.129S2-Csf2<tm1Dran> Il3<tm1Glli>
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Strain
MGI:3586503 | C.129S2-Csf2<tm1Dran> Il3<tm1Glli>
Attribute String: targeted mutation, mutant strain, congenic
•
•
•
•
•
Allele
Tg(Il4-AmCyan,Il13-DsRed*)1Wep | MGI:6118069
Name: transgene insertion 1, William E Paul
Allele Type: Transgenic
Attribute String: Reporter
•
•
•
•
•
Strain
MGI:7718109 | C57BL/6JSmoc-Sirpa<tm2(SIRPA)Smoc> Csf2<tm1(CSF2)Smoc> Cd47<em2(CD47)Smoc> Il3<tm1(IL3)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Csf2/Csf2 Il3/Il3
Background: C.129S2-Csf2 Il3
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Csf2/Csf2 Il3/Il3
Background: B6.129S2-Csf2 Il3
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
22075207 | -
First Author: Male V
Year: 2012
Journal: Trends Immunol
Title: E4BP4: an unexpected player in the immune response.
Volume: 33
Issue: 2
Pages: 98-102
•
•
•
•
•
Publication
7565758 | -
First Author: Zhang W
Year: 1995
Journal: Mol Cell Biol
Title: Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter.
Volume: 15
Issue: 11
Pages: 6055-63
•
•
•
•
•
Protein Domain
IPR016743 | NFIL3/E4BP4
Type: Family
Description: Nuclear factor interleukin-3-regulated protein (NFIL3, also known as E4BP4) was first identified as a transcriptional repressor capable of binding an activating transcription factor (ATF) DNA consensus sequence site in the adenovirus E4 promoter []. Later, it was independently identified as a transactivator of the IL3 promoter in human T cells [].E4BP4 is involved in a several biological processes, including transcriptional control of the circadian clock, neuron growth and survival, osteoblast function, and regulation of ovulation []. It is essential for the development of NK cells and CD8alpha(+) conventional dendritic cells, and is also involved in macrophage activation, polarisation of CD4(+) T cell responses and B cell class switching to IgE [].
•
•
•
•
•
Protein
P01586
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
•
•
•
•
•
Protein
Q5SX77
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
•
•
•
•
•
Protein
Q0PMN2
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
•
•
•
•
•
Strain
MGI:6118142 | C57BL/6J-Tg(Il4-AmCyan,Il13-DsRed*)1Wep/J
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Genotype
Genotype
Symbol: Il2rg/Il2rg Csf2/Il3/Csf2/Il3 Rag2/Rag2
Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Csf2/Il3/Csf2/Il3 Il2rg/Il2rg Rag2/Rag2
Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Protein
O89065
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
•
•
•
•
•
Publication
1620116 | -
First Author: Cowell IG
Year: 1992
Journal: Mol Cell Biol
Title: Transcriptional repression by a novel member of the bZIP family of transcription factors.
Volume: 12
Issue: 7
Pages: 3070-7
•
•
•
•
•
Publication
29376889 | J:260799
First Author: Ullrich E
Year: 2018
Journal: J Clin Invest
Title: BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
Volume: 128
Issue: 3
Pages: 916-930
•
•
•
•
•
Publication
36050303 | J:344134
First Author: Segaud J
Year: 2022
Journal: Nat Commun
Title: Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march.
Volume: 13
Issue: 1
Pages: 4703
•
•
•
•
•
Strain
MGI:5555036 | C;129S4-Rag2<tm1.1Flv> Csf1<tm1(CSF1)Flv> Csf2/Il3<tm1.1(CSF2,IL3)Flv> Thpo<tm1.1(TPO)Flv> Il2rg<tm1.1Flv>/J
Attribute String: mutant stock, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Csf2/Csf2 Ifng/Ifng Il3/Il3
Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Strain
MGI:5555040 | C;129S4-Rag2<tm1.1Flv> Csf1<tm1(CSF1)Flv> Csf2/Il3<tm1.1(CSF2,IL3)Flv> Thpo<tm1.1(TPO)Flv> Il2rg<tm1.1Flv> Tg(SIRPA)1Flv/J
Attribute String: targeted mutation, mutant stock, transgenic
•
•
•
•
•
Strain
MGI:4887966 | C;129S4-Rag2<tm1.1Flv> Csf2/Il3<tm1.1(CSF2,IL3)Flv> Il2rg<tm1.1Flv>/J
Attribute String: mutant stock, targeted mutation
•
•
•
•
•
Publication
25561180 | J:298975
First Author: Deng K
Year: 2015
Journal: Nature
Title: Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.
Volume: 517
Issue: 7534
Pages: 381-5
•
•
•
•
•
Genotype
Genotype
Symbol: Csf1/Csf1 Il2rg/Il2rg Csf2/Il3/Csf2/Il3 Rag2/Rag2 Tg(SIRPA)1Flv/? Thpo/Thpo
Background: involves: 129S4/SvJae * BALB/cAnNTac
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Csf1/Csf1 Csf2/Il3/Csf2/Il3 Il2rg/Il2rg Rag2/Rag2 Thpo/Thpo
Background: involves: 129S4/SvJae * BALB/cAnNTac
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Csf1/Csf1 Il2rg/Il2rg Csf2/Il3/Csf2/Il3 Rag2/Rag2 Thpo/Thpo
Background: involves: 129S4/SvJae * BALB/cAnNTac
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Csf1/Csf1 Csf2/Il3/Csf2/Il3 Il2rg/Il2rg Rag2/Rag2 Tg(SIRPA)1Flv/? Thpo/Thpo
Background: involves: 129S4/SvJae * BALB/cAnNTac
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
7796808 | J:26494
First Author: Yoshimura A
Year: 1995
Journal: EMBO J
Title: A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
Volume: 14
Issue: 12
Pages: 2816-26
•
•
•
•
•
Publication
12789265 | J:83973
First Author: Hoare K
Year: 2003
Journal: Oncogene
Title: Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling.
Volume: 22
Issue: 23
Pages: 3562-77
•
•
•
•
•
Publication
12124437 | J:77918
First Author: Hensley K
Year: 2002
Journal: J Neurochem
Title: Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Volume: 82
Issue: 2
Pages: 365-74
•
•
•
•
•
Publication
9581981 | J:115103
First Author: Harigae H
Year: 1998
Journal: Genes Cells
Title: Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells.
Volume: 3
Issue: 1
Pages: 39-50
•
•
•
•
•
Publication
28964849 | J:255426
First Author: Frelin C
Year: 2017
Journal: Biochim Biophys Acta
Title: Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.
Volume: 1864
Issue: 12
Pages: 2449-2459
•
•
•
•
•
Publication
35568199 | J:347310
First Author: Gao X
Year: 2022
Journal: J Biol Chem
Title: Binding of the erlin1/2 complex to the third intralumenal loop of IP(3)R1 triggers its ubiquitin-proteasomal degradation.
Volume: 298
Issue: 6
Pages: 102026
•
•
•
•
•
Publication
2294753 | J:24086
First Author: Huebner K
Year: 1990
Journal: Am J Hum Genet
Title: Order of genes on human chromosome 5q with respect to 5q interstitial deletions.
Volume: 46
Issue: 1
Pages: 26-36
•
•
•
•
•
Publication
10515662 | J:57700
First Author: Saitoh T
Year: 1999
Journal: Mech Ageing Dev
Title: Comparison of erythropoietic response to androgen in young and old senescence accelerated mice.
Volume: 109
Issue: 2
Pages: 125-39
•
•
•
•
•
Publication
17301289 | J:123885
First Author: Wieman HL
Year: 2007
Journal: Mol Biol Cell
Title: Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.
Volume: 18
Issue: 4
Pages: 1437-46
•
•
•
•
•
Publication
20471682 | J:160691
First Author: Precht P
Year: 2010
Journal: Mol Immunol
Title: The SNF2H chromatin remodeling enzyme has opposing effects on cytokine gene expression.
Volume: 47
Issue: 11-12
Pages: 2038-46
•
•
•
•
•
Publication
25650089 | J:221972
First Author: Chen L
Year: 2015
Journal: Leukemia
Title: Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.
Volume: 29
Issue: 6
Pages: 1290-300
•
•
•
•
•
Publication
39589268 | J:360071
 
First Author: Sá da Bandeira D
Year: 2024
Journal: Development
Title: NR4A1 and NR4A2 orphan nuclear receptors regulate endothelial-to-hematopoietic transition in mouse hematopoietic stem cell specification.
Volume: 151
Issue: 22
•
•
•
•
•
Publication
8605875 | J:31887
First Author: Yoshimura A
Year: 1996
Journal: EMBO J
Title: Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.
Volume: 15
Issue: 5
Pages: 1055-63
•
•
•
•
•
Publication
9064328 | J:35276
First Author: Lorenz U
Year: 1996
Journal: J Exp Med
Title: Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.
Volume: 184
Issue: 3
Pages: 1111-26
•
•
•
•
•
Publication
6430708 | J:7504
First Author: Palacios R
Year: 1984
Journal: Eur J Immunol
Title: Spontaneous production of interleukin 3 by T lymphocytes from autoimmune MRL/MP-lpr/lpr mice.
Volume: 14
Issue: 7
Pages: 599-605
•
•
•
•
•
Publication
19620960 | J:151543
First Author: Sanada M
Year: 2009
Journal: Nature
Title: Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Volume: 460
Issue: 7257
Pages: 904-8
•
•
•
•
•
Publication
24368564 | J:251776
First Author: Meylan F
Year: 2014
Journal: Mucosal Immunol
Title: The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells.
Volume: 7
Issue: 4
Pages: 958-68
•
•
•
•
•
Publication
37957324 | J:350466
First Author: Evans KT
Year: 2023
Journal: Nat Cell Biol
Title: Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis.
Volume: 25
Issue: 12
Pages: 1848-1859
•
•
•
•
•
Publication
25531830 | J:257213
First Author: Huang Y
Year: 2015
Journal: Nat Immunol
Title: IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.
Volume: 16
Issue: 2
Pages: 161-9
•
•
•
•
•
Publication
31552058 | J:286811
 
First Author: Pellefigues C
Year: 2019
Journal: Front Immunol
Title: The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils.
Volume: 10
Pages: 2143
•
•
•
•
•
Protein
O08750
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
•
•
•
•
•
Publication
31375314 | J:283800
First Author: Hasselmann J
Year: 2019
Journal: Neuron
Title: Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Volume: 103
Issue: 6
Pages: 1016-1033.e10
•
•
•
•
•
Publication
26104914 | J:318797
First Author: Daniels NJ
Year: 2016
Journal: Mucosal Immunol
Title: Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.
Volume: 9
Issue: 1
Pages: 229-39
•
•
•
•
•
Publication
37870318 | J:358168
First Author: Wang Y
Year: 2023
Journal: EMBO Rep
Title: Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals.
Volume: 24
Issue: 12
Pages: e57485
•
•
•
•
•
Publication
37163450 | J:335623
 
First Author: Cui W
Year: 2023
Journal: J Exp Med
Title: Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice.
Volume: 220
Issue: 8
•
•
•
•
•
Publication
33326781 | J:298831
First Author: Scheer S
Year: 2020
Journal: Cell Rep
Title: The Methyltransferase DOT1L Controls Activation and Lineage Integrity in CD4+ T Cells during Infection and Inflammation.
Volume: 33
Issue: 11
Pages: 108505
•
•
•
•
•
Publication
37550517 | J:340839
First Author: Grockowiak E
Year: 2023
Journal: Nat Cancer
Title: Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.
Volume: 4
Issue: 8
Pages: 1193-1209
•
•
•
•
•
Publication
34795444 | J:321392
First Author: Mayer JU
Year: 2021
Journal: Nat Immunol
Title: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization.
Volume: 22
Issue: 12
Pages: 1538-1550
•
•
•
•
•
Publication
33662369 | J:317281
First Author: Pellefigues C
Year: 2021
Journal: J Allergy Clin Immunol
Title: Basophils promote barrier dysfunction and resolution in the atopic skin.
Volume: 148
Issue: 3
Pages: 799-812.e10
•
•
•
•
•
Publication
39813317 | J:361219
First Author: Brandao W
Year: 2025
Journal: Sci Transl Med
Title: Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy.
Volume: 17
Issue: 781
Pages: eadk3690
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom