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Search results 401 to 486 out of 486 for Il5

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Hits by Strain

Type Details Score
Allele
Tg(CD2-Il5)5C1Ldt | MGI:2182290
Name: transgene insertion 5C1, Lindsay A Dent
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:4943285 | B6.CBACa-Tg(CD2-Il5)5C2Ldt/Apb [cc]
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:4940607 | C.CBA-Tg(CD2-IL5)5C2Ldt/Apb
Attribute String: transgenic, congenic
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Strain
MGI:4943287 | CBA/Ca-Tg(CD2-Il5)5C2Ldt/Apb
Attribute String: coisogenic, mutant strain, transgenic
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Publication
17379701 | J:122337
First Author: Tumes DJ
Year: 2007
Journal: J Leukoc Biol
Title: Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils.
Volume: 81
Issue: 6
Pages: 1362-73
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Publication
19395375 | J:149569
First Author: Tumes DJ
Year: 2009
Journal: Int Immunol
Title: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma.
Volume: 21
Issue: 6
Pages: 633-44
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Publication
15020648 | J:90468
First Author: Clark K
Year: 2004
Journal: J Leukoc Biol
Title: Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen.
Volume: 75
Issue: 6
Pages: 1001-9
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Allele
Il5<tm3Anjm> | MGI:3689810
Name: interleukin 5; targeted mutation 3, Andrew NJ McKenzie
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Il5<tm2Anjm> | MGI:3689812
Name: interleukin 5; targeted mutation 2, Andrew NJ McKenzie
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:7788725 | C57BL/6JSmoc-Il5<tm3(IL5)> Il5ra<em2(IL5RA)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Strain
MGI:7788726 | C57BL/6JSmoc-Il5ra<em3(IL5RA)Smoc> Il5<tm3(IL5)>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Il5/Il5
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
3261707 | J:9311
First Author: Sutherland GR
Year: 1988
Journal: Hum Genet
Title: Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.
Volume: 79
Issue: 4
Pages: 335-7
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Strain
MGI:7751771 | STOCK Il5ra<tm1(IL5RA)Smoc> Il5<tm3(IL5)Smoc> Prkdc<scid> Il2rg<em1Smoc>/Smoc
Attribute String: endonuclease-mediated mutation, mutant stock, spontaneous mutation, targeted mutation
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Strain
MGI:5502927 | B6.CBACa-Tg(CD2-Il5)5C1Ldt/H
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:4943286 | CBA/Ca-Tg(CD2-Il5)5C1Ldt [cc]
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tg(CD2-Il5)#Ldt | MGI:4819505
Name: transgene insertion, Lindsay A Dent
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Il5/Il5
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein
P04401
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Strain
MGI:4941608 | C.Cg-Myd88<tm1Aki> Tg(CD2-IL5)5C2Ldt
Attribute String: Not specified
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Publication
17941951 | J:127719
First Author: Scaglione BJ
Year: 2007
Journal: Br J Haematol
Title: Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model.
Volume: 139
Issue: 5
Pages: 645-57
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Allele
Il5<tm1.1(icre)Lky> | MGI:5558083
Name: interleukin 5; targeted mutation 1.1, Richard M Locksley
Allele Type: Targeted
Attribute String: Null/knockout, Recombinase, Reporter
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Genotype
Genotype
Symbol: Il13/Il13 Il5/Il5
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
20421642 | J:161234
First Author: Dyer KD
Year: 2010
Journal: J Immunol
Title: Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
Volume: 184
Issue: 11
Pages: 6327-34
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Strain
MGI:5558930 | C57BL/6-Il5<tm1.1(icre)Lky>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:5906263 | B6(C)-Il5<tm1.1(icre)Lky>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Il5/Il5 Il9/Il9
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il5/Il5 Il9/Il9
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il5/Il5 Il9/Il9
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il5/Il5<+>
Background: C57BL/6-Il5
Zygosity: ht
Has Mutant Allele: true
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Publication
21131966 | J:167446
First Author: Tanaka S
Year: 2011
Journal: Nat Immunol
Title: The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells.
Volume: 12
Issue: 1
Pages: 77-85
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Publication
30926166 | J:291052
First Author: Lownik JC
Year: 2019
Journal: Biochem Biophys Res Commun
Title: A Disintegrin and Metalloproteinase 17 is required for ILC2 responses to IL-33.
Volume: 512
Issue: 4
Pages: 723-728
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Publication
9284925 | J:42505
First Author: Spurdle AB
Year: 1997
Journal: Cytogenet Cell Genet
Title: Shared synteny between human chromosome 10 and chromosome 1 of the marsupial tammar wallaby, Macropus eugenii.
Volume: 77
Issue: 3-4
Pages: 242-5
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Publication
22118525 | J:178928
First Author: Endo Y
Year: 2011
Journal: Immunity
Title: Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3.
Volume: 35
Issue: 5
Pages: 733-45
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Publication
34709349 | J:316328
 
First Author: Hikichi Y
Year: 2021
Journal: J Exp Med
Title: Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin.
Volume: 218
Issue: 12
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Publication
24891522 | J:303116
First Author: Tani Y
Year: 2014
Journal: FASEB J
Title: Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.
Volume: 28
Issue: 9
Pages: 4036-43
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Publication
19535141 | J:151720
First Author: Knott ML
Year: 2009
Journal: Mol Immunol
Title: The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri.
Volume: 46
Issue: 13
Pages: 2714-22
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Publication
22190185 | J:180767
First Author: Wen T
Year: 2012
Journal: J Immunol
Title: The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia.
Volume: 188
Issue: 3
Pages: 1075-82
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Publication
18025204 | J:154962
First Author: Wang HB
Year: 2007
Journal: J Immunol
Title: Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells.
Volume: 179
Issue: 11
Pages: 7585-92
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Publication
24713170 | J:287021
First Author: Nakashima C
Year: 2014
Journal: J Allergy Clin Immunol
Title: Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis.
Volume: 134
Issue: 1
Pages: 100-7
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Publication
26850094 | J:309958
First Author: Frei RB
Year: 2016
Journal: Allergy
Title: Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice.
Volume: 71
Issue: 7
Pages: 944-56
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Publication
7796808 | J:26494
First Author: Yoshimura A
Year: 1995
Journal: EMBO J
Title: A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
Volume: 14
Issue: 12
Pages: 2816-26
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Publication
20200520 | J:159463
First Author: Saenz SA
Year: 2010
Journal: Nature
Title: IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.
Volume: 464
Issue: 7293
Pages: 1362-6
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Publication
20200518 | J:159464
First Author: Neill DR
Year: 2010
Journal: Nature
Title: Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
Volume: 464
Issue: 7293
Pages: 1367-70
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Publication
20023630 | J:156764
First Author: Moro K
Year: 2010
Journal: Nature
Title: Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.
Volume: 463
Issue: 7280
Pages: 540-4
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Publication
26321245 | J:325817
First Author: Chien SJ
Year: 2015
Journal: Exp Mol Pathol
Title: The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice.
Volume: 99
Issue: 3
Pages: 460-7
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Publication
32477356 | J:296790
 
First Author: Hashem T
Year: 2020
Journal: Front Immunol
Title: CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.
Volume: 11
Pages: 881
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Publication
24167278 | J:202891
First Author: Hosokawa H
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
Volume: 110
Issue: 46
Pages: 18626-31
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Publication
29339496 | J:257761
First Author: Ochiai S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells.
Volume: 115
Issue: 5
Pages: 1033-1038
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Publication
33598715 | J:315089
First Author: Germic N
Year: 2021
Journal: Blood
Title: ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions.
Volume: 137
Issue: 21
Pages: 2958-2969
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Publication
8378590 | J:21569
First Author: Stefani MM
Year: 1993
Journal: Res Immunol
Title: Leishmania major infection in BALB/c mice: protection or exacerbation by treatment with different doses of BCG.
Volume: 144
Issue: 4
Pages: 233-43
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Publication
7543372 | J:27393
First Author: Falchetti R
Year: 1995
Journal: Cell Immunol
Title: In vitro effects of cocaine on cytokine secretion induced in murine splenic CD4+ T cells by antigen-specific stimulation.
Volume: 164
Issue: 1
Pages: 57-64
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Publication
10209488 | J:51900
First Author: Di Carlo E
Year: 1998
Journal: J Pathol
Title: Interaction between endothelial cells and the secreted cytokine drives the fate of an IL4- or an IL5-transduced tumour.
Volume: 186
Issue: 4
Pages: 390-7
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Publication
15226271 | J:91541
First Author: Lee GR
Year: 2004
Journal: Int Immunol
Title: Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma.
Volume: 16
Issue: 8
Pages: 1155-60
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Publication
14662768 | J:88506
First Author: Ishino T
Year: 2004
Journal: J Biol Chem
Title: Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.
Volume: 279
Issue: 10
Pages: 9547-56
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Publication
25504587 | J:223247
First Author: Hashiguchi M
Year: 2015
Journal: Eur J Immunol
Title: IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells.
Volume: 45
Issue: 3
Pages: 876-85
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Publication
22330250 | J:265961
First Author: Kyostio-Moore S
Year: 2011
Journal: Comp Med
Title: STR/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers.
Volume: 61
Issue: 4
Pages: 346-55
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Publication
31746625 | J:285206
First Author: Nie Z
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice.
Volume: 318
Issue: 2
Pages: L242-L251
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Publication
32317758 | J:289824
First Author: Koopmans T
Year: 2020
Journal: Sci Rep
Title: Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation.
Volume: 10
Issue: 1
Pages: 6754
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Publication
34475229 | J:356752
 
First Author: Van Hulst G
Year: 2022
Journal: Eur Respir J
Title: Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma.
Volume: 59
Issue: 3
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Publication
10219247 | -
First Author: Hage T
Year: 1999
Journal: Cell
Title: Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Volume: 97
Issue: 2
Pages: 271-81
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Protein Domain
IPR015319 | IL-4_rcpt-alpha_N
Type: Domain
Description: Interleukin-4 receptor is a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Alternatively activated macrophages downregulate inflammatory mediators such as during immune responses, particularly with regards to helminth infections. This entry represents the N-terminal (extracellular) portion of interleukin-4 receptor alpha, it is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand β-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response []. Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand β-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response [].
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Publication
24465642 | J:225167
First Author: Potter CS
Year: 2014
Journal: PLoS One
Title: Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.
Volume: 9
Issue: 1
Pages: e85666
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Publication
8035837 | J:19431
First Author: Libertin CR
Year: 1994
Journal: Mol Immunol
Title: Cytokine and T-cell subset abnormalities in immunodeficient wasted mice.
Volume: 31
Issue: 10
Pages: 753-9
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Publication
29183288 | J:271780
First Author: Cloots RHE
Year: 2017
Journal: BMC Pulm Med
Title: Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
Volume: 17
Issue: 1
Pages: 158
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Publication
9130268 | J:40398
First Author: Greer JM
Year: 1997
Journal: Neurochem Res
Title: Encephalitogenicity of murine, but not bovine, DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope.
Volume: 22
Issue: 4
Pages: 541-7
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Publication
16731772 | J:111227
First Author: Forbes E
Year: 2006
Journal: J Leukoc Biol
Title: ICAM-1-dependent pathways regulate colonic eosinophilic inflammation.
Volume: 80
Issue: 2
Pages: 330-41
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Publication
17675237 | J:125347
First Author: Giacomin PR
Year: 2008
Journal: Mol Immunol
Title: The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis.
Volume: 45
Issue: 2
Pages: 446-55
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Publication
18316626 | J:136634
First Author: Munitz A
Year: 2008
Journal: Blood
Title: A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.
Volume: 111
Issue: 12
Pages: 5694-703
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Publication
26147683 | J:239648
First Author: Bettigole SE
Year: 2015
Journal: Nat Immunol
Title: The transcription factor XBP1 is selectively required for eosinophil differentiation.
Volume: 16
Issue: 8
Pages: 829-37
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Publication
31182481 | J:278410
First Author: Ma M
Year: 2019
Journal: J Immunol
Title: Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16.
Volume: 203
Issue: 2
Pages: 520-531
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Publication
36608150 | J:338986
First Author: Laky K
Year: 2023
Journal: Sci Immunol
Title: Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis.
Volume: 8
Issue: 79
Pages: eabp9940
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/? Il5/Il5<+> Rag1/Rag1
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
2495224 | J:33209
First Author: Lasky JL
Year: 1989
Journal: Eur J Immunol
Title: Characterization and growth factor requirements of SJL lymphomas. II. Interleukin 5 dependence of the in vitro cell line, cRCS-X, and influence of other cytokines.
Volume: 19
Issue: 2
Pages: 365-71
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Publication
30654796 | J:295052
First Author: Kubo F
Year: 2019
Journal: Respir Res
Title: Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells.
Volume: 20
Issue: 1
Pages: 11
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Publication
38614090 | J:349483
First Author: Liu S
Year: 2024
Journal: Immunity
Title: Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction.
Volume: 57
Issue: 5
Pages: 987-1004.e5
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Publication
29645346 | J:265358
First Author: Bolden JE
Year: 2018
Journal: J Leukoc Biol
Title: Identification of a Siglec-F+ granulocyte-macrophage progenitor.
Volume: 104
Issue: 1
Pages: 123-133
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Strain
MGI:7408319 | B6.Cg-Arg1<tm1.1Lky> Il5<tm1.1(icre)Lky>/Il13<tm2.1Lky>/Liah
Attribute String: congenic, targeted mutation, mutant strain
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Protein
A0A0U1RNW1
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
P16382
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: false
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Protein
A2VCP1
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: true
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Protein
Q3U905
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: false
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Protein
W8DLM5
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: true
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Protein
Q544A9
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Protein
Q3UE66
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Publication
- | J:17344
First Author: Estes SS
Year: 1994
Journal: Mouse Genome
Title: RAPD-PCR analysis of C57BL/10 H-2 congenic strains of mice
Volume: 92
Issue: 1
Pages: 130-32
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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