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Search results 401 to 500 out of 538 for Jak1

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Type Details Score
Publication
9096349 | -
First Author: Conway G
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos.
Volume: 94
Issue: 7
Pages: 3082-7
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Publication
9774693 | -
First Author: Danial NN
Year: 1998
Journal: Mol Cell Biol
Title: Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.
Volume: 18
Issue: 11
Pages: 6795-804
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Publication
17290288 | -
First Author: Su Q
Year: 2007
Journal: EMBO Rep
Title: Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.
Volume: 8
Issue: 3
Pages: 265-70
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Publication
15988755 | -
First Author: Huang HM
Year: 2005
Journal: J Cell Biochem
Title: Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.
Volume: 96
Issue: 2
Pages: 361-75
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HT Experiment
GSE79452 | Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
19290934 | -
First Author: Ghoreschi K
Year: 2009
Journal: Immunol Rev
Title: Janus kinases in immune cell signaling.
Volume: 228
Issue: 1
Pages: 273-87
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Publication
23990909 | -
First Author: Linossi EM
Year: 2013
Journal: PLoS One
Title: Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.
Volume: 8
Issue: 8
Pages: e70536
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GO Term
GO:0042976 | activation of Janus kinase activity
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Protein
Q3U8P8
Organism: Mus musculus/domesticus
Length: 1126  
Fragment?: false
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Protein
Q3URU8
Organism: Mus musculus/domesticus
Length: 1153  
Fragment?: false
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Protein
B1ASP2
Organism: Mus musculus/domesticus
Length: 1153  
Fragment?: false
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Publication
19275641 | -
First Author: Sharma PS
Year: 2009
Journal: Curr Pharm Des
Title: Receptor tyrosine kinase inhibitors as potent weapons in war against cancers.
Volume: 15
Issue: 7
Pages: 758-76
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Publication
16700535 | -
First Author: Li E
Year: 2006
Journal: Biochemistry
Title: Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.
Volume: 45
Issue: 20
Pages: 6241-51
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Publication
15845350 | -
First Author: Roskoski R Jr
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Src kinase regulation by phosphorylation and dephosphorylation.
Volume: 331
Issue: 1
Pages: 1-14
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Publication
22084247 | -
First Author: Zhang WN
Year: 2012
Journal: J Biol Chem
Title: CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.
Volume: 287
Issue: 1
Pages: 382-92
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Protein Domain
IPR031994 | JAKMIP_C
Type: Domain
Description: This domain is found at the C terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1 [, , ].
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Protein Domain
IPR039805 | CUE_CUED2
Type: Domain
Description: CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway []. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity []. This entry represents the CUE domain found in CUEDC2.
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Protein
Q5DTN8
Organism: Mus musculus/domesticus
Length: 844  
Fragment?: false
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Publication
14718537 | J:89173
First Author: Couve A
Year: 2004
Journal: J Biol Chem
Title: Marlin-1, a novel RNA-binding protein associates with GABA receptors.
Volume: 279
Issue: 14
Pages: 13934-43
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Publication
17532644 | J:123202
First Author: Vidal RL
Year: 2007
Journal: Mol Cell Neurosci
Title: Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.
Volume: 35
Issue: 3
Pages: 501-12
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Protein
Q8BVL9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
G3UYZ9
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
A0A1D5RLA4
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
A0A803ZCJ0
Organism: Mus musculus/domesticus
Length: 772  
Fragment?: false
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Protein
E9Q7K7
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: true
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Protein
D3YXK0
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
D3Z4U5
Organism: Mus musculus/domesticus
Length: 831  
Fragment?: false
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Publication
15277531 | -
First Author: Steindler C
Year: 2004
Journal: J Biol Chem
Title: Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules.
Volume: 279
Issue: 41
Pages: 43168-77
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Protein
G3UXP1
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
G3UY22
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Protein
G3UXP3
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
D3Z555
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: true
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Protein
Q3UPL4
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: true
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Protein
Q8CEM9
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
A0A140LIJ5
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
17347654 | -
First Author: Zhang PJ
Year: 2007
Journal: EMBO J
Title: CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.
Volume: 26
Issue: 7
Pages: 1831-42
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Protein Domain
IPR024836 | JAKMIP
Type: Family
Description: Janus kinase and microtubule interacting proteins (JAKMIPs) are predominantly expressed in neural tissues and lymphoid organs. Three family members have been identified, termed JAKMIP1-3. They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate with Janus kinase (Jak) family members, such as Tyk2 or Jak1 []. The proteins may have a role in Jak signalling and regulation of microtubule cytoskeleton rearrangements.JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [], and may be involved in microtubule-dependent transport of the GABA-B receptor [].
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Protein
Q9CXX9
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Protein
A0A494BAT2
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: false
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Protein
A0A494BBK6
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
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Protein
A0A494BB93
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q9CVB0
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Protein Domain
IPR041046 | FERM_F2
Type: Domain
Description: This is an F2 lobe domain consisting of an acyl-CoA binding protein fold found in FERM region of Jak-family tyrosine kinases []. Multidomain JAK molecules interact with receptors through their FERM and SH2-like domains, triggering a series of phosphorylation events, resulting in the activation of their kinase domains []. Overall, the FERM region maintains the typical three-lobed architecture, with an F1 lobe consisting of a ubiquitin-like fold, an F2 lobe consisting of an acyl-CoA binding protein fold, and an F3 lobe consisting of a pleckstrin-homology (PH) fold. JAK1 FERM-F2 domain has been shown to act as the interaction site for the IFNLR1 box1 motif (PxxLxF) of class II cytokine receptors which is essential for kinase activation [].
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Publication
3291115 | J:31015
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
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Publication
12368087 | -
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
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Publication
12471243 | -
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
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Publication
15078142 | -
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
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Publication
15320712 | -
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
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Publication
27018889 | J:327791
First Author: Smith GA
Year: 2016
Journal: Nat Chem Biol
Title: Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.
Volume: 12
Issue: 5
Pages: 373-9
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Publication
15987782 | J:99860
First Author: Martin P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.
Volume: 102
Issue: 28
Pages: 9866-71
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Publication
25029551 | J:259156
First Author: Yi Z
Year: 2014
Journal: Nat Immunol
Title: The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Volume: 15
Issue: 9
Pages: 866-74
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Publication
38134932 | J:352422
First Author: Tamari M
Year: 2024
Journal: Cell
Title: Sensory neurons promote immune homeostasis in the lung.
Volume: 187
Issue: 1
Pages: 44-61.e17
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Publication
28890086 | J:247614
First Author: Oetjen LK
Year: 2017
Journal: Cell
Title: Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.
Volume: 171
Issue: 1
Pages: 217-228.e13
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Publication
25161318 | J:260393
First Author: Katz G
Year: 2014
Journal: Sci Signal
Title: T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.
Volume: 7
Issue: 340
Pages: ra83
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Publication
37925520 | J:342430
First Author: Tang Q
Year: 2023
Journal: Nat Commun
Title: Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.
Volume: 14
Issue: 1
Pages: 7099
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Publication
26824662 | J:230644
First Author: Mostafavi S
Year: 2016
Journal: Cell
Title: Parsing the Interferon Transcriptional Network and Its Disease Associations.
Volume: 164
Issue: 3
Pages: 564-78
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Publication
27472900 | J:235436
   
First Author: Sullivan KD
Year: 2016
Journal: Elife
Title: Trisomy 21 consistently activates the interferon response.
Volume: 5
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Publication
35320754 | J:325472
First Author: Xiong J
Year: 2022
Journal: Mol Cell
Title: Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells.
Volume: 82
Issue: 9
Pages: 1660-1677.e10
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Publication
16710296 | J:109574
First Author: Malakhova OA
Year: 2006
Journal: EMBO J
Title: UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
Volume: 25
Issue: 11
Pages: 2358-67
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Publication
26271009 | J:229563
 
First Author: Zhao J
Year: 2015
Journal: Elife
Title: Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification.
Volume: 4
Pages: e06885
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Publication
29666307 | J:284392
 
First Author: Rollings CM
Year: 2018
Journal: Sci Signal
Title: Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs.
Volume: 11
Issue: 526
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Publication
34294846 | J:311003
First Author: Xu G
Year: 2021
Journal: Oncogene
Title: The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis.
Volume: 40
Issue: 36
Pages: 5482-5494
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Publication
27725180 | -
First Author: Zhang D
Year: 2016
Journal: J Mol Biol
Title: Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.
Volume: 428
Issue: 23
Pages: 4651-4668
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Publication
27227461 | -
First Author: McNally R
Year: 2016
Journal: PLoS One
Title: Crystal Structure of the FERM-SH2 Module of Human Jak2.
Volume: 11
Issue: 5
Pages: e0156218
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Publication
28458652 | -
 
First Author: Ferrao R
Year: 2017
Journal: Front Endocrinol (Lausanne)
Title: The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions.
Volume: 8
Pages: 71
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Publication
20484139 | J:169644
First Author: Fukushima A
Year: 2010
Journal: Diabetes
Title: T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis.
Volume: 59
Issue: 8
Pages: 1906-14
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Publication
11016959 | J:65263
First Author: Ozaki K
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.
Volume: 97
Issue: 21
Pages: 11439-44
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Publication
8007943 | J:18883
First Author: Yamamoto K
Year: 1994
Journal: Mol Cell Biol
Title: Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
Volume: 14
Issue: 7
Pages: 4342-9
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Publication
15661890 | J:96417
First Author: Huang Z
Year: 2005
Journal: J Immunol
Title: IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor.
Volume: 174
Issue: 3
Pages: 1332-7
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Publication
28757617 | J:249411
First Author: Hadzijusufovic E
Year: 2017
Journal: Leukemia
Title: Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site.
Volume: 31
Issue: 11
Pages: 2388-2397
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Publication
16397521 | J:106773
First Author: Gallucci RM
Year: 2006
Journal: J Invest Dermatol
Title: IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice.
Volume: 126
Issue: 3
Pages: 561-8
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Publication
34479964 | J:314034
First Author: Yang L
Year: 2021
Journal: Cancer Res
Title: Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness.
Volume: 81
Issue: 22
Pages: 5720-5732
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Publication
30833347 | J:274565
First Author: Banks DA
Year: 2019
Journal: J Immunol
Title: Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival.
Volume: 202
Issue: 8
Pages: 2348-2359
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Publication
38446698 | J:350972
First Author: Keenan C
Year: 2024
Journal: Blood
Title: Differential effects of itacitinib, fedratinib, and ruxolitinib in mouse models of hemophagocytic lymphohistiocytosis.
Volume: 143
Issue: 23
Pages: 2386-2400
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Publication
23359502 | J:193464
First Author: Sa Q
Year: 2013
Journal: J Immunol
Title: IL-2 produced by CD8+ immune T cells can augment their IFN-γ production independently from their proliferation in the secondary response to an intracellular pathogen.
Volume: 190
Issue: 5
Pages: 2199-207
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Publication
15356134 | J:92746
First Author: Fagerlie SR
Year: 2004
Journal: J Immunol
Title: Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice.
Volume: 173
Issue: 6
Pages: 3863-70
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Publication
14617019 | J:109408
First Author: Kato K
Year: 2003
Journal: Br J Haematol
Title: Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth.
Volume: 123
Issue: 3
Pages: 528-35
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Publication
17078933 | J:116659
First Author: Giunta B
Year: 2006
Journal: Brain Res
Title: EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia.
Volume: 1123
Issue: 1
Pages: 216-225
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Publication
15356135 | J:92745
First Author: Kamiya S
Year: 2004
Journal: J Immunol
Title: An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells.
Volume: 173
Issue: 6
Pages: 3871-7
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Publication
26269126 | J:298028
 
First Author: van der Weyden L
Year: 2015
Journal: BMC Cancer
Title: Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.
Volume: 15
Pages: 585
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Publication
25127857 | J:234895
First Author: Tao B
Year: 2014
Journal: J Immunol
Title: Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis.
Volume: 193
Issue: 6
Pages: 2801-11
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Publication
28744013 | J:271342
First Author: Girardi T
Year: 2018
Journal: Leukemia
Title: The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.
Volume: 32
Issue: 3
Pages: 809-819
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Publication
37028703 | J:335451
     
First Author: Okamoto M
Year: 2023
Journal: J Invest Dermatol
Title: The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice.
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Publication
21864028 | J:305930
First Author: Zhang Q
Year: 2011
Journal: J Interferon Cytokine Res
Title: The role of Tyk2 in regulation of breast cancer growth.
Volume: 31
Issue: 9
Pages: 671-7
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Publication
21527517 | J:174904
First Author: Zheng Y
Year: 2011
Journal: Blood
Title: A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway.
Volume: 118
Issue: 1
Pages: 156-66
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Publication
25751817 | J:227930
First Author: Lörchner H
Year: 2015
Journal: Nat Med
Title: Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.
Volume: 21
Issue: 4
Pages: 353-62
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Publication
33836560 | J:303262
 
First Author: Prado J
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways.
Volume: 118
Issue: 11
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Publication
10421845 | J:92739
First Author: Tsujino S
Year: 1999
Journal: Genes Cells
Title: Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor gammac chain in the Jak3-independent signal transduction.
Volume: 4
Issue: 6
Pages: 363-73
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Publication
26500062 | J:297037
First Author: Heltemes-Harris LM
Year: 2016
Journal: Oncogene
Title: Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Volume: 35
Issue: 26
Pages: 3454-64
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Publication
39424784 | J:357796
First Author: He G
Year: 2024
Journal: Cell Death Dis
Title: Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation.
Volume: 15
Issue: 10
Pages: 754
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Publication
37753803 | J:342566
First Author: Salimi A
Year: 2023
Journal: J Cell Mol Med
Title: XBP1 promotes NRAS(G12D) pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS.
Volume: 27
Issue: 21
Pages: 3363-3377
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Publication
29899113 | J:267151
First Author: Arndt L
Year: 2018
Journal: J Biol Chem
Title: Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow-derived macrophages.
Volume: 293
Issue: 29
Pages: 11527-11536
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Publication
35930423 | J:344937
First Author: Feng Y
Year: 2022
Journal: Am J Respir Cell Mol Biol
Title: Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.
Volume: 67
Issue: 5
Pages: 539-549
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Publication
32161097 | J:287105
First Author: McCormack R
Year: 2020
Journal: J Immunol
Title: An Essential Role for Perforin-2 in Type I IFN Signaling.
Volume: 204
Issue: 8
Pages: 2242-2256
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Publication
29180417 | J:254306
First Author: Wei J
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes.
Volume: 114
Issue: 49
Pages: 13000-13005
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Publication
7594533 | J:172922
First Author: Tortolani PJ
Year: 1995
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