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Search results 401 to 500 out of 519 for Kiss1

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Type Details Score
Publication
First Author: Hatef A
Year: 2017
Journal: Biol Reprod
Title: Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes.
Volume: 96
Issue: 3
Pages: 635-651
Publication
First Author: Babwah AV
Year: 2015
Journal: J Neurosci
Title: GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.
Volume: 35
Issue: 37
Pages: 12903-16
Genotype
Symbol: Kiss1r/Kiss1r<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Kiss1r/Kiss1r<+>
Background: involves: 129S4/SvJae
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Kiss1r/Kiss1r Tg(Gnrh1-cre)1Dlc/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kiss1r/Kiss1r Tg(Gnrh1-cre)35Awo/?
Background: involves: 129 * C57BL/6 * CD-1
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Kiss1r/Kiss1r Tg(Gnrh1-cre)1Dlc/? Tg(Gnrh1-Kiss1r)#Aeh/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
HT Experiment
Series Id: GSE12209
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication  
First Author: Mansano NDS
Year: 2023
Journal: Endocrinology
Title: Fasting Modulates GABAergic Synaptic Transmission to Arcuate Kisspeptin Neurons in Female Mice.
Volume: 164
Issue: 11
Publication
First Author: Venancio JC
Year: 2017
Journal: Endocrinology
Title: Short-Term High-Fat Diet Increases Leptin Activation of CART Neurons and Advances Puberty in Female Mice.
Volume: 158
Issue: 11
Pages: 3929-3942
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kiss1r/Kiss1r<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kiss1r/Kiss1r<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
Allele
Name: KiSS-1 metastasis-suppressor; targeted mutation 1.1, Ulrich Boehm
Allele Type: Targeted
Attribute String: Recombinase
Allele
Name: KiSS-1 metastasis-suppressor; targeted mutation 1.1, Martin G Myers, Jr
Allele Type: Targeted
Attribute String: Recombinase
Allele
Name: KiSS-1 metastasis-suppressor; targeted mutation 2, William H Colledge
Allele Type: Targeted
Attribute String: Null/knockout, Recombinase, Reporter
Publication
First Author: Szereszewski JM
Year: 2010
Journal: PLoS One
Title: GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.
Volume: 5
Issue: 9
Pages: e12964
Publication
First Author: Elias CF
Year: 2014
Journal: Am J Physiol Regul Integr Comp Physiol
Title: A critical view of the use of genetic tools to unveil neural circuits: the case of leptin action in reproduction.
Volume: 306
Issue: 1
Pages: R1-9
Publication
First Author: Coutinho EA
Year: 2024
Journal: FASEB J
Title: Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.
Volume: 38
Issue: 19
Pages: e70078
Publication  
First Author: Stephens SBZ
Year: 2021
Journal: Endocrinology
Title: Estrogen Regulation of the Molecular Phenotype and Active Translatome of AVPV Kisspeptin Neurons.
Volume: 162
Issue: 9
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: transgene insertion KG26, Carol F Elias
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant strain, targeted mutation, coisogenic
Genotype
Symbol: Kiss1/Kiss1<+> Nhlh2/Nhlh2
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Tonsfeldt KJ
Year: 2019
Journal: J Endocr Soc
Title: The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge.
Volume: 3
Issue: 4
Pages: 716-733
Publication  
First Author: Hatcher KM
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice.
Volume: 14
Pages: 1093592
Allele
Name: transgene insertion J2-4, Carol F Elias
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: transgenic, coisogenic, mutant strain
Publication  
First Author: McCosh RB
Year: 2024
Journal: J Neurosci
Title: Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice.
Volume: 44
Issue: 34
Genotype
Symbol: Esr1/Esr1 Kiss1/Kiss1<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication  
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
Strain
Attribute String: transgenic, mutant stock
Allele
Name: KiSS-1 metastasis-suppressor; targeted mutation 1.1, Robert A Steiner
Allele Type: Targeted
Attribute String: Null/knockout, Recombinase, Reporter
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kiss1/Kiss1<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Badgandi HB
Year: 2017
Journal: J Cell Biol
Title: Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Volume: 216
Issue: 3
Pages: 743-760
Publication
First Author: Satoh A
Year: 2020
Journal: iScience
Title: CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms.
Volume: 23
Issue: 3
Pages: 100930
Publication  
First Author: Xie C
Year: 2015
Journal: Mol Cell Endocrinol
Title: Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice.
Volume: 411
Pages: 223-31
Publication
First Author: Soundarapandian MM
Year: 2020
Journal: PLoS One
Title: Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.
Volume: 15
Issue: 7
Pages: e0236892
Publication
First Author: DeFazio RA
Year: 2014
Journal: J Neurosci
Title: GABAergic transmission to kisspeptin neurons is differentially regulated by time of day and estradiol in female mice.
Volume: 34
Issue: 49
Pages: 16296-308
Publication
First Author: DeFazio RA
Year: 2019
Journal: J Neurosci
Title: Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents.
Volume: 39
Issue: 48
Pages: 9532-9545
Publication  
First Author: Coutinho EA
Year: 2022
Journal: Endocrinology
Title: Conditional Deletion of KOR (Oprk1) in Kisspeptin Cells Does Not Alter LH Pulses, Puberty, or Fertility in Mice.
Volume: 163
Issue: 12
Strain
Attribute String: targeted mutation, mutant stock
Genotype
Symbol: Kiss1/Kiss1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCr
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Kiss1/Kiss1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kiss1/Kiss1<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Publication  
First Author: Ogaki S
Year: 2011
Journal: BMC Dev Biol
Title: An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.
Volume: 11
Pages: 13
Protein
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
Publication  
First Author: Tschesche H
Year: 1992
Journal: Matrix Suppl
Title: Latent collagenase and gelatinase from human neutrophils and their activation.
Volume: 1
Pages: 245-55
Publication
First Author: Van Lint P
Year: 2007
Journal: J Leukoc Biol
Title: Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation.
Volume: 82
Issue: 6
Pages: 1375-81
Publication
First Author: Bradley LM
Year: 2012
Journal: PLoS Pathog
Title: Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.
Volume: 8
Issue: 4
Pages: e1002641
Publication  
First Author: Ortega N
Year: 2003
Journal: Ann N Y Acad Sci
Title: How proteases regulate bone morphogenesis.
Volume: 995
Pages: 109-16
Publication
First Author: Ben-David D
Year: 2012
Journal: Inflamm Res
Title: The involvement of oxidants and NF-κB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells.
Volume: 61
Issue: 7
Pages: 673-88
Publication
First Author: Alvarez J
Year: 2005
Journal: J Bone Miner Res
Title: Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification.
Volume: 20
Issue: 6
Pages: 1011-21
Publication
First Author: Dziembowska M
Year: 2012
Journal: Int J Biochem Cell Biol
Title: MMP9: a novel function in synaptic plasticity.
Volume: 44
Issue: 5
Pages: 709-13
Publication
First Author: Takino T
Year: 2003
Journal: Oncogene
Title: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.
Volume: 22
Issue: 30
Pages: 4617-26
Protein Domain
Type: Family
Description: Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules []. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains []. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages []. This entry represents matrix metalloproteinase-9 (MMP9, also known as gelatinase B), which is involved in matrix remodelling during the normal processes of embryogenesis, tissue remodelling and development []. It is released extracellularly in a pro-form with the enzymatic site covered by a propeptide that has to be cleaved off to reveal the activity. MMP9 can cleave gelatin types I and V and collagen types IV and V []. It plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration [, ]. MMP9 is one of the key regulators for remodelling skeletal tissues [], and could play a role in bone osteoclastic resorption triggered by inflammatory processes [, ]. MMP9 also has a role in synaptic plasticity []. MMP9 cleaves the metastasis suppressor gene product KiSS1 [].
Publication
First Author: Altarejos JY
Year: 2008
Journal: Nat Med
Title: The Creb1 coactivator Crtc1 is required for energy balance and fertility.
Volume: 14
Issue: 10
Pages: 1112-7
Publication
First Author: Louis GW
Year: 2011
Journal: Endocrinology
Title: Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis.
Volume: 152
Issue: 6
Pages: 2302-10
Publication  
First Author: Talbi R
Year: 2021
Journal: Endocrinology
Title: Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Volume: 162
Issue: 8
Publication
First Author: León S
Year: 2021
Journal: Neuroendocrinology
Title: Tachykinin Signaling Is Required for Induction of the Preovulatory Luteinizing Hormone Surge and Normal Luteinizing Hormone Pulses.
Volume: 111
Issue: 6
Pages: 542-554
Publication
First Author: Simavli S
Year: 2015
Journal: Endocrinology
Title: Substance p regulates puberty onset and fertility in the female mouse.
Volume: 156
Issue: 6
Pages: 2313-22
Publication
First Author: Song A
Year: 2017
Journal: Endocrinology
Title: JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function.
Volume: 158
Issue: 6
Pages: 1798-1811
Publication
First Author: Ojima F
Year: 2016
Journal: J Reprod Dev
Title: Runx3 transcription factor regulates ovarian functions and ovulation in female mice.
Volume: 62
Issue: 5
Pages: 479-486
Publication
First Author: Sokanovic SJ
Year: 2023
Journal: Sci Rep
Title: Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction.
Volume: 13
Issue: 1
Pages: 355
Publication
First Author: Babey ME
Year: 2024
Journal: Nature
Title: A maternal brain hormone that builds bone.
Volume: 632
Issue: 8024
Pages: 357-365
Publication
First Author: Roepke TA
Year: 2017
Journal: Sci Rep
Title: Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice.
Volume: 7
Issue: 1
Pages: 6381
Publication
First Author: Choi I
Year: 2019
Journal: Endocrinology
Title: SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function.
Volume: 160
Issue: 6
Pages: 1547-1560
Publication  
First Author: Stincic TL
Year: 2021
Journal: eNeuro
Title: Arcuate and Preoptic Kisspeptin Neurons Exhibit Differential Projections to Hypothalamic Nuclei and Exert Opposite Postsynaptic Effects on Hypothalamic Paraventricular and Dorsomedial Nuclei in the Female Mouse.
Volume: 8
Issue: 4
Publication  
First Author: Moore AM
Year: 2021
Journal: Endocrinology
Title: Prenatal Androgen Exposure Alters KNDy Neurons and Their Afferent Network in a Model of Polycystic Ovarian Syndrome.
Volume: 162
Issue: 11
Publication  
First Author: Ho EV
Year: 2021
Journal: Endocrinology
Title: Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells.
Volume: 162
Issue: 12
Publication  
First Author: Yip SH
Year: 2021
Journal: Endocrinology
Title: Indirect Suppression of Pulsatile LH Secretion by CRH Neurons in the Female Mouse.
Volume: 162
Issue: 3
Publication  
First Author: Lavalle SN
Year: 2022
Journal: Mol Cell Endocrinol
Title: Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice.
Volume: 546
Pages: 111577
Publication    
First Author: Ross RA
Year: 2018
Journal: Elife
Title: PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse.
Volume: 7
Publication  
First Author: Cassin J
Year: 2023
Journal: JCI Insight
Title: Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms.
Volume: 8
Issue: 3
Publication  
First Author: Mansano NDS
Year: 2022
Journal: Mol Cell Endocrinol
Title: Vasoactive intestinal peptide exerts an excitatory effect on hypothalamic kisspeptin neurons during estrogen negative feedback.
Volume: 542
Pages: 111532
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kiss1/Kiss1<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Kiss1-cre)J2-4Cfe/?
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Tg(Kiss1-cre)J2-4Cfe/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Gill JC
Year: 2012
Journal: Endocrinology
Title: Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1.
Volume: 153
Issue: 10
Pages: 4883-93
Publication
First Author: Cheng XB
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice.
Volume: 305
Issue: 6
Pages: E717-26
Publication
First Author: León S
Year: 2014
Journal: Endocrinology
Title: Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.
Volume: 155
Issue: 8
Pages: 2953-65
Publication  
First Author: Gomes VCL
Year: 2023
Journal: Front Physiol
Title: Sexually dimorphic pubertal development and adipose tissue kisspeptin dysregulation in the obese and preeclamptic-like BPH/5 mouse model offspring.
Volume: 14
Pages: 1070426
Publication  
First Author: Jamieson BB
Year: 2021
Journal: Endocrinology
Title: Estrous Cycle Plasticity in the Central Clock Output to Kisspeptin Neurons: Implications for the Preovulatory Surge.
Volume: 162
Issue: 6
Publication  
First Author: Buo C
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Serotonin stimulates female preoptic area kisspeptin neurons via activation of type 2 serotonin receptors in mice.
Volume: 14
Pages: 1212854
Publication
First Author: Bizzozzero-Hiriart M
Year: 2020
Journal: Am J Physiol Endocrinol Metab
Title: GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
Volume: 318
Issue: 6
Pages: E901-E919
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
Publication  
First Author: Moinho TM
Year: 2022
Journal: J Neurosci Methods
Title: Simple method to induce denaturation of fluorescent proteins in free-floating brain slices.
Volume: 371
Pages: 109500
Publication
First Author: Hernandez-Barrantes S
Year: 2002
Journal: Semin Cancer Biol
Title: Regulation of membrane type-matrix metalloproteinases.
Volume: 12
Issue: 2
Pages: 131-8
Publication
First Author: Somerville RP
Year: 2003
Journal: Genome Biol
Title: Matrix metalloproteinases: old dogs with new tricks.
Volume: 4
Issue: 6
Pages: 216
Publication
First Author: Fenselau H
Year: 2017
Journal: Nat Neurosci
Title: A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH.
Volume: 20
Issue: 1
Pages: 42-51
Publication        
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication
First Author: Martersteck EM
Year: 2017
Journal: Cell Rep
Title: Diverse Central Projection Patterns of Retinal Ganglion Cells.
Volume: 18
Issue: 8
Pages: 2058-2072
Publication
First Author: Wang Q
Year: 2023
Journal: Cell Rep
Title: Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.
Volume: 42
Issue: 2
Pages: 112118